C/EBP, NF-κB, and c-Ets Family Members and Transcriptional Regulation of the Cell-Specific and Inducible Macrophage Inflammatory Protein 1α Immediate-Early Gene

REFERENCES

• Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897–1906.
   PubMed Web of Science ®Google Scholar
• Alam, T., and J. Papaconstontinou. 1992. Interaction of acutephase-inducible and liver enriched nuclear factors with the promoter region of the mouse alpha-l-acid glycoprotein gene 1. Biochemistry. 31:1928–1936.
   PubMedGoogle Scholar
• Ballard, D. W., W. H. Walker, S. Doerre, P. Sisto, J. A. Molltor, E. P. Dixon, N. J. Petter, Μ. Hannink, and W. C. Greene. 1990. The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Cell 63:803–814.
   PubMed Web of Science ®Google Scholar
• Bauerle, P. A. 1991. The inducible transcription activator NF- κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63–80.
   PubMed Web of Science ®Google Scholar
• Bours, V., P. R. Burd, K. Brown, J. Villalobos, S. Park, R.-P. Ryseck, R. Bravo, K. Kelly, and U. Siebenlist. 1992. A novel mitogen-inducible gene product related to p50/pl05-NF-κB participates in transactivation through a κB site. Mol. Cell. Biol. 12:685–695.
   PubMed Web of Science ®Google Scholar
• Briskin, M., Μ. D. Kuwabara, D. S. Sigman, and R. Wall. 1988. Induction of κ transcription by interferon-g without activation of NF-κB. Science 242:1036–1037.
   PubMed Web of Science ®Google Scholar
• Brown, K. D., S. Μ. Zurawski, T. D. Mosmann, and G. Zurawski. 1989. A family of inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocytes and fibroblast-derived inflammatory agents, growth factors and indicators of various activation processes. J. Immunol. 142:679–687.
   PubMed Web of Science ®Google Scholar
• Broxmeyer, H. E., B. Sherry, L. Lu, S. Cooper, C. Carow, S. D. Wolpe, and A. Cerami. 1989. Myelopoietic enhancing effects of murine macrophage inflammatory proteins 1 and 2 on colony formation in vitro by murine and human bone marrow granulocyte/macrophage progenitor cells. J. Exp. Med. 170:1583–1594.
   PubMed Web of Science ®Google Scholar
• Burd, P. R., H. W. Rogers, J. R. Gordon, C. A. Martin, S. Jayaraman, S. D. Wilson, A. Μ. Dvorak, S. J. Galli, and Μ. E. Dorf. 1989. Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J. Exp. Med. 170:245–257.
   PubMed Web of Science ®Google Scholar
• Cao, Z., R. Μ. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538–1552.
   PubMed Web of Science ®Google Scholar
• Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3’ untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA 83:1670–1674.
   PubMed Web of Science ®Google Scholar
• Chang, C.-J., T.-T. Chen, H.-Y. Lei, D.-S. Chen, and S.-C. Lee. 1990. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol. Cell. Biol. 10:6642–6653.
   PubMedGoogle Scholar
• Cortner, J., and P. J. Farnham. 1991. Cell cycle analysis of Krox-20, c-fos, and JE expression in proliferating NIH3T3 fibroblasts. Cell Growth Differ. 2:465–473.
   PubMedGoogle Scholar
• Daubersies, P. Personal communication.
   Google Scholar
• Davatelis, G., P. Tekamp-Olson, S. D. Wolpe, K. Hermsen, C. Luedke, C. Gallegos, D. Coit, J. Merryweather, and A. Cerami. 1988. Cloning and characterisation of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and Chemokinetic properties. J. Exp. Med. 167:570–581.
   PubMedGoogle Scholar
• Davatelis, G., S. D. Wolpe, B. Sherry, J.-M. Dayer, R. Chiche-portiche, and A. Cerami. 1989. Macrophage inflammatory protein 1: a prostaglandin-independent endogenous pyrogen. Science 243:1066–1068.
   PubMed Web of Science ®Google Scholar
• Descombes, P., Μ. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. 1990. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4:1541–1551.
   PubMedGoogle Scholar
• Dunlop, D. J., E. G. Wright, S. Lorimore, G. J. Graham, T. Holyoake, D. J. Kerr, S. D. Wolpe, and I. B. Pragnell. 1992. Demonstration of stem cell inhibition and myeloprotective effects of SCI∕rhMIPlα in vivo. Blood 79:2221–2225.
   PubMed Web of Science ®Google Scholar
• Goebel, Μ. G., F. Moreau-Gachelin, D. Ray, P. Tambourin, A. Tavitian, Μ. J. Klemsz, S. C. McKercher, A. Celada, C. Van Beveren, and R. A. Maki. 1990. The PU.1 transcription factor is the product of the putative oncogene Spi-1. Cell 61:1165–1666.
