Hematopoietic stromal cells and megakaryocyte development

References

• First LR, Smith BR, Lipton J, Nathan DG, Parkman R, Rappeport JM. Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes. Blood 1985;65:368–74.
   PubMed Web of Science ®Google Scholar
• Kessinger A, Armitage JO, Landmark JD, Smith DM, Weisenburger DD. Autologous peripheral hematopoietic stem cell transplantation restores hematopoietic function following marrow ablative therapy. Blood 1988:71:723–7.
   PubMed Web of Science ®Google Scholar
• Maurer AM, Liu Y, Caen JP, Han ZC. Ex vivo expansion of megakaryocytic cells. Int J Hematol 2000;71:203–10.
   PubMed Web of Science ®Google Scholar
• Gibson LF, Fortney J, Landreth KS, Piktel D, Ericson SG, Lynch JP. Disruption of bone marrow stromal cell function by etoposide. Biol Blood Marrow Transplant 1997;3:122–32.
   PubMedGoogle Scholar
• Hiwase SD, Dyson PG, To LB, Lewis ID. Cotransplantation of placental mesenchymal stromal cells enhances single and double cord blood engraftment in nonobese diabetic/severe combined immune deficient mice. Stem Cells 2009;27:2293–300.
   PubMed Web of Science ®Google Scholar
• Dorshkind K. Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol 1990;8:111–37.
   PubMed Web of Science ®Google Scholar
• Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, et al.. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol 2003;31:413–20.
   PubMed Web of Science ®Google Scholar
• Erices AA, Allers CI, Conget PA, Rojas CV, Minguell JJ. Human cord blood‐derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion. Cell Transplant 2003;12:555–61.
   PubMed Web of Science ®Google Scholar
• Gordge MP. Megakaryocyte apoptosis: sorting out the signals. Br J Pharmacol 2005;145:271–3.
   PubMed Web of Science ®Google Scholar
• Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia 2009;23:2233–41.
   PubMed Web of Science ®Google Scholar
• Yin T, Li L. The stem cell niches in bone. J Clin Invest 2006;116:1195–201.
   PubMed Web of Science ®Google Scholar
• Islam A. Haemopoietic stem cell: a new concept. Leuk Res 1985;9:1415–32.
   PubMed Web of Science ®Google Scholar
• Huang S, Terstappen LW. Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells. Nature 1992;360:745–9.
   PubMed Web of Science ®Google Scholar
• Singer JW, Keating A, Cuttner J, Gown AM, Jacobson R, Killen PD, et al.. Evidence for a stem cell common to hematopoiesis and its in vitro microenvironment: studies of patients with clonal hematopoietic neoplasia. Leuk Res 1984;8:535–45.
   PubMed Web of Science ®Google Scholar
• Simmons PJ, Torok‐Storb B. CD34 expression by stromal precursors in normal human adult bone marrow. Blood 1991;78:2848–53.
   PubMed Web of Science ®Google Scholar
• Waller EK, Olweus J, Lund‐Johansen F, Huang S, Nguyen M, Guo GR, et al.. The “common stem cell” hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood 1995;85:2422–35.
   PubMed Web of Science ®Google Scholar
• Simmons P, Gronthos S, Zannettino A. The development of stromal cells. In: Hematopoiesis: a developmental approach. New York: Oxford University Press; 2001. p. 718–26.
   Google Scholar
• Short B, Brouard N, Occhiodoro‐Scott T, Ramakrishnan A, Simmons PJ. Mesenchymal stem cells. Arch Med Res 2003;34:565–71.
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper‐Cortenbach I, Marini FC, et al.. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 2005;7:393–5.
   PubMed Web of Science ®Google Scholar
• Dominici M, Le Blanc K, Mueller I, Slaper‐Cortenbach I, Marini F, Krause D, et al.. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315–7.
   PubMed Web of Science ®Google Scholar
• Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow‐derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 1998;176:57–66.
   PubMed Web of Science ®Google Scholar
• Seshi B, Kumar S, Sellers D. Human bone marrow stromal cell: coexpression of markers specific for multiple mesenchymal cell lineages. Blood Cells Mol Dis 2000;26:234–46.
   PubMed Web of Science ®Google Scholar
• Dennis JE, Charbord P. Origin and differentiation of human and murine stroma. Stem Cells 2002;20:205–14.
   PubMed Web of Science ®Google Scholar
• Simmons PJ, Torok‐Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO‐1. Blood 1991;78:55–62.
   PubMed Web of Science ®Google Scholar
• Salles G, Chen CY, Reinherz EL, Shipp MA. CD10/NEP is expressed on Thy‐1low B220+ murine B‐cell progenitors and functions to regulate stromal cell‐dependent lymphopoiesis. Blood 1992;80:2021–9.
