4
Views
5
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Antifungal Properties of the Immunosuppressant FK-506: Identification of an FK-506-Responsive Yeast Gene Distinct from FKB1

, , &
Pages 4616-4626 | Received 28 Jan 1991, Accepted 18 Jun 1991, Published online: 31 Mar 2023

References

  • Balzi, E., W. Chen, S. Ulaszewski, E. Capieaux, and A. Goffeau. 1987. The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J. Biol. Chem. 262:16871–16879.
  • Bierer, B. E., P. S. Mattila, R. F. Standaert, L. A. Herzenberg, S. J. Burakoff, G. Crabtree, and S. L. Schreiber. 1990. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc. Natl. Acad. Sci. USA 87:9231–9235.
  • Birge, E. A., and C. G. Kurland. 1969. Altered ribosomal protein in streptomycin-dependent Escherichia coli. Science 166:1282–1284.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Breckenridge, L., and L. Gorini. 1970. Genetic analysis of streptomycin resistance in Escherichia coli. Genetics 65:9–25.
  • Brizuela, L. Unpublished data.
  • Chrebet, G., and S. A. Parent. Unpublished data.
  • Diaz, L., M. Ehrenberg, and C. G. Kurland. 1986. How do combinations of rpsL- and miaA- generate streptomycin dependence? Mol. Gen. Genet. 202:207–211.
  • Dreyfuss, M., E. Härri, H. Hofmann, H. Kobel, W. Pache, and H. Tscherter. 1976. Cyclosporin A and C. Eur. J. Appl. Microbiol. 3:125–133.
  • Dumont, F. J. (Merck Sharp and Dohme Research Laboratories). 1991. Personal communication..
  • Dumont, F. J., M. R. Melino, M. J. Staruch, S. L. Koprak, P. A. Fischer, and N. H. Sigal. 1990. The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells. J. Immunol. 144:1418–1424.
  • Dumont, F. J., M. J. Staruch, S. L. Koprak, M. R. Melino, and N. H. Sigal. 1990. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin. J. Immunol. 144:251–258.
  • Falco, S. C., K. S. Dumas, R. E. McDevitt, and J. E. Golin. 1986. Molecular biology of sulfonylurea herbicide action on Saccharomyces cerevisiae, p. 99–104. In G. G. Stewart, L. Russell, R. D. Kelin, and R. R. Hiebsch (ed.), Biological research on industrial yeasts, vol. III. CRC Press, Boca Raton, Fla.
  • Findlay, J. A., and L. Radics. 1980. On the chemistry and high field nuclear magnetic resonance spectroscopy of rapamycin. Can. J. Chem. 58:579–590.
  • Fischer, G., B. Wittmann-Liebold, K. Lang, T. Kiefhaber, and F. X. Schmid. 1989. Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature (London) 337:476–478.
  • Haendler, B., R. Keller, P. C. Hiestand, H. P. Kocher, G. Wegmann, and N. Rao Mowa. 1989. Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene. Gene 83:39–46.
  • Handschumacher, R. E., M. W. Harding, J. Rice, R. J. Drugge, and D. W. Speicher. 1984. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 226:544–547.
  • Harding, M. W., A. Galat, D. E. Uehling, and S. L. Schreiber. 1989. A receptor for the immunosuppressant FK-506 is a cis-trans peptidyl-prolyl isomerase. Nature (London) 341:758–760.
  • Harwick, H. J., P. Weiss, and F. R. Fekety, Jr. 1968. Application of microtitration techniques to bacteriostatic and bactericidal antibiotic susceptibility testing. J. Lab. Clin. Med. 72:511–516.
  • Kino, T., H. Hatanaka, M. Hashimoto, M. Nishiyama, T. Goto, M. Okuhara, M. Kohsaka, H. Aoki, and H. Imanaka. 1987. FK506, a novel immunosuppressant isolated from a Streptomy- ces. I. Fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot. 40:1249–1255.
  • Kino, T., H. Hatanaka, S. Miyata, N. Inamura, M. Nishiyama, T. Yajima, T. Goto, M. Okuhara, M. Kohsaka, H. Aoki, and T. Ochiai. 1987. FK506, a novel immunosuppressant isolated from Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J. Antibiot. 40:1256–1265.
  • Koletsky, A. J., M. W. Harding, and R. E. Handschumacher. 1986. Cyclophilin: distribution and variant properties in normal and neoplastic tissues. J. Immunol. 137:1054–1059.
  • Kronke, M., W. J. Leonard, J. M. Depper, S. K. Arya, F. Wong-Staal, R. C. Gallo, T. A. Waldmann, and W. C. Greene. 1984. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA 81:5214–5218.
  • Lang, K., F. X. Schmid, and G. Fischer. 1987. Catalysis of protein folding by prolyl isomerase. Nature (London) 329:268–270.
  • Leppert, G., R. McDevitt, S. C. Falco, T. K. Van Dyk, M. B. Ficke, and J. Golin. 1990. Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 125:13–20.
  • Martel, R. R., J. Klicius, and S. Galet. 1977. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55:48–51.
  • Metcalfe, S. M., and F. M. Richards. 1990. Cyclosporine, FK506, and rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells. Transplantation 49:798–802.
