3
Views
10
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Evidence for Differential Functions of the p50 and p65 Subunits of NF-κB with a Cell Adhesion Model

, , , &
Pages 3802-3810 | Received 13 Oct 1992, Accepted 08 Mar 1993, Published online: 01 Apr 2023

REFERENCES

  • Baeuerle, P. A., and D. Baltimore. 1988. IκB: a specific-inhibitor of the NFκB transcription factor. Science 242:540–546.
  • Baeuerle, P. A., and D. Baltimore. 1989. A 65 kD subunit of active NF-κB is required for inhibition of NF-κB. Genes Dev. 3:1689–1698.
  • Ballard, D., E. Dixon, N. Peffer, H. Bogerd, S. Doerre, B. Stein, and W. Greene. 1992. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. USA 89:1875–1879.
  • Ballard, D. W., W. H. Walker, S. Doerre, P. Sisra, J. A. Molitor, E. P. Dixon, N. J. Peffer, M. Hannink, and W. C. Greene. 1990. The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Cell 63:803–814.
  • Chiang, M.-Y., H. Chan, M. A. Zounes, S. M. Freier, W. F. Lima, and C. F. Bennett. 1991. Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J. Biol. Chem. 266:18162–18171.
  • Fujita, T., G. Nolan, S. Ghosh, and D. Baltimore. 1992. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-κB. Genes Dev. 6:775–787.
  • Ghosh, S., and D. Baltimore. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor I-kappa-B. Nature (London) 344:6789–6829.
  • Ghosh, S., A. M. Gifford, L. B. Riviere, P. Tempst, G. P. Nolan, and D. Baltimore. 1990. Cloning of the p50 DNA binding subunit of NF-κB: homology to Rel and Dorsal. Cell 62:1019–1029.
  • Goodchild, J. 1989. Inhibition of gene expression by oligonucleotides, p. 53. In J. S. Cohen (ed.), Oligodeoxynucleotides: antisense inhibitors of gene expression. CRC Press, Boca Raton, Fla.
  • Hélène, C., and J. J. Toulmé. 1990. Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim. Biophys. Acta Gene Struct. Expression 1049:99–125.
  • Higgins, K. A., et al. Submitted for publication.
  • Ito, E., J. L. Sonnenberg, and R. Narayanan. 1989. Nerve growth factor-induced differentiation in PC-12 cells is blocked by fos oncogene. Oncogene 4:1193–1199.
  • Kieran, M., V. Blank, F. Logeat, J. Vandekerchove, F. I. Lottspeich, O. LeBail, M. B. Urban, P. Kourilsky, P. A. Baeuerle, and A. Israel. 1990. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the Rel oncogene product. Cell 62:1007–1018.
  • Kitajima, I., T. Shinohara, J. Bilakovics, D. A. Brown, X. Xu, and M. Nerenberg. 1992. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science 258:1792–1795.
  • Kretzschmar, M., M. Meisterernst, C. Scheidereit, G. Li, and R. Roeder. 1992. Transcriptional regulation of the HIV-1 promoter by NF-κB in vitro. Genes Dev. 6:761–774.
  • Kunsch, C., S. M. Ruben, and C. A. Rosen. 1992. Selection of optimal κB/Rel DNA binding motifs: interaction of both sub-units of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412–4421.
  • Lawlor, K., and R. Narayanan. 1992. Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiation. Cell Growth Differ. 3:609–616.
  • Lenardo, M. J., and D. Baltimore. 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227–229.
  • Lilienbaum, A., M. Duc Dodon, C. Alexandre, L. Gazzolo, and D. Paulin. 1990. Effect of human T-cell virus type I Tax protein on activation of the human vimentin gene. J. Virol. 64:256–263.
  • Matsukura, M., K. Shinozuka, G. Zon, H. Mitsuya, M. Reitz, J. S. Cohen, and S. Broder. 1987. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 84:7706–7710.
  • Narayanan, R., and K. A. Higgins. Unpublished data.
  • Narayanan, R., K. G. Lawlor, R. Q. J Schaapveld, K. R. Cho, B. Vogelstein, P. Bui-Vinh Tran, M. P. Osborne, and N. T. Telang. 1992. Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. Oncogene 7:553–561.
  • Nolan, G. P., S. Ghosh, H. C. Liou, P. Tempst, and D. Baltimore. 1991. DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel related polypeptide. Cell 64:961–969.
  • Osborn, L., S. Kunkel, and G. J. Nabel. 1989. Tumor necrosis factor α and interleukin-1 stimulate the human immunodefi-ciency virus enhancer by activation of the nuclear factor κB. Proc. Natl. Acad. Sci. USA 86:2336–2340.
  • Rhim, J. S., J. Fujita, P. Arnstein, and S. A. Aaronson. 1986. Neoplastic conversion of human keratinocytes by adenovirus 12-SV40 virus and chemical carcinogens. Science 232:385–388.
  • Ruben, S., P. J. Dillon, R. Schreck, T. Henkel, C.-H. Chen, M. Maher, P. A. Baeuerle, and C. A. Rosen. 1991. Isolation of a Rel-related human cDNA that potentially encodes the 65-kD subunit of NF-κB. Science 251:1490–1493.
  • Ruben, S. M., R. Narayanan, J. F. Klement, C.-H. Chen, and C. Rosen. 1992. Functional characterization of the NF-κB p65 transcriptional activator and an alternatively spliced derivative. Mol. Cell. Biol. 12:444–454.
  • Schmitt, R. M., E. Bruyns, and H. R. Snodgrass. 1991. Hematopoietic development of embryonic stem cells in vitro: cyto-kine and receptor gene expression. Genes Dev. 5:728–740.
  • Sokolaski, J. A., A. C. Sartoreli, C. A. Rosen, and R. Narayanan. Inhibition of p65 subunit of NF-κB alters adhesion properties of differentiated HL-60 granulocytes. Blood, in press.
  • Urban, M. B., and P. A. Baeuerle. 1990. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specificity. Genes Dev. 4:1975–1984.
  • van der Krol, A. R., J. N. M Mol, and A. R. Stuitje. 1988. Modulation of eukaryotic gene expression by complementary RNA or DNA sequences. BioTechniques 6:958–976.
  • Voraberger, G., R. Schafer, and C. Stratowa. 1991. Cloning of the human gene for intercellular adhesion molecule I and analysis of its 5′ regulatory region: induction by cytokines and phorbol ester. J. Immunol. 147:2777–2786.
  • Whelan, J., P. Ghersa, R. H. van Huijsduijnen, J. Gray, G. Chandra, F. Talabot, and J. F. DeLamorter. 1991. An NF-κB like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule I (ELAM-1) gene transcription. Nucleic Acids Res. 19:2645–2653.
  • Wiles, M. V., and G. Keller. 1991. Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture. Development 111:259–267.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.