Mechanism of Endogenous myc Gene Down-Regulation in Eμ-N-myc Tumors

References

• Adams, J. M., A. W. Harris, C. A. Pinkert, L. M. Corcoran, W. S. Alexander, S. Cory, R. D. Palmiter, and R. L. Brinster. 1985. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (London) 318:533–538.
   PubMed Web of Science ®Google Scholar
• Alexander, W. S., J. M. Adams, and S. Cory. 1989. Oncogene cooperation in lymphocyte transformation: malignant conversion of Eμ-myc transgenic pre-B cells in vitro is enhanced by v-H-ra. or v-ra. but not v-abl. Mol. Cell. Biol. 9:67–73.
   Google Scholar
• Alt, F. W., R. DePinho, K. Zimmerman, E. Legouy, K. Hatton, P. Ferrier, A. Tesfaye, G. Yancopoulos, and P. Nisen. 1986. The human myc gene family. Cold Spring Harbor Symp. Quant. Biol. 51:931–941.
   PubMedGoogle Scholar
• Bentley, D. L., and M. Groudine. 1986. Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. Mol. Cell. Biol. 6:3481–3489.
   PubMedGoogle Scholar
• Bernards, R., S. K. Dessain, and R. A. Weinberg. 1986. N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell 47:667–674.
   PubMed Web of Science ®Google Scholar
• Biggin, M., P. Farrell, and B. Barrell. 1984. Transcription and DNA sequence of the BamH1 L fragment of B95-8 Epstein-Barr virus. EMBO J. 3:1083–1090.
   PubMed Web of Science ®Google Scholar
• Cleveland, J., M. Huleihel, P. Bressler, U. Siebenlist, L. Akiyama, R. M. Eisenman, and U. R. Rapp. 1988. Negative regulation of c-myc transcription involves myc family proteins. Oncogene Res. 3:357–375.
   PubMedGoogle Scholar
• Cole, M. 1986. The myc oncogene: its role in transformation and differentiation. Annu. Rev. Genet. 20:361–384.
   PubMed Web of Science ®Google Scholar
• Coppola, J. A., and M. D. Cole. 1986. Constitutive c-myc oncogene expression blocks mouse erythroleukemia cell differentiation but not commitment. Nature (London) 320:760–763.
   PubMed Web of Science ®Google Scholar
• Dildrop, R., A. Ma, K. Zimmerman, E. Hsu, A. Tesfaye, R. DePinho, and F. W. Alt. 1989. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J. 8:1121–1128.
   PubMed Web of Science ®Google Scholar
• Eick, D., and G. W. Bornkamm. 1989. Expression of normal and translocated c-myc alleles in Burkitt’s lymphoma cells: evidence for different regulation. EMBO J. 8:1965–1972.
   PubMedGoogle Scholar
• Fahrlander, P. D., M. Piechaczyk, and K. B. Marcu. 1985. Chromatin structure of the murine c-myc locus: implications for the regulation of normal and chromosomally translocated genes. EMBO J. 4:3195–3202.
   PubMedGoogle Scholar
• Kakkis, E., J. Prehn, and K. Calame. 1986. An active chromatin structure acquired by translocated c-myc genes. Mol. Cell. Biol. 6:1357–1361.
   PubMedGoogle Scholar
• Keath, E. J., P. G. Caimi, and M. D. Cole. 1984. Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals. Cell 39:339–348.
   PubMed Web of Science ®Google Scholar
• Kelekar, A., and M. D. Cole. 1987. Immortalization by c-myc. H-ra., and E1. oncogenes induces differential cellular gene expression and growth factor responses. Mol. Cell. Biol. 7:3899–3907.
   PubMed Web of Science ®Google Scholar
• Kohl, N. E., E. Legouy, R. A. DePinho, P. D. Nisen, R. K. Smith, C. E. Gee, and F. W. Alt. 1986. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature (London) 319:73–77.
   PubMedGoogle Scholar
• Lacy, J., W. P. Summers, and W. C. Summers. 1989. Post- transcriptional mechanisms of deregulation of myc following conversion of a human B cell line by Epstein-Barr virus. EMBO J. 8:1973–1980.
   PubMed Web of Science ®Google Scholar
• Leder, P., J. Battey, G. Lenoir, C. Moulding, W. Murphy, H. Potter, T. Stewart, and R. Taub. 1983. Translocations among antibody genes in human cancer. Science 222:765–771.
   PubMed Web of Science ®Google Scholar
• Mango, S. E., G. D. Schuler, M. E. R. Steele, and M. D. Cole. 1989. Germ line c-myc is not down-regulated by loss or exclusion of activating factors in myc-induced macrophage tumors. Mol. Cell. Biol. 9:3482–3490.
   PubMedGoogle Scholar
• Nau, M. M., B. J. Brooks, J. Battey, E. Sausville, A. F. Gazdar, I. R. Kirsch, O. W. McBride, V. Bertness, G. F. Hollis, and J. D. Minna. 1985. L-myc. a new myc-related gene amplified and expressed in human small cell lung cancer. Nature (London) 318:69–73.
   PubMed Web of Science ®Google Scholar
• Nisen, P. D., K. A. Zimmerman, S. V. Cotter, F. Gilbert, and F. W. Alt. 1986. Enhanced expression of the N-myc gene in Wilms’ tumors. Cancer Res. 46:6217–6222.
   PubMed Web of Science ®Google Scholar
• Penn, L. J. Z., M. W. Brooks, E. M. Laufer, and H. Land. 1990. Negative autoregulation of c-myc transcription. EMBO J. 9:1113–1121.
   PubMed Web of Science ®Google Scholar
• Rapp, U., J. Cleveland, K. Brightman, A. Scott, and J. Ihle. 1985. Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature (London) 317:434–438.
   PubMed Web of Science ®Google Scholar
• Richman, A., and A. Hayday. 1989. Normal expression of a rearranged and mutated c-myc oncogene after transfection into fibroblasts. Science 246:494–497.
   PubMedGoogle Scholar
• Rosenbaum, H., E. Webb, J. M. Adams, S. Cory, and A. W. Harris. 1989. N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J. 8:749–755.
   PubMed Web of Science ®Google Scholar
• Rosenberg, N., and D. Baltimore. 1976. A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J. Exp. Med. 143:1453–1463.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, N., and F. Melchers. 1986. X-5, a new light-chain- related locus selectively expressed in pre-B lymphocytes. Nature (London) 324:579–582.
   PubMedGoogle Scholar
• Stanton, L. W., R. Watt, and K. B. Marcu. 1983. Translocation breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (London) 303:401–406.
   PubMed Web of Science ®Google Scholar
• Stone, J., T. de Lange, G. Ramsay, E. Jakobovits, J. M. Bishop, H. Varmus, and W. Lee. 1987. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol. Cell. Biol. 7:1697–1709.
   PubMed Web of Science ®Google Scholar
• Zimmerman, K., G. Yancopoulos, R. Collum, R. Smith, N. Kohl, K. Denis, M. Nau, O. Witte, D. Toran-Allerand, C. Gee, J. Minna, and F. W. Alt. 1986. Differential expression of myc family genes during murine development. Nature (London) 319:780–783.
   PubMed Web of Science ®Google Scholar
• Zimmerman, K., and F. W. Alt. 1990. Expression and function of myc genes. Crit. Rev. Oncogenes 2:75–95.
   PubMedGoogle Scholar