Glucose Transporter Isotypes Switch in T-Antigen-Transformed Pancreatic β Cells Growing in Culture and in Mice

References

• Auffray, C., and F. Rougeon. 1980. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur. J. Biochem. 107:303–314.
   PubMedGoogle Scholar
• Birnbaum, M. J., H. C. Haspel, and O. M. Rosen. 1986. Cloning and characterization of a cDNA encoding the rat brain glucose transporter protein. Proc. Natl. Acad. Sci. USA 83:5784–5788.
   PubMed Web of Science ®Google Scholar
• Birnbaum, M. J., H. C. Haspel, and O. M. Rosen. 1987. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science 235:1495–1498.
   PubMed Web of Science ®Google Scholar
• Chen, L., T. Alam, J. H. Johnson, C. B. Newgard, and R. H. Unger. 1990. Regulation of beta-cell glucose transporter gene expression. Proc. Natl. Acad. Sci. USA 87:4088–4092.
   PubMedGoogle Scholar
• D'Ambra, R., M. Surana, S. Efrat, R. G. Starr, and N. Fleischer. 1990. Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology 126:2815–2822.
   PubMed Web of Science ®Google Scholar
• Efrat, S., S. Linde, H. Hofod, D. Spector, M. Delannoy, S. Grant, D. Hanahan, and S. Baekkeskov. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin geneoncogene. Proc. Natl. Acad. Sci. USA 85:9037–9041.
   PubMedGoogle Scholar
• Flier, J. S., M. Mueckler, A. L. McCall, and H. F. Lodish. 1987. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. J. Clin. Invest. 79:657–661.
   PubMedGoogle Scholar
• Flier, J. S., M. M. Mueckler, P. Usher, and H. F. Lodish. 1987. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235:1492–1495.
   PubMed Web of Science ®Google Scholar
• Gotoh, M., T. Maki, T. Kiyoizumi, S. Satomi, and A. P. Monaco. 1985. An improved method for the isolation of mouse pancreatic islets. Transplantation 40:437–441.
   PubMedGoogle Scholar
• Hanahan, D. 1985. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/ simian virus 40 oncogenes. Nature (London) 315:115–122.
   PubMed Web of Science ®Google Scholar
• Inui, K. I., L. G. Tillotson, and K. J. Isselbacher. 1980. Hexose and amino acid transport by chicken embryo fibroblasts infected with temperature-sensitive mutant of Rous sarcoma virus. Comparison of transport properties of whole cells and membrane vesicles. Biochim. Biophys. Acta 598:616–627.
   PubMedGoogle Scholar
• Johnson, H. J., A. Ogawa, L. Chen, L. Orci, C. B. Newgard, T. Alam, and R. H. Unger. 1990. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science 250:546–549.
   PubMedGoogle Scholar
• Johnson, J. H., C. B. Newgard, J. L. Milburn, H. F. Lodish, and B. Thorens. 1990. The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. J. Biol. Chem. 265:6548–6551.
   PubMed Web of Science ®Google Scholar
• Kawai, S., and H. Hanafusa. 1971. The effect of reciprocal changes in temperature on the transformed state of cells infected with a Rous sarcoma virus mutant. Virology 46:470–479.
   PubMed Web of Science ®Google Scholar
• Kayano, T., C. F. Burant, H. Fukumoto, G. W. Gould, Y.-S. Fan, R. L. Eddy, M. G. Byers, T. B. Shows, S. Seino, and G. I. Bell. 1990. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265:13276–13282.
   PubMed Web of Science ®Google Scholar
• Kayano, T., R. L. Fukumoto, R. L. Eddy, Y.-S. Fan, M. G. Byers, T. B. Shows, and G. I. Bell. 1988. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J. Biol. Chem. 263:15245–15248.
   PubMed Web of Science ®Google Scholar
• Kitagawa, K., H. Nishino, and A. Iwashima. 1985. Analysis of hexose transport in untransformed and sarcoma virus-transformed mouse 3T3 cells by photoaffinity binding of cytochalasin B. Biochim. Biophys. Acta 821:63–66.
   PubMed Web of Science ®Google Scholar
• Lehrach, H. D., J. M. Diamond, H. Wozney, and H. Boedtker. 1977. RNA molecular weight determinations by gel electrophoresis under denaturing conditions—a critical reexamination. Biochemistry 16:4743–4748.
