Tyrosine Phosphorylation of CD45 Phosphotyrosine Phosphatase by p50^csk Kinase Creates A Binding Site for p56^lck Tyrosine Kinase and Activates the Phosphatase

REFERENCES

• Abraham, N., M. C. Miceli, J. R. Parties, and A. Veillette. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature (London) 350:62–66.
   PubMedGoogle Scholar
• Amrein, K., and B. M. Sefton. 1988. Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proc. Natl. Acad. Sci. USA 85:4247–4251.
   PubMed Web of Science ®Google Scholar
• Amrein, K. E., N. A. Flint, B. Panholzer, and P. Burn. 1992. Ras GTPase-activating protein: a substrate and a potential binding protein of the protein tyrosine kinase p56lck. Proc. Natl. Acad. Sci. USA 89:3343–3346.
   PubMedGoogle Scholar
• Amrein, K. E., B. Panholzer, N. A. Flint, W. Bannwarth, and P. Burn. 1993. The SH2 domain of the protein tyrosine kinase p56lck mediates both intermolecular and intramolecular interactions. Proc. Natl. Acad. Sci. USA 90:10285–10289.
   PubMedGoogle Scholar
• Andersson, L. C., K. K. Karhi, C. G. Gahmberg, and H. Rodt. 1980. Molecular identification of T cell-specific antigens on human T lymphocytes and thymocytes. Eur. J. Immunol. 10:359–362.
   PubMed Web of Science ®Google Scholar
• Appleby, M. W., J. A. Gross, M. P. Cooke, S. D. Levin, X. Qian, and R. M. Perlmutter. 1992. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70:751–763.
   PubMedGoogle Scholar
• Autero, M., and C. G. Gahmberg. 1987. Phorbol diesters increase the phosphorylation of the leukocyte common antigen CD45 in human T cells. Eur. J. Immunol. 17:1503–1506.
   PubMedGoogle Scholar
• Bergman, M., T. Mustelin, C. Oetken, J. Partanen, N. A. Flint, K. E. Amrein, M. Autero, P. Burn, and K. Alitalo. 1992. The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. EMBO J. 11:2919–2924.
   PubMed Web of Science ®Google Scholar
• Bougeret, C., B. Rothhut, P. Jullien, S. Fischer, and R. Benarous. 1993. Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s). Oncogene 8:1241–1247.
   PubMed Web of Science ®Google Scholar
• Cahir McFarland, E. D., T. R. Hurley, J. T. Pingel, B. M. Sefton, A. Shaw, and M. L. Thomas. 1993. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc. Natl. Acad. Sci. USA 90:1402–1406.
   PubMedGoogle Scholar
• Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell 64:281–302.
   PubMed Web of Science ®Google Scholar
• Chalupny, N. J., J. A. Ledbetter, and P. Kavathas. 1991. Association of CD8 with p56lck is required for early T cell signaling events. EMBO J. 10:1201–1207.
   PubMedGoogle Scholar
• Chan, A. C., B. A. Irving, J. D. Fraser, and A. Weiss. 1991. The TCRζ chain associates with a tyrosine kinase and upon TCR-stimulation associates with ZAP-70, a 70K Mr tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 88:9166–9170.
   PubMedGoogle Scholar
• Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71:649–662.
   PubMed Web of Science ®Google Scholar
• Charbonneau, Η., N. K. Tonks, K. A. Walsh, and E. H. Fischer. 1988. The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proc. Natl. Acad. Sci. USA 85:7182–7186.
   PubMed Web of Science ®Google Scholar
• Chow, L. M. L., M. Fournel, D. Davidson, and A. Veillette. 1993. Negative regulation of T-cell receptor signalling by the tyrosine kinase p50csk. Nature (London) 365:156–160.
   PubMed Web of Science ®Google Scholar
• Cobbold, S., G. Hale, and H. Waldmann. 1987. Non-lineage, LFA-1 family, and leukocyte common antigens: new and previously defined clusters, p. 788–803. In A. J. McMichael (ed.), Leukocyte typing III, white cell differentiation antigens. Oxford University Press, Oxford.
   Google Scholar
• Cooke, M. P., K. M. Abraham, K. A. Forbush, and R. M. Perlmutter. 1991. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell 65:281–291.
