5
Views
2
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Complex Intrachromosomal Rearrangement in the Process of Amplification of the L-myc Gene in Small-Cell Lung Cancer

, , , , , , , , & show all
Pages 1747-1754 | Received 03 Sep 1991, Accepted 02 Jan 1992, Published online: 31 Mar 2023

REFERENCES

  • Begley, C. G., P. D. Aplan, S. Μ. Denning, B. F. Haynes, T. A. Waldmann, and I. R. Kirsch. 1989. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. Proc. Natl. Acad. Sci. USA 86:10128–10132.
  • Birrer, Μ. J., S. Segal, J. S. DeGreve, F. Kaye, E. A. Sausville, and J. D. Minna. 1988. L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol. Cell. Biol. 8:2668–2673.
  • De Greve, J., J. Battey, J. Fedorko, Μ. Birrer, G. Evan, F. Kaye, E. Sausville, and J. Minna. 1988. The human V-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs. Mol. Cell. Biol. 8:4381–4388.
  • Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6–13.
  • Haluska, F. G., K. Huebner, Μ. Isobe, T. Nishimura, C. Μ. Croce, and P. K. Vogt. 1988. Localization of the human JUN protooncogene to chromosome region 1p31-32. Proc. Natl. Acad. Sci. USA 85:2215–2218.
  • Hattori, K., P. Angel, Μ. Μ. Le Beau, and Μ. Karin. 1988. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc. Natl. Acad. Sci. USA 85:9148–9152.
  • Ikegaki, N., J. Minna, and R. H. Kennett. 1989. The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences. EMBO J. 8:1793–1799.
  • Johnson, B. E., D. C. Ihde, R. W. Makuch, A. F. Gazdar, D. N. Carney, H. Oie, E. Russell, Μ. Μ. Nau, and J. D. Minna. 1987. myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. J. Clin. Invest. 79:1629–1634.
  • Kaye, F., J. Battey, Μ. Nau, B. Brooks, E. Seifter, J. D. De Greve, Μ. Birrer, E. Sausville, and J. Minna. 1988. Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. Mol. Cell. Biol. 8:186–195.
  • Legouy, E., R. DePinho, K. Zimmerman, R. Collum, G. Yancopoulos, L. Mitsock, R. Kriz, and F. W. Alt. 1987. Structure and expression of the murine L-myc gene. EMBO J. 6:3359–3366.
  • Mäkelä, T. P., J. Kere, R. Winqvist, and K. Alitalo. 1991. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. Mol. Cell. Biol. 11:4015–4021.
  • Mäkelä, T. P., K. Saksela, G. Evan, and K. Alitalo. 1991. A fusion protein formed by L-myc and a novel gene in lung cancer. EMBO J. 10:1331–1335.
  • Mäkelä, T. P., Μ. Shiraishi, Μ. G. Borrello, T. Sekiya, and K. Alitalo. Oncogene, in press.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual, p. 269–294. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Mengle-Gaw, L., and T. H. Rabbitts. 1987. A human chromosome 8 region with abnormalities in B cell, HTLV-I+ T cell and c-myc amplified tumours. EMBO J. 6:1959–1965.
  • Nau, Μ. Μ., B. J. Brooks, J. Battey, E. Sausville, A. F. Gazdar, I. R. Kirsch, O. W. McBride, V. Bertness, G. F. Hollis, and J. D. Minna. 1985. L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature (London) 318:69–73.
  • Saksela, K., T. P. Mäkelä, G. Evan, and K. Alitalo. 1989. Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum. EMBO J. 8:149–157.
  • Schütte, J., J. D. Minna, and Μ. J. Birrer. 1989. Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-la cells as a single gene. Proc. Natl. Acad. Sci. USA 86:2257–2261.
  • Schwab, Μ., K.-H. Klempnauer, K. Alitalo, H. Varmus, and Μ. Bishop. 1986. Rearrangement at the 5′ end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription. Mol. Cell. Biol. 6:2752–2755.
  • Sekido, Y., Y. Obata, R. Ueda, T. Hida, Μ. Suyama, K. Shimokata, Y. Ariyoshi, and T. Takahashi. 1991. Preferential expression of c-kit protooncogene transcripts in small cell lung cancer. Cancer Res. 51:2416–2419.
  • Shtivelman, E., and J. Μ. Bishop. 1989. The PVT gene fre-quently amplifies with myc in tumor cells. Mol. Cell. Biol. 9:1148–1154.
  • Shtivelman, E., and J. Μ. Bishop. 1990. Effects of translocations on transcription from PVT. Mol. Cell. Biol. 10:1835–1839.
  • Takahashi, T., Μ. Μ. Nau, I. Chiba, Μ. J. Birrer, R. K. Rosenberg, Μ. Vinocour, Μ. Levitt, H. Pass, A. F. Gazdar, and J. D. Minna. 1989. p53: a frequent target for genetic abnormalities in lung cancer. Science 246:491–494.
  • Takahashi, T., Y. Obata, Y. Sekido, T. Hida, R. Ueda, H. Watanabe, Y. Ariyoshi, T. Sugiura, and T. Takahashi. 1989. Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics. Cancer Res. 49:2683–2688.
  • Takahashi, T., R. Ueda, X. Song, K. Nishida, Μ. Shinzato, R. Namikawa, Y. Ariyoshi, K. Ota, K. Kato, T. Nagatsu, Μ. Imaizumi, T. Abe, and T. Takahashi. 1986. Two novel cell surface antigens on small cell lung carcinoma defined by mouse monoclonal antibodies NE-25 and PE-35. Cancer Res. 46:4770–4775.
  • Watanabe, H., T. Takahashi, R. Ueda, K. R. Utsumi, T. Sato, Y. Ariyoshi, K. Ota, Y. Obata, and T. Takahashi. 1988. Antigenic phenotype and biological characteristics of two distinct sublines derived from a small cell lung carcinoma cell line. Cancer Res. 48:2544–2549.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.