Tissue-Specific, Developmental, Hormonal, and Dietary Regulation of Rat Phosphoenolpyruvate Carboxykinase-Human Growth Hormone Fusion Genes in Transgenic Mice

References

• Anderson, J. W. 1970. Pyruvate carboxylase and phosphoe-nolpyruvate carboxykinase in rat intestinal mucosa. Biochim. Biophys. Acta 208:165–167.
   PubMedGoogle Scholar
• Bartels, H., H. Herbort, and K. Jungermann. 1990. Predominant periportal expression of the phosphoenolpyruvate carboxykinase and tyrosine aminotransferase genes in rat liver. Dynamics during the daily feeding rhythm and starvation-refeeding cycle demonstrated by in situ hybridization. Histochemistry 94:637–644.
   PubMedGoogle Scholar
• Bartke, A., R. W. Steger, S. L. Hodges, T. A. Parkening, T. J. Collins, J. S. Yun, and T. E. Wagner. 1988. Infertility in trangenic female mice with human growth hormone expression: evidence for luteal failure. J. Exp. Zool. 248:121–124.
   PubMedGoogle Scholar
• Beale, E. G., N. B. Chrapkiewicz, H. A. Scoble, R. J. Metz, D. P. Quick, R. L. Noble, J. E. Donelson, K. Biemann, and D. K. Granner. 1985. Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. J. Biol. Chem. 260:10748–10760.
   PubMedGoogle Scholar
• Beale, E. G., I. M. Schaefer, and Q. Li. 1991. Culture at high density increases phosphoenolpyruvate carboxykinase messenger RNA in H4IIEC3 hepatoma cells. Mol. Endocrinol. 5:661–669.
   PubMedGoogle Scholar
• Benvenisty, N., H. Neehushtan, H. Cohen, and L. Reshef. 1989. Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. Proc. Natl. Acad. Sci. USA 86:1118–1122.
   PubMedGoogle Scholar
• Benvenisty, N., and L. Reshef. 1991. Regulation of tissue- and development-specific gene expression in the liver. Biol. Neonate 59:181–189.
   PubMedGoogle Scholar
• Birkenmeier, E. H., B. Gwynn, S. Howard, J. Jerry, J. I. Gordon, W. H. Landschulz, and S. L. McKnight. 1989. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3:1146–1156.
   PubMed Web of Science ®Google Scholar
• Braun, R. E., J. J. Peschon, R. R. Behringer, R. L. Brinster, and R. D. Palmiter. 1989. Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic mice. Genes Dev. 3:793–802.
   PubMed Web of Science ®Google Scholar
• Brinster, R. L., H. Y. Chen, M. E. Trumbauer, M. K. Yagle, and R. D. Palmiter. 1985. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA 82:4438–4442.
   PubMed Web of Science ®Google Scholar
• Chajek-Shaul, T., V. Barash, J. Weidenfeld, G. Friedman, E. Ziv, E. Shohami, and E. Shiloni. 1990. Lethal hypoglycemia and hypothermia induced by administration of low doses of tumor necrosis factor to adrenalectomized rats. Metabolism 39:242–250.
   PubMedGoogle Scholar
• Chen, C. W., and C. A. Thomas, Jr. 1980. Recovery of DNA segments from agarose gels. Anal. Biochem. 101:339–341.
   PubMed Web of Science ®Google Scholar
• Chirgwin, J. M., A. E. Pryzbyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5299.
   PubMed Web of Science ®Google Scholar
• Christ, B., A. Nath, and K. Jungermann. 1990. Mechanisms of the inhibition by insulin of the glucagon-dependent activation of the phosphenolpyruvate carboxykinase gene in rat hepatocyte cultures. Action on gene transcription, mRNA level and-stability as well as hysteresis effect. Biol. Chem. Hoppe-Seyler 371:395–402.
   PubMedGoogle Scholar
• Chu, D. T., C. M. Davis, N. B. Chrapkiewicz, and D. K. Granner. 1988. Reciprocal regulation of gene transcription by insulin. Inhibition of the phosphoenolpyruvate carboxykinase gene and stimulation of gene 33 in a single cell type. J. Biol. Chem. 263:13007–13011.
   PubMedGoogle Scholar
• Clayton, D. F., A. L. Harrelson, and J. E. Darnell, Jr. 1985. Dependence of liver-specific transcription on tissue organization. Mol. Cell. Biol. 5:2623–2632.
   PubMed Web of Science ®Google Scholar
• Clayton, D. F., M. Weiss, and J. E. Darnell, Jr. 1985. Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels. Mol. Cell. Biol. 5:2633–2641.
