Complex Regulation of the Immunoglobulin μ Heavy-Chain Gene Enhancer: μB, a New Determinant of Enhancer Function

Literature Cited

• Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter, and R. L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (London) 318:533–538.
   PubMed Web of Science ®Google Scholar
• Alt, F. W., T. K. Blackwell, R. A. Despinho, M. G. Reth, and G. D. Yancopoulos. 1986. Regulation of genome rearrangement events during lymphocyte differentiation. Immunol. Rev. 89:5–30.
   PubMed Web of Science ®Google Scholar
• Alt, F. W., N. Rosenberg, V. Enea, E. Siden, and D. Baltimore. 1982. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol. Cell. Biol. 2:386–400.
   PubMed Web of Science ®Google Scholar
• Alt, F. W., N. Rosenberg, S. Lewis, E. Thomas, and D. Baltimore. 1981. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27:381–390.
   PubMed Web of Science ®Google Scholar
• Araki, K., H. Maeda, J. Wang, P. Kitamura, and T. Watanabe. 1988. Purification of a nuclear trans-acting factor involved in the regulated transcription of a human immunoglobulin heavy chain gene. Cell 53:723–730.
   PubMedGoogle Scholar
• Augereau, P., and P. Chambon. 1986. The mouse immunoglobulin heavy-chain enhancer: effect on transcription in vitro and binding of proteins present in HeLa and lymphoid B cell extracts. EMBO J. 5:1791–1797.
   PubMed Web of Science ®Google Scholar
• Banerji, J., L. Olson, and W. Schaffner. 1983. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 33:729–740.
   PubMed Web of Science ®Google Scholar
• Born, W., J. White, J. Kappler, and P. Marrack. 1988. Rearrangement of IgH genes in normal thymocyte development. J. Immunol. 140:3228–3232.
   PubMedGoogle Scholar
• Brombacher, F., M. C. Larners, G. Kohler, and H. E. Eibel. 1989. Elimination of CD8+ thymocytes in transgenic mice expressing an anti-Ly+2.2 immunoglobulin heavy chain gene. EMBO J. 8:3719–3726.
   PubMedGoogle Scholar
• Dignam, J. D., R. M. LeBowitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
   PubMed Web of Science ®Google Scholar
• Ephrussi, A., G. M. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with factors in vitro. Science 227:134–140.
   PubMed Web of Science ®Google Scholar
• Fletcher, C., N. Heintz, and R. G. Roeder. 1989. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51:773–781.
   Google Scholar
• Gerster, T., P. Matthias, M. Thali, J. Jiricny, and W. Schaffner. 1987. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J. 6:1323–1330.
   PubMed Web of Science ®Google Scholar
• Gillies, S. D., S. Morrison, V. Oi, and S. Tonegawa. 1983. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 33:717–728.
   PubMed Web of Science ®Google Scholar
• Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol. 6:4305–4316.
   PubMed Web of Science ®Google Scholar
• Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
   PubMed Web of Science ®Google Scholar
• Graham, F. L., and A. J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467.
   PubMed Web of Science ®Google Scholar
• Griffith, I. J., N. Nabairi, S. Ghogawala, C. G. Chase, M. Rodriguez, D. J. McKean, and L. H. Glimcher. 1988. Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules. J. Exp. Med. 167:541–555.
   PubMedGoogle Scholar
• Grosschedl, R., and D. Baltimore. 1985. Cell type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 41:885–897.
   PubMed Web of Science ®Google Scholar
• Grosschedl, R., D. Weaver, D. Baltimore, and F. Constantini. 1984. Introduction of a μ immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38:647–658.
   PubMed Web of Science ®Google Scholar
• Kadesch, T., P. Zervos, and D. Ruezinsky. 1986. Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity. Nucleic Acids Res. 14:8209–8221.
   PubMed Web of Science ®Google Scholar
• Kelley, D. E., B. A. Pollok, M. L. Atchison, and R. P. Perry. 1988. The coupling between enhancer activity and hypomethylation of κ immunoglobulin genes is developmentally regulated. Mol. Cell. Biol. 8:930–937.
