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Transcriptional Regulation

Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity

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Pages 3107-3116 | Received 16 Jan 1992, Accepted 17 Apr 1992, Published online: 01 Apr 2023

References

  • Annweiler, Α., U. Müller, and T. Wirth. 1992. Functional analysis of defined mutatins in the immunoglobulin heavy-chain enhancer in transgenic mice. Nucleic Acids Res. 20:1503–1509.
  • Clerc, R. G., L. M. Corcoran, J. H. LeBowitz, D. Baltimore, and P. A. Sharp. 1988. The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes Dev. 2:1570–1581.
  • Courey, A. J., D. A. Holtzman, S. P. Jackson, and R. Tjian. 1989. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59:827–836.
  • Currie, R. Α., and R. G. Roeder. 1989. Identification of an octamer-binding site in the mouse kappa light-chain immunoglobulin enhancer. Mol. Cell. Biol. 9:4239–4247.
  • Daley, G. Q., R. A. Van Etten, and D. Baltimore. 1990. Induction of chronic myelogenous leukemia in mice by the p210 bcr/abl gene of the Philadelphia chromosome. Science 247:824–830.
  • de Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
  • Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
  • Falkner, F. G., and H. G. Zachau. 1984. Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements. Nature (London) 310:71–74.
  • Forsberg, M., and G. Westin. 1991. Enhancer activation by a single type of transcription factor shows cell type dependence. EMBO J. 10:2543–2551.
  • Gerster, T., C.-G. Balmaceda, and R. G. Roeder. 1990. The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription. EMBO J. 9:1635–1643.
  • Gerster, T., P. Matthias, M. Thali, J. Jiricny, and W. Schafifner. 1987. Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J. 6:1323–1330.
  • Giri, I., and M. Yaniv. 1988. Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains. EMBO J. 7:2823–2829.
  • Ham, J., N. Dostatni, F. Amos, and M. Yaniv. 1991. Several different upstream promoter elements can potentiate transactivation by the BPV-1 E2 protein. EMBO J. 10:2931–2940.
  • Hen, R., E. Borrelli, and P. Chambon. 1985. Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products. Science 230:1391–1394.
  • Herbomel, P., B. Bourachot, and M. Yaniv. 1984. Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell 39:653–662.
  • Hermanson, G. G., M. Briskin, D. Sigman, and R. Wall. 1989. Immunoglobulin enhancer and promoter motifs 5′ of the B29 B-cell-specific gene. Proc. Natl. Acad. Sci. USA 86:7341–7345.
  • Herr, W., R. A. Sturm, R. G. Clerc, L. M. Corcoran, D. Baltimore, P. A. Sharp, H. A. Ingraham, M. G. Rosenfeld, M. Finney, G. Ruvkun, and H. R. Horvitz. 1988. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 2:1513–1516.
  • Junker, S., S. Pedersen, E. Schreiber, and P. Matthias. 1990. Extinction of an immunoglobulin κ promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. Cell 61:467–474.
  • Kemler, I., E. Bucher, K. Seipel, Μ. Μ. Muller-Immergluck, and W. Schafifner. 1991. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Res. 19:237–242.
  • LaBella, F., H. L. Sive, R. G. Roeder, and N. Heintz. 1988. Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element. Genes Dev. 2:32–39.
  • Landolfi, N. F., J. D. Capra, and P. W. Tucker. 1986. Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequences. Nature (London) 323:548–551.
  • Lenardo, M., J. W. Pierce, and D. Baltimore. 1987. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573–1577.
  • Lewin, B. 1990. Commitment and activation at pol II promoters: a tail of protein-protein interactions. Cell 61:1161–1164.
  • Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371–378.
  • Müller, M. M., S. Ruppert, W. Schaffner, and P. Matthias. 1988. A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature (London) 336:544–551.
  • Muller-Immergluck, Μ. Μ., W. Schafifner, and P. Matthias. 1990. Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. EMBO J. 9:1625–1634.
  • Nelms, K., and B. Van Ness. 1990. Identification of an octamerbinding site in the human kappa light-chain enhancer. Mol. Cell. Biol. 10:3843–3846.
  • Okamoto, K., H. Okazawa, A. Okuda, M. Sakai, M. Muramatsu, and H. Hamada. 1990. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60:461–472.
  • Pellet, P. E., J. L. C. McKnight, F. J. Jenkins, and B. Roizman. 1985. Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing α genes. Proc. Natl. Acad. Sci. USA 82:5870–5874.
  • Pettersson, S., G. P. Cook, M. Brüggemann, G. T. Williams, and M. S. Neuberger. 1990. A second Β cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature (London) 344:165–168.
  • Schatt, M. D., S. Rusconi, and W. Schaffner. 1990. A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position. EMBO J. 9:481–487.
  • Scheidereit, C., J. A. Cromlish, T. Gerster, K. Kawakami, C.-G. Balmaceda, R. A. Currie, and R. G. Roeder. 1988. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Nature (London) 336:551–557.
  • Schöler, H. R., T. Ciesiolka, and P. Gruss. 1991. A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell 66:291–304.
  • Sorger, P. K., and H. R. B. Pelham. 1988. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54:855–864.
  • Staudt, L. M., R. G. Clerc, H. Singh, J. H. LeBowitz, P. A. Sharp, and D. Baltimore. 1988. Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. Science 241:577–580.
  • Staudt, L. M., H. Singh, R. Sen, T. Wirth, P. A. Sharp, and D. Baltimore. 1986. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (London) 323:640–643.
  • Stern, S., M. Tanaka, and W. Herr. 1989. The Oct-1 home-odomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature (London) 341:624–630.
  • Sterneck, E., C. Muller, S. Katz, and A. Leutz. 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor. EMBO J. 11:115–126.
  • Sturm, R. Α., G. Das, and W. Herr. 1988. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 2:1582–1599.
  • Suzuki, N., H. Rohdewohld, T. Neuman, P. Grass, and H. Schöler. 1990. Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain. EMBO J. 9:3723–3732.
  • Tanaka, M., and W. Herr. 1990. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60:375–386.
  • Tanaka, M., J.-S. Lai, and W. Herr. 1992. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. Cell 68:755–767.
  • Wirth, T., and D. Baltimore. 1988. Nuclear factor NF-κΒ can interact functionally with its cognate binding site to provide lymphoid-specific promoter function. EMBO J. 7:3109–3113.
  • Wirth, T., A. Priess, A. Annweiler, S. Ζwilling, and B. Oeler. 1991. Multiple Oct2 isoforms are generated by alternative splicing. Nucleic Acids Res. 19:43–51.
  • Wirth, T., L. Staudt, and D. Baltimore. 1987. An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature (London) 329:174–178.
  • Yamamoto, K. K., G. A. Gonzales, W. H. Biggs III, and M. R. Montminy. 1988. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature (London) 334:494–498.
  • Yu, Η., Β. Porton, L. Shen, and L. A. Eckhardt. 1989. Role of the octamer motif in hybrid cell extinction of immunoglobulin expression: extinction is dominant in a two enhancer system. Cell 58:441–448.
  • Zwilling, S., and T. Wirth. Unpublished data.

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