A Single Amino Acid Change in CUP2 Alters Its Mode of DNA Binding

Literature Cited

• Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
   PubMed Web of Science ®Google Scholar
• Beato, M. 1989. Gene regulation by steroid hormones. Cell 56:335-344.
   PubMed Web of Science ®Google Scholar
• Berg, J. M. 1989. DNA binding specificity of steroid hormone receptors. Cell 57:1065-1068.
   PubMedGoogle Scholar
• Buchman, C., P. Skroch, J. Welch, S. Fogel, and M. Karin. 1989. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol. Cell. Biol. 9:4091-4095.
   PubMedGoogle Scholar
• Culotta, V. C., T. Hsu, S. Hu, P. Furst, and D. Hamer. 1989. Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract. Proc. Natl. Acad. Sci. USA 86:8377-8381.
   PubMedGoogle Scholar
• Danielson, M., L. Hinck, and G. M. Ringold. 1989. Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor. Cell 57:1131-1138.
   PubMed Web of Science ®Google Scholar
• Dinter, N., R. Chiu, M. Imagawa, M. Karin, and K. A. Jones. 1987. In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. EMBO J. 6:4067-4071.
   PubMedGoogle Scholar
• Evans, R. M., and S. M. Hollenberg. 1988. Zinc fingers: gilt by association. Cell 52:1-3.
   PubMed Web of Science ®Google Scholar
• Fried, M., and A. D. Crothers. 1981. Equilibrium and kinetics of lac repressor-operator interaction by polyacrylamide gel electrophoresis. Nucleic Acids Res. 9:6505-6525.
   PubMed Web of Science ®Google Scholar
• Furst, P., and D. Hamer. 1989. Cooperative activation of a eukaryotic transcription factor: interaction between Cu(I) and yeast ACE1 protein. Proc. Natl. Acad. Sci. USA 86:5267-5271.
   PubMedGoogle Scholar
• Furst, P., S. Hu, R. Hackett, and D. Hamer. 1988. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55:705-717.
   PubMed Web of Science ®Google Scholar
• Galas, D. J., and A. Schmitz. 1978. DNase footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res. 5:3157-3170.
   PubMed Web of Science ®Google Scholar
• Garner, M., and A. Rezvin. 1981. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the E. coli lactose regulatory system. Nucleic Acids Res. 9:3047-3060.
   PubMed Web of Science ®Google Scholar
• Gibson, T. J., J. P. M. Potsma, R. S. Brown, and P. Argos. 1988. A model for the tertiary structure of the 28-residue DNA-binding motif (zinc finger) common to many eukaryotic transcription regulatory proteins. Protein Eng. 2:209-218.
   PubMedGoogle Scholar
• Gill, G., and M. Ptashne. 1988. Negative effect of the transcriptional activator GAL4. Nature (London) 334:721-724.
   PubMed Web of Science ®Google Scholar
• Hollenberg, S. M., and R. M. Evans. 1988. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell 55:899-906.
   PubMed Web of Science ®Google Scholar
• Hope, Ι. Α., and K. Struhl. 1986. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46:885-894.
   PubMed Web of Science ®Google Scholar
• Huibregtse, J. M., D. R. Engelke, and D. J. Thiele. 1989. Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences. Proc. Natl. Acad. Sci. USA 86:65-69.
   PubMedGoogle Scholar
• Karin, M., R. Najarian, A. Haslinger, J. Welch, P. Valenzuela, and S. Fogel. 1984. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc. Natl. Acad. Sci. USA 81:337-341.
   PubMed Web of Science ®Google Scholar
• Kim, K. S., and L. Guarente. 1989. Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator ΗAP1. Nature (London) 342:200-203.
   PubMedGoogle Scholar
• Klug, Α., and D. Rhodes. 1987. Zinc fingers: a novel protein motif for nucleic acid recognition. Trends Biochem. Sci. 12:464-469.
   Web of Science ®Google Scholar
• Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
   PubMed Web of Science ®Google Scholar
• Lee, M. S., G. P. Gippert, K. V. Soman, D. A. Case, and P. E. Wright. 1989. Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science 245:635-637.