   PubMedGoogle Scholar
• Kemp, D. J., A. W. Harris, S. Corey, and J. M. Adams. 1980. Expression of the immunoglobulin Cμ gene in mouse T and B lymphoid and myeloid cell lines. Proc. Natl. Acad. Sci. USA 77:2876–2880.
   PubMedGoogle Scholar
• Kiledjian, M., L.-K. Su, and T. Kadesch. 1988. Identification and characterization of two functional domains within the murine heavy-chain enhancer. Mol. Cell. Biol. 8:145–152.
   PubMedGoogle Scholar
• Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
   PubMed Web of Science ®Google Scholar
• Kurosawa, Y., H. VonBoehmer, W. Haas, H. Sakano, A. Traunecker, and S. Tonegawa. 1981. Identification of D segments of immunoglobulin heavy chain genes and their rearrangement in T lymphocytes. Nature (London) 290:565–570.
   PubMed Web of Science ®Google Scholar
• Landoffi, N. F., J. D. Capra, and P. W. Tucker. 1986. Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (London) 323:548–551.
   PubMedGoogle Scholar
• Langdon, W. Y., A. W. Harris, S. Cory, and J. Adams. 1986. The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice. Cell 47:11–18.
   PubMed Web of Science ®Google Scholar
• Lee, W., P. Mitchell, and R. Tjian. 1987. Purified transcription factor AP 1 interacts with TPA-inducible enhancer elements. Cell 49:741–752.
   PubMed Web of Science ®Google Scholar
• Lenardo, M., J. W. Pierce, and D. Baltimore. 1987. Proteinbinding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573–1577.
   PubMed Web of Science ®Google Scholar
• Lennon, G. G., and R. P. Perry. 1985. Cμ containing transcripts initiate heterogeneously within the IgH enhancer region and a novel 5′-nontranslatable exon. Nature (London) 318:475–477.
   PubMed Web of Science ®Google Scholar
• Lewis, S., N. Rosenberg, F. Alt, and D. Baltimore. 1982. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell 30:807–816.
   PubMed Web of Science ®Google Scholar
• Libermann, T. A., M. Lenardo, and D. Baltimore. 1990. Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression. Mol. Cell. Biol. 10:3155–3162.
   PubMedGoogle Scholar
• Mason, J. O., G. T. Williams, and M. S. Neuberger. 1985. Transcriptional cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence. Cell 41:479–487.
   PubMed Web of Science ®Google Scholar
• Nelsen, B., L. Heilman, and R. Sen. 1988. The NF-κB-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells. Mol. Cell. Biol. 8:3526–3531.
   PubMedGoogle Scholar
• O'Neill, E. A., C. Fletcher, C. R. Burrow, N. Heintz, R. G. Roeder, and T. J. Kelly. 1988. Transcription factor OTF-1 is functionally identical to the DNA replication factor NF-III. Science 241:1210–1213.
   PubMedGoogle Scholar
• Perez-Mutul, J., M. Macchi, and B. Waslyk. 1988. Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation. Nucleic Acids Res. 16:6085–6096.
   PubMed Web of Science ®Google Scholar
• Peterson, C. L., and K. L. Calame. 1987. Complex protein binding within the mouse immunoglobulin heavy-chain enhancer. Mol. Cell. Biol. 7:4194–4203.
   PubMedGoogle Scholar
• Peterson, C. L., S. Eaton, and K. Calame. 1988. Purified μEBP-E binds to immunoglobulin enhancers and promoters. Mol. Cell. Biol. 8:4972–4980.
   PubMedGoogle Scholar
• Peterson, C. L., K. Orth, and K. L. Calame. 1986. Binding in vitro of multiple cellular proteins to immunoglobulin heavy-chain enhancer DNA. Mol. Cell. Biol. 6:4168–4178.
