Mutations in Cell Division Cycle Genes CDC36 and CDC39 Activate the Saccharomyces cerevisiae Mating Pheromone Response Pathway

Literature Cited

• Blinder, D., S. Bouvier, and D. D. Jenness. 1989. Constitutive mutants in the yeast pheromone response: ordered function of the gene products. Cell 56:479–486.
   PubMedGoogle Scholar
• Burkholder, A. C., and L. H. Hartwell. 1985. The yeast a-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res. 13:8463–8475.
   PubMed Web of Science ®Google Scholar
• Cherry, J. R., T. R. Johnson, C. Dollard, J. R. Shuster, and C. D. Dennis. 1989. Cyclic AMP-dependent protein kinase phos-phorylates and inactivates the transcriptional activator ADR1. Cell 56:409–419.
   PubMedGoogle Scholar
• Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991–1995.
   PubMed Web of Science ®Google Scholar
• Clark, K. L., and G. F. Sprague, Jr. 1989. Yeast pheromone response pathway: characterization of a suppressor that restores mating to receptorless mutants. Mol. Cell. Biol. 9:2682–2694.
   PubMedGoogle Scholar
• Cole, G. M., D. E. Stone, and S. I. Reed. 1990. Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway. Mol. Cell. Biol. 10:510–517.
   PubMedGoogle Scholar
• Cross, F., L. H. Hartwell, C. Jackson, and J. B. Konopka. 1988. Conjugation in Saccharomyces cerevisiae. Annu. Rev. Cell Biol. 4:429–457.
   PubMedGoogle Scholar
• Dietzel, C., and J. Kurjan. 1987. The yeast SCG1 gene: a Gα-like protein implicated in the a- and a-factor response pathway. Cell 50:1001–1010.
   PubMedGoogle Scholar
• Dolan, J. W., C. Kirkman, and S. Fields. 1989. The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc. Natl. Acad. Sci. USA 86:5703–5707.
   PubMedGoogle Scholar
• Errede, B., and G. Ammerer. 1989. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1349–1361.
   PubMed Web of Science ®Google Scholar
• Gilman, A. G. 1984. G proteins and dual control of adenylate cyclase. Cell 36:577–579.
   PubMed Web of Science ®Google Scholar
• Hagen, D. C., G. McCaffrey, and G. F. Sprague, Jr. 1986. Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc. Natl. Acad. Sci. USA 83:1418–1422.
   PubMed Web of Science ®Google Scholar
• Hartwell, L. 1980. Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J. Cell Biol. 85:811–822.
   PubMed Web of Science ®Google Scholar
• Itoh, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163–168.
   PubMed Web of Science ®Google Scholar
• Jahng, K.-Y., J. Ferguson, and S. I. Reed. 1988. Mutations in a gene encoding the a subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling. Mol. Cell. Biol. 8:2484–2493.
   PubMedGoogle Scholar
• Jenness, D. D., B. S. Goldman, and L. H. Hartwell. 1987. Saccharomyces cerevisiae mutants unresponsive to α-factor pheromone: a-factor binding and extragenic suppression. Mol. Cell. Biol. 7:1311–1319.
   PubMedGoogle Scholar
• Kurjan, J. 1985. a-Factor structural gene mutations in Saccharomyces cerevisiae: effects on α-factor production and mating. Mol. Cell. Biol. 5:787–796.
   PubMed Web of Science ®Google Scholar
• Levi, J. D. 1956. Mating reaction in yeast. Nature (London) 177:753–754.
   PubMed Web of Science ®Google Scholar
• MacKay, V., and T. R. Manney. 1974. Mutations affecting sexual conjugation and related processes in Saccharomyces cerevisiae. II. Genetic analysis of nonmating mutants. Genetics 76:272–288.
   Google Scholar
• Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• McCaffrey, G., F. Clay, K. Kelsay, and G. F. Sprague, Jr. 1987. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7:2680–2690.
   PubMedGoogle Scholar
• McCormick, F. 1989. ras ATPase activating protein: signal transmitter and signal terminator. Cell 56:5–8.
   PubMed Web of Science ®Google Scholar
• Michaelis, S., and I. Herskowitz. 1988. The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol. Cell. Biol. 8:1309–1318.
   PubMed Web of Science ®Google Scholar
• Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Miyajima, I., M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K.-I. Arai, Y. Kaziro, and K. Matsumoto. 1987. GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G. Cell 50:1011–1019.
   PubMed Web of Science ®Google Scholar
• Nakafuku, M., H. Itoh, S. Nakamura, and Y. Kaziro. 1987. Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the a subunit of mammalian G proteins. Proc. Natl. Acad. Sci. USA 84:2140–2144.
   PubMedGoogle Scholar
• Nakafuku, M., T. Ohara, K. Kaibuchi, I. Miyajima, A. Miyajima, H. Itoh, S. Nakamura, K. Arai, K. Matsumoto, and Y. Kaziro. 1988. Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory proteins: studies on its structure and possible functions. Proc. Natl. Acad. Sci. USA 85:1374–1378.
