3
Views
33
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

, , , &
Pages 268-276 | Received 14 Jun 1993, Accepted 01 Oct 1993, Published online: 30 Mar 2023

REFERENCES

  • Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakjgima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897–1906.
  • Bengal, E., L. Ransone, R. Schaarfmann, V. J. Dwarki, S. J. Tapscott, H. Weintraub, and I. M. Verma. 1992. Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell 68:507–519.
  • Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538–1551.
  • Chang, C. J., T. T. Chen, H.-Y. Lei, D. S. Chen, and S.-C. Lee. 1991. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol. Cell. Biol. 10:6642–6653.
  • Chen-Kiang, S., W. Hsu, Y. Natkunam, and X. Shang. 1993. Nuclear signaling by interleukin-6. Curr. Opin. Immunol. 5:124–128.
  • Cohen, D. R., and T. Curran. 1990. Analysis of dimerization and DNA binding function in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region. Oncogene 5:929–939.
  • Descombes, P., M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. 1990. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4:1541–1551.
  • Descombes, P., and U. Schibler. 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569–579.
  • Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. Yamamoto. 1990. Transcription factor interactions: selectors of positive or negative regulation from a signal DNA element. Science 249:1266–1272.
  • Gentz, R., F. J. Rauscher III, C. Abate, and T. Curran. 1989. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243:1695–1699.
  • Goodrich, D. W., and W.-H. Lee. 1992. Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53. Nature (London) 360:177–179.
  • Hai, T., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720–3724.
  • Hsu, W., and S. Chen-Kiang. 1993. Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells. Mol. Cell. Biol. 13:2515–2523.
  • Hsu, W., and S. Chen-Kiang. Unpublished data.
  • Jain, J., P. G. McCaffrey, V. E. Valge-Archer, and A. Rao. 1992. Nuclear factor of activated T cells contains Fos and Jun. Nature (London) 356:801–804.
  • Kerppola, T. K., and T. Curran. 1991. DNA bending by Fos and Jun: the flexible hinge model. Science 254:1210–1214.
  • Kerppola, T. K., and T. Curran. 1991. Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 66:317–326.
  • Kerppola, T. K., D. Luk, and T. Curran. 1993. Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro. Mol. Cell. Biol. 13:3782–3791.
  • Klampfer, L., J. Vilcek, and S. Chen-Kiang. Unpublished data.
  • Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. USA 89:1473–1476.
  • Kishimoto, T., S. Akira, and T. Taga. 1992. Interleukin-6 and its receptor: a paradigm for cytokines. Science 258:593–597.
  • Landschulz, W. Η., P. F. Johnson, and S. L. McKnight. 1989. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243:1681–1688.
  • LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-kB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145–8149.
  • Li, L., J.-C. Chambard, M. Karin, and E. N. Olson. 1992. Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev. 6:676–689.
  • Lord, K. A., A. Abdollahi, B. Hoffman-Liebermann, and D. A. Lieberman. 1993. Proto-oncogene of the Fos/Jun family of transcription factors are positive regulators of myeloid differentiation. Mol. Cell. Biol. 13:841–851.
  • Metz, R., and E. Ziff. 1991. cAMP stimulates the C/EBP-related transcription factor rNF-IL6 to translocate to the nucleus and induce c-fos transcription. Genes Dev. 5:1754–1766.
  • Minor, J. F., and K. Yamamoto. 1992. The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element. Genes Dev. 6:2491–2501.
  • Montell, D. J., P. Rorth, and A. C. Spradling. 1993. slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes drosophila C/EBP. Cell 71:51–62.
  • Nakqjima, K., and R. Wall. 1991. Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma. Mol. Cell. Biol. 11:1409–1418.
  • Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira. 1993. Phosphorylation at threonine 235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcriptional activation of NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207–2211.
  • Natkunam, Y., X. Zhang, and S. Chen-Kiang. Unpublished data.
  • Natsuka, S., S. Akira, Y. Nishio, S. Hashimoto, T. Sugita, H. Isshiki, and T. Kishimoto. 1992. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6. Blood 79:460–466.
  • O'Shea, E. K., R. Rutkowski, and P. S. Kim. 1989. Evidence that the leucine zipper is coiled coil. Science 243:538–542.
  • O'Shea, E. K., R. Rutkowski, and P. S. Kim. 1992. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell 68:699–708.
  • Poli, P., F. P. Mancini, and R. Cortese. 1990. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction defines a new family of leucine zipper protein related to C/EBP. Cell 63:643–653.
  • Rauscher, F. J., III, P. J. Voulalas, B. R. Franza, Jr., and T. Curran. 1989. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 2:1687–1699.
  • Raynal, M. C., Z. Lui, T. Hirano, L. Mayer, T. Kishimoto, and S. Chen-Kiang. 1989. Interleukin-6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation. Proc. Natl. Acad. Sci. USA 86:8024–8028.
  • Ron, D., and J. F. Habener. 1992. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 6:439–453.
  • Rothstein, J. L., D. Johnson, J. A. DeLola, J. Skowronski, D. Solter, and B. Knowles. 1992. Gene expression during preimplanation mouse development. Genes Dev. 6:1190–1201.
  • Satoh, T., S. Nakamura, T. Taga, T. Mastuda, T. Hirano, T. Kishimoto, and Y. Kaziro. 1988. Induction of neuronal differentiation in PC12 cells by B-cell stimulation factor 2/interleukin-6. Mol. Cell. Biol. 8:3546–3549.
  • Sonnenberg, J. L., F. J. Rauscher ΙII, J. Morgan, and T. Curran. 1989. Regulation of proenkephalin by Fos and Jun. Science 246:1622–1625.
  • Spergel, J. M., and S. Chen-Kiang. 1991. Interleukin-6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation. Proc. Natl. Acad. Sci. USA 88:6472–6476.
  • Spergel, J. M., W. Hsu, S. Akira, B. Thimmappaya, T. Kishimoto, and S. Chen-Kiang. 1992. NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J. Virol. 66:1021–1030.
  • Studier, F. W., A. H. Rosenberg, and J. J. Dunn. 1990. Use of T7 RNA polymerase to direct the expression of cloned genes. Methods Enzymol. 185:60–89.
  • Ullman, K. S., J. P. Northrop, A. Admon, and G. R. Carbtree. 1993. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev. 7:188–196.
  • Umek, R. M., A. D. Friedman, and S. L. McKnight. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288–292.
  • Vallejo, M., D. Ron, C. P. Miller, and J. F. Habener. 1993. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc. Natl. Acad. Sci. USA 90:4679–4683.
  • Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911–916.
  • Wegner, M., Z. Cao, and M. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBP. Science 256:370–373.
  • Williams, S. C., C. A. Cantwell, and P. F. Johnson. 1991. A family of C/EBP related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553–1568.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.