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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 28, 2006 - Issue 7
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Articles

Genetic modification of cerebral arterial wall: implications for prevention and treatment of cerebral vasospasm

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Pages 759-768 | Published online: 19 Jul 2013

REFERENCES

  • Dorsch NW, King MT. A review of cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Part I: Incidence and effects. J Clin Neurosci 1994; 1: 19–26
  • Khurana VG, Katusic ZS. Gene transfer for cerebrovascular disease. Curr Cardiol Rep 2001; 3: 10–16
  • Heistad DD, Faraci FM. Gene therapy for cerebral vascular disease. Stroke 1996; 27: 1688–1693
  • Khurana VG, Meyer FB. Translational paradigms in cerebrovas-cular gene transfer. J Cereb Blood Flow Metab 2003; 23: 1251–1262
  • Chen AF, O'Brien T, Katusic ZS. Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system. Trends Pharmacol Sci 1998; 19: 276–286
  • Chen AF, Jiang SW, Crotty TB, et al. Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci USA 1997; 94: 12568–12573
  • Ooboshi H, Welsh MJ, Rios CD, et al. Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue. Circ Res 1995; 77: 7–13
  • Kim S, Lin H, Barr E, et al. Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo. J Clin Invest 1997; 100: 1006–1014
  • Toyoda K, Andresen JJ, Zabner J, et al. Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo. Gene Ther 2000; 7: 1284–1291
  • Toyoda K, Nakane H, Heistad DD. Cationic polymer and lipids augment adenovirus-mediated gene transfer to cerebral arteries in vivo. J Cereb Blood Flow Metab 2001; 21: 1125–1131
  • Khurana VG, Weiler DA, Witt TA, et al. A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues. Gene Ther 2003; 10: 443–452
  • Macdonald RL, Weir BKA. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991; 22: 971–982
  • Faraci FM, Brian JE, Jr. Nitric oxide and the cerebral circulation. Stroke 1994; 25: 692–703
  • Katusic ZS, Milde JH, Cosentino F, et al. Subarachnoid hemorrhage and endothelial L-arginine pathway in small brain stem arteries in dogs. Stroke 1993; 24: 392–399
  • Chen AF, O'Brien T, Tsutsui M, et al. Expression and function of recombinant endothelial nitric oxide synthase gene in canine cerebral artery. Circ Res 1997; 80: 327–335
  • Onoue H, Tsutsui M, Smith LA, et al. Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage. Stroke 1998; 29: 1959–1966
  • Khurana VG, Smith LA, Weiler DA, et al. Adenovirus-mediated gene transfer to human cerebral arteries. J Cereb Blood Flow Metab 2000; 20: 1360–1371
  • Luders JC, Weihl CC, Lin G, et al. Adenoviral gene transfer of nitric oxide synthase increases blood flow in rats. Neurosurgery 2000; 47: 1206–1215
  • Khurana VG, Smith LA, Baker TA, et al. Protective vasomotor effects of in vivo recombinant endothelial nitric oxide synthase gene expression in a canine model of cerebral vasospasm. Stroke 2002; 33: 782–789
  • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597–601
  • Dimmeler S, Fleming I, Fisslthaler B, et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphor-ylation. Nature 1999; 399: 601–605
  • Scotland RS, Morales-Ruiz M, Chen Y, et al. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomo-tion. Circ Res 2002; 90: 904–910
  • Akiyama M, Eguchi D, Weiler D, et al. Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries. Stroke 2002; 33: 1071–1076
  • Sorenson J, Santhanam AVR, Smith LA, et al. Expression and function of recombinant S1179D endothelial nitric oxide synthase in human pial arteries. Stroke 2005; 36: 158–160
  • Santhanam AVR, Smith LA, Akiyama M, et al. Role of endothelial nitric oxide synthase phosphorylation in cerebrovas-cular protective effect of erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm. Stroke 2005; 36: 2731–2737