  • Momose, H., and L. Gorini. 1971. Genetic analysis of streptomycin dependence in Escherichia coli. Genetics 67:19–38.
  • Parent, S. A., and J. R. Thompson. Unpublished data.
  • Rothstein, R. 1983. One-step gene disruption in yeast. Methods Enzymol. 101:202–211.
  • Ruusala, T., D. Andersson, M. Ehrenberg, and C. G. Kurland. 1984. Hyperaccurate ribosomes inhibit growth. EMBO J. 3:2575–2580.
  • Ruusala, T., and C. G. Kurland. 1984. Streptomycin preferentially perturbs ribosomal proofreading. Mol. Gen. Genet. 198:100–104.
  • Saunders, G. W., and G. H. Rank. 1982. Allelism of pleiotropic drug resistance in Saccharomyces cerevisiae. Can. J. Genet. Cytol. 24:493–503.
  • Sawada, S., G. Suzuki, Y. Kawase, and F. Takaku. 1987. Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J. Immunol. 139:1797–1803.
  • Schneuwly, S., R. D. Shortridge, D. C. Larrivee, T. Ono, M. Ozaki, and W. L. Pak. 1989. Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). Proc. Natl. Acad. Sci. USA 86:5390–5394.
  • Sherman, F., G. R. Fink, and J. B. Hicks. 1986. Laboratory course manual for methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Shevach, E. M. 1985. The effects of cyclosporin A on the immune system. Annu. Rev. Immunol. 3:397–423.
  • Shieh, B.-H., M. A. Stamnes, S. Seavello, G. L. Harris, and C. S. Zuker. 1989. The ninaA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein. Nature (London) 338:67–70.
  • Siekierka, J. J., S. H. Y. Hung, M. Poe, C. Shirley Lin, and N. H. Sigal. 1989. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (London) 341:755–757.
  • Siekierka, J. J., M. J. Staruch, S. H. Y. Hung, and N. H. Sigal. 1989. FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein cyclophilin. J. Immunol. 143:1580–1583.
  • Siekierka, J. J., G. Wiederrecht, H. Greulich, D. Boulton, S. H. Y. Hung, J. Cryan, P. J. Hodges, and N. H. Sigal. 1990. The cytosolic-binding protein for the immunosuppressant FK- 506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase. J. Biol. Chem. 265:21011–21015.
  • Sigal, N. H., J. J. Siekierka, and F. J. Dumont. 1990. Observations on the mechanism of action of FK-506. Biochem. Pharmacol. 40:2201–2208.
  • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19–28.
  • Sprague, G. F., Jr., and I. Herskowitz. 1981. Control of yeast cell type by the mating type locus. J. Mol. Biol. 153:305–321.
  • Starzl, T. E., S. Todo, J. Fung, A. J. Demetris, R. Venkataramman, and A. Jain. 1989. FK-506 for liver, kidney, and pancreas transplantation. Lancet ii:1000–1004.
  • Subik, J., S. Ulaszewski, and A. Goffeau. 1986. Genetic mapping of nuclear mucidin resistance mutations in Saccharomyces cerevisiae. Curr. Genet. 10:665–670.
  • Takahashi, N., T. Hayano, and M. Suzuki. 1989. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclo- philin. Nature (London) 337:473–475.
  • Tanaka, H., A. Kuroda, H. Marusawa, M. Hashimoto, H. Hatanaka, T. Kino, T. Goto, and M. Okuhara. 1987. Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant. Proc. 19:11–16.
  • Thomson, A. W. 1989. FK506: How much potential? Immunol. Today 10:6–9.
  • Thomson, A. W. 1990. FK-506 enters the clinic. Immunol. Today 11:35–36.
  • Tocci, M. J., D. A. Matkovich, K. A. Collier, P. Kwok, F. Dumont, S. Lin, S. Degudicibus, J. J. Siekierka, J. Chin, and N. I. Hutchinson. 1989. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143:718–726.
  • Tropschug, M., I. B. Barthelmess, and W. Neupert. 1989. Sensitivity to cyclosporin A is mediated by cyclophilin ir Neurospora crassa and Saccharomyces cerevisiae. Nature (London) 342:953–955.
  • Tropschug, M., D. W. Nicholson, F.-U. Hartl, H. Kohler, N. Pfanner, E. Wachter, and W. Neupert. 1988. Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa: one gene codes for both the cytosolic and mitochondrial forms. J. Biol. Chem. 263:14433–14440.
  • Tropschug, M., E. Wachter, S. Mayer, E. R. Schönbrunner, and F. X. Schmid. 1990. Isolation and sequence of an FK506-binding protein from N. crassa which catalyzes protein folding. Nature (London) 346:674–677.
  • Vézina, C., A. Kudelski, and S. N. Sehgal. 1975. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28:721–726.
  • Wiederrecht, G., L. Brizuela, K. Elliston, N. H. Sigal, and J. J. Siekierka. 1991. FKB1 encodes a nonessential FK-506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins. Proc. Natl. Acad. Sci. USA 88:1029–1033.
  • Yoshimura, N., S. Matsui, T. Hamashima, and T. Oka. 1989. Effect of a new immunosuppressive agent, FK-506, on human lymphocyte responses in vitro. II. Inhibition of the production of IL-2 and γ-IFN, but not B cell-stimulating factor a. Transplantation 47:356–359.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.