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Transcriptional Regulation

Transcriptional Transactivation Functions Localized to the Glucocorticoid Receptor N Terminus Are Necessary for Steroid Induction of Lymphocyte Apoptosis

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Pages 589-597 | Received 09 Aug 1991, Accepted 12 Nov 1991, Published online: 01 Apr 2023

REFERENCES

  • Baughman, G., M. T. Harrigan, N. F. Campbell, S. J. Nurrish, and S. Bourgeois. 1991. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol. Endocrinol. 5:637–644.
  • Bourgeois, S., and J. C. Gasson. 1985. Genetic and epigenetic bases of glucocorticoid resistance in lymphoid cell lines. Biochem. Act. Horm. 12:311–351.
  • Bourgeois, S., and R. F. Newby. 1977. Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines. Cell 11:423–430.
  • Bourgeois, S., and R. F. Newby. 1979. Correlation between glucocorticoid receptor and cytolytic response of mouse lymphoid cell lines. Cancer Res. 39:4749–4751.
  • Briehl, M. M., and R. L. Miesfeld. 1991. Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate. Mol. Endocrinol. 5:1381–1388.
  • Cress, W. D., and S. J. Triezenberg. 1991. Critical structural elements of the VP16 transcriptional activation domain. Science 251:87–90.
  • Danielsen, M., J. P. Northrop, J. Jonklaas, and G. M. Ringold. 1987. Domains of the glucocorticoid receptor involved in specific and non specific deoxyribonucleic acid binding, hormone activation, and transcriptional enchancement. Mol. Endocrinol. 1:816–822.
  • Danielsen, M., J. P. Northrop, and G. M. Ringold. 1986. The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins. EMBO J. 5:2513–2522.
  • De Cuevillas, F., and H. Lachman. 1990. Transfection of a T-cell line with neo increases dexamethasone cytotoxicity. Leukocyte Res. 14:623–627.
  • DeFranco, D., and K. R. Yamamoto. 1986. Two different factors act separately or together to specify functionally distinct activities at a single transcription enhancer. Mol. Cell. Biol. 6:993–1001.
  • Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. R. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266–1272.
  • Dieken, E. S., E. U. Meese, and R. L. Miesfeld. 1990. nti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain. Mol. Cell. Biol. 10:4574–4581.
  • Distelhorst, C. W., L. Kullman, and J. Wasson. 1987. Characterization of glucocorticoid receptors in S49 mouse lymphoma cells by affinity labeling with [3H]dexamethasone 21-mesylate. J. Steroid Biochem. 26:59–65.
  • Ellis, H. M., and H. R. Horvitz. 1986. Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817–829.
  • Fawell, S. E., J. A. Lees, R. White, and M. G. Parker. 1990. Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60:953–962.
  • Gaido, M. L., and J. A. Cidlowski. 1991. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. J. Biol. Chem. 266:18580–18585.
  • Galili, U., R. Leizerowitz, J. Moreb, H. Gamliel, D. Gurfel, and A. Polliack. 1982. Metabolic and ultrastructural aspects of the in vitro lysis of chronic lymphocytic leukemia cells by glucocorticoids. Cancer Res. 42:1433–1440.
  • Gametchu, B. 1987. Glucocorticoid receptor-like antigen in lymphoma cell membranes: correlation of cell lysis. Science 236:456–461.
  • Gehring, U., K. Mugele, and J. Ulrich. 1984. Cellular receptor levels and glucocorticoid responsiveness of lymphoma cells. Mol. Cell. Endocrinol. 36:107–113.
  • Gehring, U., and G. M. Tomkins. 1974. A new mechanism for steroid unresponsiveness: loss of nuclear binding activity of a steroid hormone receptor. Cell 3:301–306.
  • Godowski, P. J., D. Picard, and K. R. Yamamoto. 1988. Signal transduction and transcriptional regulation by glucocorticoid receptor-lexA fusion proteins. Science 241:812–816.
