The Lung-Specific Surfactant Protein B Gene Promoter Is a Target for Thyroid Transcription Factor 1 and Hepatocyte Nuclear Factor 3, Indicating Common Factors for Organ-Specific Gene Expression along the Foregut Axis

REFERENCES

• Ang, S.-L., A. Wierda, D. Wong, K. A. Stevens, S. Cascio, J. Rossant, and K. S. Zaret. 1993. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of the HNF3/forkhead proteins. Development 119:1301–1315.
   PubMed Web of Science ®Google Scholar
• Awedimento, V. E., A. M. Musti, M. Ueffing, S. Obici, A. Gallo, M. Sanchez, D. DeBrasi, and M. E. Gottesman. 1991. Reversible inhibition of a thyroid-specific taws-acting factor by Ras. Genes Dev. 5:22–28.
   PubMedGoogle Scholar
• Bingle, C. D., and J. D. Gitlin. 1993. Identification of hepatocyte nuclear factor-3 binding sites in the Clara cell secretory protein gene. Biochem. J. 295:227–232.
   PubMedGoogle Scholar
• Blumenfeld, M., M. Maury, T. Chouard, M. Yaniv, and H. Condamine. 1991. Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in the developing mouse. Development 113:589–599.
   PubMedGoogle Scholar
• Bohinski, R. J., J. A. Huffman, J. A. Whitsett, and D. L. Lattier. 1993. Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene. J. Biol. Chem. 268:11160–11166.
   PubMed Web of Science ®Google Scholar
• Bohinski, R. J., B. R. Stripp, T. R. Korfhagen, S. W. Glasser, and J. A. Whitsett. Unpublished data.
   Google Scholar
• Borgmeyer, U., J. Nowock, and A. E. Sippel. 1984. The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded DNA. Nucleic Acids Res. 12:4295–4311.
   PubMedGoogle Scholar
• Boshart, M., M. Klüppel, A. Schmidt, G. Schutz, and B. Luckow. 1992. Reporter constructs with low background activity utilizing the cat gene. Gene 110:129–130.
   PubMedGoogle Scholar
• Botas, J. 1993. Control of morphogenesis and differentiation by HOM/Hox genes. Curr. Opin. Cell Biol. 5:1015–1022.
   PubMed Web of Science ®Google Scholar
• Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3 cells. Genes Dev. 5:1538–1552.
   PubMed Web of Science ®Google Scholar
• Cascio, S., and K. S. Zaret. 1991. Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation. Development 113:217–225.
   PubMedGoogle Scholar
• Civitareale, D., R. Lonigro, A. J. Sinclair, and R. Di Lauro. 1989. A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J. 8:2537–2542.
   PubMedGoogle Scholar
• Clark, K. L., E. D. Halay, E. Lai, and S. K. Burley. 1993. Co-crystal structure of the HNF3/forkhead DNA recognition motif resembles histone H5. Nature (London) 364:412–420.
   PubMed Web of Science ®Google Scholar
• Clerc, R. G., L. M. Corcoran, J. H. LeBowitz, D. Baltimore, and P. A. Sharp. 1988. The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes Dev. 2:1570–1581.
   PubMed Web of Science ®Google Scholar
• Clevidence, D. E., D. G. Overdier, W. Tao, X. Qian, L. Pani, E. Lai, and R. H. Costa. 1993. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc. Natl. Acad. Sci. USA 90:3948–3952.
   PubMed Web of Science ®Google Scholar
• Costa, R. H., and D. R. Grayson. 1991. Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region. Nucleic Acids Res. 19:4139–4145.
   PubMedGoogle Scholar
• Costa, R. H., D. R. Grayson, and J. E. Darnell, Jr. 1989. Multiple hepatocyte-enriched nuclear factors in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 9:1415–1425.
   PubMed Web of Science ®Google Scholar
• Damante, G., and R. Di Lauro. 1991. Several regions of Antenna-pedia and thyroid transcription factor 1 homeodomains contribute to DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:5388–5392.
   PubMed Web of Science ®Google Scholar
• Damante, G., D. Fabbro, L. Pellizzari, D. Civitareale, S. Guazzi, M. Polycarpou-Schwartz, S. Cauci, F. Quadrifoglio, S. Formisano, and R. Di Lauro. Unpublished data.
