References
- Akerblom, I. A., E. C. Ridgway, and P. L. Mellon. 1990. An α-subunit-secreting cell line derived from a mouse thyrotrope tumor. Mol. Endocrinol. 4:589–596.
- Altschmied, J., M. Büscher, D. J. Steger, and P. L. Mellon. Unpublished data.
- Andersen, B., G. C. Kennedy, D. L. Hamernik, J. A. Bokar, R. Bohinski, and J. H. Nilson. 1990. Amplification of the transcriptional signal mediated by the tandem cAMP response elements of the glycoprotein hormone a-subunit gene occurs through several distinct mechanisms. Mol. Endocrinol. 4:573–582.
- Arceci, R. J., A. A. J. King, M. C. Simon, S. H. Orkin, and D. B. Wilson. 1993. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell. Biol. 13:2235–2246.
- Barnhart, K. M., and P. L. Mellon. The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone a-subunit gene in pituitary gonadotropes. Mol. Endocrinol., in press.
- Bokar, J. A., R. A. Keri, T. A. Farmene, R. A. Fenstermaker, B. Andersen, D. L. Hamernik, J. Yun, T. Wagner, and J. H. Nilson. 1989. Expression of the glycoprotein hormone a-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cw-acting element mediates pituitary-specific expression. Mol. Cell. Biol. 9:5113–5122.
- Briegel, K., K.-C. Lim, C. Plank, H. Bueg, J. D. Engel, and M. Zenke. 1993. Ectopic expression of a conditional GATA-2/estro-gen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Genes Dev. 7:1097–1109.
- Chin, W. W., and S. D. Gharib. 1986. Organization and expression of gonadotropin genes. Adv. Med. Biol. 205:245–265.
- Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform ex- traction. Anal. Biochem. 162:156–159.
- Collins, S., J. Altschmied, Ο. Herbsman, M. G. Caron, P. L. Mellon, and R. J. Lefkowitz. 1990. A cAMP response element in the β2-adrenergic receptor gene confers transcriptional autoregu-lation by cAMP. J. Biol. Chem. 265:19330–19335.
- Darnell, R. B., and I. Boime. 1985. Differential expression of the human gonadotropin α gene in ectopic and eutopic cells. Mol. Cell. Biol. 5:3157–3167.
- Delegeane, A. M., L. H. Ferland, and P. L. Mellon. 1987. Tissue-specific enhancer of the human glycoprotein hormone a-subunit gene: dependence on cyclic AMP-inducible elements. Mol. Cell. Biol. 7:3994–4002.
- Deutsch, P. J., J. L. Jameson, and J. F. Habener. 1987. Cyclic AMP responsiveness of human gonadotropin-α gene transcription is directed by a repeated 18-base pair enhancer. J. Biol. Chem. 262:12169–12174.
- Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489.
- Dorfman, D. M., D. B. Wilson, G. A. P. Bruns, and S. H. Orkin. 1992. Human transcription factor GATA-2. J. Biol. Chem. 267:1279–1285.
- Dugaiczyk, A., J. A. Haron, E. M. Stone, Ο. Ε. Dennison, Κ. Ν. Rothblum, and R. J. Schwartz. 1983. Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle. Biochemistry 22:1605–1613.
- Evans, T., and G. Felsenfeld. 1989. The erythroid-specific transcription factor Eryfl: a new finger protein. Cell 58:877–885.
- Evans, T., M. Reitman, and G. Felsenfeld. 1988. An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc. Natl. Acad. Sci. USA 85:5976–5980.
- Fenstermaker, R. A., T. A. Farmene, C. M. Clay, D. L. Hamernik, and J. H. Nilson. 1990. Different combinations of regulatory elements may account for expression of the glycoprotein hormone α-subunit gene in primate and horse placenta. Mol. Endocrinol. 4:1480–1487.
- Fiddes, J. C., and H. M. Goodman. 1981. The gene encoding the common alpha subunit of the four human glycoprotein hormones. J. Mol. Appl. Genet. 1:3–18.
