Characterization of a Fusion cDNA (RARA/myl) Transcribed from the t(15;17) Translocation Breakpoint in Acute Promyelocytic Leukemia

REFERENCES

• Aviv, H., and P. Leder. 1972. Purification of biologically active globin mRNA by chromatography on oligothymidylic acidcellulose. Proc. Natl. Acad. Sci. USA 69:1408–1412.
   PubMed Web of Science ®Google Scholar
• Bennett, J. M., D. Catovsky, M. T. Daniel, G. Flandrin, D. A. G. Galton, H. R. Gralnick, and C. Sultan. 1976. Proposals for the classification of the acute leukemia (FAB co-operative group). Br. J. Haematol. 33:451–458.
   PubMed Web of Science ®Google Scholar
• Borrow, J., A. D. Goddard, D. Sheer, and E. Soloman. 1990. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577–1580.
   PubMed Web of Science ®Google Scholar
• Boylan, J. F., and L. J. Gudas. 1991. Overexpression of the cellular retinoic acid binding protein-1 (CRABP-1) results in a reduction in differentiation-specific gene expression in F9 tera- tocarcinoma cells. J. Cell Biol. 112:965–979.
   PubMed Web of Science ®Google Scholar
• Brand, N. J., M. Petkovich, and P. Chambon. 1990. Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-α). Nucleic Acids Res. 18:6799–6806.
   PubMed Web of Science ®Google Scholar
• Brand, N., M. Petkovich, A. Krust, P. Chambon, H. de The, A. Marchio, P. Tiollais, and A. Dejean. 1988. Identification of a second human retinoic acid receptor. Nature (London) 332:850–853.
   PubMed Web of Science ®Google Scholar
• Brickell, P. M., and C. Tickle. 1989. Morphogens in chick limb development. Bioessays 11:145–149.
   PubMed Web of Science ®Google Scholar
• Butturini, A., and R. P. Gale. 1990. Oncogenes and leukemia. Leukemia 4:138–160.
   PubMed Web of Science ®Google Scholar
• Castaigne, S., C. Chomienne, M. T. Daniel, P. Ballerini, R. Berger, P. Fenaux, and L. Degos. 1990. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia and clinical results. Blood 76:1704–1709.
   PubMed Web of Science ®Google Scholar
• Chang, K. S., J. M. Trujillo, T. Ogura, C. M. Castiplione, K. K. Kidd, S. Zhao, E. J. Freireich, and S. A. Stass. 1991. Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 5:200–204.
   PubMed Web of Science ®Google Scholar
• Chang, K. S., J. M. Trujillo, W. C. Pugh, E. Freireich, and S. A. Stass. 1990. Developmental and differential regulations of human myeloperoxidase gene in leukemia cells. Leukemia 4:497–501.
   PubMed Web of Science ®Google Scholar
• Chomienne, C., P. Ballerini, N. Balitrand, M. T. Daniel, P. Fenaux, S. Castaigne, and L. Degos. 1990. All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structurefunction relationship. Blood 76:1710–1717.
   PubMed Web of Science ®Google Scholar
• Chomienne, C., P. Ballerini, N. Balitrand, M. E. Huang, I. Krawice, S. Castaigne, P. Fenaux, P. Tiollais, A. Dejean, L. Degos, and H. de The. 1990. The retinoic acid receptor a gene is rearranged in retinoic acid-sensitive promyelocytic leukemias. Leukemia 4:802–807.
   PubMed Web of Science ®Google Scholar
• Deaven, L. L., M. A. van Dilla, M. F. Bartholdi, A. V. Carrono, L. S. Cram, J. C. Fuscoe, J. W. Gray, C. E. Hildebrand, R. K. Moyzis, and J. Perlman. 1986. Construction of human chromosome-specific DNA libraries from flow-sorted chromosome. Cold Spring Harbor Symp. Quant. Biol. 51:159–168.
