Biased T-cell receptor δ element recombination in scid thymocytes

REFERENCES

• Aguilar, L. K., and J. W. Belmont. 1991. Vγ3 T cell receptor rearrangement and expression in the adult thymus. J. Immunol. 146:1348–1352.
   PubMedGoogle Scholar
• Blackwell, T. K., and F. W. Alt. 1989. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu. Rev. Genet. 23:605–636.
   PubMed Web of Science ®Google Scholar
• Blackwell, T. K., B. A. Malynn, R. A. Pollack, P. Ferrier, L. R. Covey, G. M. Fulop, R. A. Phillips, G. D. Yancopoulos, and F. W. Alt. 1989. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joints. EMBO J. 8:735–742.
   PubMed Web of Science ®Google Scholar
• Blin, N., and D. W. Stafford. 1976. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:2302–2308.
   Google Scholar
• Bosma, G. C., R. P. Custer, and M. J. Bosma. 1983. A severe combined immunodeficiency mutation in the mouse. Nature (London) 301:527–530.
   PubMed Web of Science ®Google Scholar
• Bosma, G. C., M. Fried, R. P. Custer, A. Carroll, D. Gibson, and M. J. Bosma. 1988. Appearance of functional T cells in some (“leaky”) scid mice. J. Exp. Med. 167:1016–1033.
   PubMed Web of Science ®Google Scholar
• Carroll, A. M., and M. J. Bosma. 1991. T lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor δ recombination. Genes Dev. 5:1357–1366.
   PubMedGoogle Scholar
• Carroll, A. M., R. R. Hardy, and M. J. Bosma. 1989. Occurrence of mature B (IgM+) and T (CD3+) lymphocytes in scid mice. J. Immunol. 143:1087–1093.
   PubMed Web of Science ®Google Scholar
• Carroll, A. M., J. K. Slack, and X. Mu. 1993. V(D)J recombination generates a high frequency of non-standard TCR Dδ- associated rearrangements in thymocytes. J. Immunol. 150:2222–2230.
   PubMedGoogle Scholar
• Chien, Y. H., M. Iwashima, D. A. Weltstein, K. B. Kaplan, J. F. Elliott, W. Born, and M. M. Davis. 1987. T cell receptor δ rearrangements in early thymocytes. Nature (London) 330:722–727.
   PubMed Web of Science ®Google Scholar
• Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabeling DNA endonuclease restriction fragments to high specific activity. Anal. Biochem. 132:6–13.
   PubMed Web of Science ®Google Scholar
• Ferrier, P., B. Krippl, T. K. Blackwell, A. J. W Furley, H. Suh, A. Winoto, W. D. Cook, L. Hood, F. Constantini, and F. W. Alt. 1990. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 9:117–125.
   PubMedGoogle Scholar
• Garman, R. D., P. J. Doherty, and D. H. Raulet. 1986. Diversity, rearrangement and expression of murine T cell gamma genes. Cell 45:733–742.
   PubMedGoogle Scholar
• Garni Wagner, B. A., P. L. Witte, M. M. Tutt, W. A. Kuziel, P. W. Tucker, M. Bennett, and V. Kumar. 1990. Natural killer cells in the thymus: studies in mice with severe combined immune deficiency. J. Immunol. 144:796–803.
   PubMedGoogle Scholar
• Harrington, J., C.-L. Hsieh, J. Gerton, G. Bosma, and M. R. Lieber. 1992. Analysis of the defect in DNA end joining in the murine scid mutation. Mol. Cell. Biol. 12:4758–4768.
   PubMed Web of Science ®Google Scholar
• Hendrickson, E. A., D. G. Schatz, and D. T. Weaver. 1988. The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. Genes Dev. 2:817–829.
   PubMed Web of Science ®Google Scholar
• Hendrickson, E. A., M. S. Schüssel, and D. T. Weaver. 1990. Wild-type V(D)J recombination in scid pre-B cells. Mol. Cell. Biol. 10:5397–5407.
   PubMedGoogle Scholar
• Hesse, J. E., M. R. Lieber, K. Mizuuchi, and M. Gellert. 1989. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3:1053–1061.
   PubMed Web of Science ®Google Scholar
• Hockett, R. D., G. Nunez, and S. J. Korsmeyer. 1989. Evolutionary comparison of murine and human δ T-cell receptor deleting elements. New Biol. 1:266–274.
   PubMedGoogle Scholar
• Iwamoto, A. F., F. Rupp, P. S. Ohashi, C. L. Walker, H. Pircher, R. Johs, H. Hengartner, and T. W. Mak. 1986. T cell specific 7 genes in C57B1/10 mice. J. Exp. Med. 163:1203–1212.
   PubMedGoogle Scholar
• Iwasoto, T., and H. Yamegishi. 1992. Novel excision products of T cell receptor γ gene rearrangements and developmental stage specificity implied by the frequency of nucleotide insertion at joints. Eur. J. Immunol. 22:101–106.
