Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity

References

• Gilbert NE, O'Reilly JE, Chang CJ, Lin YC. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci 1995; 57: 61–67.
   PubMed Web of Science ®Google Scholar
• Coutinho EM. Gossypol: a contraceptive for men. Contraception 2000; 65: 259–263.
   Web of Science ®Google Scholar
• Tuszynski GP, Cossu G. Differential effect of gossypol on humanmelanoma, colon carcinoma, and other tissue culture cell lines. Cancer Res 1984; 44: 768–771.
   PubMed Web of Science ®Google Scholar
• Le Blanc M, Russo J, Kudelka AP, Smith JA. An in vitro study ofinhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. Pharmacol Res 2002; 46: 551–555.
   PubMed Web of Science ®Google Scholar
• Wu YVV, Chik CL, Knazek RA. An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Cancer Res 1989; 49: 3754–3758.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang J, Wong SC et al. Cytotoxic effect of gossypol oncolon carcinoma cells. Life Sci 2000; 67: 2663–2671.
   PubMed Web of Science ®Google Scholar
• Flack MR, Pyle RG, Mullen NM et al. Oral gossypol in the treatment of metastatic adrenal cancer. J Clin Endocrinol Metab 1993; 76: 1019–1024.
   PubMed Web of Science ®Google Scholar
• Stein RC, Joseph AE, Matlin SA, Cunningham DC, Ford HT, Coombes RC. A preliminary clinical study of gossypol in advanced human cancer. Cancer Chemother Pharmacol 1992; 30: 480–482.
   PubMed Web of Science ®Google Scholar
• Thomas M, von Hagen V, Moustafa Y, Montmasson MP, Monet JD. Effects of gossypol on the cell cycle phases in T-47D human breast cancer cells. Anticancer Res 1991; 11: 1469–1476.
   PubMed Web of Science ®Google Scholar
• Becattini B, Kitada S, Leone M et al. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bc1-XL, Chem Biol 2004; 11: 389–395.
   PubMed Web of Science ®Google Scholar
• Moon DO, Kim MO, Lee JD, Kim GY. Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. Cancer Lett 2008; 264: 192–200.
   PubMed Web of Science ®Google Scholar
• Mohammad RM, Wang S, Banerjee S, Wu X, Chen J, Sarkar FH. Nonpeptidic small-molecule inhibitor of Bc1-2 and Bc1-XL, (—)-gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. Pancreas 2005; 31: 317–324.
   PubMed Web of Science ®Google Scholar
• Avci CB, Sahin F, Gunduz C et al. Protein phosphatase 2A (PP2A) has a potential role in CAPE-induced apoptosis of CCRF-CEM cells via effecting human telomerase reverse transcriptase activity. Hematology 2007; 12: 519–525.
   PubMed Web of Science ®Google Scholar
• Eichhorn Pi, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta 2009; 1795: 1–15.
   PubMed Web of Science ®Google Scholar
• Schönthal AH. Role of serine/threonine protein phosphatase 2A in cancer. Cancer Lett 2001; 170: 1–13.
   PubMed Web of Science ®Google Scholar
• Liu WJ, Jiang JF, Xiao D, Ding J. Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis. Biochem Pharmacol 2002; 64: 1677–1687.
   PubMed Web of Science ®Google Scholar
• Uzunoglu S, Uslu R, Tobu M et al. Augmentation of methyl-prednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors. Leuk Res 1999; 3: 5507–5512.
   Google Scholar
• Saydam G, Aydin HH, Sahin F et al. Involvement of protein phosphatase 2A in interferon-alpha-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells. Leuk Res 2003; 27: 709–717.
   PubMed Web of Science ®Google Scholar
• Chang JS, Hsu YL, Kuo PL, Chiang LC, Lin CC. Upregulation of Fas/Fas ligand mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. Clin Exp Pharmacol Physiol 2004; 31: 716–722.
   PubMed Web of Science ®Google Scholar
• Liu S, Kulp SK, Sugimoto Y et al. The (—)-enantiomer of gossypol possess higher anticancer potency than racemic gossypol in human breast cancer. Anticancer Res 2002; 22: 33–38.
   PubMed Web of Science ®Google Scholar
• Xu L, Yang D, Wang S et al. (—)-gossypol enhances response to radiation therapy and results in tumor regression of human prostate caner. Mol Cancer Ther 2005; 4: 197–205.
   PubMed Web of Science ®Google Scholar
• Wang G, Nikolovska-Coleska Z, Yang CY et al. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bc1-2 proteins. J Med Chem 2006; 49: 6139–6142.
   PubMed Web of Science ®Google Scholar
• Meng Y, Li Y, Li H et al. (—)gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemia cells. Leuk Lymphoma 2007; 48: 2204–2212.
   PubMed Web of Science ®Google Scholar
• van Poznak C, Seidman AC, Reidenberg MM et al. Oral gossypol in the treatment of patients with refractory metastatic breast cancer; a phase I/II clinical trial. Breast Cancer Res Treat 2001; 66: 239–248.
   PubMed Web of Science ®Google Scholar
• Politzer WM. Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). Phytomedicine 2008; 15: 563–565.
   PubMed Web of Science ®Google Scholar
• Baumgrass R, Weiwad M, Erdmann F et al. Reversible inhibition of calcineurin by polyphenolic aldehyde gossypol. J Biol Chem 2001; 276: 47914–47921.
   PubMed Web of Science ®Google Scholar
• Carruthers Ni, Dowd MK, Stemmer PM. Gossypol inhibits calcineurin activity at multiple sites. Eur J Pharmacol 2007; 555: 106–114.
   PubMed Web of Science ®Google Scholar
• Groth RD, Dunbar RL, Mermelstein PG. Calcineurin regulation of neuronal plasticity. Biochem Biophys Res Commun 2003; 311: 1159–1171.
   PubMed Web of Science ®Google Scholar
• Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood 1995; 85: 2315–2320
   PubMed Web of Science ®Google Scholar
• Kim HR, Christensen R, Park NH, Sapp P, Kang MK, Park NH. Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ. Clin Cancer Res 2001; 7: 3079–3086.
   PubMed Web of Science ®Google Scholar
• Nakamura TM, Morin GB, Chapman KB et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955–959.
   PubMed Web of Science ®Google Scholar
• Meyerson M. Role of telomerase in normal and cancer cells. J Clin Oncol 2000; 18: 2626–2634.
   PubMed Web of Science ®Google Scholar