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Transcriptional Regulation

Functional Dissection of the lck Proximal Promoter

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Pages 2758-2768 | Received 17 Dec 1991, Accepted 27 Mar 1992, Published online: 31 Mar 2023

References

  • Abraham, Κ. Μ., S. D. Levin, J. D. Marth, K. A. Forbush, and R. M. Perlmutter. 1991. Delayed thymocyte development induced by augmented expression of p56lck. J. Exp. Med. 173:1421–1432.
  • Abraham, K. M., S. D. Levin, J. D. Marth, K. A. Forbush, and R. M. Perlmutter. 1991. Thymic tumorigenesis induced by overexpression of p56lck. Proc. Natl. Acad. Sci. USA 88:3977–3981.
  • Barber, E. K., J. D. Dasgupta, S. F. Schlossman, J. M. Trevillyan, and C. E. Rudd. 1989. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. Natl. Acad. Sci. USA 86:3277–3281.
  • Breathnach, R., and P. Chambon. 1981. Organization and expression of eukaryotic split genes coding for proteins. Annu. Rev. Biochem. 50:349–383.
  • Brinster, R. L., J. M. Allen, R. R. Behringer, R. E. Gelinas, and R. D. Palmiter. 1988. Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. USA 85:836–840.
  • Buskin, J. N., and S. D. Hauschka. 1989. Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene. Mol. Cell. Biol. 9:2627–2640.
  • Casadaban, M. J., A. Martinez-Arias, S. K. Shapira, and J. Chou. 1983. β-Galactosidase gene fusions for analyzing gene expression in Escherichia coli and yeast. Methods Enzymol. 100:293–308.
  • Cathala, G., J. Savouret, B. Mendez, B. L. West, M. Karin, J. A. Martial, and J. D. Baxter. 1983. Laboratory methods: a method for isolation of intact, translationally active ribonucleic acid. DNA 2:329–335.
  • Chaffin, K. E., C. R. Beals, T. M. Wilke, K. A. Forbush, M. I. Simon, and R. M. Perlmutter. 1990. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9:3821–3829.
  • Chodosh, L. Α., A. S. Baldwin, R. W. Carthew, and P. A. Sharp. 1988. Human CCAAT-binding proteins have heterologous sub-units. Cell 53:11–24.
  • Choi, T., M. Huang, C. Gorman, and R. Jaenisch. 1991. A generic intron increases gene expression in transgenic mice. Mol. Cell. Biol. 11:3070–3074.
  • Clevers, H., N. Lonberg, S. Dunlap, E. Lacy, and C. Terhorst. 1989. An enhancer located in a CpG-island 3′ to the TCR/CD3-ε gene confers Τ lymphocyte-specificity to its promoter. EMBO J. 8:2527–2535.
  • Cooke, M. P., K. M. Abraham, K. A. Forbush, and R. M. Perlmutter. 1991. Regulation of Τ cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 65:281–291.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
  • Elder, J. T., W. C. Forrester, C. Thompson, D. Mager, P. Henthorn, M. Peretz, T. Papayannopoulou, and M. Groudine. 1990. Translocation of an erythroid-specific hypersensitive site in deletion-type hereditary persistence of fetal hemoglobin. Mol. Cell. Biol. 10:1382–1389.
  • Garvin, A. M., K. M. Abraham, K. A. Forbush, A. G. Farr, B. L. Davison, and R. M. Perlmutter. 1990. Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int. Immunol. 2:173–180.
  • Garvin, A. M., S. Pawar, J. D. Marth, and R. M. Perlmutter. 1988. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol. Cell. Biol. 8:3058–3064.
  • Georgopoulos, K., P. van den Elsen, E. Bier, A. Maxam, and C. Terhorst. 1988. A T cell-specific enhancer is located in a DNase 1-hypersensitive area at the 3′ end of the CD3-δ gene. EMBO J. 7:2401–2407.
  • Gidoni, D., W. S. Dynan, and R. Tijan. 1984. Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature (London) 312:409–413.
  • Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level, Τ cell-specific, position-independent gene expression in transgenic mice. Cell 56:979–986.
  • Grosveld, F., G. B. van Assendelft, D. R. Greaves, and G. Kollias. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975–985.
  • Hammer, R. E., G. H. Swift, D. M. Ornitz, C. J. Quaife, R. D. Palmiter, R. L. Brinster, and R. J. MacDonald. 1987. The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol. Cell. Biol. 7:2956–2967.
  • Hatakeyama, M., T. Kono, N. Kobayashi, A. Kawahara, S. D. Levin, R. M. Perlmutter, and T. Taniguchi. 1991. Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association. Science 252:1523–1528.
  • Ho, I.-C., and J. M. Leiden. 1990. Regulation of the human T-cell receptor α gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements. Mol. Cell. Biol. 10:4720–4727.
  • Ho, I.-C., L.-H. Yang, G. Morle, and J. M. Leiden. 1989. A T-cell-specific transcriptional enhancer element 3′ of Cα in the human T-cell receptor α locus. Proc. Natl. Acad. Sci. USA 86:6714–6718.
  • Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
  • Jones, N. C., P. W. J. Rigby, and Ε. Β. Ziff. 1988. Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses. Genes Dev. 2:267–281.