   PubMed Web of Science ®Google Scholar
• Danielian, S., A. Alcover, L. Polissard, M. Stefanescu, O. Acuto, S. Fischer, and R. Fagard. 1992. Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcksR-CD3-independent and CD45-dependent activation of p56lck. Eur. J. Immunol. 22:2915–2921.
   PubMed Web of Science ®Google Scholar
• Da Silva, A. J., M. Yamamoto, C. H. Zalvan, and C. E. Rudd. 1992. Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kd. Mol. Immunol. 29:1417–1425.
   PubMedGoogle Scholar
• Desai, D. M., J. Sap, J. Schlessinger, and A. Weiss. 1993. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell 73:541–554.
   PubMed Web of Science ®Google Scholar
• Eck, M. J., S. E. Shoelson, and S. C. Harrison. 1993. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature (London) 362:87–91.
   PubMed Web of Science ®Google Scholar
• Feng, G.-S., C.-C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607–1611.
   PubMed Web of Science ®Google Scholar
• Gahmberg, C. G., and L. C. Andersson. 1977. Selective radioactive labeling of cell surface sialoglycoproteins by periodatetritiated borohydride. J. Biol. Chem. 252:5888–5894.
   PubMedGoogle Scholar
• Gahmberg, C. G., P. Häyry, and L. C. Andersson. 1976. Characterization of surface glycoproteins of mouse lymphoid cells. J. Cell Biol. 68:642–653.
   PubMed Web of Science ®Google Scholar
• Garcia-Morales, P., Y. Minami, E. Luong, R. D. Klausner, and L. E. Samelson. 1990. Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide. Proc. Natl. Acad. Sci. USA 87:9255–9259.
   PubMed Web of Science ®Google Scholar
• Gassmann, M., K. E. Amrein, and P. Burn. 1993. CD4:p56lck association studied in vivo using antibody-induced capping and double indirect immunofluorescence microscopy. J. Receptor Res. 13:711–724.
   PubMed Web of Science ®Google Scholar
• Gassmann, M., M. Guttinger, K. E. Amrein, and P. Burn. 1992. Protein tyrosine kinase p59fyn is associated with the T cell receptor-CD3 complex in functional human lymphocytes. Eur. J. Immunol. 22:283–286.
   PubMed Web of Science ®Google Scholar
• Glaichenhaus, N., N. Shastri, D. R. Littman, and J. M. Turner. 1991. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511–520.
   PubMed Web of Science ®Google Scholar
• Guttinger, M., M. Gassmann, K. E. Amrein, and P. Burn. 1992. CD45 phosphotyrosine phosphatase and p56lck protein tyrosine kinase: a functional complex crucial in T cell signal transduction. Int. Immunol. 4:1325–1330.
   PubMedGoogle Scholar
• Hsi, E. D., J. N. Siegel, Y. Minami, E. T. Luong, R. D. Klausner, and L. E. Samelson. 1989. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J. Biol. Chem. 264:10836–10842.
   PubMedGoogle Scholar
• Hunter, T. 1989. Protein-tyrosine phosphatases: the other side of the coin. Cell 58:1013–1016.
   PubMed Web of Science ®Google Scholar
• Hunter, T., and J. A. Cooper. 1985. Protein-tyrosine kinases. Annu. Rev. Biochem. 54:897–930.
   PubMed Web of Science ®Google Scholar
• Hunter, T., and B. M. Sefton. 1980. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77:1311–1315.
   PubMed Web of Science ®Google Scholar
• Hurley, T. R., R. Hyman, and B. M. Sefton. 1993. Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases. Mol. Cell. Biol. 13:1651–1656.
   PubMedGoogle Scholar
• Julius, M. Η., E. Simpson, and L. A. Herzenberg. 1973. A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol. 3:645–650.
   PubMed Web of Science ®Google Scholar
• June, C. Η., M. C. Fletcher, J. A. Ledbetter, and L. E. Samelson. 1990. Increases in tyrosine phosphorylation are detected before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1591–1598.
   PubMed Web of Science ®Google Scholar
• June, C. Η., M. C. Fletcher, J. A. Ledbetter, G. L. Schieven, J. N. Siegel, A. F. Phillips, and L. E. Samelson. 1990. Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc. Natl. Acad. Sci. USA 87:7722–7727.
   PubMed Web of Science ®Google Scholar
• Justement, L. B., K. S. Campbell, N. C. Chien, and J. C. Cambier. 1991. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 252:1839–1842.
