2
Views
4
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Oncogenic Activation of the Lck Protein Accompanies Translocation of the LCK Gene in the Human HSB2 T-Cell Leukemia

, &
Pages 2429-2437 | Received 03 Sep 1993, Accepted 20 Jan 1994, Published online: 30 Mar 2023

REFERENCES

  • Abraham, N., M. C. Miceli, J. R. Parnes, and A. Veillette. 1991. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase, p56lck. Nature (London) 350:62–66.
  • Adams, R. A., A. Flowers, and B. J. Davis. 1968. Direct implantation and serial transplantation of human acute lymphoblastic leukemia in hamsters, SB-2. Cancer Res. 28:1121–1125.
  • Adams, R. A., L. Pothier, A. Flowers, H. Lazarus, S. Farber, and G. Foley. 1970. The question of stemlines in human acute leukemia. Exp. Cell Res. 62:5–10.
  • Adler, H. T., and B. M. Sefton. 1992. Generation and characterization of transforming variants of the lack tyrosine protein kinase. Oncogene 7:1191–1199.
  • Amrein, K. E., and B. M. Sefton. 1988. Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proc. Natl. Acad. Sci. USA 85:4247–4251.
  • Anderson, S. M., P. M. Carroll, and F. D. Lee. 1990. Abrogation of IL-3 dependent growth requires a functional v-src gene product: evidence for an autocrine growth cycle. Oncogene 5:317–325.
  • Beemon, K., and T. Hunter. 1978. Characterization of Rous sarcoma virus src gene product synthesized in vitro. J. Virol. 28:551–566.
  • Bolen, J. B., A. Veillette, A. Schwartz, V. DeSeau, and N. Rosen. 1987. Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc. Natl. Acad. Sci. USA 84:2251–2255.
  • Brown, L., J. T. Cheng, Q. Chen, M. J. Siciliano, W. Crist, G. Buchanan, and R. Baer. 1990. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J. 9:3343–3351.
  • Burnett, R. C., J. C. David, A. M. Harden, M. M. Le Beau, J. D. Rowley, and M. O. Diaz. 1991. The LCK gene is involved in the t(l;17)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2. Genes Chromosomes Cancer 3:461–467.
  • Cartwright, C. A., M. P. Kamps, A. I. Meisler, J. M. Pipas, and W. Eckhart. 1989. pp60c-src activation in human colon carcinoma. J. Clin. Invest. 83:2025–2033.
  • Cartwright, C. A., A. I. Meisler, and W. Eckhart. 1990. Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis. Proc. Natl. Acad. Sci. USA 87:558–562.
  • Casnellie, J. E., L. E. Gentry, L. R. Rohrschneider, and E. G. Krebs. 1984. Identification of the tyrosine protein kinase from LSTRA cells by the use of site-specific antibodies. Proc. Natl. Acad. Sci. USA 81:6676–6680.
  • Cooke, M. P., K. M. Abraham, K. A. Forbush, and R. M. Perlmutter. 1985. Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell 41:677–683.
  • Cooper, J. A. 1990. The Src family of tyrosine kinases, p. 85–113. In B. E. Kemp (ed.), Peptides and protein phosphorylation. CRC Press, Inc., Boca Raton, Fla.
  • Doyle, C., and J. L. Strominger. 1987. Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature (London) 330:256–259.
  • Dymecki, S. M., J. E. Niederhuber, and S. V. Desiderio. 1990. Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science 247:332–336.
  • Glaichenhaus, N., N. Shastri, D. Littman, and J. Turner. 1991. Requirement for association of p561ck with CD4 in antigen-specific signal transduction in T cells. Cell 64:511–520.
  • Horak, I. D., R. E. Gress, P. J. Lucas, E. M. Horak, T. A. Waldmann, and J. B. Bolen. 1991. T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proc. Natl. Acad. Sci. USA 88:1996–2000.
  • Hsi, E. D., J. N. Siegel, Y. Minami, E. T. Luong, R. D. Klausner, and L. E. Samelson. 1989. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J. Biol. Chem. 264:10836–10842.
  • Hunter, T., and B. M. Sefton. 1980. The transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77:1311–1315.
  • Hurley, T., and B. M. Sefton. 1989. Analysis of the activity and phosphorylation of the lck protein in lymphoid cells. Oncogene 4:265–272.
  • Kamps, M. P., and B. M. Sefton. 1988. Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine. Oncogene 2:305–315.
  • Kamps, M. P., and B. M. Sefton. 1989. Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates the analysis of the phosphoamino acids in gel-fractionated proteins. Anal. Biochem. 176:22–27.
  • Koch, C., D. Anderson, M. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252:668–674.
  • Koga, Y., N. Caccia, B. Toyonaga, R. Spolski, Y. Yanagi, Y. Yoshikai, and T. W. Mak. 1986. A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein tyrosine kinases. Eur. J. Immunol. 16:1643–1646.
  • Luo, K., and B. M. Sefton. 1990. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol. Cell. Biol. 10:5305–5313.
