Activation of the Mouse mdr3 Gene by Insertion of Retroviruses in Multidrug-Resistant P388 Tumor Cells

References

• Algate, P. A., and J. A. McCubrey. 1993. Autocrine transformation of hemopoietic cells resulting from cytokine message stabilization after intracisternal A particle transposition. Oncogene 8:1221–1232.
   PubMed Web of Science ®Google Scholar
• ä, R. J., F. Baas, R. Raponi, S. B. Horwitz, D. Housman, and J. M. Croop. 1990. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol. Reprod. Dev. 25:101–109.
   PubMedGoogle Scholar
• Bénard, J., J. Da Silva, J.-R. Teyssier, and G. Riou. 1989. Over-expression of MDR1 gene with no DNA amplification in a multiple-drug-resistant human ovarian carcinoma cell line. Int. J. Cancer 43:471–477.
   PubMed Web of Science ®Google Scholar
• Blankenstein, T., Z. Qin, W. Li, and T. Diamantstein. 1990. DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma. J. Exp. Med. 171:965–970.
   PubMed Web of Science ®Google Scholar
• Blatt, C., D. Aberdam, R. Schwartz, and L. Sachs. 1988. DNA rearrangement of a homeobox gene in myeloid leukemia cells. EMBO J. 7:4283–4290.
   PubMed Web of Science ®Google Scholar
• Chaudhary, P. M., and I. B. Roninson. 1993. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl. Cancer Inst. 85:632–639.
   PubMed Web of Science ®Google Scholar
• Chen, C.-J., J. E. Chin, K. Ueda, D. P. Clark, I. Pastan, M. M. Gottesman, and I. B. Roninson. 1986. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from human multidrug-resistant cells. Cell 47:381–389.
   PubMed Web of Science ®Google Scholar
• Chin, K.-V., S. S. Chauhan, I. Pastan, and M. M. Gottesman. 1990. Regulation of the mdr RNA levels in response to cytotoxic drugs in rodent cells. Cell Growth Differ. 1:361–365.
   PubMedGoogle Scholar
• Chin, K.-V., S. Tanaka, G. Darlington, I. Pastan, and M. M. Gottesman. 1990. Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J. Biol. Chem. 265:221–226.
   PubMed Web of Science ®Google Scholar
• Chin, K.-V., K. Ueda, I. Pastan, and M. M. Gottesman. 1992. Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Science 255:459–462.
   PubMed Web of Science ®Google Scholar
• Chirgwin, J. M., A. A. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294–5306.
   PubMed Web of Science ®Google Scholar
• Christy, R. J., and R. C. C. Huang. 1988. Functional analysis of the long terminal repeats of intracisternal A-particle genes: sequences within the U3 region determine both the efficiency and direction of promoter activity. Mol. Cell. Biol. 8:1093–1102.
   PubMed Web of Science ®Google Scholar
• Clausse, N., D. Baines, R. Moore, S. Brookes, C. Dickson, and G. Peters. 1993. Activation of both wnt-1 and fgf-3 by insertion of mouse mammary tumor virus downstream in the reverse orientation: a reappraisal of the enhancer insertion model. Virology 194:157–165.
   PubMedGoogle Scholar
• Cohen, D., S. M. Higman, S. I.-H. Hsu, and S. B. Horwitz. 1992. The involvement of a LINE-1 element in a DNA rearrangement upstream of the mdr1a gene in a taxol multidrug-resistant murine cell line. J. Biol. Chem. 267:20248–20254.
   PubMedGoogle Scholar
• Cohen, D., R. L. Piekarz, S. I.-H. Hsu, R. A. DePinho, N. Carrasco, and S. B. Horwitz. 1991. Structural and functional analysis of the mouse mdr1b gene promoter. J. Biol. Chem. 266:2239–2244.
   PubMedGoogle Scholar
• Cohen, J. B., T. Unger, G. Rechavi, E. Canaani, and D. Givol. 1983. Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas. Nature (London) 306:797–799.
   PubMedGoogle Scholar
• Corrias, M. V., P. Cornaglia-Ferraris, D. Di Martino, A. M. Stenger, E. Lanino, L. Boni, and G. P. Tonini. 1990. Expression of multiple drug resistance gene, MDR1 and N-myc oncogene in an Italian population of human neuroblastoma patients. Anticancer Res. 10:897–902.
   PubMedGoogle Scholar
• Danø, K. 1973. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochim. Biophys. Acta 323:466–483.
   PubMed Web of Science ®Google Scholar
• Devault, A., and P. Gros. 1990. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol. Cell. Biol. 10:1652–1663.
