3
Views
14
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

The Cellular Oncogene c-myb Can Interact Synergistically with the Epstein-Barr Virus BZLF1 Transactivator in Lymphoid Cells

, , , , , , & show all
Pages 136-146 | Received 03 May 1991, Accepted 04 Oct 1991, Published online: 01 Apr 2023

References

  • Bender, T., and M. Kuehl. 1987. Differential expression of the c-myb proto-oncogene marks the pre-B cell/B cell junction in murine B lymphoid tumors. J. Immunol. 139:3822–3827.
  • Biedenkapp, H., U. Borgmeyer, A. E. Sippel, and K. H. Klempnauer. 1988. Viral myb oncogene encodes a sequence-specific DNA-binding activity. Nature (London) 335:835–837.
  • Boyle, W., J. Lipsick, and M. Baluda. 1986. Antibodies to the evolutionarily conserved amino-terminal region of the v-myb- encoded protein detect the c-myb protein in widely divergent metazoan species. Proc. Natl. Acad. Sci. USA 83:4685–4689.
  • Chang, Y.-N., D. Dong, G. Hayward, and S. D. Hayward. 1990. The Epstein-Barr virus Zta transactivator: a member of the bZip family with unique DNA-binding specificity and a dimerization domain that lacks the characteristic heptad leucine zipper motif. J. Virol. 64:3358–3369.
  • Chevallier-Greco, A., H. Gruffat, E. Manet, A. Calender, and A. Sergeant. 1989. The Epstein-Barr virus (EBV) DR enhancer contains two functionally different domains: domain A is constitutive and cell specific, domain B is transactivated by the EBV early protein R. J. Virol. 63:615–623.
  • Chevallier-Greco, A., H. Gruffat, E. Manet, P. Chavrier, C. Mosnier, J. Daillie, and A. Sergeant. 1986. Both Epstein-Barr virus (EBV)-encoded transactivators, EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J. 5:3243–3249.
  • Countryman, J., H. Jenson, R. Seibl, H. Wolf, and G. Miller. 1987. Polymorphic proteins encoded within the BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J. Virol. 61:3672–3679.
  • Cox, M. A., J. Leahy, and J. M. Hardwick. 1990. An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators. J. Virol. 64:313–321.
  • Diamond, M., J. Miner, S. Yoshinaga, and K. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266–1272.
  • Evans, J. L., T. L. Moore, W. M. Kuehl, T. Bender, and J. P.-Y. Ting. 1990. Functional analysis of c-Myb protein in T-lympho- cytic cell lines shows that it trans-activates the c-myc promoter. Mol. Cell. Biol. 10:5747–5752.
  • Farrell, P., D. Rowe, C. Rooney, and J. T. Kouzarides. 1989. Epstein-Barr virus BZLF1 trans-activator specifically binds to consensus AP-1 site and is related to c-fos. EMBO J. 8:127–132.
  • Favaloro, J., R. Treisman, and R. Kamen. 1980. Transcription maps of polyoma virus-specific RNA; analysis by two dimensional S1 gel mapping. Methods Enzymol. 65:718–728.
  • Flemington, E., and S. H. Speck. 1990. Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1. J. Virol. 64:1227–1232.
  • Garcia, A., K. Montagne, D. Reavis, U. Stober-Grasser, and J. Lipsick. 1991. Determinants of sequence-specific DNA-binding by p48 v-myb. Oncogene 6:265–273.
  • Gilman, M. 1988. Preparation of cytoplasmic RNA from tissue culture cells, p. 4.1.2–4.1.6. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. Greene Publishing Associates and Wiley Interscience, New York.
  • Giot, J.-F., I. Mikaelian, M. Buisson, E. Manet, I. Joab, J.-C. Nicolas, and A. Sergeant. 1991. Transcriptional synergy and interference between the EBV transcription factors EB1 and R require both the basic region and the activation domain 2 of EB1. Nucleic Acids Res. 19:1251–1258.
  • Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044–1051.
