LITERATURE CITED
- Angel, P., E. A. Allegretto, S. T. Okino, K. Hattori, W. J. Boyle, T. Hunter, and M. Karin. 1988. Oncogene jun encodes a sequence-specific transactivator similar to AP-1. Nature (London) 332:166–171.
- Byrd, J., R. M. Berger, D. R. McMillin, C. F. Wright, D. Hamer, and D. R. Winge. 1988. Characterization of the copperthiolate cluster in yeast metallothionein and two truncated mutants. J. Biol. Chem. 263:6688–6694.
- Fogel, S., and J. W. Welch. 1982. Tandem gene amplification mediates copper resistance in yeast. Proc. Natl. Acad. Sci. USA 79:5342–5346.
- Fogel, S., J. W. Welch, G. Cathala, and M. Karin. 1983. Gene amplification in yeast. Development of copper resistance is mediated by an increase in CUP1 gene copy number. Curr. Genet. 7:1–9.
- Fried, M., and A. D. Crothers. 1981. Equilibrium and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res. 9:6505–6525.
- Furst, P., S. Hu, R. Hackett, and D. Hamer. 1988. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA-binding protein. Cell 55:705–717.
- Garner, M., and A. Rezvin. 1981. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the E. coli lactose regulatory system. Nucleic Acid Res. 9:3047–3060.
- George, G. N., J. Byrd, and D. Winge. 1988. X-ray absorption studies of yeast copper metallothionein. J. Biol. Chem. 263:8199–8203.
- Hamer, D. J.. 1986. Metallothionein. Annu. Rev. Biochem. 55:913–951.
- Hope, I. A., and K. Struhl. 1986. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 43:885–894.
- Huibregtse, J. H., D. R. Engelke, and D. J. Thiele. 1989. Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences. Proc. Natl. Acad. Sci. USA 86:65–69.
- Karin, M.. 1985. Metallothionein: proteins in search of function. Cell 41:9–10.
- Karin, M., R. Najarian, A. Haslinger, J. Welch, P. Valenzuela, and S. Fogel. 1984. Structure and transcription of an amplified genetic locus: the CUPI locus of yeast. Proc. Natl. Acad. Sci. USA 81:337–341.
- Ma, J., and M. Ptashne. 1987. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847–853.
- Mullis, K. B., and F. A. Faloona. 1987. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Meth- ods Enzymol. 155:335–350.
- Saiki, R. K., S. Scharf, F. Faloona, K. B. Mollis, G. T. Horn, H. A. Erlich, and N. Arnheim. 1987. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350–1354.
- Stent, G. S., and R. Calender. 1978. Molecular genetics. W. H. Freeman & Co., San Francisco.
- Szczypka, M. S., and D. J. Thiele. 1989. A cysteine-rich nuclear protein activates yeast metallothionein gene transcription. Mol. Cell. Biol. 9:421–429.
- Thiele, D. J.. 1988. ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene. Mol. Cell. Biol. 8:2745–2752.
- Thiele, D. J., and D. H. Hamer. 1986. Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene. Mol. Cell. Biol. 6:1158–1163.
- Welch, J., S. Fogel, C. Buchman, and M. Karin. 1989. The CUP2 gene product regulates the expression of the CUP1 gene, coding for yeast metallothionein. EMBO J. 8:255–260.
- Welch, J. W., S. Fogel, G. Cathala, and M. Karin. 1983. Industrial yeasts display tandem gene iteration at the CUP1 region. Mol. Cell. Biol. 3:1353–1361.
- Welch, J. W., D. H. Maloney, and S. Fogel. 1987. Synoptic relations in meiotic gene conversion at the iterated CUP1 locus of S. cerevisiae, p. 431–437. In J. H. R. Kagi, and Y. Kojima (ed.), Metallothionein II. Birkhauser Verlag, Basel.
- Winge, D. R., K. B. Nielson, W. R. Gray, and D. H. Hamer. 1985. Yeast metallothionein sequence and metal binding properties. J. Biol. Chem. 260:14464–14470.