The K-fgf/hst Oncogene Induces Transformation through an Autocrine Mechanism That Requires Extracellular Stimulation of the Mitogenic Pathway

REFERENCES

• Bejcek, B. E., D. Y. Li, and T. F. Deuel. 1989. Transformation by v-sis occurs by an internal autoactivation mechanism. Science 245:1496-1499.
   PubMed Web of Science ®Google Scholar
• Blam, S. B., R. Mitchell, E. Tischer, J. S. Rubin, M. Silva, S. Silver, J. C. Fiddes, J. A. Abraham, and S. A. Aaronson. 1988. Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene 3:129-136.
   PubMed Web of Science ®Google Scholar
• Burgess, W. H., and T. Maciag. 1989. The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Bio-chem. 58:575-606.
   PubMed Web of Science ®Google Scholar
• Delli-Bovi, P., A. M. Curatola, F. G. Kern, A. Greco, M. Ittmann, and C. Basilico. 1987. An oncogene isolated by trans-fection of Kaposi’s sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell 50:729-737.
   PubMed Web of Science ®Google Scholar
• Delli-Bovi, P., A. M. Curatola, K. M. Newman, Y. Sato, D. Moscatelli, R. M. Hewick, D. B. Rifkin, and C. Basilico. 1988. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol. Cell. Biol. 8:2933-2941.
   PubMed Web of Science ®Google Scholar
• Dunbar, C. E., T. M. Browder, J. S. Abrams, and A. W. Nienhuis. 1989. COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth. Science 245:1493-1496.
   PubMed Web of Science ®Google Scholar
• Fleming, T. P., T. Matsui, C. J. Molloy, K. C. Robbins, and S. A. Aaronson. 1989. Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc. Natl. Acad. Sci. USA 86:8063-8067.
   PubMed Web of Science ®Google Scholar
• Hannink, M., and D. J. Donoghue. 1988. Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. J. Cell Biol. 107:287-298.
   PubMed Web of Science ®Google Scholar
• Hebert, J. M., C. Basilico, M. Goldfarb, O. Haub, and G. R. Martin. 1990. Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev. Biol. 38:454-463.
   Google Scholar
• Huang, S. S., and J. S. Huang. 1988. Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. J. Biol. Chem. 263:12608-12617.
   PubMed Web of Science ®Google Scholar
• Keating, M. T., and L. T. Williams. 1988. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science 239:914-916.
   PubMed Web of Science ®Google Scholar
• Kern, F. G., and C. Basilico. 1985. Transcription from the polyoma late promoter in cells stably transformed by chimeric plasmids. Mol. Cell. Biol. 5:797-807.
   PubMedGoogle Scholar
• Kunkel, T. A., J. D. Roberts, and R. A. Lakowe. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
   PubMed Web of Science ®Google Scholar
• Jaye, M., R. M. Lyall, R. Mudd, J. Schlessinger, and N. Sarver. 1988. Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells. EMBO J. 7:963-969.
   PubMed Web of Science ®Google Scholar
• Luthman, H., and G. Magnusson. 1983. High efficiency polyoma DNA transfection of chloroquine treated cells. Nucleic Acids Res. 11:1295-1308.
   PubMed Web of Science ®Google Scholar
• Mansukhani, A., D. Moscatelli, D. Talarico, V. Levytska, and C. Basilico. 1990. A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc. Natl. Acad. Sci. USA 87:4378-4382.
   PubMed Web of Science ®Google Scholar
• Moscatelli, D., and N. Quarto. 1989. Transformation of NIH3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin. J. Cell Biol. 109:2519-2527.
   PubMed Web of Science ®Google Scholar
• Munro, S., and H. R. B. Pelham. 1987. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48:899-907.
   PubMed Web of Science ®Google Scholar
• Neufeld, G., R. Mitchell, P. Ponte, and D. Gospodarowicz. 1988. Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth. J. Cell Biol. 106:1385-1393.
   PubMed Web of Science ®Google Scholar
• Paabo, S., B. M. Bhat, W. S. M. Wold, and P. A. Peterson. 1987. A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Cell 50:311-317.
   PubMedGoogle Scholar
• Pelham, H. R. B. 1988. Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment. EMBO J. 7:913-918.
   PubMedGoogle Scholar
• Quarto, N., D. Talarico, A. Sommer, R. Florkiewicz, C. Basilico, and D. B. Rifkin. 1989. Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf. Oncogene Res. 5:101-110.
   PubMedGoogle Scholar
• Rogelj, S., R. A. Weinberg, P. Fanning, and M. Klagsbrun. 1988. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature (London) 331:173-178.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
   PubMed Web of Science ®Google Scholar
• Sasada, R., T. Kurokawa, M. Iwane, and K. Igarashi. 1988. Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA. Mol. Cell. Biol. 8:588-594.
   PubMed Web of Science ®Google Scholar
• Talarico, D., M. Ittmann, A. Balsari, P. Delli-Bovi, R. S. Basch, and C. Basilico. 1990. Protection of mice against tumor growth by immunization with an oncogene-encoded growth factor. Proc. Natl. Acad. Sci. USA 87:4222-4225.
   PubMedGoogle Scholar
• Vekich, A., P. Delli-Bovi, A. Mansukhani, E. B. Ziff, and C. Basilico. 1989. Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells. Oncogene Res. 5:31-37.
   PubMedGoogle Scholar
• Wigler, M., R. Sweet, G. K. Sim, A. Pellicer, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. 1979. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. Cell 16:777-785.
   PubMed Web of Science ®Google Scholar
• Wong, G. G., J. S. Witek, P. A. Temple, K. M. Wilkens, A. C. Leary, D. P. Luxenberg, S. S. Jones, E. L. Brown, R. M. Kay, E. C. Orr, C. Shoemaker, D. W. Golde, R. J. Kaufman, R. M. Hewick, E. A. Wang, and S. C. Clark. 1985. Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228:810-815.
   PubMed Web of Science ®Google Scholar