   PubMed Web of Science ®Google Scholar
• Marder, S., V. Kumar, H. de Verneuil, and P. Chambon. 1989. Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid responsive element. Nature (London) 338:271-274.
   PubMedGoogle Scholar
• McCormick, Α., D. Wu, J. L. Castrillo, S. Dana, J. Strobl, Ε. Β. Thompson, and M. Karin. 1988. Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell 55:379-389.
   PubMed Web of Science ®Google Scholar
• Miller, J., A. D. McLachlan, and A. Klug. 1985. Repetitive zinc-binding domain in the protein transcription factor ΠΙΑ from Xenopus oocytes. EMBO J. 4:1609-1614.
   PubMed Web of Science ®Google Scholar
• Pabo, C. O., and R. T. Sauer. 1984. Protein-DNA recognition. Annu. Rev. Biochem. 53:293-321.
   PubMed Web of Science ®Google Scholar
• Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature (London) 335:683-689.
   PubMed Web of Science ®Google Scholar
• Rhodes, D., and A. Klug. 1986. An underlying repeat in some transcriptional control sequences corresponding to half a double helical turn of DNA. Cell 46:123-132.
   PubMed Web of Science ®Google Scholar
• Sakonju, S., D. F. Bogenhagen, and Β. Β. Brown. 1980. A control region in the center of the 5S RNA gene directs specific initiation of transcription. I. The 5′ border of the region. Cell 19:13-25.
   PubMed Web of Science ®Google Scholar
• Severnne, Y., S. Wieland, W. Schaffner, and S. Rusconi. 1988. Metal binding "finger" structures in the glucocorticoid receptor defined by site-directed mutagenesis. EMBO J. 7:2503-2508.
   PubMedGoogle Scholar
• Siebenlist, U., and W. Gilbert. 1980. Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7. Proc. Natl. Acad. Sci. USA 77:122-126.
   PubMed Web of Science ®Google Scholar
• Slater, E. P., O. Rabenau, M. Karin, J. D. Baxter, and M. Beato. 1985. Glucocorticoid receptor binding and activation of a heterologous promoter by the first intron of the human growth hormone gene. Mol. Cell. Biol. 5:2984-2992.
   PubMed Web of Science ®Google Scholar
• Sorger, P. K., and H. R. B. Pelham. 1988. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54:855-864.
   PubMed Web of Science ®Google Scholar
• Szczypka, M. S., and D. J. Thiele. 1989. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. Mol. Cell. Biol. 9:421-429.
   PubMedGoogle Scholar
• Thiele, D. J. 1988. ACE1 regulates expression of the Saccharo-tnyces cerevisiae metallothionein gene. Mol. Cell. Biol. 8:2745-2752.
   PubMed Web of Science ®Google Scholar
• Tsai, S. Y., M. J. Tsai, and B. W. O’Malley. 1989. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Cell 57:443-448.
   PubMedGoogle Scholar
• Tullius, T. D., and B. A. Dombroski. 1985. Iron (II) EDTA used to measure the helical twist along any DNA molecule. Science 230:679-681.
   PubMed Web of Science ®Google Scholar
• Tullius, T. D., and B. A. Dombroski. 1986. Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to repressor and cro protein. Proc. Natl. Acad. Sci. USA 83:5469-5473.
   PubMed Web of Science ®Google Scholar
• Unesono, K., and R. M. Evans. 1989. Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146.
   PubMedGoogle Scholar
• Vrana, K. E., M. E. A. Churchill, T. D. Tullius, and D. D. Brown. 1988. Mapping functional regions of transcription factor IIIA. Mol. Cell. Biol. 8:1684-1696.
   PubMed Web of Science ®Google Scholar
• Welch, J., S. Fogel, C. Buchman, and M. Karin. 1989. The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J. 8:255-260.
   PubMed Web of Science ®Google Scholar
• Wolffe, Α., P. E. Jordan, and D. D. Brown. 1986. A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without displacing it. Cell 44:381-389.
   PubMedGoogle Scholar