Four of the Seven Zinc Fingers of the Evi-1 Myeloid-Transforming Gene Are Required for Sequence-Specific Binding to GA(C/T)AAGA(T/C)AAGATAA

REFERENCES

• Bartholomew, C., and J. N. Ihle. 1991. Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter. Mol. Cell. Biol. 11:1820–1828.
   PubMed Web of Science ®Google Scholar
• Bartholomew, C., K. Morishita, D. Askew, A. Buchberg, N. A. Jenkins, N. G. Copeland, and J. N. Ihle. 1989. Retroviral insertions in the CB-l/Fim-3 common site of integration activate expression of the Evi-1 gene. Oncogene 4:529–534.
   PubMed Web of Science ®Google Scholar
• Desjariais, J. R., and J. M. Berg. 1992. Redesigning the DNA-binding specificity of a zinc finger protein: a data base-guided approach. Proteins 12:101–104.
   PubMedGoogle Scholar
• Desjariais, J. R., and J. M. Berg. 1992. Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proc. Natl. Acad. Sci. USA 89:7345–7349.
   PubMedGoogle Scholar
• Funabiki, T., R. Delwel, K. Morishita, and J. N. Ihle. Unpublished data.
   Google Scholar
• Funabiki, T., and J. N. Ihle. Unpublished data.
   Google Scholar
• Garriga, G., C. Guenther, and H. R. Horvitz. Unpublished data.
   Google Scholar
• Ho, I.-C., P. Vorhees, N. Marin, B. K. Oakley, S.-F. Tsai, S. H. Orkin, and J. M. Leiden. 1991. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor a gene. EMBO J. 10:1187–1192.
   PubMed Web of Science ®Google Scholar
• Keller, A. D., and T. Maniatis. 1992. Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding. Mol. Cell. Biol. 12:1940–1949.
   PubMed Web of Science ®Google Scholar
• Klevit, R. 1991. Recognition of DNA by Cys2, His2 zinc fingers. Science 253:1367–1393.
   PubMedGoogle Scholar
• Kreider, B. L., S. H. Orkin, and J. N. Ihle.Loss of erythropoi-etin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid transforming gene Proc. Natl. Acad. Sci. USA, in press
   Google Scholar
• Matsugi, T., K. Morishita, and J. N. Ihle. 1990. Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 murine myeloid transforming gene. Mol. Cell. Biol. 10:1259–1264.
   PubMed Web of Science ®Google Scholar
• Min, S. L., G. P. Gippert, K. V. Soman, D. A. Case, and P. E. Wright. 1989. Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science 245:635–637.
   PubMedGoogle Scholar
• Morishita, K., E. Parganas, T. Matsugi, and J. N. Ihle. 1992. Expression of the Evi-1 zinc finger gene in 32Dcl3 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol. Cell. Biol. 12:183–189.
   PubMed Web of Science ®Google Scholar
• Morishita, K., E. Parganas, D. Parham, T. Matsugi, and J. N. Ihle. 1990. The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes. Oncogene 5:1419–1423.
   PubMedGoogle Scholar
• Morishita, K., E. Parganas, C. L. Willman, M. H. Whittaker, H. Drabkin, J. Oval, R. Taetle, and J. N. Ihle. 1992. Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome 3q26. Proc. Natl. Acad. Sci. USA 89:3937–3941.
   PubMed Web of Science ®Google Scholar
• Morishita, K., D. S. Parker, M. L. Mucenski, N. A. Jenkins, N. G. Copeland, and J. N. Ihle. 1988. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54:831–840.
   PubMed Web of Science ®Google Scholar
• Pavletich, N. P., and C. O. Pabo. 1991. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science 252:809–817.
   PubMed Web of Science ®Google Scholar
• Perkins, A. S., R. Fishel, N. A. Jenkins, and N. G. Copeland. 1991. Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol. Cell. Biol. 11:2665–2674.
   PubMedGoogle Scholar
• Perkins, A. S., J. A. Mercer, N. A. Jenkins, and N. G. Copeland. 1991. Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development. Development 111:479–498.
   PubMed Web of Science ®Google Scholar
• Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S.-F. Tsai, V. D'Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (London) 349:257–260.
   PubMed Web of Science ®Google Scholar
• Tsai, S.-F., D. I. K. Martin, L. I. Zon, A. D. D'Andrea, G. G. Wong, and S. H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expres-sion in mammalian cells. Nature (London) 339:446–451.
   PubMed Web of Science ®Google Scholar