  • Luo, K., and B. M. Sefton. 1992. Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells. Mol. Cell. Biol. 12:4724–4732.
  • Marth, J. D., J. A. Cooper, C. S. King, S. F. Ziegler, D. A. Tinker, R. W. Overell, E. G. Krebs, and R. M. Perlmutter. 1988. Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol. Cell. Biol. 8:540–550.
  • Marth, J. D., R. Peet, E. G. Krebs, and R. M. Perlmutter. 1985. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 43:393–404.
  • Mayer, B. J., P. K. Jackson, R. A. Van Etten, and D. Baltimore. 1992. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo. Mol. Cell. Biol. 12:609–618.
  • Mayer, K. M., I. J. Ansotegui, and W. G. Ballhausen. 1992. The human lck cDNA clone YT16 is a transforming oncogene. Anticancer Res. 12:485–488.
  • Miceli, M., C. P. von Hoegen, and J. R. Parnes. 1991. Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc. Natl. Acad. Sci. USA 88:2623–2627.
  • Muller, A. J., J. C. Young, A.-M. Pendergast, M. Pondel, N. R. Landau, D. R. Littman, and O. N. Witte. 1991. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol. Cell. Biol. 11:1785–1792.
  • Nishizawa, M., K. Semba, M. Yoshida, T. Yamamoto, M. Sasaki, and K. Toyoshima. 1986. Structure, expression, and chromosomal location of the human c-fgr gene. Mol. Cell. Biol. 6:511–517.
  • Paillard, F., G. Sterkers, and C. Vaquero. 1992. Correlation between up-regulation of lymphokine mRNA and down-regulation of TcR, CD4, CD8, and lck mRNA as shown by the effect of CsA on activated T lymphocytes. Biochem. Biophys. Res. Commun. 186:603–611.
  • Paillard, F., and C. Vaquero. 1991. Down-regulation of Ick mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms. Nucleic Acids Res. 19:4655–4661.
  • Perlmutter, R. M., J. D. Marth, D. B. Lewis, R. Peet, S. F. Ziegler, and C. B. Wilson. 1988. Structure and expression of lck transcripts in human lymphoid cells. J. Cell. Biochem. 38:117–126.
  • Pierce, J. H., P. P. Di Fiore, S. A. Aaronson, M. Potter, J. Pumphrey, A. Scott, and J. N. Ihle. 1985. Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell 41:685–693.
  • Quintrell, N., R. Lebo, H. Varmus, J. M. Bishop, M. Pettenati, M. M. Le Beau, M. O. Diaz, and J. D. Rowley. 1987. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Mol. Cell. Biol. 7:2267–2275.
  • Reynolds, P. J., T. R. Hurley, and B. M. Sefton. 1992. Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase. Oncogene 7:1949–1955.
  • Rouer, E., T. Van Huynh, S. de Souza, M.-C. Lang, S. Fischer, and R. Benarous. 1989. Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons. Gene 84:105–113.
  • Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190–5194.
  • Semba, K., M. Nishizawa, N. Miyajima, M. Yoshida, J. Sukegawa, Y. Yamanashi, M. Sasaki, T. Yamamoto, and K. Toyoshima. 1986. yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc. Natl. Acad. Sci. USA 83:5459–5463.
  • Shaw, A. S., K. E. Amrein, C. Hammond, D. F. Stern, B. M. Sefton, and J. K. Rose. 1989. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59:627–636.
  • Sleckman, B. P., A. Peterson, J. A. Foran, J. C. Gorga, C. J. Kara, J. L. Strominger, S. J. Burakoff, and J. L. Greenstein. 1988. Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule. J. Immunol. 141:49–54.
  • Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585–593.
  • Sukegawa, J., K. Semba, Y. Yamanashi, M. Nishizawa, N. Miyajima, T. Yamamoto, and K. Toyoshima. 1987. Characterization of cDNA clones for the human c-yes gene. Mol. Cell. Biol. 7:41–47.
  • Takeya, T., and H. Hanafusa. 1983. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell 32:881–890.
  • Tycko, B., S. Smith, and J. Sklar. 1991. Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. J. Exp. Med. 174:867–873.
  • Veillette, A., M. A. Bookman, E. M. Horak, and J. B. Bolen. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase, pp56lck. Cell 44:301–308.
  • Voronova, A. F., J. E. Buss, T. Patschinsky, T. Hunter, and B. M. Sefton. 1985. Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. Mol. Cell. Biol. 4:2705–2713.
  • Waksman, G., D. Kominos, S. C. Robertson, N. Pant, D. Baltimore, R. B. Birge, D. Cowburn, H. Hanafusa, B. Mayer, M. Overduin, M. Resh, C. Rios, L. Silverman, and J. Kuriyan. 1992. Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature (London) 358:646–653.
  • Yamanashi, Y., S.-I. Fukushige, K. Semba, J. Sukegawa, N. Miyajima, K.-I. Matsubara, T. Yamamoto, and K. Toyoshima. 1987. The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol. Cell. Biol. 7:237–243.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.