   PubMed Web of Science ®Google Scholar
• Karnitz, L., S. L. Sutor, T. Torigoe, J. C. Reed, M. P. Bell, D. J. McKean, P. J. Leibson, and R. T. Abraham. 1992. Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line. Mol. Cell. Biol. 12:4521–4530.
   PubMedGoogle Scholar
• Kawakami, T., Y. Kawakami, S. A. Aaronson, and K. C. Robbins. 1988. Acquisition of transforming activity by FYN, a normal SRC-related human gene. Proc. Natl. Acad. Sci. USA 85:3870–3874.
   PubMed Web of Science ®Google Scholar
• Kiener, P. A., and R. S. Mittler. 1989. CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells. J. Immunol. 143:23–28.
   PubMed Web of Science ®Google Scholar
• Klausner, R. D., and L. E. Samelson. 1991. T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell 64:875–878.
   PubMed Web of Science ®Google Scholar
• Koch, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. 1990. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668–674.
   Google Scholar
• Koretzky, G. A., M. A. Kohmetscher, T. Kadlecek, and A. Weiss. 1992. Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. J. Immunol. 149:1138–1142.
   PubMedGoogle Scholar
• Koretzky, G. A., J. Picus, T. Schultz, and A. Weiss. 1991. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88:2037–2041.
   PubMedGoogle Scholar
• Koretzky, G. A., J. Picus, M. L. Thomas, and A. Weiss. 1990. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature (London) 346:66–68.
   PubMed Web of Science ®Google Scholar
• Krueger, N. X., M. Streuli, and H. Saito. 1990. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9:3241–3252.
   PubMedGoogle Scholar
• Ledbetter, J. A., N. K. Tonks, E. H. Fischer, and E. A. Clark. 1988. CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proc. Natl. Acad. Sci. USA 85:8628–8633.
   PubMed Web of Science ®Google Scholar
• Liu, X., S. R. Brodeur, G. Gish, Z. Songyang, L. C. Cantley, A. P. Laudano, and T. Pawson. 1993. Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene 8:1119–1126.
   PubMed Web of Science ®Google Scholar
• Luo, K., T. R. Hurley, and B. M. Sefton. 1990. Transfer of proteins to membranes facilitates both cyanogen bromide cleavage and two-dimensional proteolytic mapping. Oncogene 5:921–923.
   PubMedGoogle Scholar
• Luo, K., and B. M. Sefton. 1992. Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells. Mol. Cell. Biol. 12:4724–4732.
   PubMedGoogle Scholar
• Marth, J. D., J. A. Cooper, C. S. King, S. F. Ziegler, D. A. Tinker, R. W. Overell, E. G. Krebs, and R. Perlmutter. 1988. Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol. Cell. Biol. 8:540–550.
   PubMed Web of Science ®Google Scholar
• Matthews, R. J., D. B. Bowne, E. Flores, and M. Thomas. 1992. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol. Cell. Biol. 12:2396–2405.
   PubMed Web of Science ®Google Scholar
• Molina, T. J., K. Kishihara, D. P. Siderowski, W. van Ewyk, A. Narendran, E. Timms, A. Wakeham, C. J. Paige, K.-U. Hartman, A. Veillette, D. Davidson, and T. W. Mak. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature (London) 357:161–164.
   PubMed Web of Science ®Google Scholar
• Mustelin, T., and A. Altman. 1990. Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45). Oncogene 5:809–813.
   PubMed Web of Science ®Google Scholar
• Mustelin, T., and P. Burn. 1993. Regulation of src-family tyrosine kinases in lymphocytes. Trends Biochem. Sci. 18:215–220.
   PubMedGoogle Scholar
• Mustelin, T., K. M. Coggeshall, and A. Altman. 1989. Rapid activation of the T cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc. Natl. Acad. Sci. USA 86:6302–6306.
   PubMed Web of Science ®Google Scholar
• Mustelin, T., K. M. Coggeshall, Ν. Isakov, and A. Altman. 1990. Tyrosine phosphorylation is required for T cell antigen receptor-mediated activation of phospholipase C. Science 247:1584–1587.
   PubMed Web of Science ®Google Scholar
• Mustelin, T., T. Pessa-Morikawa, M. Autero, M. Gassman, C. G. Gahmberg, L. C. Andersson, and P. Burn. 1992. Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase. Eur. J. Immunol. 22:1173–1178.