  • Eguchi D, d'Uscio LV, Wambi C, et al. Inhibitory effect of recombinant iNOS gene expression on vasomotor function of canine basilar artery. Am] Physiol Heart Circ Physiol 2002; 283: H2560—H2566
  • Gunnett CA, Lund DD, Chu Y, et al. NO-dependent vasorelaxa-tion is impaired after gene transfer of inducible NO-synthase. Arterioscler Thromb Vasc Biol 2001; 21: 1281–1287
  • Gunnett CA, Lund DD, Howard MA 3rd, et al. Gene transfer of inducible nitric oxide synthase impairs relaxation in human and rabbit cerebral arteries. Stroke 2002; 33: 2292–2296
  • Katusic ZS. Vascular endothelial dysfunction: Does tetrahydro-biopterin play a role? Am Physiol 2001; 281: H981—H986
  • Dumont AS, Dumont RJ, Lin C, et al. Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation. Neurosurgery 2003; 53: 123–135
  • Beasley D, Cohen RA, Levinsky NG. Endotoxin inhibits contrac-tion of vascular smooth muscle in vitro. Am] Physiol 1990; 258: H1187—H1192
  • Parker JL, Adams HR. Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia. Circ Res 1993; 72: 539–551
  • Horky LL, Pluta RM, Boock RJ, et al. Role of ferrous iron chelator 2,2'-dipyridyl in preventing delayed vasospasm in a primate model of subarachnoid hemorrhage. Neurosurg 1998; 88: 298–303
  • Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991; 22: 971–982
  • Pluta RM, Afshar JK, Boock RJ, et al. Temporal changes in perivascular concentration of oxyhemoglobin, deoxyhemoglobin, and methemoglobin after subarachnoid hemorrhage.] Neurosurg 1998; 88: 557–561
  • Mori T, Nagata K, Town T, et al. Intracisternal increase of superoxide anion production in a canine subarachnoid hemor-rhage model. Stroke 2001; 32: 636–642
  • Marks GS, Brien JF, Nakatsu K, et al. Does carbon monoxide have a physiological function? Trends Pharmacol Sci 1991; 12: 185–188
  • Stocker R, Yamamoto Y, Mcdonagh EF, et al. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043–1046
  • Verma A, Hirsch DJ, Glatt CE, et al. Carbon monoxide: A putative neural messenger. Science 1993; 259: 381–384
  • Matz P, Turner C, Weinstein PR, et al. Heme oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res 1996; 713: 211–222
  • Kuroki M, Kanamaru K, Suzuki H, et al. Effect of vasospasm on heme oxygenases in a rat model of subarachnoid hemorrhage. Stroke 1998; 29: 683–689
  • Suzuki H, Kanamaru K, Tsunoda H, et al. Heme oxygenase-1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats. Clin Invest 1999; 104: 59–66
  • Eguchi D, Weiler D, Alam J, et al. Protective effect of heme oxygenase-1 gene transfer against oxyhemoglobin-induced endothelial dysfunction. J Cereb Blood Flow Metab 2001; 21: 1215–1222
  • Ono S, Komuro T, Macdonald RL. Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J Neurosurg 2002; 96: 1094–1102
  • Kim DE, Suh YS, Lee MS, et al. Vascular NAD(P)H oxidase triggers delayed cerebral vasospasm after subarachnoid hemor-rhage in rats. Stroke 2002; 33: 2687–2691
  • Kamii H, Kato I, Kinouchi H, et al. Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase. Stroke 1999; 30: 867–872
  • McGirt MJ, Parra A, Sheng H, et al. Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpres-sing extracellular superoxide dismutase. Stroke 2002; 33: 2317–2323
  • Shishido T, Suzuki R, Qian L, et al. The role of superoxide anions in the pathogenesis of cerebral vasospasm. Stroke 1994; 25: 864–868
  • Macdonald RL, Weir BK, Runzer TD, et al. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery 1992; 30: 529–539
  • Kajita Y, Suzuki Y, Oyama H, et al. Combined effect of L-arginine and superoxide dismutase on the spastic basilar artery after subarachnoid hemorrhage in dogs. Neurosurg 1994; 80: 476–483