   Google Scholar
• Damante, G., G. Tell, S. Formisano, D. Fabbro, L. Pellizzari, and R. Di Lauro. 1993. Effect of salt concentration on TTF-1 HD binding to specific and non-specific DNA sequences. Biochem. Biophys. Res. Commun. 197:632–638.
   PubMedGoogle Scholar
• Darnell, J. E. 1982. Variety in the level of gene control in eukaryotic cells. Nature (London) 297:365–371.
   PubMed Web of Science ®Google Scholar
• Davis, R. L., H. Weintraub, and A. B. Lassar. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987–1000.
   PubMed Web of Science ®Google Scholar
• De Simone, V., and R. Cortese. 1991. Transcriptional regulation of liver-specific gene expression. Curr. Opin. Cell Biol. 3:960–965.
   PubMed Web of Science ®Google Scholar
• Drewes, T., L. Klein-Hitpass, and G. U. Ryffel. 1991. Liver specific transcription factors of the HNF3-, C/EBP-, and LFBl-families interact with the A-activator binding site. Nucleic Acids Res. 19:6383–6389.
   PubMedGoogle Scholar
• Faisst, S., and S. Meyer. 1992. Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 20:3–26.
   PubMed Web of Science ®Google Scholar
• Felsenfeld, G. 1992. Chromatin as an essential part of the transcriptional mechanism. Nature (London) 355:219–224.
   PubMed Web of Science ®Google Scholar
• Francis-Lang, H., M. Price, M. Polycarpou-Schwartz, and R. Di Lauro. 1992. Cell-type-specific expression of the rat thyroperoxi-dase promoter indicates common mechanisms for thyroid-specific gene expression. Mol. Cell. Biol. 12:576–588.
   PubMed Web of Science ®Google Scholar
• Francis-Lang, H., M. Zannini, M. De Felice, M. T. Berlingieri, A. Fusco, and R. Di Lauro. 1992. Multiple mechanisms of interference between transformation and differentiation in thyroid cells. Mol. Cell. Biol. 12:5793–5800.
   PubMedGoogle Scholar
• Gazdar, A. F., R. I. Linnoila, Y. Kurita, H. K. Oie, J. L. Mulshine, J. C. Clark, and J. A. Whitsett. 1990. Peripheral airway cell differentiation in human lung cancer cell lines. Cancer Res. 50:5481–5487.
   PubMed Web of Science ®Google Scholar
• Grange, T., J. Roux, G. Rigaud, and R. Pictet. 1990. Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res. 19:131–139.
   Google Scholar
• Guazzi, S., M. Price, M. De Felice, G. Damante, M.-G. Mattei, and R. Di Lauro. 1990. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 9:3631–3639.
   PubMed Web of Science ®Google Scholar
• Haugen, B. R., W. M. Wood, D. F. Gordon, and E. C. Ridgway. 1993. A Thyrotrope-specific variant of Pit-1 transactivates the thyrotropin β promoter. J. Biol. Chem. 268:20818–20824.
   PubMed Web of Science ®Google Scholar
• Hennighausen, L., and H. Lubon. 1987. Interaction of protein with DNA in vitro. Methods Enzymol. 152:721–735.
   PubMedGoogle Scholar
• Ingraham, H. A., R. Chen, H. J. Mangalam, H. P. Elsholtz, S. E. Flynn, C. R. Lin, D. M. Simmons, L. Swanson, and M. G. Rosenfeld. 1988. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55:519–529.
   PubMed Web of Science ®Google Scholar
• Jackson, D. A., K. E. Rowander, K. Stevens, C. Jiang, P. Milos, and K. S. Zaret. 1993. Modulation of liver-specific transcription by interactions between hepatocyte nuclear factor 3 and nuclear factor 1 binding DNA in close apposition. Mol. Cell. Biol. 13:2401–2410.
   PubMedGoogle Scholar
• Jaenisch, R. 1988. Transgenic animals. Science 240:1468–1474.
   PubMed Web of Science ®Google Scholar
• Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem. 58:799–839.
   PubMed Web of Science ®Google Scholar
• Kapiloff, M. S., Y. Farkash, M. Wegner, and M. G. Rosenfeld. 1991. Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. Science 253:786–789.