   PubMed Web of Science ®Google Scholar
• Nada, S., M. Okada, A. MacAuley, J. A. Cooper, and H. Nakagawa. 1991. Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature (London) 351:69–72.
   PubMed Web of Science ®Google Scholar
• Oetken, C., M. von Willebrand, M. Autero, T. Ruutu, L. C. Andersson, and T. Mustelin. 1992. Phenylarsine oxide augments tyrosine phosphorylation in hematopoietic cells. Eur. J. Hematol. 49:208–214.
   PubMedGoogle Scholar
• Okada, M., S. Nada, Y. Yamanishi, T. Yamamoto, and H. Nakagawa. 1991. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem. 266:24249–24252.
   PubMed Web of Science ®Google Scholar
• O'Shea, J. J., D. W. McVivar, T. L. Bailey, C. Burns, and M. J. Smyth. 1992. Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc. Natl. Acad. Sci. USA 89:10306–10310.
   PubMedGoogle Scholar
• Ostergaard, H. L., D. A. Shackelford, T. R. Hurley, P. Johnson, R. Hyman, B. M. Sefton, and I. S. Trowbridge. 1989. Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc. Natl. Acad. Sci. USA 86:8959–8963.
   PubMed Web of Science ®Google Scholar
• Ostergaard, H. L., and I. S. Trowbridge. 1990. Negative regulation of CD45 protein tyrosine phosphatase activity by ionomycin in T cells. Science 253:1423–1425.
   Google Scholar
• Ostergaard, H. L., and I. S. Trowbridge. 1990. Coclustering of CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck. J. Exp. Med. 172:347–350.
   PubMed Web of Science ®Google Scholar
• Partanen, J., E. Armstrong, M. Bergman, T. P. Mäkelä, H. Hirvonen, K. Huebner, and K. Alitalo. 1991. Cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src). Oncogene 6:2013–2018.
   PubMed Web of Science ®Google Scholar
• Pingel, J. T., and M. L. Thomas. 1989. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58:1055–1065.
   PubMed Web of Science ®Google Scholar
• Roussel, R. R., S. R. Brodeur, D. Shalloway, and A. P. Laudano. 1991. Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src. Proc. Natl. Acad. Sci. USA 88:10696–10700.
   PubMedGoogle Scholar
• Samelson, L. E., A. F. Phillips, E. T. Luong, and R. D. Klausner. 1990. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA 87:4358–4362.
   PubMed Web of Science ®Google Scholar
• Samelson, L. E., W. F. Davidson, H. C. Morse, and R. D. Klausner. 1986. Abnormal tyrosine phosphorylation of the T-cell receptor in lymphoproliferative disorders. Nature (London) 324:674–677.
   PubMed Web of Science ®Google Scholar
• Schraven, B., H. Kirchgessner, B. Gaber, Y. Samstag, and S. Meuer. 1991. A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and pp32, a possible common substrate. Eur. J. Immunol. 21:2469–2477.
   PubMedGoogle Scholar
• Secrist, J. P., L. A. Burns, L. Karnitz, G. A. Koretzky, and R. T. Abraham. 1993. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268:5886–5893.
   PubMed Web of Science ®Google Scholar
• Shackelford, D. A., and I. S. Trowbridge. 1986. Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin 2 receptor, class I HLA antigens, and T200 glycoprotein. J. Biol. Chem. 261:8334–8339.
   PubMedGoogle Scholar
• Shiroo, M., L. Goff, M. Biffen, E. Shivnan, and D. Alexander. 1992. CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx. EMBO J. 11:4887–4897.
   PubMedGoogle Scholar
• Sieh, M., J. B. Bolen, and A. Weiss. 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12:315–321.
   PubMedGoogle Scholar
• Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Leichleider, B. G. Neel, R. B. Birge, J. E. Fajardo, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. C. Cantley. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778.
   PubMed Web of Science ®Google Scholar
• Stein, P. L., H.-M. Lee, S. Rich, and P. Soriano. 1992. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741–750.
   PubMed Web of Science ®Google Scholar
• Stover, D. R., H. Charbonneau, N. K. Tonks, and K. A. Walsh. 1991. Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells. Proc. Natl. Acad. Sci. USA 88:7704–7707.
