Assembly of Mitochondrial Ribonucleoprotein Complexes Involves Specific Guide RNA (gRNA)-Binding Proteins and gRNA Domains but Does Not Require Preedited mRNA

REFERENCES

• Benne, R. K. (ed.). 1993. RNA editing: the alternation of protein coding sequences of RNA. Simon and Schuster International Group, Hemel Hempstead, Herts, United Kingdom.
   Google Scholar
• Blum, B., N. Bakalara, and L. Simpson. 1990. A model for RNA editing in kinetoplastid mitochondria: “guide” RNA molecules transcribed from maxicircle DNA provide the edited information. Cell 60:189–198.
   PubMed Web of Science ®Google Scholar
• Blum, B., and L. Simpson. 1992. Formation of gRNA/mRNA chimeric molecules in vitro, the initial step of RNA editing, is dependent on an anchor sequence. Proc. Natl. Acad. Sci. USA 89:11944–11948.
   PubMed Web of Science ®Google Scholar
• Blum, B., N. R. Sturm, A. M. Simpson, and L. Simpson. 1991. Chimeric gRNA-mRNA molecules with oligo(U) tails covalently linked at sites of RNA editing suggest that U addition occurs by transesterification. Cell 65:543–550.
   PubMed Web of Science ®Google Scholar
• Brewer, G. 1991. An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol. Cell. Biol. 11:2460–2466.
   PubMed Web of Science ®Google Scholar
• Cech, T. R. 1991. RNA editing: world's smallest introns? Cell 64:667–669.
   PubMedGoogle Scholar
• Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156–159.
   PubMed Web of Science ®Google Scholar
• Corell, R. A., J. E. Feagin, G. R. Riley, T. Strickland, J. A. Guderian, P. J. Myler, and K. Stuart. 1993. Trypanosoma brucei minicircles encode multiple guide RNAs which can direct editing of extensively overlapping sequences. Nucleic Acids Res. 21:4313–4320.
   PubMedGoogle Scholar
• Goringer, H. U., D. J. Koslowsky, T. H. Morales, and K. D. Stuart. The formation of mitochondrial ribonucleoprotein complexes involving gRNA molecules in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA, in press.
   Google Scholar
• Gottlieb, E., and J. A. Steitz. 1989. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. EMBO J. 8:851–861.
   PubMed Web of Science ®Google Scholar
• Hajduk, S. L., M. E. Harris, and V. W. Pollard. 1993. RNA editing in kinetoplastid mitochondria. FASEB J. 7:54–63.
   PubMedGoogle Scholar
• Harris, M. E., and S. L. Hajduk. 1992. Kinetoplastid RNA editing: in vitro formation of cytochrome b gRNA-mRNA chimeras from synthetic substrate RNAs. Cell 68:1091–1099.
   PubMedGoogle Scholar
• Harris, M. E., D. R. Moore, and S. L. Hajduk. 1990. Addition of uridines to edited RNAs in trypanosome mitochondria occurs independently of transcription. J. Biol. Chem. 265:11368–11376.
   PubMedGoogle Scholar
• Jacob, A. N. K., R. A. Corell, L. K. Read, G. R. Riley, and K. Stuart. 1993. Unpublished data.
   Google Scholar
• Kenan, D. J., C. C. Query, and J. D. Keene. 1991. RNA recognition: towards identifying determinants of specificity. Trends Biochem. Sci. 16:214–220.
   PubMedGoogle Scholar
• Köller, J., G. Norskau, A. S. Paul, K. Stuart, and H. U. Goringer. Different Trypanosoma brucei guide RNA molecules associate with an identical complement of mitochondrial proteins in vitro. Submitted for publication.
   Google Scholar
• Koslowsky, D. J., H. U. Goringer, T. Morales, and K. Stuart. 1992. In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing. Nature (London) 356:807–809.
   PubMedGoogle Scholar
• Koslowsky, D. J., G. R. Riley, J. E. Feagin, and K. Stuart. 1992. Guide RNAs for transcripts with developmentally regulated RNA editing are present in both life cycle stages of Trypanosoma brucei. Mol. Cell. Biol. 12:2043–2049.