  • Watanabe Y, Chu Y, Andresen JJ, et al. Gene transfer of extracellular superoxide dismutase reduces cerebral vasospasm after subarachnoid hemorrhage. Stroke 2003; 34: 434–440
  • Yamaguchi M, Zhou C, Heistad DD, et al. Gene transfer of extracellular superoxide dismutase failed to prevent cerebral vasospasm after experimental subarachnoid hemorrhage. Stroke 2004; 35: 2512–2517
  • Nelson MT, Huang Y, Brayden JE, et al. Arteriolar dilations in response to CGRP involve activation of K+ channels. Nature 1990; 344: 770–773
  • Kitazono T, Heistad DD, Faraci FM. Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol 1993; 265: H 581—H 585
  • Nozaki K, Uemura Y, Okamoto S, et al. Relaxant effect of calcitonin gene-related peptide on cerebral arterial spasm induced by experimental subarachnoid hemorrhage in dogs. J Neurosurg 1989; 71: 558–564
  • Toshima M, Kassell NF, Tanaka Y, et al. Effect of intracisternal and intravenous calcitonin gene-related peptide on experimental cerebral vasospasm in rabbits. Acta Neurochir 1992; 119: 134–138
  • Toyoda K, Farad i FM, Watanabe Y, et al. Gene transfer of calcitonin gene-related peptide prevents vasoconstriction after subarachnoid hemorrhage. Circ Res 2000; 87: 818–824
  • Satoh M, Perkins E, Kimura H, et al. Posttreatment with adenovirus-mediated gene transfer of calcitonin gene-related peptide to reverse cerebral vasospasm in dogs. ] Neurosurg 2002; 97: 136-142
  • Katusic ZS, Shepherd JT. Endothelium-derived vasoactive factors: II. Endothelium-dependent contractions. Hypertension 1991; 18 (Suppl. III): 11186-11192
  • Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411–415
  • Yanagisawa M, Masaki T. Endothelin, a novel endothelium-derived peptide: Pharmacological activities, regulation and possible roles in cardiovascular control. Biochem Pharmacol 1989; 38: 1877–1883
  • Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27–36
  • Cosentino F, Katusic ZS. Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm? Stroke 1994; 25: 904–908
  • Onoda K, Ono S, Ogihara K, et al. Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model. J Neurosurg 1996; 85: 846–852
  • Ohkuma H, Parney I, Megyesi J, et al. Antisense preproendothe-lin-oligoDNA therapy for vasospasm in a canine model of subarachnoid hemorrhage. J Neurosurg 1999; 90: 1105–1114
  • Lin CL, Jeng AY, Howng SL, et al. Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: Pathogenesis and treatment. Curr Med Chem 2004; 11: 1779–1791
  • Wood MJ, Trulzsch B, Abdelgany A, et al. Therapeutic gene silencing in the nervous system. Hum Mol Gen 2003; 12: R279—R284
  • Fountaine TM, Wood MJ, Wade-Martins R. Delivering RNA interference to the mammalian brain. Curr Gene Ther 2005; 5: 399–410
  • Chen X, Dudgeon N, Shen L, et al. Chemical modification of gene silencing oligonucleotides for drug discovery and development. Drug Disc Today 2005; 10: 587–593
  • Ono S, Date I, Onoda K, et al. Decoy administration of NF-kappaB into the subarachnoid space for cerebral angiopathy. Hum Gene Ther 1998; 9:1003–1011
  • Epstein AM, Throckmorton D, Brophy CM. Mitogen-activated protein kinase activation: An alternate signaling pathway for sustained vascular smooth muscle contraction. J Vasc Surg 1997; 26: 337–332
  • Zubkov AY, Ogihara K, Tumu P, et al. Mitogen-activated protein kinase mediation of hemolysate-induced contraction in rabbit basilar artery. J Neurosurg 1999; 90: 1091–1097
  • Zubkov AY, Rollings KS, Parent AD, et al. Mechanism of endothelin-1-induced contraction in rabbit basilar artery. Stroke 2000; 31: 526–533
  • Satoh M, Parent AD, Zhang JH. Inhibitory effect with antisense mitogen-activated protein kinase oligodeoxynucleotide against cerebral vasospasm in rats. Stroke 2002; 33: 775–781
  • Katusic ZS, Milde JH, Cosentino F, et al. Subarachnoid hemorrhage and endothelial L-arginine pathway in small brainstem arteries in dogs. Stroke 1993; 24: 392–399
