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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 23, 2001 - Issue 2-3: Neurotrauma
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Articles

Design and statistical issues in multicenter trials of severe head injury

Sung C. ChoiMedical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
&
Ross BullockMedical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
Pages 190-192 | Published online: 19 Jul 2013

REFERENCES

  • Choi SC, Marmarou A, Bullock R, et al. Primary endpoints in Phase III trials of severe head trauma: DRS versus GOS. J Neurotrauma, 1998; 15: 771–776
  • Choi SC. Sample size in clinical trials with dichotomous endpoints: Use of covariables. J Biopharm Stat 1998; 8: 367–375
  • O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979; 35: 549-556
  • Whitehead J, Stratton I. Group sequential clinical trials with triangular continuation regions. Biometrics 1983; 39: 227–236
  • Ederer P. Practical problems in collaborative clinical trials. Am J Epidemio 11975; 102: 111-118
  • Sylvester RJ, Pinedo HM, Depauw N, et al. Quality of institutional participation in multicenter clinical trials. N Eng1J Med 1981; 305: 852–855
  • Bracken MB. Methodological issues in the design of traumatic brain injury Phase III trials: A call for larger, simpler trials. Neurosurgery 2001 (in press)
  • Doppenberg E, Bullock R. Clinical neuroprotection trials in severe traumatic brain injury: Lessons from previous studies. J Neurotrauma 1997; 14: 71–79

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