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Gene Expression

Identification of DNA Elements Cooperatively Activating Proopiomelanocortin Gene Expression in the Pituitary Glands of Transgenic Mice

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Pages 3978-3990 | Received 10 Mar 1992, Accepted 11 Jun 1992, Published online: 01 Apr 2023

References

  • Aguilera, G., J. P. Harwood, J. X. Wilson, J. Moreth, J. H. Brown, and K. J. Catt. 1983. Mechanism of action of CRF and other regulators of corticotropin release in rat pituitary cells. J. Biol. Chem. 258:8039–8046.
  • Autelitano, D. J., J. R. Lundblad, M. Blum, and J. L. Roberts. 1989. Hormonal regulation of POMC gene expression. Annu. Rev. Physiol. 51:715–726.
  • Bodner, M., J. L. Castrillo, L. E. Theill, T. Deerinek, M. Ellisman, and M. Karin. 1988. The pituitary-specific transcriptional factor GHF-1 is a homeobox-containing protein. Cell 55:505–518.
  • Castrillo, J. L., L. E. Thrill, and M. Karin. 1991. Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science 253:197–199.
  • Civelli, O., N. Birnberg, and E. Herbert. 1982. Detection and quantitation of POMC mRNA in pituitary and brain tissues from different species. J. Biol. Chem. 257:6783–6788.
  • Cordingley, M. G., A. T. Riegel, and G. L. Hager. 1987. Steroid dependent interaction of transcription with an inducible promoter of mouse mammary tumor virus in vivo. Cell 48:261–270.
  • Crenshaw, E. B., III, K. Kalla, D. M. Simmons, L. W. Swanson, and M. G. Rosenfeld. 1989. Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements. Genes Dev. 3:959–972.
  • Dallman, M. F., G. B. Makara, J. L. Roberts, N. Levin, and M. Blum. 1985. Corticotrope response to removal of releasing factors and corticosteroids in vivo. Endocrinology 117:2190–2197.
  • Daniel, W. D., K. M. Scully, D. M. Simmons, M. Wegner, K. Chu, L. W. Swanson, and M. G. Rosenfeld. 1991. TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 5:1739–1753.
  • Distel, R. J., H. S. Ro, B. S. Rosen, D. L. Groves, and B. M. Spiegelman. 1987. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell 49:835–844.
  • Drouin, J., M. A. Trifiro, R. K. Plante, M. Nemer, P. Eriksson, and O. Wrange. 1989. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol. Cell. Biol. 9:5305–5314.
  • Edlund, T., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for the role of two distinct 5′ flanking elements. Science 230:912–916.
  • Elkabes, S., Y. P. Loh, A. Niebergs, and S. Wray. 1989. Prenatal ontogenesis of POMC in the mouse central nervous system and pituitary gland: an in situ hybridization and immunocytochemical study. Dev. Brain Res. 46:85–95.
  • Hammer, G. D., V. Fairchild-Huntress, and M. J. Low. 1990. Pituitary-specific and hormonally regulated gene expression directed by the rat POMC promoter in transgenic mice. Mol. Endocrinol. 4:1689–1697.
  • Hatfield, J. M., D. I. Daikh, J. P. Adelman, J. Douglass, C. T. Bond, and R. G. Allen. 1989. In situ hybridization detection of marked differences in POMC mRNA content of individual corticotropes and melanotropes. Endocrinology 124:1359–1364.
  • Hogan, B., N. Costantini, and E. Lacy. 1986. Manipulating the mouse embryo: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
  • Hollt, V., I. Haarmann, B. R. Seizinger, and A. Herz. 1982. Chronic haloperidol treatment increases the level of in vitro translatable mRNA coding for the β-endorphin/ACTH precursor POMC in the pars intermedia of the rat pituitary. Endocrinology 110:1885–1891.
  • Ingraham, H. A., R. P. Chen, H. J. Mangalam, H. P. Elsholtz, S. E. Flynn, C. R. Lin, D. M. Simmons, L. Swanson, and M. G. Rosenfeld. 1988. A tissue-specific transcription factor containing homeodomain specifies a pituitary phenotype. Cell 55:519–529.
  • Jeannotte, L., M. A. Trifiro, R. K. Plante, M. Chamberland, and J. Drouin. 1987. Tissue specific activity of the pro-opiomelano-cortin gene promoter. Mol. Cell. Biol. 7:4058–4064.
  • Jones, K. A., K. R. Yamamoto, and R. Tjian. 1985. Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell 42:559–572.
  • Kadonaga, J., and R. Tjian. 1986. Affinity purification of sequence-specific DNA binding proteins. Proc. Natl. Acad. Sci. USA 83:5889–5893.