  • Balicki D, Beutler E. Gene therapy of human disease. Medicine 2002; 81: 69–86
  • Dyer MR, Herrling PL. Progress and potential for gene-based medicines. Mol Ther 2000; 1: 213–224
  • Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33–40
  • Richter M, lwata A, Nyhuis J, et al. Adeno-associated virus transduction of vascular smooth muscle cells in vivo. Physiol Genom 2000; 2: 117–127
  • Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964–967
  • Liu C, Nath KA, Katusic ZS, et al. Smooth muscle progenitor cells in vascular disease. Trends Cardiovasc Med 2004; 14: 288–293
  • Gulati R, Jevremovic D, Peterson TE, et al. Autologous culture-modified mononuclear cells confer vascular protection against arterial injury. Circulation 2003; 108: 1520–1526
  • Griese DP, Ehsan A, Melo LG, et al, Isolation and transplantation of autologous circulating endothelial progenitor cells into denuded vessels and prosthetic grafts: Implications for cell-based therapy. Circulation 2003; 108: 2710–2715
  • Werner K, Junk S, Laufs U, et al. Intravenous infusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003; 93: 17–24
  • He T, Smith LA, Harrington S, et al. Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 2004; 35: 2378–2384
  • Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogen-esis in physiological and pathological neovascularization. Circ Res 1999; 85: 221–228
  • lba 0, Matsubara H, Nozawa Y, et al. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs. Circulation 2002; 106: 2019–2025
  • Assmus B, Schachinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myo-cardial infarction. Circulation 2002; 106: 3009–3017
  • Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomized controlled trial. Lancet 2002; 360: 427–435
  • He T, Peterson TE, Holmuhamedov EL, et al. Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol 2004; 24: 2021–2027
  • Dernbach E, Urbich C, Brandes RP, et al. Antioxidative stress-associated genes in circulating progenitor cells: Evidence for enhanced resistance against oxidative stress. Blood 2004; 104: 3591–3597
  • He T, Peterson TE, Katusic ZS. Paracrine mitogenic effect of human endothelial progenitor cells: Role of interleukin-8. Am] Physiol Heart Circ Physiol 2005; 289: H968—H972
  • Lu D, Mahmood A, Wang L, et al. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 2001; 12: 559–563
  • Li Y, Chen J, Wang L, et al. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology 2001; 56: 1666–1672
  • Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogen-esis in physiological and pathological neovascularization. Circ Res 1999; 85: 221–228
  • lwaguro H, Yamaguchi J, Kalka C et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration. Circulation 2002; 105: 732–738
  • Herder C, Tonn T, Oostendorp R, et al. Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells. Hypertension 2003; 23: 2266–2272
  • Kong D, Melo LG, Mangi AA, et al. Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation 2004; 109: 1769–1775
  • Onoue H, Tsutsui M, Smith L, et al. Adventitial expression of recombinant endothelial nitric oxide synthase gene reverses vasoconstrictor effect of endothelin-1. J Cereb Blood Flow Metab 1999; 19: 1029–1037
  • Tsutsui M, Onoue H, lida Y, et al. Adventitia-dependent relaxations of canine basilar arteries transduced with recombi-nant eNOS gene. Am] Physiol 1999; 276: H1846—H1852
  • Tsutsui M, Onoue H, lida Y, et al. Effects of recombinant eNOS gene expression on reactivity of small cerebral arteries. Am J Physiol Heart Circ Physiol 2000; 278: H420—H427
  • Stoodley M, Weihl CC, Zhang ZD, et al. Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 2000; 45: 1195–1203

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