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Transcriptional Regulation

An In Vitro Transcription Analysis of Early Responses of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat to Different Transcriptional Activators

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Pages 1883-1893 | Received 24 Aug 1990, Accepted 09 Jan 1991, Published online: 31 Mar 2023

REFERENCES

  • Ares, M., Jr., M. Mangin, and A. M. Weiner. 1985. Orientationdependent transcriptional activator upstream of a human U2 snRNA gene. Mol. Cell. Biol. 5:1560–1570.
  • Baeuerle, P. A., and D. Baltimore. 1988. Activation of DNA- binding activity in an apparently cytoplasmic precursor of the NF-ΚB transcription factor. Cell 53:211–217.
  • Baeuerle, P. A., and D. Baltimore. 1988. IΚB: a specific inhibitor of the NF-ΚB transcription factor. Science 242:540–546.
  • Baeuerle, P. A., and D. Baltimore. 1989. A 65-kd subunit of active NF-ΚB is required or inhibition of NF-ΚB by IΚB. Genes Dev. 3:1689–1698.
  • Baldwin, A. S., and P. A. Sharp. 1988. Two transcription factors, NF-ΚB and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. Proc. Natl. Acad. Sci. USA 85:723–727.
  • Bours, V., J. Villalobos, P. R. Burd, K. Kelly, and U. Siebenlist. 1990. Cloning of a mitogen-inducible gene encoding a ΚB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs. Nature (London) 348:76–80.
  • Brownell, E., B. Mathieson, H. A. Young, J. Keller, J. N. Ihle, and N. R. Rice. 1987. Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines. Mol. Cell. Biol. 7:1304–1309.
  • Bull, P., T. Hunter, and I. M. Verma. 1989. Transcriptional induction of the murine c-rel gene with serum and phorbol-12- myristate-13-acetate in fibroblasts. Mol. Cell. Biol. 9:5239–5243.
  • Colamonici, O. R., J. B. Trepel, C. A. Vidal, and L. M. Neckers. 1986. Phorbol ester induces c-sis gene transcription in stem cell line K-562. Mol. Cell. Biol. 6:1847–1850.
  • Cullen, B. R. 1986. Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46:973–982.
  • Curran, T., and B. R. Franza Jr., 1988. Fos and Jun: the AP-1 connection. Cell 55:395–397.
  • Dery, C. V., C. H. Herrmann and M. B. Mathews. 1987. Response of individual adenovirus promoters to the products of the E1A gene. Oncogene 2:15–23.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
  • Dinter, H., R. Chiu, M. Imagawa, M. Karin, and K. A. Jones. 1987. In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter. EMBO J. 6:4067–4071.
  • Fauci, A. S. 1988. The human immunodeficiency virus: infectivity and mechanism of pathogenesis. Science 239:617–622.
  • Franza, B. R., Jr., 1988. Direct, comparative analysis of cellular proteins that interact with genetically defined regulatory elements, p. 159-174. In B. R. Franza, B. R. Cullen, and F. Wong-Staal (ed.), The control of human retrovirus gene expression. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Franza, B. R., Jr., 1990. Complex protein interactions at the HIV-1 direct repeat enhancer structure: a paradigm for database analysis of protein-nucleic acid interactions, UCLA Symp. Mol. Cell. Biol. New Ser. 119:181–189.
  • Franza, B. R., Jr., Unpublished data.
  • Franza, B. R., Jr., S. F. Josephs, M. Z. Gilman, W. Ryan, and B. Clarkson. 1987. Characterization of cellular proteins that recognize the human immunodeficiency virus enhancer using a microscale DNA-affinity precipitation assay. Nature (London) 330:391–395.
  • Franza, B. R., Jr., F. J. Rauscher III, S. F. Josephs, and T. Curran. 1988. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding site. Science 239:1150–1153.
  • Fujita, T., H. Shibuya, T. Ohashi, K. Yamanishi, and T. Taniguchi. 1986. Regulation of human interleukin-2 gene: functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes. Cell 46:401–405.
  • Gallo, R. C., and L. Montagnier. 1987. The chronology of AIDS research. Nature (London) 326:435–436.
  • Garcia, J. A., F. K. Wu, R. Mitsuyasu, and R. B. Gaynor. 1987. Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus. EMBO J. 6:3761–3770.