   PubMedGoogle Scholar
• Costa, R. H., T. A. Van Dyke, C. Yan, F. Kuo, and J. E. Darnell, Jr. 1990. Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus. Proc. Natl. Acad. Sci. USA 87:6589–6593.
   PubMed Web of Science ®Google Scholar
• Courtois, G., J. G. Morgan, L. A. Campbell, G. Fourel, and G. R. Crabtree. 1987. Interaction of a liver specific nuclear factor with the fibrinogen and α1-antitrypsin promoters. Science 238:688–692.
   PubMed Web of Science ®Google Scholar
• Durnam, D. M., and R. D. Palmiter. 1983. A practical approach for quantitating specific mRNAs by solution hybridization. Anal. Biochem. 131:385–393.
   PubMed Web of Science ®Google Scholar
• Flores, H., and G. A. Alleyne. 1971. Phosphoenolpyruvate carboxykinase of kidney. Subcellular distribution and response to acid-base changes. Biochem. J. 123:35–39.
   PubMedGoogle Scholar
• Garcia-Ruiz, J. P., M. F. Lobato, M. Ros, and F. J. Moreno. 1983. Presence of cytosolic phosphoenolpyruvate carboxyki- nase activity in rat mammary gland. Enzyme 30:265–268.
   PubMedGoogle Scholar
• Girard, J. 1986. Gluconeogenesis in late fetal and early neonatal life. Biol. Neonate 50:237–258.
   PubMedGoogle Scholar
• Granner, D. K., K. Sasaki, and D. Chu. 1986. Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. Ann. N.Y. Acad. Sci. 478:175–190.
   PubMedGoogle Scholar
• Habener, J. F. 1990. Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol. Endocrinol. 4:1087–1094.
   PubMedGoogle Scholar
• Hammer, R. E., R. Krumlauf, S. A. Camper, R. L. Brinster, and S. M. Tilghman. 1987. Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science 235:53–58.
   PubMedGoogle Scholar
• Hammer, R. E., S. D. Maika, J. A. Richardson, J.-P. Tang, and J. D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: an animal model of HLA-B27-associated human disorders. Cell 63:1099–1112.
   PubMed Web of Science ®Google Scholar
• Hammer, R. E., R. D. Palmiter, and R. L. Brinster. 1984. The introduction of metallothionein-growth hormone fusion genes into mice, p. 52–55. In F. Ahmad, S. Black, J. Schultz, and W. J. Whelan (ed.), Advances in gene technology: human genetic disorders. ICSU Press, Miami.
   Google Scholar
• Hammer, R. E., R. D. Palmiter, and R. L. Brinster. 1984. Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene. Nature (London) 311:65–67.
   PubMed Web of Science ®Google Scholar
• Hanson, R. W., and A. J. Garber. 1972. Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis. Am. J. Clin. Nutr. 25:1010–1021.
   PubMed Web of Science ®Google Scholar
• Hardon, E. M., M. Frain, G. Paonessa, and R. Cortese. 1988. Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J. 7:1711–1719.
   PubMed Web of Science ®Google Scholar
• Hauft, S. M., D. A. Sweetser, P. S. Rotwein, R. Lajara, P. C. Hoppe, E. H. Birkenmeier, and J. I. Gordon. 1989. A transgenic mouse model that is useful for analyzing cellular and geographic differentiation of the intestine during fetal development. J. Biol. Chem. 264:8418–8429.
   Google Scholar
• Hod, Y., and R. W. Hanson. 1988. Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation. J. Biol. Chem. 263:7747–7752.
   PubMedGoogle Scholar
• Idzerda, R. L., R. R. Behringer, M. Theisen, J. I. Huggenvik, G. S. McKnight, and R. L. Brinster. 1989. Expression from the transferrin gene promoter in transgenic mice. Mol. Cell. Biol. 9:5154–5162.
   PubMedGoogle Scholar
• Imai, E., P.-E. Stromstedt, P. G. Quinn, J. Carlstedt-Duke, J.-A. Gustafsson, and D. K. Granner. 1990. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 10:4712–4719.
   PubMed Web of Science ®Google Scholar
• Kumara-Siri, M. H., and M. I. Surks. 1985. Regulation of growth hormone mRNA synthesis by 5-triiodo-L-thyronine in cultured growth hormone-producing rat pituitary tumor cells (GC cells). Dissociation between nuclear iodothyronine receptor concentration and growth hormone mRNA synthesis during the deoxyribonucleic acid synthesis phase of the cell cycle. J. Biol. Chem. 260:14529–14537.
