7
Views
20
CrossRef citations to date
0
Altmetric
Cell Growth and Development

The SH2 and SH3 Domain-Containing Nek Protein Is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors

, , , &
Pages 5824-5833 | Received 16 Jul 1992, Accepted 15 Sep 1992, Published online: 01 Apr 2023

REFERENCES

  • Aaronson, S. A. 1991. Growth factors and cancer. Science 254:1146–1153.
  • Bond, V. C., and B. Wold. 1987. Poly-L-ornithine-mediated transformation of mammalian cells. Mol. Cell. Biol. 7:2286–2293.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.
  • Bustelo, X. R., J. A. Ledbetter, and M. Barbacid. 1992. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature (London) 356:68–71.
  • Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell 64:281–302.
  • Chou, M. M., J. E. Fajardo, and H. Hanafiisa. 1992. The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol. Cell. Biol. 12:5834–5842.
  • Clark, S. G., M. Stern, and H. R. Horvitz. 1992. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature (London) 356:340–344.
  • Cooper, J. A., B. M. Sefton, and T. Hunter. 1983. Detection and quantification of phosphotyrosine in proteins. Methods Enzymol. 99:387–405.
  • Davis, S., M. L. Lu, S. H. Lo, S. Lin, J. A. Bulter, B. J. Druker, T. M. Roberts, Q. An, and L. B. Chen. 1991. Presence of an SH2 domain in the actin-binding protein tensin. Science 252:712–715.
  • Escobedo, J., D. R. Kaplan, W. M. Kavanaugh, C. W. Truck, and L. T. Williams. 1991. A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol. Cell Biol. 11:1125–1132.
  • Escobedo, J. A., S. Navankasattusas, W. M. Kavanaugh, D. Milfay, V. A. Fried, and L. T. Williams. 1991. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor. Cell 65:65–82.
  • Gould, K. L., and T. Hunter. 1988. Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Mol. Cell. Biol. 8:3345–3356.
  • Heldin, C.-H. 1991. SH2 domains: elements that control protein interactions during signal transduction. Trends Biochem. Sci. 16:450–452.
  • Hu, P., B. Margolis, E. Y. Skolnik, R. Lammers, A. Ullrich, and J. Schlessinger. 1992. Interaction of phosphatidylinositol 3-ki- nase-associated p85 with epidermal growth factor and platelet- derived growth factor receptors. Mol. Cell. Biol. 12:981–990.
  • Kashishian, A., A. Kazlauskas, and J. A. Cooper. 1992. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J. 11:1373–1382.
  • Katzav, S., J. L. Cleveland, H. E. Heslop, and D. Pulido. 1991. Loss of the amino-terminal helix-loop-helix domain of vav proto-oncogene activates its transforming potential. Mol. Cell. Biol. 11:1912–1920.
  • Katzav, S., D. Martin-Zanca, and M. Barbacid. 1989. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8:2283–2290.
  • Kazlauskas, A., and J. A. Cooper. 1990. Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphotidylinositol 3 kinase. EMBO J. 9:3279–3286.
  • Kazlauskas, A., A. Kashishian, J. A. Cooper, and M. Valius. 1992. GTPase-activating protein and phosphatidylinositol 3-ki- nase bind to distinct regions of the platelet-derived growth factor receptor β subunit. Mol. Cell. Biol. 12:2534–2544.
  • Koch, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668–674.
  • Kypta, R. M., Y. Goldberg, E. T. Ulug, and S. A. Courtneidge. 1990. Association between the PDGF receptor and members of the sre family of tyrosine kinases. Cell 62:481–492.
  • Lehmann, J. M., G. Riethmuller, and J. Johnson. 1990. Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the sre homology units SH2 and SH3. Nucleic Acids Res. 18:1048.
  • Li, W., G. C. Deanin, B. Margolis, J. Schlessinger, and J. M. Oliver. 1992. FceRI-mediated tyrosine phosphorylation of multiple proteins, including phospholipase Cγl and the receptor βγ2 complex, in RBL-2H3 rat basophilic leukemia cells. Mol. Cell Biol. 12:3176–3182.
  • Li, W., Y. G. Yeung, and E. R. Stanley. 1991. Tyrosine phosphorylation of a common 57-kDa protein in growth factor- stimulated and transformed cells. J. Biol. Chem. 266:6808–6814.
  • Liu, F. T., J. W. Bohn, E. L. Ferry, H. Yanamoto, C. A. Molinaro, L. A. Sherman, N. R. Klinman, and D. H. Katz. 1980. Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. J. Immunol. 124:2728–2736.
