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Chromosome Structure and Dynamics

Mutations, Duplication, and Deletion of Recombined Switch Regions Suggest a Role for DNA Replication in the Immunoglobulin Heavy-Chain Switch

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Pages 1850-1856 | Received 21 Nov 1988, Accepted 28 Jan 1989, Published online: 31 Mar 2023

LITERATURE CITED

  • Alberini, C., R. Biassoni, S. DeAmbrosis, D. Vismara, and R. Sitia. 1987. Differentiation in the murine B cell lymphoma I.29: individual μ+ clones may be induced by lipopolysaccharide to both IgM secretion and isotype switching. Eur. J. Immunol. 17:555–562.
  • Borzillo, G. V., M. D. Cooper, H. Kubagawa, A. Landay, and P. D. Burrows. 1987. Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination. J. Immunol. 139:1326–1335.
  • Davis, M. M., S. K. Kim, and L. E. Hood. 1980. DNA sequences mediating class switches in alpha-immunoglobulins. Science 209:1360–1365.
  • Gearhart, P. J., and D. F. Bogenhagen. 1983. Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc. Natl. Acad. Sci. USA 80:3439–3443.
  • Gerondakis, S., S. Cory, and J. M. Adams. 1984. Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange. Cell 36:973–982.
  • Hummel, M., J. K. Berry, and W. Dunnick. 1987. Switch region content of hybridomas: the two spleen cell Igh loci tend to rearrange to the same isotype. J. Immunol. 138:3539–3548.
  • Hurwitz, J. L., and J. J. Cebra. 1982. Rearrangements between the immunoglobulin heavy chain gene JH and Cμ regions accompany normal B lymphocyte differentiation in vitro. Nature (London) 299:742–744.
  • Katzenberg, D. R., and B. K. Birshstein. 1988. Sites of switch recombination in IgG2b- and IgG2a-producing hybridomas. J. Immunol. 140:3219–3227.
  • Kenter, A. L., and J. V. Watson. 1987. Cell cycle kinetics model of LPS-stimulated spleen cells correlates switch region rearrangements with S phase. J. Immunol. Methods 97:111–117.
  • Kim, S., M. Davis, E. Sinn, P. Patten, and L. Hood. 1981. Antibody diversity: somatic hypermutation of rearranged VH genes. Cell 27:573–581.
  • Klein, D., J. Nietupski, S. Sirlin, and J. Stavnezer. 1988. I.29 lymphoma cells express a non-mutated immunoglobulin heavy chain variable region gene before and after heavy chain switch. J. Immunol. 140:1676–1684.
  • Marcu, K. B., R. B. Lang, L. W. Stanton, and L. J. Harris. 1982. A model for the molecular requirements of immunoglobulin heavy chain class switching. Nature (London) 298:87–89.
  • Nikaido, T., S. Nakai, and T. Honjo. 1981. Switch region of Ig Cμ gene is composed of simple tandem repetitive sequences. Nature (London) 292:845–848.
  • Obata, M., T. Kataoka, S. Nakai, H. Yamagishi, N. Takahashi, Y. Yamakami-Kataoka, T. Nikaido, A. Shimizu, and T. Honjo. 1981. Structure of a rearranged γ1 chain gene and its implication to immunoglobulin class-switch mechanism. Proc. Natl. Acad. Sci. USA 78:2437–2441.
  • Pech, M., J. Hochtl, H. Schnell, and H. G. Zachua. 1981. Differences between germline and rearranged immunoglobulin V coding sequences suggest a localized mutation mechanism. Nature (London) 291:668–671.
  • Petrini, J., B. Shell, M. Hummel, and W. Dunnick. 1987. The immunoglobulin heavy chain switch: structural features of γ1 recombinant switch regions. J. Immunol. 138:1940–1946.
  • Sakano, H., R. Maki, Y. Kurosawa, W. Roeder, and S. Tonegawa. 1980. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy chain genes. Nature (London) 286:676–683.
  • Sanger, F., A. R. Coulson, B. G. Barrell, A. J. H. Smith, and B. A. Roe. 1980. Cloning in single stranded bacteriophage as an aid to rapid DNA sequencing. J. Mol. Biol. 143:161–178.
  • Severinson, E., S. Bergstedt-Lindquist, W. Van der Roo, and C. Fernandez. 1982. Characterization of the IgG response induced by polyclonal B cell activators. Immunol. Rev. 67:73–85.
  • Siekevitz, M., C. Kocks, K. Rajewsky, and R. Dildrop. 1987. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses. Cell 48:757–770.
  • Sitia, R., A. Rubartelli, and U. Hammerling. 1981. Expression of two immunoglobulin isotypes, IgM and IgA, with identical idiotype in the B cell lymphoma I.29. J. Immunol. 127:1388–1394.
  • Stavnezer, J., K. B. Marcu, S. Sirlin, B. Alhadeff, and U. Hammerling. 1982. Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29. Mol. Cell. Biol. 2:1002–1013.
  • Stavnezer, J., S. Sirlin, and J. Abbott. 1985. Induction of immunoglobulin isotype switching in cultured I.29 lymphoma cells. J. Exp. Med. 161:577–601.
  • Szurek, P., J. Petrini, and W. Dunnick. 1985. Complete nucleotide sequence of the murine γ3 switch region and analysis of switch recombination sites in two γ3-expressing hybridomas. J. Immunol. 135:620–626.
  • Winter, E., U. Krawinkel, and A. Radbruch. 1987. Directed Ig class switch recombination in activated murine B cells. EMBO J. 6:1663–1671.

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