- Fiddes, J. C., and K. Talmadge. 1984. Structure, expression, and evolution of the genes for the human glycoprotein hormones. Recent Prog. Horm. Res. 40:43–78.
- Gharib, S. D., M. E. Wierman, M. A. Shupnik, and W. W. Chin. 1990. Molecular biology of the pituitary gonadotropins. Endocr. Rev. 11:177–199.
- Gonzalez, G. A., Κ. Κ. Yamamoto, W. Η. Fischer, D. Darr, P. Menzel, W. Briggs, W. Vale, and M. Montminy. 1989. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature (London) 337:749–752.
- Ho, I.-C., P. Vorhees, N. Marin, B. Karpinski Oakley, S.-F. Tsai, S. H. Orkin, and J. M. Leiden. 1991. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the Τ cell receptor alpha gene. EMBO J. 10:1187–1192.
- Hoeffler, J. P., T. E. Meyer, Y. Yun, J. L. Jameson, and J. F. Habener. 1988. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science 242:1430–1433.
- Horn, F., J. J. Windle, Κ. M. Barnhart, and P. L. Mellon. 1992. Tissue-specific gene expression in the pituitary: the glycoprotein hormone α-subunit gene is regulated by a gonadotrope-specific protein. Mol. Cell. Biol. 12:2143–2153.
- Ikeda, Y., D. S. Lala, X. R. Luo, E. Kim, M. P. Moisan, and K. L. Parker. 1993. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol. Endocrinol. 7:852–860.
- Jameson, J. L., C. Albanese, and J. F. Habener. 1989. Distinct adjacent protein-binding domains in the glycoprotein hormone alpha gene interact independently with a cAMP-responsive enhancer. J. Biol. Chem. 264:16190–16196.
- Jameson, J. L., R. C. Jaffe, P. J. Deutsch, C. Albanese, and J. F. Habener. 1988. The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription. J. Biol. Chem. 263:9879–9886.
- Jameson, J. L., A. C. Powers, G. D. Gallagher, and J. F. Habener. 1989. Enhancer and promoter element interactions dictate cyclic adenosine monophosphate mediated and cell-specific expression of the glycoprotein hormone α-gene. Mol. Endocrinol. 3:763–772.
- Joulin, V., D. Bories, J.-F. Eléouet, M.-C. Lavastie, S. Chretien, M.-G. Mattéi, and P.-H. Roméo. 1991. A T-cell specific TCR δ DNA binding protesti is a member of the human GATA family. EMBO J. 10:1809–1816.
- Kelley, C., H. Blumberg, L. I. Zon, and T. Evans. 1993. GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development 118:817–827.
- Kemler, I., E. Bücher, Κ. Seipel, M. M. Müller-Immerglück, and W. Schaffner. 1991. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Res. 19:237–242.
- Kennedy, G. C., B. Andersen, and J. H. Nilson. 1990. The human alpha subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor. J. Biol. Chem. 265:6279–6285.
- Ko, L. J., M. Yamamoto, M. W. Leonard, Κ. M. George, P. Ting, and J. D. Engel. 1991. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor δ gene enhancer. Mol. Cell. Biol. 11:2778–2784.
- Köhler, P. O., and W. E. Bridson. 1971. Isolation of hormone-producing clonal lines of human choriocarcinoma. J. Clin. Endocrinol. Metab. 32:683.
- Lee, M.-E., D. H. Temizer, J. A. Clifford, and T. Quertermous. 1991. Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. J. Biol. Chem. 266:16188–16192.
- Linzer, D. I. Personal communication.
- Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- Maniatis, T., S. Goodbourn, and J. A. Fischer. 1987. Regulation of inducible and tissue-specific gene expression. Science 236:1237–1245.
- Martin, D. I. K., and S. H. Orkin. 1990. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-El/Eryf 1. Genes Dev. 4:1886–1898.
- Martin, D. I. K., S. Tsai, and S. H. Orkin. 1989. Increased gamma-globin expression in nondeletion HPFH mediated by an erythroid-specific DNA-binding factor. Nature (London) 338:435–438.