   PubMedGoogle Scholar
• Graham, G. J., E. G. Wright, R. Hewick, S. D. Wolpe, N. Μ. Wilkie, D. Donaldson, S. Lorimore, and I. B. Pragnell. 1990. Identification and characterisation of an inhibitor of haemopoietic stem cell proliferation. Nature (London) 344:442–444.
   PubMed Web of Science ®Google Scholar
• Gravallese, E. Μ., Μ. R. Boothby, C. Μ. Smas, and L. H. Glimcher. 1989. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-κB. Mol. Cell. Biol. 9:3184–3192.
   PubMedGoogle Scholar
• Grove, Μ., S. Lowe, G. Graham, I. Pragnell, and Μ. Plumb. 1990. Sequence of the murine haemopoietic stem cell inhibitor/ macrophage inflammatory protein lα gene. Nucleic Acids Res. 18:5561.
   PubMedGoogle Scholar
• Grumont, R. J., and S. Gerondakis. 1990. The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene Res. 5:245–254.
   PubMedGoogle Scholar
• Haas, J. G., Μ. Strobel, A. Leutz, P. Wendelgab, C. Muller, E. Sterneck, G. Riethmuller, and H. W. L. Ziegler-Heitbrock. 1992. Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif. J. Immunol. 149:237–245.
   PubMedGoogle Scholar
• Han, J., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 171:465–475.
   PubMed Web of Science ®Google Scholar
• Henthorn, P., P. Zervos, Μ. Raducha, H. Harris, and T. Kadesch. 1988. Expression of a human placental alkaline phosphatase gene in transfected cells: use as a reporter for studies of gene expression. Proc. Natl. Acad. Sci. USA 85:6342–6346.
   PubMedGoogle Scholar
• Kessler, D. J., D. B. Spicer, F. A. La Rosa, and G. E. Sonen-shein. 1992. A novel NF-κB element within exon 1 of the murine c-myc gene. Oncogene 7:2447–2453.
   PubMedGoogle Scholar
• Kessler, D. S., S. A. Veals, X.-Y. Fu, and D. E. Levy. 1990. Interferon-α regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4:1753–1765.
   PubMed Web of Science ®Google Scholar
• Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6b, forms a heterodimer and transcriptionally synergises with NF-IL6. Proc. Natl. Acad. Sci. USA 89:1473–1476.
   PubMedGoogle Scholar
• Klemsz, Μ. J., S. R. McKercher, A. Celada, C. Van Beveren, and R. A. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113–124.
   PubMed Web of Science ®Google Scholar
• Landschulz, W. H., P. F. Johnson, E. Y. Adashi, B. J. Graves, and S. L. McKnight. 1988. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 2:786–800.
   PubMed Web of Science ®Google Scholar
• LeClair, K. P., Μ. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145–8149.
   PubMedGoogle Scholar
• Lee, Y.-M., W.-H. Tsai, D.-S. Chen, and S.-C. Lee. 1993. Induction of liver alpha-1 acid glycoprotein gene expression involves both positive and negative transcription factors. Mol. Cell. Biol. 13:432–442.
   PubMedGoogle Scholar
• Lenardo, Μ. J., A. Kuang, A. Gifford, and D. Baltimore. 1988. NF-κB protein purification from bovine spleen: nucleotide stimulation and binding site specificity. Proc. Natl. Acad. Sci. USA 85:8825–8829.
   PubMedGoogle Scholar
• Lord, B. I., T. Μ. Dexter, J. Μ. Clements, Μ. A. Hunter, and A. J. H. Gearing. 1992. Macrophage inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo. Blood 79:2605–2609.
   PubMed Web of Science ®Google Scholar
• Maciejewski, J. P., J. Μ. Liu, S. W. Green, C. E. Walsh, Μ. Plumb, I. B. Pragnell, and N. S. Young. 1992. Expression of the stem cell inhibitor (SCI) gene in bone marrow and peripheral blood from normal individuals and patients with bone marrow failure. Exp. Haematol. 20:1112–1117.
   PubMedGoogle Scholar
• Macleod, K., and Μ. Plumb. 1991. Derepression of mouse β-major globin gene transcription during erythroid differentiation. Mol. Cell. Biol. 11:4324–4332.
   PubMedGoogle Scholar
• Martin, C. A., and Μ. E. Dorf. 1991. Differential regulation of interleukin-6, macrophage inflammatory protein-1, and JE/ MCP-I cytokine expression in macrophage cell lines. Cell. Immunol. 135:245–258.