  • Kappes, D. J., C. P. Browne, and S. Tonegawa. 1991. Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor γ chain. Proc. Natl. Acad. Sci. USA 88:2204–2208.
  • Krimpenfort, P., R. de Jong, Y. Uematsu, Z. Dembic, S. Ryser, H. von Boehmer, M. Steinmetz, and A. Berns. 1988. Transcription of Τ cell receptor β-chain genes is controlled by a downstream regulatory element. EMBO J. 7:745–750.
  • Lehrach, H., D. Diamond, J. M. Wozney, and H. Boedtker. 1977. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry 16:4743–4751.
  • Lo, K., N. R. Landau, and S. T. Smale. 1991. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11:5229–5243.
  • Locker, J., and G. Buzard. 1990. A dictionary of transcriptional control sequences. DNA Seq. J. 1:3–11.
  • Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Marth, J. D., D. B. Lewis, C. B. Wilson, M. E. Gearn, E. G. Krebs, and R. M. Perlmutter. 1987. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6:2727–2734.
  • Marth, J. D., R. Peet, E. G. Krebs, and R. M. Perlmutter. 1985. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine Τ cell lymphoma LSTRA. Cell 43:393–404.
  • Maxam, A. M., and W. Gilbert. 1980. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:499–560.
  • Oosterwegel, M., M. van de Wetering, D. Dooijes, L. Klomp, A. Winoto, K. Georgopoulos, F. Meijlink, and H. Clevers. 1991. Cloning of murine TCF-1, a T cell-specific transcription factor with functional motifs in the CD3-ε and Τ cell receptor α enhancers. J. Exp. Med. 173:1133–1142.
  • Orkin, S. 1990. Globin gene regulation and switching: circa 1990. Cell 63:665–672.
  • Palmiter, R. D., E. P. Sandgren, M. R. Avarbock, D. D. Allen, and R. L. Brinster. 1991. Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci. USA 88:478–482.
  • Perlmutter, R. M. 1989. Τ cell signaling. Science 245:344.
  • Peschon, J. J., R. R. Behringer, R. L. Brinster, and R. D. Palmiter. 1987. Spermatid-specific expression of protamine-1 in transgenic mice. Proc. Natl. Acad. Sci. USA 84:5316–5319.
  • Reynolds, P. J., J. Lesley, J. Trotter, R. Schulte, R. Hyman, and Β. Μ. Sefton. 1990. Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development. Mol. Cell. Biol. 10:4266–4270.
  • Sartor, O., F. S. Gregory, N. S. Templeton, S. Pawar, R. M. Perlmutter, and N. Rosen. 1989. Selective expression of alternative lck mRNAs in human malignant cell lines. Mol. Cell. Biol. 9:2983–2988.
  • Sawada, S., and D. R. Littman. 1991. Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene. Mol. Cell. Biol. 11:5506–5515.
  • Searle, P. F., B. L. Davison, G. W. Stuart, Τ. Μ. Wilke, G. Norstedt, and R. D. Palmiter. 1984. Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol. Cell. Biol. 4:1221–1230.
  • Spanopoulou, E., V. Giguere, and F. Grosveld. 1991. The functional domains of the murine Thy-1 gene promoter. Mol. Cell. Biol. 11:2216–2228.
  • Stefanova, I., Y. Horejsi, I. J. Ansotegui, W. Knapp, and H. Stockinger. 1991. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254:1016–1019.
  • Takadera, T., S. Leung, A. Gernone, Y. Koga, Y. Takihara, N. G. Miyamoto, and T. W. Mak. 1989. Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in Τ cells. Mol. Cell. Biol. 9:2173–2180.
  • Thiesen, H.-J., and C. Bach. 1990. Target detection assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein. Nucleic Acids Res. 18:3203–3209.
  • Travis, Α., A. Amsterdam, C. Belanger, and R. Grosschedl. 1991. LEF-1, a gene encoding a lymphoid-specific with protein, an HMG domain, regulates T-cell receptor α enhancer function. Genes Dev. 5:880–894.
  • van de Wetering, M., M. Oosterwegel, D. Dooijes, and H. Clevers. 1991. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10:123–132.
  • Yeillette, Α., Μ. A. Bookman, Ε. Μ. Horak, L. E. Samelson, and J. B. Bolen. 1989. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (London) 338:257–259.
  • Waterman, M. L., W. H. Ficher, and K. A. Jones. 1991. A thymus-specific member of the HMG family regulates the human Τ cell receptor Cα enhancer. Genes Dev. 5:656–669.
  • Waterman, M. L., and K. A. Jones. 1990. Purification of TCF-1α, a T-cell-specific transcription factor that activates the T-cell receptor Ca gene enhancer in a context-dependent manner. New Biol. 2:621–636.
  • Wildin, R. S., A. M. Garvin, S. Pawar, D. B. Lewis, Κ. Μ. Abraham, K. A. Forbush, S. F. Ziegler, J. M. Allen, and R. M. Perlmutter. 1991. Developmental regulation of lck gene expression in Τ lymphocytes. J. Exp. Med. 173:383–393.
  • Wu, L., R. Scollay, M. Egerton, M. Pearse, G. J. Spangrude, and K. Shortman. 1991. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature (London) 349:71–74.

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