- Matthias, P., M. M. Müller, E. Schreiber, S. Rusconi, and W. Schaffner. 1989. Eukaryotic expression vectors for the analysis of mutant proteins. Nucleic Acids Res. 17:6418.
- Mellon, P. L., V. Parker, Y. Gluzman, and T. Maniatis. 1981. Identification of DNA sequences required for transcription of the human alpha, globin gene using a new SV40 host-vector system. Cell 27:279–288.
- Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371–378.
- Ocran, K. W., V. D. Sarapura, W. M. Wood, D. F. Gordon, A. Gutierrez-Hartmann, and E. C. Ridgway. 1990. Identification of cis-acting promoter elements important for expression of the mouse glycoprotein hormone α-subunit gene in thyrotropes. Mol. Endocrinol. 4:766–772.
- Orkin, S. H. 1992. GATA-binding transcription factors in hematopoietic cells. Blood 80:575–581.
- Parker, K. L., and B. P. Schimmer. 1993. Transcriptional regulation of the adrenal steroidogenic enzymes. Trends Endocrinol. Metab. 4:46–50.
- Pevny, L., M. C. Simon, E. Robertson, W. H. Klein, S.-F. Tsai, V. D'Agati, S. H. Orkin, and F. Costantini. 1991. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (London) 349:257–260.
- Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
- Sarapura, V. D., W. M. Wood, D. F. Gordon, K. W. Ocran, M. Υ. Kao, and E. C. Ridgway. 1990. Thyrotrope expression and thyroid hormone inhibition map to different regions of the mouse glycoprotein hormone α-subunit gene promoter. Endocrinology 127:1352–1361.
- Sawadogo, M., M. W. Van Dyke, P. D. Gregor, and R. G. Roeder. 1988. Multiple forms of the human gene-specific transcription factor USF. J. Biol. Chem. 263:11985–11993.
- Schoderbek, W. E., K. E. Kim, E. C. Ridgway, P. L. Mellon, and R. A. Maurer. 1992. Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone α-subunit gene. Mol. Endocrinol. 6:893–903.
- Seed, B., and J. Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67:271–277.
- Silver, B. J., J. A. Bokar, J. B. Virgin, E. A. Valien, A. Milsted, and J. H. Nilson. 1987. Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element. Proc. Natl. Acad. Sci. USA 84:2198–2202.
- Steger, D. J., J. Altschmied, M. Büscher, and P. L. Mellon. 1991. Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin α-subunit genes. Mol. Endocrinol. 5:243–255.
- Steger, D. J., M. Büscher, J. H. Hecht, and P. L. Mellon. 1993. Coordinate control of the α- and β-subunit genes of human chorionic gonadotropin by trophoblast-specific element binding protein, TSEB. Mol. Endocrinol. 7:1579–1588.
- Tanaka, M., and W. Herr. 1990. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 60:375–386.
- Tanaka, M., J.-S. Lai, and W. Herr. 1992. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. Cell 68:755–767.
- Taylor, C. A., J. L. Workman, T. J. Schuetz, and R. E. Kingston. 1991. Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains. Genes Dev. 5:1285–1298.
- Tsai, S.-F., D. I. Martin, L. I. Zon, A. D. D'Andrea, G. G. Wong, and S. H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (London) 339:446–451.
- Wall, L., E. deBoer, and F. Grosveld. 1988. The human β-globin gene 3′-enhancer contains multiple binding sites for an erythroid-specific protein. Genes Dev. 2:1089–1100.
- Weintraub, H. 1993. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell 75:1241–1244.
- Wilson, D. B., D. M. Dorfman, and S. H. Orkin. 1990. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol. Cell. Biol. 10:4854–4862.
- Windle, J. J., R. I. Weiner, and P. L. Mellon. 1990. Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol. Endocrinol. 4:597–603.
- Yamamoto, M., L. J. Ko, M. W. Leonard, H. Beug, S. H. Orkin, and J. D. Engel. 1990. Activity and tissue-specific expression of the transcription factor NF-ΕΙ multigene family. Genes Dev. 4:1650–1662.