   PubMed Web of Science ®Google Scholar
• Dickson, C., R. Smith, S. Brookes, and G. Peters. 1984. Tumor-igenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2. Cell 37:529–536.
   PubMed Web of Science ®Google Scholar
• Dickson, C., R. Smith, S. Brookes, and G. Peters. 1990. Proviral insertions within the int-2 gene can generate multiple anomalous transcripts but leave the protein-coding domain intact. J. Virol. 64:784–793.
   PubMed Web of Science ®Google Scholar
• Dudley, J. P.%% 1988. Mouse mammary tumor proviruses from a T-cell lymphoma are associated with the retroposon LIMd. J. Virol. 62:472–478.
   PubMedGoogle Scholar
• Endicott, J. A., and V. Ling. 1989. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137–171.
   PubMed Web of Science ®Google Scholar
• Falzon, M., and E. L. Kuff. 1988. Multiple protein-binding sites in an intracisternal A particle long terminal repeat. J. Virol. 62:4070–4077.
   PubMedGoogle Scholar
• Feinberg, A. P., and B. Vogelstein. 1984. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:266–267.
   PubMed Web of Science ®Google Scholar
• Frohman, M. A., M. K. Dush, and G. R. Martin. 1988. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA 85:8998–9002.
   PubMed Web of Science ®Google Scholar
• Goldsmith, M. E., M. J. Madden, C. S. Morrow, and K. H. Cowan. 1993. A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene. J. Biol. Chem. 268:5856–5860.
   PubMedGoogle Scholar
• Gottesman, M. M., and I. Pastan. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385–427.
   PubMed Web of Science ®Google Scholar
• Gros, P., Y. Ben-Neriah, J. M. Croop, and D. E. Housman. 1986. Isolation and expression of complementary DNA that confers multidrug resistance. Nature (London) 323:728–731.
   PubMed Web of Science ®Google Scholar
• Gros, P., J. Croop, and D. Housman. 1986. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47:371–380.
   PubMed Web of Science ®Google Scholar
• Gros, P., M. Raymond, J. Bell, and D. Housman. 1988. Cloning and characterization of a second member of the mouse mdr gene family. Mol. Cell. Biol. 8:2770–2778.
   PubMed Web of Science ®Google Scholar
• Hawley, R. G., M. J. Shulman, and N. Hozumi. 1984. Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Mol. Cell. Biol. 4:2565–2572.
   PubMedGoogle Scholar
• Heberlein, C., M. Kawai, M.-J. Franz, G. Beck-Engeser, C. P. Daniel, W. Ostertag, and C. Stocking. 1990. Retrotransposons as mutagens in the induction of growth autonomy in hematopoietic cells. Oncogene 5:1799–1807.
   PubMedGoogle Scholar
• Herzog, C. E., M. Tsokos, S. E. Bates, and A. T. Fojo. 1993. Increased mdr1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists. J. Biol. Chem. 268:2946–2952.
   PubMed Web of Science ®Google Scholar
• Holmes, J., A. Jacobs, G. Carter, A. Janowska-Wieczorek, and R. A. Padua. 1989. Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia. Br. J. Cancer 72:40–44.
   Google Scholar
• Horowitz, M., S. Luria, G. Rechavi, and D. Givol. 1984. Mechanism of activation of the mouse c-mos oncogene by the LTR of an intracisternal A-particle gene. EMBO J. 3:2937–2941.
   PubMedGoogle Scholar
• Hsu, S. I.-H., D. Cohen, L. S. Kirchner, M. Hartstein, and S. B. Horwitz. 1990. Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol. Cell. Biol. 10:3596–3606.
   PubMed Web of Science ®Google Scholar
• Hsu, S. I.-H., L. Lothstein, and S. B. Horwitz. 1989. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J. Biol. Chem. 264:12053–12062.
   PubMed Web of Science ®Google Scholar
• Ikeguchi, M., L. D. Teeter, T. Eckersberg, R. Ganapathi, and M. T. Kuo. 1991. Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site. DNA Cell Biol. 10:639–649.
   PubMed Web of Science ®Google Scholar
• Ito, Y., M. Tanimoto, T. Kumazawa, M. Okumura, Y. Morish-ima, R. Ohno, and H. Saito. 1989. Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found is fresh acute leukemia cells. Cancer 63:1534–1538.
   PubMed Web of Science ®Google Scholar
• Kohno, K., S. Sato, H. Takano, K. Matsuo, and M. Kuwano. 1989. The direct activation of human multidrug resistance gene (MDR1) by anticancer agents. Biochem. Biophys. Res. Com-mun. 165:1415–1421.
   PubMed Web of Science ®Google Scholar
• Kuff, E. L., and K. K. Lueders. 1988. The intracistemal A-par-ticle gene family: structure and functional aspects. Adv. Cancer Res. 51:183–276.