  • Ghosh, S., and D. Baltimore. 1990. Activation in vitro of NF-ΚB by phosphorylation of its inhibitor IΚB. Nature (London) 344:678–682.
  • Ghosh, S., A. M. Gifford, L. R. Riviere, P. Tempst, G. P. Nolan, and D. Baltimore. 1990. Cloning of the p50 DNA binding subunit of NF-ΚB: homology to rel and dorsal. Cell 62:1019–1029.
  • Greenberg, M. E., and E. B. Ziff. 1984. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (London) 311:433–438.
  • Hannink, M., and H. M. Temin. 1989. Transactivation of gene expression by nuclear and cytoplasmic rel proteins. Mol. Cell. Biol. 9:4323–4336.
  • Harada, S., Y. Koyanagi, H. Nakashima, N. Kobayashi, and N. Yamamoto. 1986. Tumor promoter, TPA, enhances replication of HTLV-III/LAV. Virology 154:249–258.
  • Heintz, N., and R. G. Roeder. 1982. Transcription of eukaryotic genes in soluble cell-free systems, p. 57-89. In J. K. Setles and A. Hollaender (ed.), Genetic engineering, vol. 4. Plenum Press, New York.
  • Ho, D. D., R. J. Pomerantz, and J. C. Kaplan. 1987. Pathogenesis of infection with human immunodeficiency virus. N. Engl. J. Med. 317:278–286.
  • Hoffmann, A., M. Horikoshi, C. K. Wang, S. Schroeder, P. A. Weil, and R. G. Roeder. 1990. Cloning of the Schizosaccharo- myces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae. Genes Dev. 4:1141–1148.
  • Horikoshi, M., C. K. Wang, H. Fujii, J. A. Cromlish, P. A. Weil, and R. G. Roeder. 1989. Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box. Nature (London) 341:299–303.
  • Imbra, R. J., and M. Karin. 1986. Phorbol ester induces the transcriptional stimulatory activity of SV40 enhancer. Nature (London) 323:555–558.
  • Jones, K. A., J. T. Kadonaga, P. A. Luciw, and R. Tjian. 1986. Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science 232:755–759.
  • Kabrun, N., J. W. Hodgson, M. Doemer, G. Mak, B. R. Franza, and P. J. Enrietto. 1990. Interaction of the Rel protein with a NF-ΚB DNA binding site. Proc. Natl. Acad. Sci. USA, in press.
  • Kamens, J., P. Richardson, G. Mosialos, R. Brent, and T. Gilmore. 1990. Oncogenic transformation by v-Rel requires an amino-terminal activation domain. Mol. Cell. Biol. 10:28402847.
  • Kaufman, J. D., G. Valandra, G. Roderiquez, G. Bushar, C. Giri, and M. A. Norcross. 1987. Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element. Mol. Cell. Biol. 7:3759–3766.
  • Kelly, K., B. H. Cochran, C. D. Stiles, and P. Leder. 1983. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35:603–610.
  • Kieran, M., V. Blank, F. Logeat, J. Vandekerckhove, F. Lottspe- ich, O. Le Bail, M. B. Urban, P. Kourilsky, P. A. Baeuerle, and A. Israel. 1990. The DNA binding subunit of NF-ΚB is identical to factor KBF1 and homologous to the rel oncogene product. Cell 62:1007–1018.
  • Kimura, A., A. Israel, O. Le Bail, and P. Kourilsky. 1986. Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Cell 44:261–272.
  • Klatzman, D., F. Barre-Sinoussi, M. T. Nugeyre, C. Daugnet, E. Vilmer, C. Griscelli, F. Brun-Vezinet, C. Rouzioux, J.-C. Gluck- man, J.-C. Chermann, and L. Montagnier. 1984. Selective tropism of lymphadenopathy associated virus (LAV) for helperinducer T lymphocytes. Science 225:59–63.
  • Klatzman, D., E. Champagne, S. Chamaret, J. Gruest, D. Gustard, T. Hercend, J.-C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature (London) 312:767–768.
  • Kruijer, W., J. A. Cooper, T. Hunter, and I. M. Verma. 1984. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (London) 312:711–716.
  • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
  • Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367–382.
  • Lee, J., Y. Li, S. Doerre, P. Sista, D. W. Ballard, W. C. Greene, and B. R. Franza. 1990. A member of the set of ΚB binding proteins, HIVEN86A, is a product of the human c-rel protooncogene. Oncogene, in press.
  • Lee, K. A., A. Bindereif, and M. R. Green. 1988. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene. Anal. Tech. 5:22–31.
  • Leonard, J., C. Parrott, A. J. Buckler-White, W. Turner, E. K. Ross, M. A. Martin, and A. B. Rabson. 1989. The NF-ΚB binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity. J. Virol. 63:4919-4924.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Manley, J. L. 1982. Transcription of mammalian genes in vitro, p. 37-56. In J. K. Setles and A. Hollaender (ed.), Genetic engineering, vol. 4. Plenum Press, New York.