  • Gritz, L., and J. Davies. 1983. Plasmid encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae. Gene 25:179–188.
  • Harris, A. W. 1970. Differentiated functions expressed by cultured mouse lymphoma cells. Exp. Cell Res. 60:341–353.
  • Hollenberg, S. M., and R. M. Evans. 1988. Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell 55:899–906.
  • Horibata, K., and A. W. Harris. 1970. Mouse myelomas and lymphomas in culture. Exp. Cell Res. 60:61–77.
  • Ingles, C. J., M. Shales, W. D. Cress, S. J. Triezenberg, and J. Greenblatt. 1991. Reduced binding of TFIID to transcriptionally compromised mutants of VP16. Nature 351:588–590.
  • Ip, M. M., W. K. Shea, D. Sykes, and D. A. Young. 1991. The truncated glucocorticoid receptor in the P1798 mouse lymphosarcoma is associated with resistance to glucocorticoid lysis but not to other glucocorticoid-induced functions. Cancer Res. 51:2786–2796.
  • Iwata, M., S. Hanaoka, and K. Sato. 1991. Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21:643–648.
  • Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
  • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680–685.
  • Lin, Y.-S., and M. R. Green. 1991. Mechanism of action of an acidic transcriptional activator in vitro. Cell 64:971–981.
  • Martin, D. P., R. E. Schmidt, P. S. DiStefano, O. H. Lowry, J. G. Carter, and E. M. Johnson, Jr. 1988. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:829–844.
  • Miesfeld, R. L. 1989. The structure and function of steroid receptor proteins. Crit. Rev. Biochem. Mol. Biol. 24:101–117.
  • Miesfeld, R. L. 1990. Molecular genetics of corticosteroid action. Am. Rev. Respir. Dis. 141:S11–S17.
  • Miesfeld, R. L., P. J. Godowski, B. A. Maler, and K. R. Yamamoto. 1987. Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science 236:423–427.
  • Miesfeld, R. L., S. Okret, A.-C. Wikström, Ö. Wrange, J. K. Gustafsson, and K. R. Yamamoto. 1984. Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells. Nature (London) 312:779–781.
  • Miesfeld, R. L., S. Rusconi, S. Okret, A.-C. Wilkstrom, J.-A. Gustafsson, and K. R. Yamamoto. 1985. Preliminary analyses of the glucocorticoid receptor gene and its expression: a DNA- binding protein essential for hormone-dependent transcriptional enhancement. UCLA Symp. Mol. Cell. Biol. 30:535–545.
  • Miesfeld, R. L., D. Sakai, A. Inoue, M. Schena, P. J. Godowski, and K. R. Yamamoto. 1988. Glucocorticoid receptor sequences that confer positive and negative transcriptional regulation. UCLA Symp. Steroid Horm. Act. 75:193–200.
  • Nazareth, L. V., D. V. Harbour, and E. B. Thompson. 1991. Mapping the human glucocorticoid receptor for leukemic cell death. J. Biol. Chem. 266:12976–12980.
  • Norman, M. R., and E. B. Thompson. 1977. Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Res. 37:3785–3791.
  • Northrop, J. P., B. Gametchu, R. W. Harrison, and G. M. Ringold. 1985. Characterization of wild type and mutant glucocorticoid receptors from rat hepatoma and mouse lymphoma cells. J. Biol. Chem. 260:6398–6403.
  • Oliviero, S., and K. Struhl. 1991. Synergistic transcriptional enhancement does not depend on the number of acidic activation domains bound to the promoter. Proc. Natl. Acad. Sci. USA 88:224–228.
  • Oppenheim, R. W., D. Prevette, M. Tytell, and S. Homma. 1990. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev. Biol. 138:104–113.
  • Oro, A. E., S. M. Hollenberg, and R. M. Evans. 1988. Transcriptional inhibition by a glucocorticoid receptor β-galactosidase fusion protein. Cell 55:1109–1114.
  • Patterson, M. K., Jr. 1979. Measurement of growth and viability of cells in culture. Methods Enzymol. 58:141–152.
