0
Views
4
CrossRef citations to date
0
Altmetric
Gene Expression

Evidence that the Middle T Antigen of Polyomavirus Interacts with the Membrane Skeleton

, &
Pages 4703-4713 | Received 17 Nov 1992, Accepted 19 May 1993, Published online: 31 Mar 2023

REFERENCES

  • Aguzzi, A., P. Kleihues, K. Heckl, and O. D. Wiestler. 1991. Cell type-specific tumor induction in neural transplants by retrovi-rus-mediated oncogene transfer. Oncogene 6:113–118.
  • Azarnia, R., and W. R. Loewenstein. 1987. Polyomavirus middle T antigen downregulates junctional cell-to-cell communication. Mol. Cell. Biol. 7:946–950.
  • Azarnia, R., S. Reddy, T. E. Kmiecik, D. Shalloway, and W. R. Loewenstein. 1988. The cellular src gene product regulates junctional cell-to-cell communication. Science 239:398–401.
  • Ballmer-Hofer, K., and T. L. Benjamin. 1985. Phosphorylation of polyoma middle T antigen and cellular proteins in purified plasma membranes of polyoma virus-infected cells. EMBO J. 4:2321–2327.
  • Bendzko, P., S. Prehn, W. Pfeil, and T. A. Rapoport. 1982. Different modes of membrane interactions of the signal sequence of carp preproinsulin and of the insertion sequence of rabbit cytochrome b5. Eur. J. Biochem. 123:121–126.
  • Ben-Ze'ev, A., A. Duerr, F. Solomon, and S. Penman. 1979. The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins. Cell 17:859–865.
  • Bolen, J. B., C. J. Thiele, M. A. Israel, L. A. Yonemoto, L. A. Lipsich, and J. S. Brugge. 1984. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell 38:767–777.
  • Bordier, C. 1981. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256:1604–1607.
  • Carmichael, G. G., B. S. Schaffhausen, D. I. Dorsky, D. B. Oliver, and T. L. Benjamin. 1982. Carboxy terminus of polyoma middle sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation. Proc. Natl. Acad. Sci. USA 79:3579–3583.
  • Cheng, S. H., P. C. Espino, J. Marshall, R. Harvey, and A. E. Smith. 1990. Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex. Mol. Cell. Biol. 10:5569–5574.
  • Cheng, S. H., R. Harvey, P. C. Espino, K. Semba, T. Yamamoto, K. Toyoshima, and A. E. Smith. 1990. Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle T antigen of polyomavirus. EMBO J. 7:3845–3855.
  • Cohen, B., Y. Liu, B. Druker, T. M. Roberts, and B. S. Schaffhausen. 1990. Characterization of pp85, a target of oncogenes and growth factor receptors. Mol. Cell. Biol. 10:2909–2915.
  • Cook, D. N., N. Pavloff, and J. A. Hasseu. 1990. Simultaneous overexpression of avian pp60c-src and polyomavirus middle T antigen in mammalian cells. J. Virol. 64:2392–2395.
  • Cooper, J. A. 1987. Effects of cytochalasin and phalloidin on actin. J. Cell Biol. 105:1473–1478.
  • Courtneidge, S. A., and A. E. Smith. 1983. Polyoma virus transforming protein associates with the product of the c-src cellular gene. Nature (London) 303:435–439.
  • Dailey, H. A., and P. Strittmatter. 1978. Structural and functional properties of the membrane binding segment of cytochrome b5. J. Biol. Chem. 253:8203–8209.
  • Dirworth, S. M., and B. E. Griffin. 1982. Monoclonal antibodies against polyoma virus tumor antigen. Proc. Natl. Acad. Sci. USA 79:1059–1063.
  • Dirworth, S. M., H.-A. Hansson, C. Darnfors, G. Bjursell, C. H. Streuli, and B. E. Griffin. 1986. Subcellular localization of the middle and large T-antigens of polyoma virus. EMBO J. 5:491–499.
