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Molecular and Cellular Biology Volume 9, 1989 - Issue 12
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Gene Expression

The FER Gene Is Evolutionarily Conserved and Encodes a Widely Expressed Member of the FPS/FES Protein-Tyrosine Kinase Family

Tony Pawson1 Division of Molecular and Developmental Biology, Mt. Sinai Hospital Research Institute, 600 University Avenue, Toronto, OntarioM5G 1X5, Canada;2 Department of Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A1, Canada
,
Kenneth Letwin1 Division of Molecular and Developmental Biology, Mt. Sinai Hospital Research Institute, 600 University Avenue, Toronto, OntarioM5G 1X5, Canada;2 Department of Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A1, Canada
,
Theresa Lee1 Division of Molecular and Developmental Biology, Mt. Sinai Hospital Research Institute, 600 University Avenue, Toronto, OntarioM5G 1X5, Canada
,
Qian-Lin Hao3 Department of Pathology, Section of Molecular Diagnosis, Children's Hospital of Los Angeles, Los Angeles, California90027
,
Nora Heisterkamp3 Department of Pathology, Section of Molecular Diagnosis, Children's Hospital of Los Angeles, Los Angeles, California90027
&
John Groffen3 Department of Pathology, Section of Molecular Diagnosis, Children's Hospital of Los Angeles, Los Angeles, California90027
Pages 5722-5725 | Received 07 Jul 1989, Accepted 14 Sep 1989, Published online: 31 Mar 2023

LITERATURE CITED

  • Brooks-Wilson, A. R., E. Ball, and T. Pawson. 1989. The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps. Mol. Cell. Biol. 9:2214–2219.
  • Feldman, R. A., J. L. Gabrilove, J. P. Tam, M. A. S. Moore, and H. Hanafusa. 1985. Specific expression of the human cellular fps/fes-encoded protein NCP92 in normal and leukemic myeloid cells. Proc. Natl. Acad. Sci. USA 82:2379–2383.
  • Feldman, R. A., J. P. Tam, and H. Hanafusa. 1986. Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein. Mol. Cell. Biol. 6:1065–1073.
  • Greer, P. A., K. Meckling-Hansen, and T. Pawson. 1988. The human c-fps/fes gene product expressed ectopically in rat fibre- blasts is nontransforming and has restrained protein-tyrosine kinase activity. Mol. Cell. Biol. 8:578–587.
  • Hao, Q.-L., N. Heisterkamp, and J. Groffen. 1989. Isolation and sequence analysis of a novel tyrosine kinase gene. Mol. Cell. Biol. 9:1587–1593.
  • Heisterkamp, N., J. Groffen, and J. R. Stephenson. 1983. The human v-abl cellular homologue. J. Mol. Appl. Genet. 2:57–68.
  • Kmiecik, T. E., and D. Shalloway. 1987. Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49:65–73.
  • Letwin, K., S.-P. Yee, and T. Pawson. 1988. Novel proteintyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene 3:621–627.
  • MacDonald, I., J. Levy, and T. Pawson. 1985. Expression of the mammalian c-fes protein in hematopoietic cells and identification of a distinct fes-related protein. Mol. Cell. Biol. 5:2543–2551.
  • Meckling-Hansen, K., R. Nelson, P. Branton, and T. Pawson. 1987. Enzymatic activation of Fujinami sarcoma virus gag-fps transforming proteins by autophosphorylation at tyrosine. EMBO J. 6:659–666.
  • Moss, P., K. Radke, V. C. Carter, J. Young, T. Gilmore, and G. S. Martin. 1984. Cellular localization of the transforming protein of wild-type and temperature-sensitive Fujinami sarcoma virus. J. Virol. 52:557–565.
  • Pawson, T.. 1988. Non-catalytic domains of cytoplasmic proteintyrosine kinases: regulatory elements in signal transduction. Oncogene 3:491–495.
  • Roebrook, A. J. M., J. A. Schalken, J. S. Verbeek, A. M. W. Van den Ouweland, C. Onnekink, H. P. J. Bloemers, and W. J. M. Van de Ven. 1985. The structure of the human c-fes/fps protooncogene. EMBO J. 4:2897–2903.
  • Sadowski, I., J. C. Stone, and T. Pawson. 1986. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol. Cell. Biol. 6:4396–4408.
  • Shibuya, M., and H. Hanafusa. 1982. Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other viruses. Cell 30:787–795.
  • Weinmaster, G., M. J. Zoller, M. Smith, E. Hinze, and T. Pawson. 1984. Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation modulates its biological activity. Cell 37:559–568.
  • Young, J. C., and G. S. Martin. 1984. Cellular localization of c-fps gene product NCP98. J. Virol. 52:913–918.

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