   PubMedGoogle Scholar
• Koslowsky, D. J., and K. Stuart. 1993. Unpublished observations reported at the Cold Spring Harbor RNA Processing Meeting, May 1993.
   Google Scholar
• Maniatis, T., and R. Reed. 1987. The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (London) 325:673–678.
   PubMed Web of Science ®Google Scholar
• Mathews, M. B., and A. M. Francoeur. 1984. La antigen recognizes and binds to the 3′-oligouridylate tail of a small RNA. Mol. Cell. Biol. 4:1134–1140.
   PubMed Web of Science ®Google Scholar
• McGrew, L. L., and J. D. Richter. 1990. Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF. EMBO J. 9:3743–3751.
   PubMed Web of Science ®Google Scholar
• Morris, D. R., T. Kakegawa, R. L. Kaspar, and M. W. White. 1993. Polypyrimidine tracts and their binding proteins: regulatory sites for posttranscriptional modulation of gene expression. Biochemistry 32:2931–2937.
   PubMedGoogle Scholar
• Pollard, V. W., M. E. Harris, and S. L. Hajduk. 1992. Native mRNA editing complexes from Trypanosoma brucei mitochondria. EMBO J. 11:4429–4438.
   PubMedGoogle Scholar
• Pollard, V. W., S. P. Rohrer, E. F. Michelotti, K. Hancock, and S. L. Hajduk. 1990. Organization of minicircle genes for guide RNAs in Trypanosoma brucei. Cell 63:783–790.
   PubMedGoogle Scholar
• Read, L. K., R. A. Corell, and K. Stuart. 1992. Chimeric and truncated RNAs in Trypanosoma brucei suggest transesterifications at non-consecutive sites during RNA editing. Nucleic Acids Res. 20:2341–2347.
   PubMedGoogle Scholar
• Riley, G. R., R. A. Corell, and K. Stuart. Multiple guide RNAs for identical editing of T brucei apocytochrome b mRNA have an unusual minicircle location and are developmentally regulated. J. Biol. Chem., in press.
   Google Scholar
• Rouault, T. A., C. K. Tang, S. Kaptain, W. H. Burgess, D. J. Haile, F. Samaniego, O. W. McBride, J. B. Harford, and R. D. Klausner. 1990. Cloning of the cDNA encoding an RNA regulatory protein—the human iron-responsive element-binding protein. Proc. Natl. Acad. Sci. USA 87:7958–7962.
   PubMedGoogle Scholar
• Stuart, K. 1991. RNA editing in trypanosomatid mitochondria. Annu. Rev. Microbiol. 45:327–344.
   PubMedGoogle Scholar
• Stuart, K., E. Gobright, L. Jenni, M. Milhausen, L. Thomashow, and N. Agabian. 1984. The IsTaR 1 serodeme of Trypanosoma brucei: development of a new serodeme. J. Parasitol. 70:747–754.
   PubMedGoogle Scholar
• Stuart, K. D. 1993. The RNA editing process in Trypanosoma brucei. Semin. Cell Biol. Ser. 4:251–260.
   PubMedGoogle Scholar
• Stuart, K. D., and S. B. Gelvin. 1982. Localization of kinetoplast DNA maxicircle transcripts in bloodstream and procyclic form Trypanosoma brucei. Mol. Cell. Biol. 2:845–852.
   PubMedGoogle Scholar
• Tiley, L. S., M. H. Malim, H. K. Tewary, P. G. Stockley, and B. R. Cullen. 1992. Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type I Rev protein. Proc. Natl. Acad. Sci. USA 89:758–762.
   PubMed Web of Science ®Google Scholar
• Vakalopoulou, E., J. Schaack, and T. Shenk. 1991. A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs. Mol. Cell. Biol. 11:3355–3364.
   PubMed Web of Science ®Google Scholar
• Weeks, K. M., and D. M. Crothers. 1991. RNA recognition by Tat-derived peptides: interaction in the major groove? Cell 66:577–588.
   PubMed Web of Science ®Google Scholar
• You, Y., C.-Y. A. Chen, and A.-B. Shyu. 1992. U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3′ untranslated region of the c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol. Cell. Biol. 12:2931–2940.
   PubMedGoogle Scholar