   PubMedGoogle Scholar
• Kuo, C. J., P. B. Conley, L. Chen, F. M. Sladek, J. E. Darnell, Jr., and G. R. Crabtree. 1992. A transcriptional hierarchy involved in mammalian cell-type specification. Nature (London) 355:457–461.
   PubMed Web of Science ®Google Scholar
• Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488–492.
   PubMed Web of Science ®Google Scholar
• Lai, E., V. R. Prezioso, W. Tao, W. S. Chen, J. E. Darnell, Jr. 1991. Hepatocyte nuclear factor 3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 5:416–427.
   PubMed Web of Science ®Google Scholar
• Lazzaro, D., M. Price, M. De Felice, and R. Di Lauro. 1991. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113:1093–1104.
   PubMed Web of Science ®Google Scholar
• Luo, Y., H. Fujii, T. Gerster, and R. G. Roeder. 1992. A novel B cell-derived coactivator potentiates the activation of immunoglo-bin promoters by octamer-binding transcription factors. Cell 71:231–241.
   PubMed Web of Science ®Google Scholar
• MacGregor, G. R., and C. T. Caskey. 1989. Construction of plasmids that express E. coli β-galactosidase in mammalian cells. Nucleic Acids Res. 6:2365.
   Google Scholar
• MacGregor, G. R., G. P. Nolan, S. Fiering, M. Roederer, and L. A. Herzenberg. 1991. Use of E. coli lacZ (β-galactosidase) as a reporter gene, p. 217–235. In E. J. Murray (ed.), Methods in molecular biology, vol. 7. Humana Press, Clifton, N.J.
   Google Scholar
• Maniatis, T., S. Goodbourn, and J. A. Fischer. 1987. Regulation of inducible and tissue-specific gene expression. Science 236:1237–1244.
   PubMed Web of Science ®Google Scholar
• McPherson, C. E., E.-Y. Shim, D. S. Friedman, and K. S. Zaret. 1993. An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array. Cell 75:387–398.
   PubMedGoogle Scholar
• Milos, P. M., and K. S. Zaret. 1992. A ubiquitous factor is required for C/EBP-related proteins to form stable transcription complexes on an albumin promoter segment in vitro. Genes Dev. 6:991–1004.
   PubMedGoogle Scholar
• Miner, J. H., J. B. Miller, and B. J. Wold. 1992. Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart. Development 114:853–860.
   PubMed Web of Science ®Google Scholar
• Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371–378.
   PubMed Web of Science ®Google Scholar
• Monaghan, P. A., K. H. Kaestner, E. Grau, and G. Schutz. 1993. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3α.β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119:567–578.
   PubMed Web of Science ®Google Scholar
• Nerlov, C., and E. B. Ziff. 1994. Three levels of functional interaction determine the activity of the CCAAT/enhancer binding protein-α on the serum albumin promoter. Genes Dev. 8:350–362.
   PubMedGoogle Scholar
• Nitsch, D., M. Boshart, and G. Schutz. 1993. Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone responsive elements. Proc. Natl. Acad. Sci. USA 90:5479–5483.
   PubMed Web of Science ®Google Scholar
• Nitsch, D., M. Boshart, and G. Schutz. 1993. Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcriptional activators. Genes Dev. 7:308–319.
   PubMedGoogle Scholar
• O'Reilly, M. A., A. F. Gazdar, R. E. Morris, and J. A. Whitsett. 1988. Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line. Biochim. Biophys. Acta 970:194–204.
   PubMed Web of Science ®Google Scholar
• Overdier, D. G., A. Porcella, and R. H. Costa. 1994. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:2755–2766.
   PubMedGoogle Scholar
• Pani, L., X. Qian, D. Clevidence, and R. H. Costa. 1993. The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3β involves a cell specific factor and positive autoactivation. Mol. Cell. Biol. 12:552–562.
   Google Scholar
• Phelps, D. S., and J. Floros. 1991. Localization of pulmonary surfactant proteins using immunohistochemistry and tissue in situ hybridization. Exp. Lung Res. 17:985–995.
   PubMed Web of Science ®Google Scholar
• Plachov, D. K., K. Chowdhury, C. Walther, D. Simon, J. L. Guenet, and P. Grass. 1990. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110:643–651.