  • Karin, M., J. L. Castrillo, and L. E. Theill. 1990. Growth hormone gene regulation: a paradigm for cell type specific gene activation. Trends Genet. 6:92–96.
  • Kumar, T. R., V. F. Huntress, and M. J. Low. 1992. Gonadotrope-specific expression of the human follicle-stimulating hormone β-subunit gene in pituitaries of transgenic mice. Mol. Endocrinol. 6:81–90.
  • Lee, W., A. Haslinger, M. Karin, and R. Tjian. 1987. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (London) 325:369–372.
  • Lenardo, M. J., and D. Baltimore. 1989. NF-kappa B: a pleio-tropic mediator of inducible and tissue specific gene control. Cell 58:227–229.
  • Li, S., E. B. Crenshaw III, E. J. Rawson, O. M. Simmons, L. W. Swanson, and M. G. Rosenfeld. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene Pit-1. Nature (London) 347:528–533.
  • Lin, Y. S., M. Carey, M. Ptashne, and M. R. Green. 1990. How different eukaryotic transcriptional activators can cooperate promiscuously. Nature (London) 345:359–361.
  • Lira, S. A., E. B. Crenshaw III, C. K. Glass, L. W. Swanson, and M. G. Rosenfeld. 1988. Identification of the rat growth hormone genomic sequences targeting pituitary expression in transgenic mice. Proc. Natl. Acad. Sci. USA 85:4755–4759.
  • Low, M. J., R. H. Goodman, and K. M. Ebert. 1989. Cryptic human growth hormone gene sequences direct gonadotroph-specific expression in transgenic mice. Mol. Endocrinol. 3:2028–2033.
  • Lundblad, J. R., and J. L. Roberts. 1988. Regulation of POMC gene expression in pituitary. Endocr. Rev. 9:135–158.
  • Nelson, C., V. R. Albert, H. P. Elsholtz, L. I. W. Lu, and M. G. Rosenfeld. 1988. Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor. Science 239:1400–1405.
  • Ohlsson, H., and T. Edlund. 1986. Sequence-specific interaction of nuclear factors with the insulin gene enhancer. Cell 45:35–44.
  • Pintar, J. E., and D. I. Lugo. 1987. POMC gene expression, pro-hormone processing and secretion during rat pituitary development. Ann. N.Y. Acad. Sci. 512:318–327.
  • Riegel, A. T., Y. Lu, J. Remenick, R. G. Walford, D. S. Berard, and G. L. Hager. 1991. Proopiomelanocortin gene promoter elements required for constitutive and glucocorticoid-repressed transcription. Mol. Endocrinol. 5:1973–1982.
  • Riegel, A. T., J. Remenick, R. G. Walford, D. S. Berard, and G. L. Hager. 1990. A novel transcriptional activator (PO-B) binds between the TATA box and cap site of the pro-opiome-lanocortin gene. Nucleic Acids Res. 18:4513–4521.
  • Rubinstein, M., B. Liu, R. H. Goodman, and M. J. Low. 1992. Targeted expression of somatostatin in vasopressinergic mag-nocellular hypothalamic neurons of transgenic mice. Mol. Cell. Neurosci. 3:152–161.
  • Schwind, J. L. 1928. The development of the hypophysis cerebri of the albino rat. Am. J. Anat. 41:295–319.
  • Shupnik, M. A., B. A. Rosenzweig, K. E. Friend, and M. E. Mason. 1992. Thyrotropin (TSH)-releasing hormone-responsive elements in the rat TSHβ gene have distinct biological and nuclear protein binding properties. Mol. Endocrinol. 6:43–52.
  • Smith, A. I., and J. W. Funder. 1988. POMC processing in the pituitary, central nervous system, and peripheral tissues. Endocr. Rev. 9:159–179.
  • Therrien, M., and J. Drouin. 1991. Pituitary proopiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Mol. Cell. Biol. 11:3492–3503.
  • Walton, K. M., R. P. Rehfuss, J. C. Chrivia, J. E. Lochner, and R. H. Goodman. 1992. A dominant repressor of CREB activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo. Mol. Endocrinol. 6:647–655.
  • Watanabe, Y. G., and S. Daikoku. 1979. An immunohistochemical study on the cytogenesis of adenohypophysial cells in fetal rats. Dev. Biol. 68:557–567.
  • Wellstein, A., A. F. Dobrenski, M. N. Radonovich, J. F. Brady, and A. T. Riegel. 1991. Purification of PO-B, a protein that has increased affinity for the POMC promoter after dephosphorylation. J. Biol. Chem. 266:12234–12241.
  • Zhu, J., P. W. Rice, M. Chamberlain, and C. N. Cole. 1991. Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J. Virol. 65:2778–2790.

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