  • Druker, B., L. E. Ling, B. Cohen, T. M. Roberts, and B. S. Schaffhausen. 1990. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. J. Virol. 64:4454–4461.
  • Fox, J. E. B., J. K. Boyles, M. C. Berndt, P. K. Steffen, and L. K. Anderson. 1988. Identification of a membrane skeleton in platelets. J. Cell Biol. 106:1525–1538.
  • Fujiki, Y., A. D. Hubbard, S. Fowler, and P. B. Lazarow. 1982. Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. J. Cell Biol. 93:97–102.
  • Grussenmeyer, T., A. Carbone-Wiley, K. H. Scheidtmann, and G. Walter. 1987. Interactions between polyomavirus medium T antigen and three cellular proteins of 88, 61, and 37 kilodaltons. J. Virol. 61:3902–3909.
  • Grussenmeyer, T., K. H. Scheidtmann, M. A. Hutchinson, W. Eckhart, and G. Walter. 1985. Complexes of polyoma virus medium T antigen and cellular proteins. Proc. Natl. Acad. Sci. USA 82:7952–7954.
  • Hamaguchi, M., and H. Hanafusa. 1989. Localization of major potential substrates of p60v-src kinase in the plasma membrane matrix fraction. Oncogene Res. 4:29–37.
  • Horak, I. D., T. Kawakami, F. Gregory, K. C. Robbins, and J. B. Bolen. 1989. Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. J. Virol. 63:2343–2347.
  • Horvath, A. R., L. Muszbek, and S. Kellie. 1992. Translocation of pp60c-src to the cytoskeleton during platelet aggregation. EMBO J. 11:855–861.
  • Ishikawa, H., and N. Fujimaki. 1986. Electron microscopic observations on the plasmalemmal undercoat. p. 1913–1916. In @ (ed.), Proceedings of the XIth International Congress on Electron Microscopy. Japanese Society of Electron Microscopy, Tokyo.
  • Ito, Y., J. R. Brocklehurst, and R. Dulbecco. 1977. Virus-specific proteins in the plasma membrane of cells lytically infected or transformed by polyoma virus. Proc. Natl. Acad. Sci. USA 74:4666–4670.
  • Janiak, F., et al. Submitted for publication.
  • Kornbluth, S., S. H. Cheng, W. Markland, Y. Fukui, and H. Hanafusa. 1990. Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability. J. Virol. 64:1584–1589.
  • Kornbluth, S., M. Sudol, and H. Hanafusa. 1987. Association of the polyomavirus middle T-antigen with c-yes protein. Nature (London) 325:171–173.
  • Liebl, E. C, and S. Martin. 1992. Intracellular targeting of pp60src expression: localization of v-src to adhesion plaques is sufficient to transform chicken embryo fibroblasts. Oncogene 7:2417–2428.
  • Lin, K.-H., and S.-Y. Cheng. 1991. An efficient method to purify active eukaryotic proteins from the inclusion bodies in Escherichia coli. BioTechniques 6:748–753.
  • Ling, L. E., B. J. Druker, L. C. Cantley, and T. M. Roberts. 1992. Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J. Virol. 66:1702–1708.
  • Markland, W., S. H. Cheng, B. A. Oostra, and A. E. Smith. 1986. In vitro mutagenesis of the putative membrane-binding domain of polyomavirus middle T antigen. J. Virol. 59:82–89.
  • Markland, W., and A. E. Smith. 1987. Mutants of polyomavirus middle T antigen. Biochem. Biophys. Acta 907:299–321.
  • Pallas, D. C, V. Cherington, W. Morgan, J. DeAnda, D. Kaplan, B. Schaffhausen, and T. M. Roberts. 1988. Cellular proteins that associate with the middle and small T antigens of polyomavirus. J. Virol. 62:3934–3940.
  • Pallas, D. C, W. Morgan, and T. M. Roberts. 1989. The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins. J. Virol. 63:4533–4539.