   PubMed Web of Science ®Google Scholar
• Kuo, C. J., P. B. Conley, C.-L. Hsieh, U. Francke, and G. R. Crabtree. 1990. Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc. Natl. Acad. Sci. USA 87:9838–9842.
   PubMed Web of Science ®Google Scholar
• Labarca, C., and K. Paigen. 1980. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344–352.
   PubMed Web of Science ®Google Scholar
• Lamers, W. H., R. W. Hanson, and H. M. Meisner. 1982. cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei. Proc. Natl. Acad. Sci. USA 79:5137–5141.
   PubMed Web of Science ®Google Scholar
• Landschulz, W. H., P. F. Johnson, E. Y. Adashi, B. J. Graves, and S. L. McKnight. 1988. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 2:786–800.
   PubMed Web of Science ®Google Scholar
• Leff, T., K. Reue, A. Melian, H. Culver, and J. L. Breslow. 1989. A regulatory element in the ApoCIII promoter that directs hepatic specific transcription binds to proteins in expressing and nonexpressing cell types. J. Biol. Chem. 264:16132–16137.
   PubMedGoogle Scholar
• Loose, D. S., D. K. Cameron, H. P. Short, and R. W. Hanson. 1985. Thyroid hormone regulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat liver. Biochemistry 24:4509–4512.
   PubMedGoogle Scholar
• Lucas, P. C., R. M. O'Brien, J. A. Mitchell, C. M. Davis, E. Imai, B. M. Forman, H. H. Samuels, and D. K. Granner. 1991. A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc. Natl. Acad. Sci. USA 88:2184–2188.
   PubMed Web of Science ®Google Scholar
• McGrane, M. M., J. de Vente, J. Yun, J. Bloom, E. Park, A. Wynshaw-Boris, T. Wagner, F. M. Rottman, and R. W. Hanson. 1988. Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice. J. Biol. Chem. 263:11443–11451.
   PubMed Web of Science ®Google Scholar
• McGrane, M. M., J. S. Yun, A. F. M. Moorman, W. H. Lamers, G. K. Hendrick, B. M. Arafah, E. A. Park, T. E. Wagner, and R. W. Hanson. 1990. Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice. J. Biol. Chem. 265:22371–22379.
   PubMedGoogle Scholar
• McKnight, S. L., M. D. Lane, and S. Gluecksohn-Waelsch. 1989. Is CCAAT/enhancer-binding protein a central regulator of energy metabolism? Genes Dev. 3:2021–2024.
   PubMed Web of Science ®Google Scholar
• Meisner, H., D. S. Loose, and R. W. Hanson. 1985. Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney. Biochemistry 24:421–425.
   PubMedGoogle Scholar
• Nechushtan, H., N. Benvenisty, R. Brandeis, and L. Reshef. 1987. Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner. Nucleic Acids Res. 15:6405–6417.
   PubMedGoogle Scholar
• O'Brien, R. M., P. C. Lucas, C. D. Forest, M. A. Magnuson, and D. K. Granner. 1990. Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249:533–537.
   PubMedGoogle Scholar
• Palmiter, R. D., and R. L. Brinster. 1986. Germ-line transformation of mice. Annu. Rev. Genet. 20:465–499.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D., R. L. Brinster, R. E. Hammer, M. E. Trum-bauer, M. G. Rosenfeld, N. C. Birnberg, and R. M. Evans. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (London) 300:611–615.
   PubMed Web of Science ®Google Scholar
• Palmiter, R. D., G. Norstedt, R. E. Gelinas, R. E. Hammer, and R. L. Brinster. 1983. Metallothionein-human GH fusion genes stimulate growth of mice. Science 222:809–814.
   PubMed Web of Science ®Google Scholar
• Park, E. A., W. J. Roesler, J. Liu, D. J. Klemm, A. L. Gurney, J. D. Thatcher, J. Shuman, A. Friedman, and R. W. Hanson. 1990. The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol. Cell. Biol. 10:6264–6272.
   PubMedGoogle Scholar
• Perdereau, D., M. Narkewicz, C. Coupe, P. Ferre, and J. Girard. 1990. Hormonal control of specific gene expression in the rat liver during the suckling-weaning transition. Adv. Enzyme Regul. 30:91–108.
   PubMedGoogle Scholar
• Petersen, D. D., S. R. Koch, and D. K. Granner. 1989. 3' noncoding region of phosphoenolpyruvate carboxykinase messenger RNA contains a glucocorticoid-responsive messenger RNA-stabilizing element. Proc. Natl. Acad. Sci. USA 86:7800–7804.
