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DNA Dynamics and Chromosome Structure

CpG Island Promoter Region Methylation Patterns of the Inactive-X-Chromosome Hypoxanthine Phosphoribosyltransferase (Hprt) Gene

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Pages 7975-7983 | Received 10 Jun 1994, Accepted 06 Sep 1994, Published online: 30 Mar 2023

References

  • Ackerman, S. L., A. G. Minden, and C.-Y. Yeung. 1993. The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry. Proc. Natl. Acad. Sci. USA 90:11865–11869.
  • Adra, C. N., P. H. Boer, and M. W. McBurney. 1987. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. Gene 60:65–74.
  • Barlow, D. P. 1993. Methylation and imprinting: from host defense to gene regulation? Science 260:309–310.
  • Bartlett, M. H., C. N. Adra, J. Park, V. M. Chapman, and M. W. McBurney. 1991. DNA methylation of two X chromosome genes in female somatic and embryonal carcinoma cells. Somatic Cell Mol. Genet. 17:35–47.
  • Bird, A. P. 1986. CpG-rich islands and the function of DNA methylation. Nature (London) 321:209–213.
  • Bird, A. P. 1992. The essentials of DNA methylation. Cell 70:5–9.
  • Borsani, G., R. Tonlorenzi, M. C. Simmler, L. Dandolo, D. Arnaud, V. Capra, M. Grompe, A. Pizzuti, D. Muzny, C. Lawrence, H. F. Willard, P. Avner, and A. Ballabio. 1991. Characterization of a murine gene expressed from the inactive X chromosome. Nature (London) 351:325–329.
  • Boyes, J., and A. P. Bird. 1991. DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 64:1123–1134.
  • Boyes, J., and A. P. Bird. 1992. Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein. EMBO J. 11:327–333.
  • Brandeis, M., T. Kafri, M. Ariel, J. R. Chaillet, J. MaCarrey, A. Razin, and H. Cedar. 1993. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse. EMBO J. 12:3669–3677.
  • Bressler, S. L., K.-H. Lee, D. A. Adler, V. M. Chapman, and C. M. Disteche. 1993. Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system. Somatic Cell. Mol. Genet. 19:29–37.
  • Chapman, V. M., P. G. Kratzer, L. D. Siracusa, B. A. Quarantillo, R. Evans, and R. M. Liskay. 1982. Evidence for DNA modification in the maintenance of X-chromosome inactivation of adult mouse tissues. Proc. Natl. Acad. Sci. USA 79:5357–5361.
  • Chapman, V. M., D. R. Miller, D. Armstrong, and C. T. Caskey. 1989. Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice. Proc. Natl. Acad. Sci. USA 86:1292–1296.
  • Frank, D., I. Keshet, M. Shani, A. Levine, A. Razin, and H. Cedar. 1991. Demethylation of CpG islands in embryonic cells. Nature (London) 351:239–241.
  • Frommer, M., L. E. McDonald, D. S. Miller, C. M. Collis, F. Watt, G. W. Grigg, P. L. Molloy, and C. L. Paul. 1992. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl. Acad. Sci. USA 89:1827–1831.
  • Grant, S. G., and V. M. Chapman. 1988. Mechanisms of X-chromosome regulation. Annu. Rev. Genet. 22:199–233.
  • Gruenbaum, Y., H. Cedar, and A. Razin. 1982. Substrate and sequence specificity of a eukaryotic DNA methylase. Nature (London) 295:620–622.
  • Hansen, R. S., N. A. Ellis, and S. M. Gartler. 1988. Demethylation of specific sites in the 5′ region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression. Mol. Cell. Biol. 8:4692–4699.
  • Holler, M., G. Weistin, J. Jiricny, and W. Schaffner. 1988. Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. Genes Dev. 2:1127–1135.
  • Hooper, M., K. Hardy, A. Handyside, S. Hunter, and M. Monk. 1987. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature (London) 326:292–295.
  • Hornstra, I. K., and T. P. Yang. 1992. Multiple in vivo footprints are specific to the active allele of the X-linked human hypoxanthine phosphoribosyltransferase gene 5′ region: implication for X-chromosome inactivation. Mol. Cell. Biol. 12:5345–5354.
  • Hornstra, I. K., and T. P. Yang. 1994. High-resolution methylation analysis of the human hypoxanthine phosphoribosyltransferase gene 5′ region on the active and inactive X chromosomes: correlation with binding sites for transcription factors. Mol. Cell. Biol. 14:1419–1430.
  • Johnson, G. G., T. A. Larsen, P. Blakely, and V. M. Chapman. 1985. Elevated levels of erythrocyte hypoxanthine phosphoribosyltransferase associated with allelic variation of murine Hprt. Biochemistry 24:5083–5089.