   PubMedGoogle Scholar
• Kallenbach, S., N. Doyen, M. Fanton D’Andon, and F. Rougeon. 1992. Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes. Proc. Natl. Acad. Sci. USA 89:2799–2803.
   PubMedGoogle Scholar
• Kienker, L. J., W. A. Kuziel, B. A. Garni-Wagner, V. Kumar, and P. W. Tucker. 1991. T cell receptor γ and δ gene rearrangements in scid thymocytes. Similarity to those in normal thymocytes. J. Immunol. 147:4351–4359.
   PubMedGoogle Scholar
• Kienker, L. J., W. A. Kuziel, and P. W. Tucker. 1991. T cell receptor γ and δ gene junctional sequences in scid mice: excessive P nucleotide insertion. J. Exp. Med. 174:769–773.
   PubMedGoogle Scholar
• Kim, M. G., W. Schuler, M. J. Bosma, and K. Marcu. 1988. Abnormal recombination of IgH D and J segments in trans-formed pre-B cells of scid mice. J. Immunol. 141:1341–1347.
   PubMed Web of Science ®Google Scholar
• LaFaille, J. J., A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa. 1989. Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859–870.
   PubMed Web of Science ®Google Scholar
• Lewis, S., and M. Gellert. 1989. The mechanism of antigen receptor gene assembly. Cell 59:585–588.
   PubMedGoogle Scholar
• Lewis, S. M., J. E. Hesse, K. Mizuuchi, and M. Gellert. 1988. Novel strand exchanges in V(D)J recombination. Cell 55:1099–1107.
   PubMedGoogle Scholar
• Lieber, M. R. 1992. The mechanism of V(D)J recombination: a balance of diversity, specificity and stability. Cell 70:873–875.
   PubMed Web of Science ®Google Scholar
• Lieber, M. R., J. E. Hesse, S. Lewis, G. Bosnia, N. Rosenberg, K. Mizuuchi, M. Bosnia, and M. Gellert. 1988. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7–16.
   PubMed Web of Science ®Google Scholar
• Lieber, M. R., J. E. Hesse, K. Mizuuchi, and M. Gellert. 1988. Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc. Natl. Acad. Sci. USA 85:8588–8592.
   PubMed Web of Science ®Google Scholar
• Malynn, B., T. K. Blackwell, G. Fulop, G. Rathbun, A. Furley, P. Ferrier, L. B. Heinke, R. Phillips, G. Yancopoulos, and F. Alt. 1088. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell 54:5453–5460.
   Google Scholar
• Morzycka-Wroblewska, E., F. Lee, and S. Desiderio. 1988. Unusual immunoglobulin gene rearrangement leads to replace-ment of recombinational signal sequences. Science 242:261–263.
   PubMedGoogle Scholar
• Okazaki, K., S. Nishikawa, and H. Sakano. 1988. Aberrant immunoglobulin gene rearrangements in scid mouse bone mar-row cells. J. Immunol. 141:1348–1352.
   PubMed Web of Science ®Google Scholar
• Petrini, J., A. Carroll, and M. Bosma. 1990. T cell receptor gene rearrangements in functional T cell clones from scid mice: reversion of the scid phenotype in individual lymphocyte progenitors. Proc. Natl. Acad. Sci. USA 87:3450–3452.
   PubMedGoogle Scholar
• Roth, D. B., J. P. Menetski, P. J. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983–991.
   PubMed Web of Science ®Google Scholar
• Rothenberg, E., and D. Triglia. 1983. Clonal proliferation unlinked to terminal deoxynucleotidyl transferase in thymocytes of young mice. J. Immunol. 130:1627–1633.
   PubMedGoogle Scholar
• Saiki, R., D. Gelfland, S. Stoffel, S. Scharf, R. Higushi, G. Horn, K. Mullis, and H. Erlich. 1988. Primer-directed enzymatic amplification of DNA with thermostable polymerase. Science 239:487–494.
   PubMed Web of Science ®Google Scholar
• Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
   PubMed Web of Science ®Google Scholar
• Schüssel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa transcription. Cell 58:1001–1007.
   PubMedGoogle Scholar
• Schuler, W., A. Schuler, and M. J. Bosma. 1990. Defective V to J recombination of T cell receptor γ chain genes in scid mice. Eur. J. Immunol. 20:545–550.
   PubMed Web of Science ®Google Scholar
• Schuler, W., I. Weiler, A. Schuler, R. Phillips, N. Rosenberg, T. Mak, J. Kearney, R. Perry, and M. Bosma. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46:963–972.
   PubMed Web of Science ®Google Scholar
• Takeshita, S., M. Toda, and H. Yamegishi. 1989. Excision products of the T cell receptor gene support a progressive rearrangement model of the α/δ locus. EMBO J. 8:3261–3270.
   PubMed Web of Science ®Google Scholar
• Wu, G. Personal communication.
   Google Scholar