  • Pallas, D. C, L. K. Shahrik, B. L. Martin, S. Jaspers, T. B. Miller, D. L. Brautigan, and T. M. Roberts. 1990. Polyoma small and middle T antigens and SV40 small T antigen form stable complexes with protein phosphatase 2A. Cell 60:167–176.
  • Piwnica-Worms, H., N. G. Williams, S. H. Cheng, and T. M. Roberts. 1990. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J. Virol. 64:61–68.
  • Rassoulzadegan, M., S. A. Courtneidge, R. Loubiere, P. El Blaze, and F. Cuzin. 1990. A variety of tumours induced by the middle T antigen of polyoma virus in a transgenic mouse family. Oncogene 5:1507–1510.
  • Sabatini, D. D., G. Kreibich, T. Morimoto, and M. Adesnick. 1982. Mechanisms for the incorporation of proteins in membranes and organelles. J. Cell Biol. 92:1–22.
  • Schaffhausen, B. S., H. Dorai, G. Arakere, and T. L. Benjamin. 1982. Polyomavirus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity. Mol. Cell. Biol. 2:1187–1198.
  • Schagger, H., and G. Von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1-100 kDa. Anal. Biochem. 166:368–379.
  • Sefton, B. M., T. Hunter, E. H. Ball, and S. J. Singer. 1981. Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell 24:165–174.
  • Segawa, K., and Y. Ito. 1982. Differential subcellular localization of in vivo-phosphorylated and nonphosphorylated middle sized tumor antigen of polyoma virus and its relationship to middle sized tumor antigen phosphorylating activity in vitro. Proc. Natl. Acad. Sci. USA 79:6812–6816.
  • Serunian, L. A., K. R. Auger, T. M. Roberts, and L. C. Cantley. 1990. Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen. J. Virol. 64:4718–4725.
  • Simon, K. O., C. A. Otey, F. M. Pavalko, and K. Burridge. 1991. Protein interactions linking actin to the plasma membrane in focal adhesions. p. 57–64. In M. S. Mooseker and J. S. Morrow (ed.), Ordering the membrane-cytoskeleton trilayer. Academic Press, Inc., San Diego, Calif.
  • Templeton, D., A. Voronova, and W. Eckhart. 1984. Construction and expression of a recombinant DNA gene encoding a polyomavirus middle size tumor antigen with the carboxyl terminus of the vesicular stomatitis virus glycoprotein G. Mol. Cell. Biol. 4:282–289.
  • Theisen, N., E. S. Lohoff, K. von Figura, and A. Hasilik. 1986. Sequential detection of antigens in western blots with differently colored products. Anal. Biochem. 152:211–214.
  • Treisman, R., U. Novak, J. Favaloro, and R. Kamen. 1981. Transformation of rat cells by an altered polyoma virus genome expressing only the middle T protein. Nature (London) 292:595–600.
  • Ulug, E. T., A. J. Cartwright, and S. A. Courtneidge. 1992. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase. J. Virol. 66:1458–1467.
  • Wang, R., and V. L. Bautch. 1991. The polyomavirus early region gene in transgenic mice causes vascular and bone tumors. J. Virol. 65:5174–5183.
  • Whitman, M., D. R. Kaplan, B. S. Schaffhausen, L. C. Cantley, and T. M. Roberts. 1985. Association of phosphatidylinositol kinase activity with polyoma middle T competent for transformation. Nature (London) 315:239–242.
  • Wigler, M., A. Pellicer, S. Silverstein, and R. Axel. 1978. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14:725–731.
  • Williams, R. L., W. Risau, H.-G. Zerwes, H. Drexler, A. Aguzzi, and E. F. Wagner. 1989. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 57:1053–1063.
  • Zhu, Z., G. M. Veldman, A. Cowie, A. Carr, B. Schaffhausen, and R. Kamen. 1984. Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins. J. Virol. 51:170–180.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.