4
Views
14
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression

&
Pages 871-879 | Received 03 Aug 1993, Accepted 28 Oct 1993, Published online: 30 Mar 2023

REFERENCES

  • Ashcroft, S. J. H. 1980. Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia 18:5–15.
  • Bengal, E., L. Ransone, R. Scharfmann, V. J. Dwarki, S. J. Tapscott, H. Weintraub, and I. M. Verma. 1992. Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell 68:507–519.
  • Boam, D. S. W., and K. Docherty. 1989. A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer. Biochem. J. 264:233–239.
  • Brundstedt, J., and S. Chan. 1982. Direct effects of glucose on the preproinsulin mRNA levels in isolated pancreatic islets. Biochem. Biophys. Res. Commun. 106:1383–1389.
  • Campos-Ortega, J. A., and E. Knust. 1990. Genetics of early neurogenesis in Drosophila melanogaster. Annu. Rev. Genet. 24:387–407.
  • Chrapkiewicz, N. B., C. M. Davis, D. T.-W. Chu, C. M. Caldwell, and D. K. Granner. 1989. Rat gene 33: analysis of its structure, messenger RNA and basal promoter. Nucleic Acids Res. 17:6651–6667.
  • Clark, J. L., and D. F. Steiner. 1969. Insulin biosynthesis in the rat: demonstration of two proinsulins. Proc. Natl. Acad. Sci. USA 62:278–285.
  • Cordell, B., D. Diamond, S. Smith, J. Punter, Η. H. Schone, and Η. M. Goodman. 1982. Disproportionate expression of the two insulin nonallelic rat insulin genes in a pancreatic tumor is due to translational control. Cell 31:531–542.
  • Cordle, S. R., E. Henderson, H. Masuoka, P. A. Weil, and R. Stein. 1991. Pancreatic β-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol. Cell. Biol. 11:1734–1738.
  • Crowe, D. T., and M.-J. Tsai. 1989. Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT cells. Mol. Cell. Biol. 9:1784–1789.
  • De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725–737.
  • Edlund, Τ., M. D. Walker, P. J. Barr, and W. J. Rutter. 1985. Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′-flanking sequences. Science 230:912–916.
  • Efrat, S., M. Surana, and N. Fleischer. 1991. Glucose induces insulin gene transcription in a murine pancreatic β-cell line. J. Biol. Chem. 266:11141–11143.
  • Falvey, E., and U. Schibler. 1991. How are the regulators regulated? FASEB J. 5:309–314.
  • German, M. S., M. A. Blanar, C. Nelson, L. G. Moss, and W. J. Rutter. 1991. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol. Endocrinol. 5:292–299.
  • German, M. S., L. G. Moss, and W. J. Rutter. 1990. Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. J. Biol. Chem. 265:22063–22066.
  • German, M. S., L. G. Moss, J. Wang, and W. J. Rutter. 1992. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol. Cell. Biol. 12:1777–1788.
  • Giddings, S., J. Chirgwin, and M. A. Permutt. 1982. Effects of glucose on proinsulin messenger RNA in rat in vivo. Diabetes 31:624–629.
  • Goodison, S., S. Kenna, and S. J. H. Ashcroft. 1992. Control of insulin gene expression by glucose. Biochem. J. 285:563–568.
  • Hedeskov, C. J. 1980. Mechanism of glucose-induced insulin secretion. Physiol. Rev. 60:442–509.
  • Henderson, E., and R. Stein. 1994. c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control. Mol. Cell. Biol. 14:655–662.
  • Hunter, T., and M. Karin. 1992. The regulation of transcription by phosphorylation. Cell 70:375–386.
  • Inagaki, N., T. Maekawa, T. Sudo, S. Ishii, Y. Seino, and H. Imura. 1992. c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc. Natl. Acad. Sci. USA 89:1045–1049.
  • Li, L., J. C. Chambard, M. Karin, and E. N. Olson. 1992. Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev. 6:676–689.
  • Melloul, D., Y. Ben-Neriah, and E. Cerasi. 1993. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc. Natl. Acad. Sci. USA 90:3865–3869.
  • Nordeen, S. K., P. P. Green III, and D. M. Fowles. 1987. Laboratory methods. A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferase. DNA 6:173–178.
  • Ohlsson, H., S. Thor, and T. Edlund. 1991. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic a and β cells. Mol. Endocrinol. 5:897–904.
  • Olson, E. N. 1990. MyoD family: a paradigm for development? Genes Dev. 4:1454–1461.
  • Robinson, G., M. Peshavaria, E. Henderson, S.-Y. Shieh, M.-J. Tsai, G. Teitelman, and R. Stein. Expression of the trans-active factors that stimulate insulin control element mediated activity precedes insulin transcription. J. Biol. Chem., in press.
  • Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullis, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–491.
  • Sartorelli, V., K. A. Webster, and L. Kedes. 1990. Muscle-specific expression of the cardiac α-actin gene requires MyoD1, CArG-box binding factor, and Sp1. Genes Dev. 4:1811–1822.
  • Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffher. 1989. Rapid detection of octamer binding proteins with ‘miniextracts’, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
  • Sharma, A. Unpublished data.
  • Shieh, S.-Y., and M.-J. Tsai. 1991. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J. Biol. Chem. 266:16708–16714.
  • Shih, H.-M., and H. C. Towle. 1992. Definition of the carbohydrate response element of the rat S14 gene. J. Biol. Chem. 267:13222–13228.
  • Smeal, T., B. Binetruy, D. A. Mercola, M. Birrer, and M. Karin. 1991. Oncogenic and transcriptional cooperation with Ha-ras requires phosphorylation on c-jun on serines 63 and 73. Nature (London) 354:494–496.
  • Stein, R. 1993. Factors regulating insulin gene transcription. Trends Endocrinol. Metabol. 4:96–100.
  • Steiner, D. F., S. J. Chan, J. M. Welsh, and S. C. K. Kwok. 1985. Structure and evolution of the insulin gene. Annu. Rev. Genet. 19:463–484.
  • Thompson, K. S., and H. C. Towle. 1991. Definition of the carbohydrate response element of the rat S14 gene: evidence for a common factor required for carbohydrate regulation of the hepatic genes. J. Biol. Chem. 266:8679–8682.
  • Walker, M. D., T. Edlund, A. M. Boulet, and W. J. Rutter. 1983. Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature (London) 306:557–561.
  • Walker, M. D., C. W. Park, A. Rosen, and A. Aronheim. 1990. A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene. Nucleic Acids Res. 18:1159–1166.
  • Weintraub, H. R., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, S. Hollenberg, Y. Zhuang, and A. B. Lassar. 1991. The MyoD gene family: nodal point during specification of the muscle cell lineage. Science 251:761–766.
  • Welsh, M., D. A. Nielsen, A. J. MacKrell, and D. F. Steiner. 1985. Control of insulin gene expression in pancreatic β-cells and in an insulin-producing cell line, RIN-5F cells. J. Biol. Chem. 260:13590–13594.
  • Whelan, J., S. R. Cordle, E. Henderson, P. A. Weil, and R. Stein. 1990. Identification of a pancreatic β-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence. Mol. Cell. Biol. 10:1564–1572.
  • Whelan, J., D. Poon, P. A. Weil, and R. Stein. 1989. Pancreatic β-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative transcriptional elements. Mol. Cell. Biol. 9:3253–3259.
  • Zhang, H.-J., T. F. Walseth, and R. P. Robertson. 1989. Insulin secretion and cAMP metabolism in HIT cells. Diabetes 38:44–48.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.