   PubMed Web of Science ®Google Scholar
• McDaniel, M. L., J. R. Coloca, N. Kotagal, and P. E. Lacy. 1983. A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol. 98:182–200.
   PubMed Web of Science ®Google Scholar
• McLean, I. W., and F. P. Nakane. 1974. Periodate-lysine paraformaldehyde fixative: a new fixative for immunoelectron microscopy. J. Histochem. Cytochem. 61:1077–1083.
   Google Scholar
• Meglasson, M. D., and F. M. Matschinsky. 1986. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab. Rev. 2:163–214.
   PubMedGoogle Scholar
• Miyazaki, K., K. Araki, E. Yamato, H. Ikegami, T. Asano, Y. Shibasaki, Y. Oka, and K. Yamamura. 1990. Establishment of a pancreatic b cell line that retains glucose-inducible transporter isoforms. Endocrinology 127:127–132.
   Google Scholar
• Orci, L., B. Thorens, M. Ravazzola, and H. F. Lodish. 1989. Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science 245:295–297.
   PubMed Web of Science ®Google Scholar
• Orci, L., R. H. Unger, M. Ravazzola, A. Ogawa, I. Komiya, D. Bactens, H. F. Lodish, and B. Thorens. 1990. Reduced b-cell glucose transporter in new onset diabetic BB rats. J. Clin. Invest. 86:1615–1622.
   PubMed Web of Science ®Google Scholar
• Pawson, T., J. Guyden, T.-S. Kung, K. Radke, T. Gilmore, and G. S. Martin. 1980. A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell 22:767–775.
   PubMed Web of Science ®Google Scholar
• Pedersen, P. L. 1978. Tumor mitochondria and bioenergetics of cancer cells. Prog. Exp. Tumor Res. 13:190–274.
   Google Scholar
• Permutt, M. A., L. Koranyi, K. Keller, P. E. Lacy, D. W. Sharp, and M. Mueckler. 1989. Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA. Proc. Natl. Acad. Sci. USA 86:8688–8692.
   PubMed Web of Science ®Google Scholar
• Rhoads, D. B., M. Takano, C. S. Gattoni, C. C. Chen, and K. J. Isselbacher. 1988. Evidence for expression of the facilitated glucose transporter in rat hepatocytes. Proc. Natl. Acad. Sci. USA 85:9042–9046.
   PubMedGoogle Scholar
• Suzue, K., H. F. Lodish, and B. Thorens. 1989. Sequence of the mouse liver glucose transporter. Nucleic Acids Res. 17:10099.
   PubMedGoogle Scholar
• Tal, M., B. B. Kahn, and H. F. Lodish. 1991. Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats. Endocrinology, in press.
   Google Scholar
• Tal, M., and H. F. Lodish. Unpublished observation.
   Google Scholar
• Tal, M., H. F. Lodish, G. Christofori, and D. Hanahan. Unpublished observation.
   Google Scholar
• Tai, M., D. L. Schneider, B. Thorens, and H. F. Lodish. 1990. Restricted expression of the "erythroid/brain" glucose transporter isoform to perivenous hepatocytes in rats: modulation by glucose. J. Clin. Invest. 86:982–992.
   Google Scholar
• Thorens, B., H. F. Lodish, and D. Brown. 1990. Differential expression of two glucose transporter isoforms in rat kidney. Am. J. Physiol. 259:C286–C294.
   PubMedGoogle Scholar
• Thorens, B., H. K. Sarkar, H. R. Kaback, and H. F. Lodish. 1988. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell 55:281–290.
   PubMed Web of Science ®Google Scholar
• Thorens, B., G. C. Weir, J. L. Leahy, H. F. Lodish, and S. Bonner-Weir. 1990. Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc. Natl. Acad. Sci. USA 87:6492–6496.
   PubMed Web of Science ®Google Scholar
• Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350–4354.
   PubMed Web of Science ®Google Scholar
• Warburg, O., K. Posener, and F. Negelein. 1924. Uber den Stoffwechsel der Carcinomzelle. Biochem. Z. 152:309–344.
   Google Scholar
• Wheeler, T. J., and P. C. Hinkle. 1981. Kinetic properties of the reconstituted glucose transporter from human erythrocytes. J. Biol. Chem. 256:8907–8914.
   PubMedGoogle Scholar