   Google Scholar
• Kung, H.-J., C. Boerkoel, and T. H. Carter. 1991. Retroviral mutagenesis of cellular oncogenes: a review with insights into the mechanisms of insertional mutation. Curr. Top. Microbiol. Immunol. 171:1–25.
   PubMedGoogle Scholar
• Kuo, M. T., J.-Y. Zhao, L. D. Teeter, M. Ikeguchi, and F. V. Chisari. 1992. Activation of multidrug resistance (P-glycoprotein) mdr3/mdrla gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell Growth Differ. 3:531–540.
   PubMedGoogle Scholar
• Lemontt, J. F., M. Azzaria, and P. Gros. 1988. Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells. Cancer Res. 48:6348–6353.
   PubMed Web of Science ®Google Scholar
• Lepage, P., and P. Gros. Unpublished data.
   Google Scholar
• Lepage, P., M. Raymond, A. Nepveu, and P. Gros. 1993. Transcriptional activation of the mouse mdr3 gene coincides with the appearance of novel transcription initiation sites in multidrug-resistant P388 tumor cells. Cancer Res. 53:1657–1664.
   PubMedGoogle Scholar
• Loeb, D. D., R. W. Padgett, S. C. Hardies, W. R. Shehee, M. B. Comer, M. H. Edgell, and C. A. Hutchison III. 1986. The sequence of a large LIMd element reveals a tandemly repeated 5′ end and several features found in retrotransposons. Mol. Cell. Biol. 6:168–182.
   PubMed Web of Science ®Google Scholar
• Lueders, K. K., and E. L. Kuff. 1977. Sequences associated with intracistemal A-particles are reiterated in the mouse genome. Cell 12:963–972.
   PubMed Web of Science ®Google Scholar
• Lueders, K. K., and J. A. Mietz. 1986. Structural analysis of type II variants within the mouse intracistemal A-particle sequence family. Nucleic Acids Res. 14:1495–1510.
   PubMedGoogle Scholar
• Madden, M. J., C. S. Morrow, M. Nakagawa, M. E. Goldsmith, C. R. Fairchild, and K. H. Cowan. 1993. Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J. Biol. Chem. 268:8290–8297.
   PubMedGoogle Scholar
• Majors, J. E., and H. E. Varmus. 1981. Nucleotide sequences at host-proviral junctions for mouse mammary tumour vims. Nature (London) 289:253–258.
   PubMed Web of Science ®Google Scholar
• Marchuk, D., M. Drumm, A. Saulino, and F. S. Collins. 1991. Construction of T vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res. 19:1154.
   PubMed Web of Science ®Google Scholar
• Mickley, L. A., S. E. Bates, N. D. Richert, S. Currier, S. Tanaka, F. Foss, N. Rosen, and A. T. Fojo. 1989. Modulation of the expression of a multidrug resistance gene (mdr-7/P-glycoprotein) by differentiating agents. J. Biol. Chem. 264:18031–18040.
   PubMed Web of Science ®Google Scholar
• Mietz, J. A., Z. Grossman, K. K. Lueders, and E. L. Kuff. 1987. Nucleotide sequence of a complete mouse intracistemal A-particle genome: relationship to known aspects of particle assembly and function. J. Virol. 61:3020–3029.
   PubMed Web of Science ®Google Scholar
• Moore, R., M. Dixon, R. Smith, and C. Dickson. 1987. Complete nucleotide sequence of a milk-transmitted mouse mammary tumor vims: two frameshift suppression events are required for translation of gap and pol. J. Virol. 61:480–490.
   PubMed Web of Science ®Google Scholar
• Nusse, N., H. Theunissen, E. Wagenaar, F. Rgsewgk, A. Gen-nissen, A. Otte, E. Schuuring, and A. van Ooyen. 1990. The Wnt-1 (int-l) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor vims. Mol. Cell. Biol. 10:4170–4179.
   PubMedGoogle Scholar
• Nusse, R.%% 1991. Insertional mutagenesis in mouse mammary tumorigenesis. Curr. Top. Microbiol. Immunol. 171:43–65.
   PubMedGoogle Scholar
• Nusse, R., A. van Ooyen, D. Cox, Y. K. T. Fung, and H. Varmus. 1984. Mode of proviral activation of a putative mammary oncogene int-1 on mouse chromosome 15. Nature (London) 307:131–136.
   PubMed Web of Science ®Google Scholar
• Peters, G., S. Brookes, R. Smith, M. Placzek, and C. Dickson. 1989. The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc. Natl. Acad. Sci. USA 86: 5678–5682.