   PubMedGoogle Scholar
• Pinkert, C. A., D. M. Ornitz, R. L. Brinster, and R. D. Palmiter. 1987. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev. 1:268–276.
   PubMed Web of Science ®Google Scholar
• Quinn, P. G., T. W. Wong, M. A. Magnuson, J. B. Shabb, and D. K. Granner. 1988. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 8:3467–3475.
   PubMed Web of Science ®Google Scholar
• Reshef, L., R. W. Hanson, and F. J. Ballard. 1970. A possible physiological role for glyceroneogenesis in rat adipose tissue. J. Biol. Chem. 245:5979–5984.
   PubMedGoogle Scholar
• Roesler, W. J., G. R. Vandenbark, and R. W. Hanson. 1989. Identification of multiple protein binding domains in the promot- er-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene. J. Biol. Chem. 264:9657–9664.
   PubMedGoogle Scholar
• Ross, S. R., R. A. Graves, A. Greenstein, K. A. Piatt, H.-L. Shyu, B. Mellovitz, and B. M. Spiegelman. 1990. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. Proc. Natl. Acad. Sci. USA 87:9590–9594.
   PubMed Web of Science ®Google Scholar
• Russell, E. L., L. B. Russell, and J. S. Gower. 1959. Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc. Natl. Acad. Sci. USA 45:554–560.
   PubMedGoogle Scholar
• Santoro, C., N. Mermod, P. C. Andrews, and R. Tjian. 1988. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature (London) 334:218–224.
   PubMedGoogle Scholar
• Schubart, U. K. 1986. Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase. Endocrinology 119:1741–1749.
   PubMedGoogle Scholar
• Selden, R. F., K. B. Howie, M. E. Rowe, H. M. Goodman, and D. D. Moore. 1986. Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6:3173–3179.
   PubMed Web of Science ®Google Scholar
• Short, J. M., A. Wynshaw-Boris, H. P. Short, and R. W. Hanson. 1986. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. J. Biol. Chem. 261:9721–9726.
   PubMedGoogle Scholar
• Sladek, F. M., W. Zhong, E. Lai, and J. E. Darnell, Jr. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353–2363.
   PubMed Web of Science ®Google Scholar
• Swift, G. H., F. Kruse, R. J. MacDonald, and R. E. Hammer. 1989. Differential requirements for cell-specific elastase I enhancer domains in transfected cells and transgenic mice. Genes Dev. 3:687–696.
   PubMedGoogle Scholar
• Tilghman, S. M., F. J. Ballard, and R. W. Hanson. 1976. Hormonal regulation of phosphoenolpyruvate carboxykinase (GTP) in mammalian tissues, p. 47. In R. W. Hanson and M. A. Mehlman (ed.), Gluconeogenesis: its regulation in mammalian species. Wiley and Sons, New York.
   Google Scholar
• Trus, M., N. Benvenisty, H. Cohen, and L. Reshef. 1990. Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter. Mol. Cell. Biol. 10:2418–2422.
   PubMedGoogle Scholar
• Utter, M. F., and K. Kurahashi. 1954. Purification of oxalacetic carboxylase from chicken liver. J. Biol. Chem. 207:787–802.
   PubMed Web of Science ®Google Scholar
• Weber, L. W. D., M. Lebofsky, H. Greim, and K. Rozman. 1991. Key enzymes of gluconeogenesis are dose-dependently reduced in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Arch. Toxicol. 65:119–123.
   PubMed Web of Science ®Google Scholar
• Wynshaw-Boris, A., J. M. Short, and R. W. Hanson. 1987. Regulation of gene transcription by multiple hormones: organization of regulatory elements. Prog. Nucleic Acid Res. Mol. Biol. 34:59–87.
   PubMedGoogle Scholar
• Xanthopoulos, K. G., V. R. Prezioso, W. S. Chen, F. M. Sladek, R. Cortese, and J. E. Darnell, Jr. 1991. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc. Natl. Acad. Sci. USA 88:3807–3811.
   PubMed Web of Science ®Google Scholar
• Zabala, M. T., and J. P. Garcia-Ruiz. 1989. Regulation of expression of the messenger ribonucleic acid encoding the cytosolic form of phosphoenolpyruvate carboxykinase in liver and small intestine of lactating rats. Endocrinology 125:2587–2593.
   PubMedGoogle Scholar
• Zimmer, D. B., and M. A. Magnuson. 1990. Immunohistochem-ical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues. J. Histochem. Cytochem. 38:171–178.
   PubMedGoogle Scholar