   PubMedGoogle Scholar
• de The, H., C. Chomienne, M. Lanotte, L. Degos, and A. Dejean. 1990. The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature (London) 347:558–561.
   PubMed Web of Science ®Google Scholar
• de The, H., C. Lavau, A. Marchio, C. Chomienne, L. Degos, and A. Dejean. 1991. The PML-RARA fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675–684.
   PubMed Web of Science ®Google Scholar
• Dobrovic, A., K. J. Trainor, and A. A. Morley. 1988. Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction. Blood 72:3063–3065.
   Google Scholar
• Fainstein, E., C. Marcelle, A. Rosner, E. Cenaci, R. P. Gale, O. Dreazen, S. D. Smith, and C. M. Croce. 1987. A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukemia. Nature (London) 330:386–388.
   PubMed Web of Science ®Google Scholar
• Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6–13.
   PubMed Web of Science ®Google Scholar
• Freemont, P. S., I. M. Hanson, and J. Trowsdale. 1991. A novel cysteine-rich sequence motif. Cell 64:483–484.
   PubMed Web of Science ®Google Scholar
• Gale, R. P., and E. Canaani. 1984. An 8-kilobase abl RNA transcript in chronic myelogeneous leukemia. Proc. Natl. Acad. Sci. USA 81:5648–5652.
   PubMed Web of Science ®Google Scholar
• Giguere, V., E. S. Ong, P. Sequi, and R. N. Evan. 1987. Identification of a receptor for the morphogen retinoic acid. Nature (London) 330:624–629.
   PubMed Web of Science ®Google Scholar
• Gubler, U., and B. J. Hoffman. 1983. A simple and very efficient method for generating cDNA libraries. Gene 25:263–268.
   PubMed Web of Science ®Google Scholar
• Gyllensten, U. B., and H. A. Erlich. 1988. Generation of singlestranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proc. Natl. Acad. Sci. USA 85:7652–7656.
   PubMed Web of Science ®Google Scholar
• Holt, J. T., C. C. Morton, A. W. Nienhuis, and P. Leder. 1987. Molecular mechanism of hematological neoplasms, p. 347–376. In G. Stamatoyannopoulos, A. W. Nienhuis, P. Leder, and P. W. Majerus (ed.), The molecular basis of blood diseases. W. B. Saunders Co., Philadelphia.
   Google Scholar
• Huang, M., Y. D. Ye, B. R. Chen, J. R. Chai, J. X. Lu, L. Zhoa, L. J. Eu, and Z. Y. Wang. 1988. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567–572.
   PubMed Web of Science ®Google Scholar
• Kakizuka, A., W. H. Miller, K. Umesono, R. P. Warrell, S. R. Frankel, V. V. V. S. Murty, E. Dmitrovsky, and R. M. Evans. 1991. Chromosomal translocation t(15;17) in human acute leukemia fuses RARA with a novel putative transcription factor, PML. Cell 66:663–674.
   PubMed Web of Science ®Google Scholar
• Kawasaki, E. S., S. S. Clark, M. Y. Coyne, S. D. Smith, R. Champlin, O. N. Witte, and F. P. McCormick. 1988. Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro. Proc. Natl. Acad. Sci. USA 85:5698–5702.
   PubMed Web of Science ®Google Scholar
• Koeffler, H. P. 1983. Induction of differentiation of human acute myelogenous leukemia cells. Blood 62:709–721.
   PubMed Web of Science ®Google Scholar
• Krust, A., P. Kastner, M. Petkovich, A. Zelant, and P. Chambon. 1989. A third human retinoic acid receptor, HRAR-gamma. Proc. Natl. Acad. Sci. USA 86:5310–5314.
   PubMed Web of Science ®Google Scholar
• Leroy, P., A. Krust, A. Zelent, C. Mendelsohn, J. M. Garnier, P. Kastner, A. Dierich, and P. Chambon. 1991. Multiple isoforms of the mouse retinoic acid receptor a are generated by alternative splicing and differential induction by retinoic acid. EMBO J. 10:59–69.