   PubMed Web of Science ®Google Scholar
• Nakayama, N., K.-I. Arai, and K. Matsumoto. 1988. Role of SGP2, a suppressor of a gpa1 mutation, in the mating-factor signaling pathway of Saccharomyces cerevisiae. Mol. Cell. Biol. 8:5410–5416.
   PubMedGoogle Scholar
• Nakayama, N., Y. Kaziro, K.-I. Arai, and K. Matsumoto. 1988. Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae. Mol. Cell. Biol. 8:3777–3783.
   PubMedGoogle Scholar
• Nakayama, N., A. Miyajima, and K. Arai. 1985. Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J. 4:2643–2648.
   PubMed Web of Science ®Google Scholar
• Peterson, T. A., J. Yochem, B. Byers, M. F. Nunn, P. H. Duesberg, R. F. Doolittle, and S. I. Reed. 1984. A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26. Nature (London) 309:556–558.
   PubMed Web of Science ®Google Scholar
• Reed, S. I. 1980. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95:561–577.
   PubMed Web of Science ®Google Scholar
• Reed, S. I., J. Ferguson, and J. C. Groppe. 1982. Preliminary characterization of the transcriptional and translational products of the Saccharomyces cerevisiae cell division cycle gene CDC28. Mol. Cell. Biol. 2:412–425.
   PubMedGoogle Scholar
• Reed, S. I., J. Ferguson, and K.-Y. Jahng. 1988. Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Cold Spring Harbor Symp. Quant. Biol. 53:621–627.
   PubMedGoogle Scholar
• Reed, S. I., J. A. Hadwiger, and A. T. Lorincz. 1985. Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc. Natl. Acad. Sci. USA 82:4055–4059.
   PubMed Web of Science ®Google Scholar
• Reid, B. J., and L. H. Hartwell. 1977. Regulation of mating in the cell cycle of Saccharomyces cerevisiae. J. Cell Biol. 75:355–365.
   PubMedGoogle Scholar
• Rothstein, R. J. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202–211.
   PubMed Web of Science ®Google Scholar
• Sherman, F., G. Fink, and J. B. Hicks. 1982. Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Shuster, J. R. 1982. 'Start' mutants of Saccharomyces cerevisiae are suppressed in carbon catabolite-derepressing medium. J. Bacteriol. 151:1059–1061.
   PubMedGoogle Scholar
• Shuster, J. R. 1982. Mating-defective ste mutations are suppressed by cell division cycle start mutations in Saccharomyces cerevisiae. Mol. Cell. Biol. 2:1052–1063.
   PubMed Web of Science ®Google Scholar
• Sprague, G. F., Jr., L. C. Blair, and J. Thorner. 1983. Cell interactions and regulation of cell type in the yeast Saccharomyces cerevisiae. Annu. Rev. Microbiol. 37:623–660.
   PubMed Web of Science ®Google Scholar
• Stetler, G. L., and J. Thorner. 1984. Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 81:1144–1148.
   PubMedGoogle Scholar
• Stryer, L., and H. R. Bourne. 1986. G proteins: a family of signal transducers. Annu. Rev. Cell Biol. 2:391–419.
   PubMedGoogle Scholar
• Teague, M. A., D. T. Chaleff, and B. Errede. 1986. Nucleotide sequence of the yeast regulator gene STE7 predicts a protein homologous to protein kinases. Proc. Natl. Acad. Sci. USA 83:7371–7375.
   PubMedGoogle Scholar
• Toda, T., S. Camerson, P. Sass, M. Zoller, and R. M. Wigler. 1987. Three different genes in S. cerevisiae encode the catalytic subunit of the cAMP-dependent protein kinase. Cell 50:277–287.
   PubMed Web of Science ®Google Scholar
• Trahey, M., and F. McCormick. 1987. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542–545.
   PubMed Web of Science ®Google Scholar
• Trueheart, J., J. D. Boeke, and G. R. Fink. 1987. Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein. Mol. Cell. Biol. 7:2316–1328.
   PubMedGoogle Scholar
• Van Arsdell, S. W., G. L. Stetler, and J. Thorner. 1987. The yeast repeated element sigma contains a hormone-inducible promoter. Mol. Cell. Biol. 7:749–759.
   PubMedGoogle Scholar
• Whiteway, M., L. Hougan, D. Dignard, D. Y. Thomas, L. Bell, G. C. Saari, F. J. Grant, P. O'Hara and V. L. MacKay. 1989. The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein. Cell 56:467–477.
   PubMed Web of Science ®Google Scholar
• Whiteway, M., L. Hougan, and D. Y. Thomas. 1990. Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae. Mol. Cell. Biol. 10:217–222.
   PubMedGoogle Scholar