  • Gregory, C., C. Kirchgens, C. Edwards, L. Young, M. Rowe, A. Forster, T. Rabbits, and A. Rickenson. 1987. Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes. Eur. J. Immunol. 17:1199–1207.
  • Gruffat, H., E. Manet, A. Rigolet, and A. Sergeant. 1990. The enhancer factor R of Epstein-Barr virus (EBV) is a sequencespecific DNA binding protein. Nucleic Acids Res. 18:6835–6843.
  • Gutsch, D. Unpublished data.
  • Hardwick, J. M., P. Lieberman, and S. D. Hayward. 1988. A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen. J. Virol. 62:2274–2284.
  • Holley-Guthrie, E., E. B. Quinlivan, E.-C. Mar, and S. Kenney. 1990. The Epstein-Barr virus promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner. J. Virol. 64:3753–3759.
  • Howe, K. M., C. F. L. Reakes, and R. J. Watson. 1990. Characterization of the sequence-specific interaction of mouse c-myb protein with DNA. EMBO J. 9:161–169.
  • Ibanez, C., and J. Lipsick. 1988. Structural and functional domains of the myb oncogene: requirements for nuclear transport, myeloid transformation, and colony formation. J. Virol. 62:1981–1988.
  • Ibanez, C., and J. Lipsick. 1990. Transactivation of gene expression by v-myb. Mol. Cell. Biol. 10:2285–2293.
  • Introna, M., J. Golay, J. Frampton, T. Nakano, S. Ness, and T. Graf. 1990. Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene. Cell 63:1287–1297.
  • Kenney, S. Unpublished data.
  • Kenney, S., E. Holley-Guthrie, E. C. Mar, and M. Smith. 1989. The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J. Virol. 63:3878–3883.
  • Klempnauer, K.-H., H. Arnold, and H. Biedenkapp. 1989. Activation of transcription by v-myb: evidence for two different mechanisms. Genes Dev. 3:1582–1589.
  • Klempnauer, K.-H., and A. E. Sippel. 1987. The highly conserved amino-terminal region of the protein encoded by the v-myb oncogene functions as a DNA-binding domain. EMBO J. 6:2719–2725.
  • Kouzarides, T., G. Packham, A. Cook, and P. Farrell. 1991. The BZLF1 protein of EBV has a coiled coil dimerization domain without a heptad leucine repeat but homology to the C/EBP leucine zipper. Oncogene 6:195–204.
  • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
  • Laimins, L., P. Gruss, R. Pozatti, and G. Khoury. 1984. Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J. Virol. 49:183–189.
  • Lane, T., C. Ibanez, A. Garcia, T. Graf, and J. Lipsick. 1990. Transformation by v-myb correlates with transactivation of gene expression. Mol. Cell. Biol. 10:2591–2598.
  • Lee, W., P. Mitchell, and R. Tjian. 1987. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49:741–752.
  • Li, R., J. Knight, S. Jackson, R. Tjian, and M. Botchan. 1991. Direct interaction between the Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell 65:493–505.
  • Lieberman, P., and A. Berk. 1990. In vitro transcriptional activation, dimerization, and DNA-binding specificity of the Epstein-Barr virus Zta protein. J. Virol. 64:2560–2568.
  • Lillie, J., and M. Green. 1989. Transcription activation by the adenovirus E1a protein. Nature (London) 338:39–44.
  • Lipsick, J. S., and W. J. Boyle. 1987. c-myb expression is a late event during T-lymphocyte activation. Mol. Cell. Biol. 7:3358–3360.
  • Luscher, B., and B. Eisenman. 1990. New light on myc and myb. Part II. Myb. Genes Dev. 4:2235–2241.
  • Mizuguchi, G., H. Nakagoshi, T. Nagase, N. Nomura, T. Date, Y. Ueno, and S. Ishii. 1990. DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-myb. J. Biol. Chem. 265:9280–9284.
  • Nakagoshi, H., T. Nagase, Y. Ueno, and S. Ishii. 1989. Transcriptional transrepression by the c-myb proto-oncogene product. Nucleic Acids Res. 17:7315–7324.