   PubMedGoogle Scholar
• Matsue, H., P. D. Cruz, P. R. Bergstresser, and A. Takashima. 1992. Langerhans cells are the major source of mRNA for IL-Ia and MIP-1α among unstimulated mouse epidermal cells. J. Invest. Dermatol. 99:537–541.
   PubMed Web of Science ®Google Scholar
• Merlin, G., E. Falcoff, and Μ. Aguet. 1985. 125I-labelled human interferons alpha, beta and gamma: comparative receptor-binding data. J. Gen. Virol. 66:1149–1152.
   PubMedGoogle Scholar
• Metz, R., and E. Ziff. 1991. The helix-loop-helix protein rE12 and the C/EBP-related factor rNFIL-6 bind to neighbouring sites within the c-fos serum response element. Oncogene 6:2165–2178.
   PubMedGoogle Scholar
• Minano, F. J., Μ. Sansibrian, Μ. Vizcaino, X. Paez, G. Davat-elis, T. Fahey, B. Sherry, A. Cerami, and R. D. Myers. 1990. Macrophage inflammatory protein-1; unique action on the hypothalamus to evoke fever. Brain Res. Bull. 24:849–852.
   PubMedGoogle Scholar
• Moreau-Gachelin, F., D. Ray, M.-G. Mattei, P. Tambourin, and A. Tavitian. 1989. The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukaemias. Oncogene 4:1449–1456.
   PubMedGoogle Scholar
• Nakao, M., H. Nomiyama, and K. Shimada. 1990. Structures of human genes coding for cytokine LD78 and their expression. Mol. Cell. Biol. 10:3646–3658.
   PubMed Web of Science ®Google Scholar
• Nakayama, K., H. Shimizu, K. Mitomo, T. Watanabe, S.-I. Okamoto, and K.-I. Yamamoto. 1992. A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 κB-related motifs whose activities are repressed in lymphoid cells. Mol. Cell. Biol. 12:1736–1746.
   PubMedGoogle Scholar
• Nishizawa, Μ., and S. Nagata. 1990. Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol. Cell. Biol. 10:2002–2011.
   PubMed Web of Science ®Google Scholar
• Obaru, K., Μ. Fukuda, S. Maeda, and K. Shimada. 1986. A cDNA clone used to study mRNA inducible in human tonsillar lymphocytes by a tumor promoter. J. Biochem. 99:885–894.
   PubMed Web of Science ®Google Scholar
• Plumb, Μ. A., V. V. Lobanenkov, R. H. Nicolas, C. A. Wright, S. Zavou, and G. H. Goodwin. 1986. Characterisation of the chicken erythroid nuclear proteins which bind to the nuclease hypersensitive regions upstream of the βA-and βH-globin genes. Nucleic Acids Res. 14:7675–7693.
   PubMedGoogle Scholar
• Poll, V., F. P. Mancini, and R. Cortese. 1990. IL-6BP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643–653.
   PubMedGoogle Scholar
• Ravid, K., T. Doi, D. L. Beeler, D. J. Kuter, and R. D. Rosenberg. 1991. Transcriptional regulation of the rat platelet factor 4 gene: interaction between enhancer/silencer domain and the GATA site. Mol. Cell. Biol. 11:6116–6127.
   PubMedGoogle Scholar
• Ray, D., R. Bosselut, J. Ghysdael, M.-G. Mattei, A. Tavitian, and F. Moreau-Gachelin. 1992. Characterisation of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/ PU.1. Mol. Cell. Biol. 12:4297–4304.
   PubMedGoogle Scholar
• Roman, C., J. S. Platero, J. Shuman, and K. Calarne. 1990. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev. 4:1404–1415.
   PubMedGoogle Scholar
• Schall, T. J. 1991. Biology of the RANTES/SIS cytokine family. Cytokine 3:165–183.
   PubMed Web of Science ®Google Scholar
• Scott, L. Μ., C. I. Civin, P. P. Rorth, and A. D. Friedman. 1992. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725–1735.
   PubMed Web of Science ®Google Scholar
• Selden, R. F., K. B. Howie, Μ. E. Rowe, H. Μ. Goodman, and D. D. Moore. 1986. Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6:3173–3179.
   PubMed Web of Science ®Google Scholar
• Shannon, Μ. F., J. R. Gamble, and Μ. A. Vadas. 1988. Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene. Proc. Natl. Acad. Sci. USA 85:674–678.
   PubMed Web of Science ®Google Scholar
• Shannon, Μ. F., L. Μ. Pell, Μ. J. Lenardo, E. S. Kuczek, F. S. Occhiodoro, S. Μ. Dunn, and Μ. A. Vadas. 1990. A novel tumor necrosis factor-responsive transcription factor which recognises a regulatory element in hemopoietic growth factor genes. Mol. Cell. Biol. 10:2950–2959.