   PubMedGoogle Scholar
• Stover, D. R., and K. A. Walsh. 1993. A novel method of identifying phosphorylation sites using a thiophosphorylated peptide and ESI-MS, p. 193–200. In Techniques in protein chemistry IV. Academic Press, Inc., New York.
   Google Scholar
• Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593.
   PubMed Web of Science ®Google Scholar
• Streuli, M., L. R. Hall, Y. Saga, S. F. Schlossman, and H. Saito. 1987. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J. Exp. Med. 166:1548–1566.
   PubMed Web of Science ®Google Scholar
• Streuli, M., Ν. X. Krueger, A. Y. M. Tsai, and H. Saito. 1989. A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc. Natl. Acad. Sci. USA 86:8698–8702.
   PubMed Web of Science ®Google Scholar
• Tan, X., D. R. Stover, and K. A. Walsh. 1993. Demonstration of protein tyrosine phosphatase activity in the second of two homologous domains of CD45. J. Biol. Chem. 268:6835–6838.
   PubMedGoogle Scholar
• Thomas, M. L. 1989. The leukocyte common antigen family. Annu. Rev. Immunol. 7:339–369.
   PubMed Web of Science ®Google Scholar
• Thompson, P. A., J. S. Gutkind, K. C. Robbins, J. A. Ledbetter, and J. B. Bolen. 1992. Identification of distinct populations of PI-3 kinase activity following T-cell activation. Oncogene 7:719–725.
   PubMedGoogle Scholar
• Tonks, Ν. K., H. Charbonneau, C. D. Diltz, E. H. Fischer, and K. A. Walsh. 1988. Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry 27:8695–8701.
   PubMedGoogle Scholar
• Trowbridge, I. S. 1991. CD45. A prototype for transmembrane protein tyrosine phosphatases. J. Biol. Chem. 266:23517–23520.
   PubMedGoogle Scholar
• Trowbridge, I. S., P. Ralph, and M. J. Bevan. 1975. Differences in the surface proteins of mouse B and T cells. Proc. Natl. Acad. Sci. USA 72:157–161.
   PubMedGoogle Scholar
• Tsygankov, A. Y., B. M. Broker, J. Fargnoli, J. A. Ledbetter, and J. B. Bolen. 1992. Activation of tyrosine kinase p60fyn following T cell antigen receptor crosslinking. J. Biol. Chem. 267:18259–18262.
   PubMedGoogle Scholar
• Turka, L. A., S. B. Kanner, G. L. Schieven, C. B. Thompson, and J. A. Ledbetter. 1992. CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation. Eur. J. Immunol. 22:551–557.
   PubMedGoogle Scholar
• Ullrich, A., and J. Schlessinger. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203–212.
   PubMed Web of Science ®Google Scholar
• Vogel, W., R. Lammers, J. Huang, and A. Ullrich. 1993. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611–1614.
   PubMed Web of Science ®Google Scholar
• Volarevic, S., B. B. Niklinska, C. M. Burns, H. Yamada, C. H. June, F. J. Dumont, and J. D. Ashwell. 1992. The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations. J. Exp. Med. 176:835–844.
   PubMedGoogle Scholar
• von Willebrand, M., C. Oetken, T. Jascur, T. Pessa-Morikawa, N. A. Flint, P. Burn, and T. Mustelin. Activation of phosphatid-ylinositol 3-kinase by tyrosine phosphorylation in T cells. Submitted for publication.
   Google Scholar
• Weber, J. R., G. M. Bell, M. Y. Han, T. Pawson, and J. B. Imboden. 1992. Association of the tyrosine kinase LCK with phospholipase-Cγ1 after stimulation of the T cell antigen receptor. J. Exp. Med. 176:373–379.
   PubMedGoogle Scholar
• Yamada, N., Y. Kawakami, H. Kimura, H. Fukamachi, G. Baier, A. Altman, T. Kato, Y. Inagaki, and T. Kawakami. 1993. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Biochem. Biophys. Res. Commun. 192:231–240.
   PubMedGoogle Scholar
• Yang, Q., and N. K. Tonks. 1991. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. Proc. Natl. Acad. Sci. USA 88:5949–5953.
   PubMed Web of Science ®Google Scholar
• Zheng, X. M., Y. Wang, and C. J. Fallen. 1992. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature (London) 359:336–339.
   PubMed Web of Science ®Google Scholar