  • Nishina, Y., H. Nakagoshi, F. Imamoto, T. J. Gonda, and S. Ishii. 1989. Trans-activation by the c-myb proto-oncogene. Nucleic Acid Res. 17:107–117.
  • Nomura, N., M. Takahashi, M. Matsui, S. Ishii, T. Date, S. Sasamoto, and R. Ishizaki. 1988. Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. Nucleic Acid Res. 16:11075–11085.
  • Packham, G., A. Economou, C. Rooney, D. Rowe, and P. Farrell. 1990. Structure and function of the Epstein-Barr virus BZLF1 protein. J. Virol. 64:2110–2116.
  • Quinlivan, E., et al. Submitted for publication.
  • Rooney, C., N. Taylor, J. Countryman, H. Jenson, J. Kolman, and G. Miller. 1988. Genome rearrangements activate the Epstein-Barr virus gene whose product disrupts latency. Proc. Natl. Acad. Sci. USA 85:9801–9805.
  • Rooney, C. M., D. T. Rowe, T. Ragot, and P. J. Farrell. 1989. The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle. J. Virol. 63:3109–3116.
  • Sakura, H., C. Kanei-Ishii, T. Nagase, H. Nakagoshi, T. Gonda, and S. Ishii. 1989. Delineation of three functional domains of the transcriptional activator encoded by the c-myb proto-oncogene. Proc. Natl. Acad. Sci. USA 86:5758–5762.
  • Shen-ong, G., B. Luscher, and R. Eisenman. 1989. A second c-myb protein is translated from an alternatively spliced mRNA expressed from normal and 5' disrupted myb loci. Mol. Cell. Biol. 9:5456–5463.
  • Takada, K., N. Shimuzu, S. Sakuma, and Y. Ono. 1986. Transactivation of the latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment. J. Virol. 57:1016–1022.
  • Takimoto, T., H. Ogura, H. Sato, R. Umeda, and M. Hatano. 1985. Isolation of transforming and early antigen-producing Epstein-Barr virus from nasopharyngeal carcinoma hybrid cells (NPC-KT). J. Natl. Cancer Inst. 74:57–59.
  • Taylor, N., E. Flemington, J. Kolman, R. Baumann, S. Speck, and G. Miller. 1991. ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein- Barr virus BZLF1 promoter. J. Virol. 65:4033–4041.
  • Thiele, C., P. S. Cohen, and M. S. Israel. 1988. Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation. Mol. Cell. Biol. 8:1677–1683.
  • Thompson, C. B., P. B. Chailoner, P. E. Neiman, and M. Groudine. 1986. Expression of the c-myb proto-oncogene during cellular proliferation. Nature (London) 319:374–380.
  • Tice-Baldwin, K., G. Fink, and K. Arndt. 1989. BAS1 has an Myb motif and activates HIS4 transcription only in combination with BAS2. Science 246:931–935.
  • Tonneguzzo, F., A. C. Hayday, and A. Keating. 1986. Electric field-mediated DNA transfer: transient and stable gene expression in human and mouse lymphoid cells. Mol. Cell. Biol. 6:703–706.
  • Urier, G., M. Buisson, P. Chambard, and A. Sergeant. 1989. The Epstein-Barr virus early protein EB1 activates transcription from different responsive elements including AP-1 binding sites. EMBO J. 8:1447–1453.
  • Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors- grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911–916.
  • Weber, B., E. Westin, and M. Clarke. 1990. Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Science 249:1291–1293.
  • Westin, E., K. Gorse, and M. Clarke. 1990. Alternative splicing of the human c-myb gene. Oncogene 5:1117–1124.
  • Weston, K., and J. M. Bishop. 1989. Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell 58:85–93.
  • Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. Schmidt, J. Drouin, and M. Karin. 1990. Transcription interference between c-Jun and glucocorticoid receptor: mutual inhibition of DNA-binding due to direct protein-protein interaction. Cell 62:1205–1215.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.