   PubMed Web of Science ®Google Scholar
• Ramakrishnan, V., J. T. Finch, V. Granziano, P. L. Lee, and R. M. Sweet 1993. Globular domain of histone H5 and its implications for nucleosome binding. Nature (London) 362:219–223.
   PubMed Web of Science ®Google Scholar
• Rigaud, G., J. Roux, R. Pictet, and T. Grange. 1991. In vivo footprinting of the rat TAT gene: dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Cell 67:977–986.
   PubMed Web of Science ®Google Scholar
• Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152:704–720.
   PubMed Web of Science ®Google Scholar
• Rupp, R. A. W., U. Krase, G. Multhaup, U. Gobel, K. Beyreuther, and A. E. Sippel. 1990. Chicken NF1/TGCCA proteins are encoded by at least three independent genes: NF1/A, NF1-B, and NF1-C with homologies in mammalian genomes. Nucleic Acids Res. 18:2607–2616.
   PubMedGoogle Scholar
• Sasaki, H., and B. L. M. Hogan. 1993. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118:47–59.
   PubMed Web of Science ®Google Scholar
• Sawaya, P. L., B. R. Stripp, J. A. Whitsett, and D. S. Luse. 1993. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol. Cell. Biol. 13:3860–3871.
   PubMed Web of Science ®Google Scholar
• Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res. 17:6419.
   PubMed Web of Science ®Google Scholar
• Shaw-White, J., and J. A. Whitsett. Unpublished data.
   Google Scholar
• Simmons, D. M., J. W. Voss, H. A. Ingraham, J. M. Holloway, R. S. Broide, M. G. Rosenfeld, and L. W. Swanson. 1990. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev. 4:695–711.
   PubMed Web of Science ®Google Scholar
• Stahlman, M. T., and J. A. Whitsett. Unpublished data.
   Google Scholar
• Stripp, B. R., J. A. Huffman, and R. J. Bohinski. Structure and regulation of the murine Clara cell secretory protein gene. Genomics 20:27–35.
   Google Scholar
• Tsai, S.-F., D. I. K. Martin, L. I. Zon, A. D. D'Andrea, G. G. Wong, and S. H. Orkin. 1989. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (London) 339:446–451.
   PubMed Web of Science ®Google Scholar
• Weaver, T. E., and J. A. Whitsett. 1991. Function and regulation of expression of pulmonary surfactant-associated proteins. Biochem. J. 273:249–264.
   PubMed Web of Science ®Google Scholar
• Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, S. Hollenberg, Y. Zhuang, and A. Lassar. 1991. The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251:761–766.
   PubMed Web of Science ®Google Scholar
• Weintraub, H., S. J. Tapscott, R. L. Davis, M. J. Thayer, M. A. Adam, A. B. Lassar, and D. A. Miller. 1989. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86:5434–5438.
   PubMed Web of Science ®Google Scholar
• Wert, S. E., S. W. Glasser, T. R. Korfhagen, and J. A. Whitsett. 1993. Transcriptional elements from the human SP-C gene direct expression in the primordial respiratory epithelium of transgenic mice. Dev. Biol. 156:426–443.
   PubMed Web of Science ®Google Scholar
• Wikenheiser, K. A., D. K. Vorbroker, W. R. Rice, J. C. Clark, C. J. Bachurski, H. K. Oie, and J. A. Whitsett. 1993. Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc. Natl. Acad. Sci. USA 90:11029–11033.
   PubMed Web of Science ®Google Scholar
• Wikenheiser, K. A., S. E. Wert, J. R. Wispe, M. Stahlman, M. D'Amore-Bruno, G. Singh, S. L. Katyal, and J. A. Whitsett. 1992. Distinct effects of oxygen on surfactant protein B expression in bronchiolar and alveolar epithelium. Am. J. Physiol. 262:L32–L39.
   PubMedGoogle Scholar
• Xanthopoulos, K. G., V. R. Prezioso, W. S. Chen, F. M. Sladek, R. Cortese, and J. E. Darnell, Jr. 1991. The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc. Natl. Acad. Sci. USA 88:3807–3811.
   PubMed Web of Science ®Google Scholar
• Zannini, M., H. Francis-Lang, D. Plachov, and R. Di Lauro. 1992. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol. Cell. Biol. 12:4230–4241.
   PubMedGoogle Scholar