  • Lowenstein, E., R. Daly, A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431–442.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Margolis, B. 1992. Proteins with SH2 domains: transducers in the tyrosine kinase signalling pathway. Cell Growth Differ. 3:73–80.
  • Margolis, B., P. Hu, S. Katzav, W. Li, J. M. Oliver, A. Ullrich, A. Weiss, and J. Schlessinger. 1992. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature (London) 356:71–74.
  • Mayer, B. J., M. Hamaguchi, and H. Hanafusa. 1988. A novel viral oncogene with structural similarity to phospholipase C. Nature (London) 332:272–275.
  • Mayer, B. J., and H. Hanafiisa. 1990. Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. Proc. Natl. Acad. Sci. USA 87:2638–2642.
  • Meisenhelder, J., and T. Hunter. 1992. The SH2/SH3 domaincontaining protein Nck is recognized by certain anti phospholipase C-γl monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor or epidermal growth factor treatment. Mol. Cell. Biol. 12:5843–5856.
  • Miller, A. D., and G. J. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. BioTechniques 7:980–986.
  • Mohammadi, M., A. M. Honegger, D. Rotin, R. Fischer, F. Bellot, W. Li, C. A. Dionne, M. Jaye, M. Rubinstein, and J. Schlessinger. 1991. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γl. Mol. Cell. Biol. 11:5068–5078.
  • Otsu, M., I. Hiles, I. Gout, M. J. Fry, F. Ruiz-Larrea, G. Panayotou, A. Thompson, R. Dhand, J. Hsuan, N. Totty, A. D. Smith, S. J. Morgan, S. A. Courtneidge, P. J. Parker, and M. D. Waterfield. 1991. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3 kinase. Cell 65:91–104.
  • Park, D. J., H. K. Min, and S. G. Rhee. 1991. IgE-mediated tyrosine phosphorylation of phospholipase Cγl in rat basophilic leukemia cells. J. Biol. Chem. 266:24237–24240.
  • Park, D. J., and S. G. Rhee. 1992. Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP. Mol. Cell. Biol. 12:5816–5823.
  • Reedijk, M., X. Liu, P. van der Geer, K. Letwin, M. D. Waterfield, T. Hunter, and T. Pawson. 1992. Tyr 721 regulates specific binding of the CSF-1 receptor kinase inert to PI 3′- kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J. 11:1365–1372.
  • Rotin, D., B. Margolis, M. Mohammadi, R. J. Daly, G. Daum, N. U. E. H. Fisher, W. H. Burgess, A. Ullrich, and J. Schlessinger. 1992. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr 992 as the high-affinity binding site for SH2 domains of phospholipase Cy. EMBO J. 11:559–567.
  • Schlessinger, J. 1988. Signal transduction by allosteric receptor oligomerization. Trends Biochem. Sci. 13:443–447.
  • Shen, S.-H., L. Bastein, B. I. Posner, and P. Chrétien. 1991. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature (London) 352:736–739.
  • Skolnik, E. Y., B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83–90.
  • Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31–40.
  • Suh, P.-G., S. H. Ryu, K. H. Moon, H. W. Suh, and S. G. Rhee. 1988. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Proc. Natl. Acad. Sci. USA 85:5419–5423.
  • Thomas, G. 1992. Map kinase by any other name smells just as sweet. Cell 8:3–6.
  • Trahey, M., G. Wong, R. Halenbeck, B. Rubinfield, G. Martin, M. Ladner, C. M. Long, W. J. Crosier, K. Katt, K. Koths, and F. McCormick. 1988. Molecular cloning of two types of GAP complementary DNA from human placenta. Science 242:1696–1700.
  • Ullrich, A., and J. Schlessinger. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203–212.
  • van der Geer, P., and T. Hunter. 1991. Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription. Mol. Cell. Biol. 11:4698–4709.
  • Vogel, U. S., R. A. F. Dixon, M. D. Schaber, R. E. Diehl, M. S. Marshall, E. M. Scolnick, I. S. Sigal, and J. B. Gibbs. 1988. Cloning of bovine GAP and its interaction with oncogenic ras. Nature (London) 335:90–93.
  • Yi, T., J. L. Cleveland, and J. N. Ihle. 1992. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12pl2-pl3. Mol. Cell. Biol. 12:836–846.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.