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Transcriptional Regulation

A Position-Dependent Silencer Plays a Major Role in Repressing α-Fetoprotein Expression in Human Hepatoma

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Pages 5885-5893 | Received 15 May 1991, Accepted 06 Sep 1991, Published online: 31 Mar 2023

REFERENCES

  • Abelev, G. I. 1971. Alpha-fetoprotein in ontogenesis and its association with malignant tumors. Adv. Cancer Res. 14:295-355.
  • Baniahmad, Α., Μ. Muller, and R. Renkawitz. 1987. Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements? EMBO J. 6:2297-2303.
  • Bodner, M., and M. Karin. 1987. A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell 50:267-275.
  • Camper, S. Α., R. Godbout, and S. M. Tilghman. 1989. The developmental regulation of albumin and α-fetoprotein gene expression. Prog. Nucleic Acid Res. Mol. Biol. 36:131-144.
  • Camper, S. Α., and S. M. Tilghman. 1989. Postnatal repression of the α-fetoprotein gene is enhancer independent. Genes Dev. 3:537-546.
  • Cao, S. X., P. D. Gutman, H. P. G. Dave, and A. N. Schechter. 1989. Identification of a transcriptional silencer in the 5′-flanking region of the human ε-globin gene. Proc. Natl. Acad. Sci. USA 86:5306-5309.
  • Cereghini, S., M. Blumenfeld, and M. Yaniv. 1988. A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Dev. 2:957-974.
  • Ciliberto, G., L. Dente, and R. Cortese. 1985. Cell specific expression of a transfected human α1antitrypsin gene. Cell 41:531-540.
  • Courtois, G., J. G. Morgan, L. A. Campbell, G. Fourel, and G. R. Crabtree. 1987. Interaction of a liver-specific nuclear factor with the fibrinogen and α1-antitrypsin promoters. Science 238:688-692.
  • De Simone, V., G. Ciliberto, E. Hardon, G. Paonessa, F. Palla, L. Lundberg, and R. Cortese. 1987. Cis- and rrans-acting elements responsible for the cell-specific expression of the human antitrypsin gene? EMBO J. 6:2759-2766.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
  • Farrell, F. X., C. M. Sax, and Ζ. Ε. Zehner. 1990. A negative element involved in vimentin gene expression. Mol. Cell. Biol. 10:2349-2358.
  • Feuerman, M. H., R. Godbout, R. S. Ingram, and S. M. Tilghman. 1989. Tissue-specific transcription of the mouse α-fetoprotein gene promoter is dependent on HNF-1. Mol. Cell. Biol. 9:4204-4212.
  • Frain, M., E. Hardon, G. Ciliberto, and J. M. Sala-Trepat. 1990. Binding of a liver-specific factor to the human albumin gene promoter and enhancer. Mol. Cell. Biol. 10:991-999.
  • Gorman, C. M., L. F. Moffat, and Β. Η. Howard. 1982. Recombinant genomes which express chloramphenicol acetyl-transferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
  • Herbst, R. S., E. M. Boczko, J. E. Darnell, and L. E. Babiss. 1990. The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein. Mol. Cell. Biol. 10:3896-3905.
  • Huh, N., and T. Utakoji. 1981. Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone. Gann 72:178-179.
  • Imagawa, M., S. Osada, A. Okuda, and M. Muramatsu. 1991. Silencer binding proteins function on multiple cis-elements in the glutathione transferase Ρ gene. Nucleic Acids Res. 19:5-10.
  • Jones, Κ. Α., J. T. Kadonaga, P. J. Rosenfeld, T. J. Kelly, and R. Tjian. 1987. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell 48:79-89.
  • Lichtsteiner, S., and U. Schibler. 1989. A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene. Cell 57:1179-1187.
  • Morinaga, T., M. Sakai, T. G. Wegmann, and T. Tamaoki. 1983. Primary structures of human α-fetoprotein and its mRNA. Proc. Natl. Acad. Sci. USA 80:4604-4608.
  • Muglia, L., and L. B. Rothman-Denes. 1986. Cell type-specific negative regulatory element in the control region of the rat α-fetoprotein gene. Proc. Natl. Acad. Sci. USA 83:7653-7657.
  • Nakabayashi, H., K. Taketa, K. Miyano, T. Yamane, and J. Sato. 1982. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res. 42:3858-3863.
  • Nakabayashi, Η., Κ. Taketa, Τ. Yamane, Μ. Miyazaki, K. Miyano, and J. Sato. 1984. Phenotypic stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium. Gann 75:151-158.
  • Nakabayashi, H., K. Taketa, T. Yamane, M. Oda, and J. Sato. 1985. Hormonal control of α-fetoprotein secretion in human hepatoma cell lines proliferating in chemically defined medium. Cancer Res. 45:6379-6383.
  • Nakabayashi, H., and T. Tamaoki. Unpublished data.
  • Nakabayashi, H., K. Watanabe, A. Saito, A. Otsuru, K. Sawadaishi, and T. Tamaoki. 1989. Transcriptional regulation of α-fetoprotein expression by dexamethasone in human hepatoma cells. J. Biol. Chem. 264:266-271.
  • Nakamura, N., D. W. Burt, M. Paul, and V. J. Dzau. 1989. Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. Proc. Natl. Acad. Sci. USA 86:56-59.
  • Ptashne, M. 1986. Gene regulation by proteins acting nearby and at a distance. Nature (London) 322:697-701.
  • Ruoqian-Shen, S. K. Goswami, E. Mascareno, A. Kumar, and M. A. Q. Siddiqui. 1991. Tissue-specific transcription of the cardiac myosin light-chain 2 gene is regulated by an upstream repressor element. Mol. Cell. Biol. 11:1676-1685.
  • Sakai, M., T. Morinaga, Y. Urano, K. Watanabe, T. G. Wegmann, and T. Tamaoki. 1985. The human α-fetoprotein gene. Sequence organization and the 5′ flanking region. J. Biol. Chem. 260:5055-5060.
  • Sawadaishi, Κ., Τ. Morinaga, and T. Tamaoki. 1988. Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human α-fetoprotein and albumin gene. Mol. Cell. Biol. 8:5179-5187.
  • Shapiro, D. J., P. A. Sharp, W. W. Wahli, and M. J. Keller. 1988. A high-efficiency HeLa cell nuclear transcription extract? DNA 7:47-55.
  • Sleigh, M. J. 1986. A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Anal. Biochem. 156:251-256.
  • Steiner, C., M. Muller, A. Baniahmad, and R. Renkawitz. 1987. Lysozyme gene activity in chicken macrophages is controlled by positive and negative regulatory elements. Nucleic Acids Res. 15:4163-4178.
  • Tamaoki, T., and N. Fausto. 1984. Expression of the α-fetoprotein gene during development, regeneration and carcinogenesis, p. 145-168 In G. Stein and J. Stein (ed.), Recombinant DNA and cell proliferation. Academic Press, Inc., New York.
  • Urano, Y., K. Watanabe, M. Sakai, and T. Tamaoki. 1986. The human albumin gene. Characterization of the 5′ and 3′ flanking regions and the polymorphic gene transcripts. J. Biol. Chem. 261:3244-3251.
  • Vacher, J., and S. M. Tilghman. 1990. Dominant negative regulation of the mouse α-fetoprotein gene in adult liver. Science 250:1732-1735.
  • Watanabe, K., A. Saito, and T. Tamaoki. 1987. Cell-specific enhancer activity in a far upstream region of the human α-fetoprotein gene. J. Biol. Chem. 262:4812-4818.

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