  • Kass, S. U., J. P. Goddard, and R. L. P. Adams. 1993. Inactive chromatin spreads from a focus of methylation. Mol. Cell. Biol. 13:7372–7379.
  • Kay, G. F., G. D. Penny, D. Patel, A. Ashworth, N. Brockdorff, and S. Rastan. 1993. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Cell 72:171–182.
  • Kratzer, P. G., V. M. Chapman, H. Lambert, R. Evans, and R. M. Liskay. 1983. Differences in the DNA of the inactive X-chromosomes of fetal and extraembryonic tissues of mice. Cell 33:37–42.
  • Li, E., C. Beard, and R. Jaenisch. 1993. Role of DNA methylation in genomic imprinting. Nature (London) 366:362–365.
  • Lock, L. F., N. Takagi, and G. R. Martin. 1987. Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell 48:39–46.
  • Means, A. L., and P. J. Farnham. 1990. Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP binding at the initiation site. Mol. Cell. Biol. 10:653–661.
  • Meehan, R. R., J. D. Lewis, S. Mckay, E. L. Kleiner, and A. P. Bird. 1989. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 58:499–507.
  • Melton, D. W., D. S. Konecki, J. Brennand, and C. T. Caskey. 1984. Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc. Natl. Acad. Sci. USA 81:2147–2151.
  • Mohandas, T., R. S. Sparkes, and L. J. Shapiro. 1981. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation. Science 211:393–396.
  • Monk, M., and M. Grant. 1990. Preferential X-chromosome inactivation, DNA methylation and imprinting, p. 55–62. In M. Monk, and A. Surani (ed.), Genomic imprinting (development 1990 supplement). The Company of Biologists Ltd., Cambridge.
  • Paterno, G. D., C. N. Adra, and M. W. McBurney. 1985. X-chromosome reactivation in mouse embryonal carcinoma cells. Mol. Cell. Biol. 5:2705–2712.
  • Pfeifer, G. P., and A. D. Riggs. 1991. Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev. 5:1102–1113.
  • Pfeifer, G. P., S. D. Steigerwald, R. S. Hansen, S. M. Gartler, and A. D. Riggs. 1990. Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc. Natl. Acad. Sci. USA 87:8252–8256.
  • Pfeifer, G. P., S. D. Steigerwald, P. R. Mueller, B. Wold, and A. D. Riggs. 1989. Genomic sequencing and methylation analysis by ligation mediated PCR. Science 246:810–813.
  • Pfeifer, G. P., R. L. Tanguay, S. D. Steigerwald, and A. D. Riggs. 1990. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Genes Dev. 4:1277–1287.
  • Riggs, A. D., and G. P. Pfeifer. 1992. X-chromosome inactivation and cell memory. Trends Genet. 8:169–174.
  • Saluz, H. P., J. Jiricny, and J. P. Jost. 1986. Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocor-ticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis. Proc. Natl. Acad. Sci. USA 83:7167–7171.
  • Silva, A. J., K. Ward, and R. White. 1993. Mosaic methylation in clonal tissue. Dev. Biol. 156:391–398.
  • Singer-Sam, J., M. Grant, J. M. LeBon, K. Okuyama, V. M. Chapman, M. Monk, and A. D. Riggs. 1990. Use of an HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol. Cell. Biol. 10:4987–4989.
  • Stoeger, R., P. Kubicka, C.-G. Liu, T. Kafri, A. Razin, H. Cedar, and D. P. Barlow. 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73:61–71.
  • Sutcliffe, J. S., D. L. Nelson, F. Zhang, M. Pierretti, S. T. Caskey, D. Saxe, and S. T. Warren. 1992. DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum. Mol. Genet. 1:397–400.
  • Thompson, S., A. R. Clarke, A. M. Pow, M. L. Hooper, and D. W. Melton. 1989. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56:313–321.
  • Viegas-Pequignot, E., B. Dutrillaux, and G. Thomas. 1988. Inactive X chromosome has the highest concentration of unmethylated HhaI sites. Proc. Natl. Acad. Sci. USA 85:7657–7660.
  • Wolf, S. F., and B. R. Migeon. 1982. Studies of X chromosome DNA methylation in normal human cells. Nature (London) 295:667–671.
  • Yen, P. H., T. Mohandas, and L. J. Shapiro. 1986. Stability of DNA methylation of the human hypoxanthine phosphoribosyl-transferase gene. Somatic Cell. Mol. Genet. 12:153–161.
  • Zuker, M., and P. Stiegler. 1981. Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res. 9:133–148.

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