  • Mattaj, I. W., and R. Zeller. 1983. Xenopus laevis U2 snRNA genes: tandemly repeated transcriptional units sharing 5′ and 3′ flanking homology with other RNA polymerase II transcribed genes. EMBO J. 2:1883–1891.
  • McDougal, J. S., A. Mawle, S. F. Cort, J. K. A. Nicholson, G. D. Cross, J. A. Scheppler-Campbell, D. Hicks, and J. Sligh. 1985. Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen. J. Immunol. 135:3151–3162.
  • Morrison, L. E., N. Kabrun, S. Mudri, M. J. Hayman, and P. J. Enrietto. 1989. Viral rel and cellular rel associate with cellular proteins in transformed and normal cells. Oncogene 4:677–683.
  • Muesing, M. A., D. H. Smith, and D. J. Capon. 1987. Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell 48:691–701.
  • Nabel, G., and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (London) 326:711–713.
  • Nabel, G., S. A. Rice, D. M. Knipe, and D. Baltimore. 1988. Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells. Science 239:1299–1302.
  • Nishizuka, Y. 1984. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature (London) 308:693–698.
  • Nishizuka, Y. 1986. Studies and perspectives of protein kinase C. Science 233:305–312.
  • Peterlin, B. M., P. A. Luciw, P. J. Barr, and M. D. Walker. 1986. Elevated levels of mRNA can account for the transactivation of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 83:9734–9738.
  • Peterson, M. G., N. Tanese, B. F. Pugh, and R. Tjian. 1990. Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248:1625–1630.
  • Ratnasabapathy, R., M. Sheldon, L. Johal, and N. Hernandez. 1990. The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters. Genes Dev. 4:2061–2074.
  • Rosen, C. A., J. G. Sodroski, and W. A. Haseltine. 1985. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 41:813–823.
  • Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer- directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
  • Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed., p. 15.76-15.79. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716.
  • Siekevitz, M., S. F. Josephs, M. Dukovich, N. Peffer, F. Wong- Staal, and W. C. Greene. 1987. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of hTLV-1. Science 238:1575–1578.
  • Simek, S., and N. R. Rice. 1988. p59v-rel, the transforming protein of reticuloendotheliosis virus, is complexed with at least four other proteins in transformed chicken lymphoid cells. J. Virol. 62:4730–4736.
  • Sodroski, J., C. Rosen, F. Wong-Staal, S. Z. Salahuddin, M. Popovic, S. Arya, R. C. Gallo, and W. A. Haseltine. 1985. Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science 227:171–173.
  • Starcich, B., L. Ratner, S. F. Josephs, T. Okamoto, R. C. Gallo, and F. Wong-Staal. 1985. Characterization of long terminal repeat sequences of HTLV-III. Science 227:538–540.
  • Tong-Starksen, S. E., P. A. Luciw, and B. M. Peterlin. 1987. The human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc. Natl. Acad. Sci. USA 84:68456849.
  • Wasylyk, C., J. L. Imler, J. Perez-Mutul, and B. Wasylyk. 1987. The c-Ha-ras oncogene and a tumor promoter activate the polyoma virus enhancer. Cell 48:525–534.
  • Wiskocil, R., A. Weiss, J. Imboden, R. Kamin-Lewis, and J. Stobo. 1985. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and γ-interferon genes. J. Immunol. 134:1599–1603.
  • Wright, C. M., B. K. Felber, H. Paskalis, and G. N. Pavlakis. 1986. Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science 234:988–992.
  • Wu, F., J. Garcia, R. Mitsuyasu, and R. B. Gaynor. 1988. Alterations in binding characteristics of the human immunodeficiency virus enhancer factor. J. Virol. 62:218–225.
  • Zagury, D., J. Bernard, R. Leonard, R. Cheynier, M. Feldman, P. S. Sarin, and R. C. Gallo. 1986. Long-term cultures of HTLV-III-infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science 231:850–853.

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