   PubMed Web of Science ®Google Scholar
• Mangelsdorf, D. J., E. S. Ong, J. A. Dyck, and R. M. Evans. 1990. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature (London) 345:224–229.
   PubMed Web of Science ®Google Scholar
• Mattei, M. G., M. Petkovich, J. F. Mattei, N. Brand, and P. Chambon. 1988. Mapping of the human retinoic acid receptor to the Q21 band of chromosome 17. Hum. Genet. 80:186–188.
   PubMed Web of Science ®Google Scholar
• Miller, W. H., Jr., R. P. Warrell, Jr., S. R. Frankel, A. Jakubowski, J. L. Gabrilove, J. Muindi, and E. Dmitrovsky. 1990. Novel retinoic acid receptor-a transcripts in acute promyelocytic leukemia responsive to all-trans retinoic acid. J. Natl. Cancer Inst. 82:1932–1933.
   PubMed Web of Science ®Google Scholar
• Murray, S. S., L. L. Deaven, D. W. Burton, D. T. O'Connor, P. L. Mellon, and L. J. Deftos. 1987. The gene for human chromogranin A (CgA) is located on chromosome 14. Biochem. Biophys. Res. Commun. 142:141–146.
   PubMedGoogle Scholar
• Pandolfi, P. P., F. Grignani, M. Alcalay, A. Mencarelli, A. Biondi, F. LoCoco, F. Grignani, and P. G. Pelicci. 1991. Structure and origin of the acute promyelocytic leukemias myl/RARA cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6:1285–1292.
   PubMed Web of Science ®Google Scholar
• Petkovich, M., N. J. Brand, A. Krust, and P. Chambon. 1987. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature (London) 330:444–450.
   PubMed Web of Science ®Google Scholar
• Rodaway, A. R. F., C. G. Teahan, C. M. Casimir, A. W. Segal, and D. L. Bentley. 1990. Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. Mol. Cell. Biol. 10:5388–5396.
   PubMed Web of Science ®Google Scholar
• Rowley, J. D. 1984. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res. 44:3159–3168.
   PubMed Web of Science ®Google Scholar
• Saito, H., A. C. Hayday, K. Wiman, K. S. Wyward, and S. Tonegawa. 1983. Activation of the cMYC gene by translocation: a model for translational control. Proc. Natl. Acad. Sci. USA 80:7476–7480.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, p. 846–851. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
   Google Scholar
• Sani, B. P., R. K. Singh, L. Reddy, and M. P. Gaub. 1990. Isolation, partial purification and characterization of nuclear retinoid acid receptors from chick skin. Arch. Biochem. Biophys. 283:107–113.
   PubMed Web of Science ®Google Scholar
• Sawyers, C. L., C. T. Denny, and O. N. Witte. 1991. Leukemia and the disruption of normal hematopoiesis. Cell 64:337–350.
   PubMed Web of Science ®Google Scholar
• Sherman, M. L. (ed.) 1986. Retinoids and cell differentiation, p. 161–186. CRC Press, Inc., Boca Raton, Fla.
   Google Scholar
• Shtivelman, E., B. Lifshitz, R. P. Gale, B. A. Roe, and E. Canaani. 1986. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr/abl fused gene. Cell 47:277–284.
   PubMed Web of Science ®Google Scholar
• Strickland, S., and V. Mahdavi. 1978. Induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 15:393–401.
   PubMed Web of Science ®Google Scholar
• Suggs, S. V., R. B. Wallace, T. Hirose, E. H. Kawashima, and K. Itakura. 1982. Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequence for human (32-microglobulin. Proc. Natl. Acad. Sci. USA 78:6613–6617.
   Google Scholar
• Zagursky, R., N. Baumeister, N. Lomax, and M. Berman. 1985. Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA. Gene Anal. Tech. 2:89–94.
   Google Scholar