   PubMed Web of Science ®Google Scholar
• Reik, W., G. Williams, S. Barton, M. Norris, M. Neuberger, and M. A. Surani. 1987. Provision of the immunoglobulin heavy chain enhancer downstream of a test gene is sufficient to confer lymphoid-specific expression in transgenic mice. Eur. J. Immunol. 17:465–469.
   PubMedGoogle Scholar
• Scheidereit, C., A. Heguy, and R. Roeder. 1987. Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro. Cell 51:783–793.
   PubMed Web of Science ®Google Scholar
• Schlokat, U., D. Bohmann, H. Schöler, and P. Gruss. 1986. Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements. EMBO J. 5:3251–3258.
   PubMed Web of Science ®Google Scholar
• Schmidt, E. V., P. K. Pattengale, L. Weir, and P. Leder. 1988. Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model. Proc. Natl. Acad. Sci. USA 85:6047–6051.
   PubMed Web of Science ®Google Scholar
• Scholer, H. R., and P. Gruss. 1985. Cell type-specific transcriptional enhancement in vitro requires the presence of trans-acting factors. EMBO J. 4:3005–3013.
   PubMed Web of Science ®Google Scholar
• Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716.
   PubMed Web of Science ®Google Scholar
• Singh, H., R. Sen, D. Baltimore, and P. A. Sharp. 1986. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (London) 319:154–158.
   PubMed Web of Science ®Google Scholar
• Sive, H. L., and R. G. Roeder. 1986. Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulins, and U2 small nuclear (snRNA) genes. Proc. Natl. Acad. Sci. USA 83:6382–6386.
   PubMed Web of Science ®Google Scholar
• Staudt, L. M., R. G. Clerc, H. Singh, J. H. LeBowitz, P. A. Sharp, and D. Baltimore. 1988. Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. Science 241:577–580.
   PubMed Web of Science ®Google Scholar
• Staudt, L. M., H. Singh, R. Sen, T. Wirth, P. A. Sharp, and D. Baltimore. 1986. A lymphoid-specific protein binding to the octamer motif in immunoglobulin genes. Nature (London) 323:640–643.
   PubMed Web of Science ®Google Scholar
• Storb, U., C. Pinkert, B. Arp, P. Engler, K. Gollahon, J. Manoz, W. Brady, and R. L. Brinster. 1986. Transgenic mice with μ and κ genes encoding anti-phosphorylcholine antibodies. J. Exp. Med. 164:627–641.
   PubMedGoogle Scholar
• Sturm, R., T. Baumraker, B. R. Franza, Jr., and W. Herr. 1987. A 100-kd HeLa cell octamer binding protein (OBP/100) interacts differently with two separate octamer-related sequences within the SV40 enhancer. Genes Dev. 1:1147–1160.
   PubMedGoogle Scholar
• Tsao, B. P., X. Wang, C. L. Peterson, and K. Calame. 1988. In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer. Nucleic Acids Res. 16:3239–3253.
   PubMedGoogle Scholar
• Weinberger, J., D. Baltimore, and P. Sharp. 1986. Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer. Nature (London) 322:846–848.
   PubMed Web of Science ®Google Scholar
• Winoto, A., and D. Baltimore. 1989. A novel, inducible and T cell-specific enhancer located at the 3′ end of the T cell receptor and locus. EMBO J. 8:729–733.
   PubMed Web of Science ®Google Scholar
• Winter, J. N., S. Variakiojis, and A. L. Epstein. 1984. Phenotypic analysis of established diffuse histocytic lymphoma cell lines utilizing monoclonal-antibodies and cytochemical techniques. Blood 63:140–146.
   PubMedGoogle Scholar
• Yancopoulos, G. D., and F. W. Alt. 1985. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell 40:271–281.
   PubMed Web of Science ®Google Scholar
• Yon, J., and M. Fried. 1989. Precise gene fusion by PCR. Nucleic Acids Res. 17:4895.
   PubMed Web of Science ®Google Scholar