   PubMed Web of Science ®Google Scholar
• Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3’-untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659–667.
   PubMed Web of Science ®Google Scholar
• Sherry, B., P. Tekamp-Olson, C. Gallegos, D. Bauer, G. Davatelis, S. D. Wolpe, A. Masiarz, D. Coit, and A. Cerami. 1988. Resolution of the components of macrophage inflammatory protein 1, and cloning and characterisation of one of those components, macrophage inflammatory protein 1β. J. Exp. Med. 168:2251–2259.
   PubMed Web of Science ®Google Scholar
• Sica, A., T. Tan, N. Rice, Μ. Kretzschmar, P. Ghosh, and H. A. Young. 1992. The c-rel protooncogene product c-Rel but not NF-κB binds to the intronic region of the human interferon-γ gene at a site related an interferon-stimulable response element. Proc. Natl. Acad. Sci. USA 89:1740–1744.
   PubMed Web of Science ®Google Scholar
• Spandidos, D., and N. Wilkie. 1984. Malignant transformation of early passage rodent cells by a single mutated oncogene. Nature (London) 310:469–474.
   PubMed Web of Science ®Google Scholar
• Sterneck, E. S., C. Muller, S. Katz, and A. Leutz. 1992. Autocrine growth induced by kinase type oncogenes in myeloid cells requires AP-1 and NF-M, a myeloid specific, C/EBP-like factor. EMBO J. 11:115–126.
   PubMedGoogle Scholar
• Tebo, J. Μ., and T. A. Hamilton. 1992. Lipopolysaccharide induces DNA binding activity specific for the IFN-Stimulated response element in murine peritoneal macrophages. J. Immunol. 149:2352–2357.
   PubMedGoogle Scholar
• Thomassin, H., D. Hamel, D. Bernier, Μ. Guertin, and L. Belanger. 1992. Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alfetoprotein gene. Further analysis of the C/EBPβ and C/EBPγ. Nucleic Acids Res. 20:3091–3098.
   PubMedGoogle Scholar
• Tso, J. Y., T. Sun, K. S. Reece, and R. Wu. 1985. Isolation and characterisation of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs; genomic and molecular evolution of the gene. Nucleic Acids Res. 13:2485–2492.
   PubMed Web of Science ®Google Scholar
• Vincenti, Μ. P∙, T. A. Burrell, and S. Μ. Taffet. 1992. Regulation of NF-kappa B activity in murine macrophages: effect of bacterial lipopolysaccharide and phorbol ester. J. Cell. Physiol. 150:204–213.
   PubMedGoogle Scholar
• Widmer, U., Z. Yang, S. van Deventer, K. R. Manogue, B. Sherry, and A. Cerami. 1991. Genomic structure of murine macrophage inflammatory protein-la and conservation of potential regulatory sequences with a human homolog, LD78. J. Immunol. 146:4031–4040.
   PubMed Web of Science ®Google Scholar
• WiUiams, S. C., C. A. Cantwell, and P. F. Johnson. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553–1567.
   PubMedGoogle Scholar
• Wolpe, S. D., G. Davatelis, B. Sherry, B. Beutler, D. G. Hesse, H. T. Nguyen, L. L. Moldawer, C. F. Nathan, S. F. Lowry, and A. Cerami. 1988. Macrophages secrete a novel heparin binding protein with inflammatory and neutrophil Chemokinetic properties. J. Exp. Med. 167:570–581.
   PubMed Web of Science ®Google Scholar
• Wright, E., P. Sheridan, and Μ. A. Moore. 1980. An inhibitor of murine stem cell proliferation produced by normal human bone marrow. Leukemia Res. 4:309–319.
   PubMedGoogle Scholar
• Wright, E. G., and B. I. Lord. 1977. Regulation of CFU-S proliferation by locally produced endogenous factors. Biomedicine 27:215–218.
   PubMedGoogle Scholar
• Yamamura, Y., T. Hattori, K. Obaru, K. Sakai, N. Asou, K. Takatsuki, Y. Ohmoto, and H. Nomiyama. 1989. Synthesis of a novel cytokine and its gene (LD78) expressions in haemopoietic fresh tumour cells and cell lines. J. Clin. Invest. 84:1707–1712.
   PubMed Web of Science ®Google Scholar
• Zipfel, P. F., J. Balke, S. G. Irving, K. Kelly, and U. Siebenlist. 1989. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors. J. Immunol. 142:1582–1590.
   PubMedGoogle Scholar