   PubMedGoogle Scholar
• Piekarz, R. L., D. Cohen, and S. B. Horwitz. 1993. Progesterone regulates the murine multidmg resistance mdr1b gene. J. Biol. Chem. 268:7613–7616.
   PubMed Web of Science ®Google Scholar
• Raymond, M., and P. Gros. 1990. Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1. Mol. Cell. Biol. 10:6036–6040.
   PubMedGoogle Scholar
• Raymond, M., E. Rose, D. E. Housman, and P. Gros. 1990. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol. Cell. Biol. 10:1642–1651.
   PubMed Web of Science ®Google Scholar
• Robbins, J., B. J. Blondel, D. Gallahan, and R. Callahan. 1992. Mouse mammary tumor gene int-3 a member of the notch gene family transforms mammary epithelial cells. J. Virol. 66:2594–2599.
   PubMedGoogle Scholar
• Roelink, H., E. Wagenaar, S. Lopes Da Silva, and R. Nusse. 1990. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-l/wnt-1 and is normally expressed in mouse embryos and adult brain. Proc. Natl. Acad. Sci. USA 87:4519–4523.
   PubMed Web of Science ®Google Scholar
• Rothenberg, M. L., L. A. Mickley, D. E. Cole, F. M. Balis, T. Tsuruo, D. G. Poplack, and A. T. Fojo. 1989. Expression of the mdr-1/P170 gene in patients with acute lymphoblastic leukemia. Blood 74:1388–1395.
   PubMed Web of Science ®Google Scholar
• Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
   Google Scholar
• Schinkel, A. H., M. E. M. Roelofs, and P. Borst. 1991. Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Res. 51:2628–2635.
   PubMed Web of Science ®Google Scholar
• Shen, D., A. Fojo, J. E. Chin, I. B. Roninson, N. Richert, I. Pastan, and M. M. Gottesman. 1986. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science 232:643–645.
   PubMed Web of Science ®Google Scholar
• Sheng-Ong, G. L. C., and M. D. Cole. 1982. Differing populations of intracistemal A-particle genes in myeloma tumors and mouse subspecies. J. Virol. 42:411–421.
   PubMedGoogle Scholar
• Takatori, T., M. Ogura, and T. Tsuruo. 1993. Purification and characterization of NF-R2 that regulates the expression of the human multidmg resistance (MDR1) gene. Jpn. J. Cancer Res. 84:298–303.
   Google Scholar
• Teeter, L. D., F. F. Becker, F. V. Chisari, D. Li, and M. T. Kuo. 1990. Overexpression of the multidmg resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol. Cell. Biol. 10:5728–5735.
   PubMed Web of Science ®Google Scholar
• Teeter, L. D., T. Eckersberg, Y. Tsai, and M. T. Kuo. 1991. Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity. Cell Growth Differ. 2:429–437.
   PubMedGoogle Scholar
• Ueda, K., C. Cardarelli, M. M. Gottesman, and I. Pastan. 1987. Expression of a full-length cDNA clone from the human MDR1 gene confers resistance to colchicine, doxorubicin and vinblastine. Proc. Natl. Acad. Sci. USA 84:3004–3008.
   PubMed Web of Science ®Google Scholar
• Ueda, K., D. P. Clark, C.-J. Chen, I. B. Roninson, M. M. Gottesman, and I. Pastan. 1987. The human multidmg resistance (mdr1) gene: cDNA cloning and transcription initiation. J. Biol. Chem. 262:505–508.
   PubMed Web of Science ®Google Scholar
• Ueda, K., I. Pastan, and M. M. Gottesman. 1987. Isolation and sequence of the promoter of the human multidrug-resistance (mdr1) gene. J. Biol. Chem. 262:17432–17436.
   PubMed Web of Science ®Google Scholar
• van der Bliek, A. M., P. M. Kooiman, C. Schneider, and P. Borst. 1988. Sequence of mdr3 cDNA encoding a human P-glycoprotein. Gene 71:401–411.
   PubMed Web of Science ®Google Scholar
• Yanagawa, S.-I., K. Kakimi, H. Tanaka, A. Murakami, Y. Nakagawa, Y. Kubo, Y. Yamada, H. Hiai, K. Kuribayashi, T. Masuda, and A. Ishimoto. 1993. Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas. J. Virol. 67:112–118.
   PubMedGoogle Scholar
• Ymer, S., W. Q. J. Tucker, C. J. Sanderson, H. D. Campbell, and I. G. Young. 1985. Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene. Nature (London) 317:255–258.
   PubMed Web of Science ®Google Scholar
• Yu, L., D. Cohen, R. L. Piekarz, and S. B. Horwitz. 1993. Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene. J. Biol. Chem. 268: 7520–7526.
   PubMedGoogle Scholar