  • Payvar, F. P., D. DeFranco, G. L. Firestone, B. Edgar, O. Wrange, S. Okert, J.-A. Gustafsson, and K. R. Yamamoto. 1983. Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell 35:381–392.
  • Perlmann, T., P. Eriksson, and Ö. Wrange. 1990. Quantitative analysis of the glucocorticoid receptor-DNA interaction at the mouse mammary tumor virus glucocorticoid response element. J. Biol. Chem. 265:17222–17229.
  • Picard, D., and K. R. Yamamoto. 1987. Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J. 6:3333–3340.
  • Ptashne, M. 1988. How eukaryotic transcriptional activators work. Nature (London) 335:683–689.
  • Puck, T. T., P. I. Marcus, and S. J. Cieciura. 1955. Clonal growth of mammalian cells in vitro. J. Exp. Med. 103:273–289.
  • Rabindran, S. K., M. Danielsen, and M. R. Stallcup. 1987. Glucocorticoid-resistant lymphoma cell variants that contain functional glucocorticoid receptors. Mol. Cell. Biol. 7:4211–4217.
  • Rehmus, E. H., K. J. Howard, K. E. Janiga, and C. W. Distelhorst. 1987. Immunochemical comparison of mutant glucocorticoid receptors and wild type receptor fragments produced by neutrophil elastase and chymotrypsin. J. Steroid Biochem. 28:167–177.
  • Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152:704–720.
  • Rundlett, S., X. P. Wu, and R. L. Miesfeld. 1990. Functional characterizations of the androgen receptor confirm that a primary effect of androgens is transcriptional regulation. Mol. Endocrinol. 4:708–714.
  • Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature (London) 335:563–564.
  • Sakai, D. D., S. Helms, J. Carlstedt-Duke, J.-A. Gustafsson, F. M. Rottman, and K. R. Yamamoto. 1988. Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2:1144–1154.
  • Scheidereit, C., and M. Beato. 1984. Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus. Proc. Natl. Acad. Sci. USA 81:3029–3033.
  • Schwartz, L. M., L. Kosz, and B. K. Kay. 1990. Gene activation is required for developmentally programmed cell death. Proc. Natl. Acad. Sci. USA 87:6594–6598.
  • Sibley, C. H., and G. M. Tomkins. 1974. Isolation of lymphoma cell variants resistant to killing by glucocorticoids. Cell 2:213–220.
  • Simons, S. S., R. E. Schleenbaker, and H. J. Eisen. 1983. Activation of covalent affinity labeled glucocorticoid receptor- steroid complexes. J. Biol. Chem. 258:2229–2238.
  • Simons, S. S., and E. B. Thompson. 1981. Dexamethasone 21-mesylate: an affinity label of glucocorticoid receptors from rat hepatoma tissue culture cells. Proc. Natl. Acad. Sci. USA 78:3541–3545.
  • Spaete, R. R., and E. S. Mocarski. 1985. Regulation of cytomegalovirus gene expression: a and b promoters are trans activated by viral functions in permissive human fibroblasts. J. Virol. 56:135–143.
  • Tsai, S. Y., J. Carlstedt-Duke, N. L. Weigel, K. Dahhnan, J.-A. Gustafsson, M. J. Tsai, and B. W. O'Malley. 1988. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell 55:361–369.
  • Vanderbilt, J. N., R. L. Miesfeld, B. A. Maler, and K. R. Yamamoto. 1987. Interacellular receptor concentration limits glucocorticoid-dependent enhancer activity. Mol. Endocrinol. 1:68–74.
  • Wrange, Ö., P. Eriksson, and T. Perlmann. 1989. The purified activated glucocorticoid receptor is a homodimer. J. Biol. Chem. 264:5253–5259.
  • Wyllie, A. H., J. F. R. Kerr, and A. R. Currie. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251–307.
  • Yamamoto, K. R. 1985. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:209–252.
  • Yamamoto, K. R., U. Gehring, M. R. Stampfer, and C. H. Sibley. 1976. Genetic approaches to steroid hormone action. Recent. Prog. Horm. Res. 32:3–32.

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