   PubMed Web of Science ®Google Scholar
• Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow‐derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992;13:69–80.
   PubMed Web of Science ®Google Scholar
• Guerriero A, Worford L, Holland HK, Guo GR, Sheehan K, Waller EK. Thrombopoietin is synthesized by bone marrow stromal cells. Blood 1997;90:3444–55.
   PubMed Web of Science ®Google Scholar
• Rokhlin O, Cohen M, Kubagawa H, Letarte M, Cooper M. Differential expression of endoglin on fetal and adult hematopoietic cells in human bone marrow. J Immunol 1995;154:4456.
   PubMed Web of Science ®Google Scholar
• Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok‐Storb B, Gallatin WM. Vascular cell adhesion molecule‐1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 1992;80:388–95.
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al.. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7.
   PubMed Web of Science ®Google Scholar
• Tolar J, Hippen KL, Blazar BR. Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells. Br J Haematol 2009;147:200–6.
   PubMed Web of Science ®Google Scholar
• Kohler T, Plettig R, Wetzstein W, Schaffer B, Ordemann R, Nagels HO, et al.. Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, early‐acting cytokines and agitation of culture vessels. Stem Cells 1999;17:19–24.
   PubMed Web of Science ®Google Scholar
• Barker JN, Wagner JE. Umbilical cord blood transplantation: current practice and future innovations. Crit Rev Oncol Hematol 2003;48:35–43.
   PubMed Web of Science ®Google Scholar
• Gao L, Chen X, Zhang X, Liu Y, Kong P, Peng X, et al.. Human umbilical cord blood‐derived stromal cell, a new resource of feeder layer to expand human umbilical cord blood CD34+ cells in vitro. Blood Cells Mol Dis 2006;36:322–8.
   PubMed Web of Science ®Google Scholar
• Hao L, Zhang C, Chen XH, Zou ZM, Zhang X, Kong PY, et al.. Human umbilical cord blood‐derived stromal cells suppress xenogeneic immune cell response in vitro. Croat Med J 2009;50:351–60.
   PubMed Web of Science ®Google Scholar
• Oh W, Kim DS, Yang YS, Lee JK. Immunological properties of umbilical cord blood‐derived mesenchymal stromal cells. Cell Immunol 2008;251:116–23.
   PubMed Web of Science ®Google Scholar
• Feng Y, Chen X, Gao L. Hypothesis: human umbilical cord blood‐derived stromal cells promote megakaryocytopoiesis through the influence of SDF‐1 and PECAM‐1. Cell Biochem Biophys 2010;58:25–30.
   PubMed Web of Science ®Google Scholar
• Gao L, Chen XH, Feng YM, Zhang X, Yu SC, Zhang C, et al.. Human umbilical cord blood‐derived stromal cells: multifaceted regulators of megakaryocytopoiesis. Cell Cycle 2010;9:1342–53.
   PubMed Web of Science ®Google Scholar
• Schick PK, Wojenski CM, He X, Walker J, Marcinkiewicz C, Niewiarowski S. Integrins involved in the adhesion of megakaryocytes to fibronectin and fibrinogen. Blood 1998;92:2650–6.
   PubMed Web of Science ®Google Scholar
• Miyake K, Medina K, Ishihara K, Kimoto M, Auerbach R, Kincade PW. A VCAM‐like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J Cell Biol 1991;114:557–65.
   PubMed Web of Science ®Google Scholar
• Juneja HS, Schmalsteig FC, Lee S, Chen J. Vascular cell adhesion molecule‐1 and VLA‐4 are obligatory adhesion proteins in the heterotypic adherence between human leukemia/lymphoma cells and marrow stromal cells. Exp Hematol 1993;21:444–50.
   PubMed Web of Science ®Google Scholar
• Cui L, Ramsfjell V, Borge OJ, Veiby OP, Lok S, Jacobsen SE. Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule‐1: role of activation of very late antigen (VLA)‐4 and VLA‐5. J Immunol 1997;159:1961–9.
   PubMed Web of Science ®Google Scholar
• Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood 1994;83:2126–32.
   PubMed Web of Science ®Google Scholar
• Avraham H, Cowley S, Chi SY, Jiang S, Groopman JE. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J Clin Invest 1993;91:2378–84.
   PubMed Web of Science ®Google Scholar
• Avraham H, Scadden DT, Chi S, Broudy VC, Zsebo KM, Groopman JE. Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c‐kit ligand. Blood 1992;80:1679–84.
   PubMed Web of Science ®Google Scholar
• Dhanjal TS, Pendaries C, Ross EA, Larson MK, Protty MB, Buckley CD, et al.. A novel role for PECAM‐1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 2007;109:4237–44.
   PubMed Web of Science ®Google Scholar
• Wu Y, Welte T, Michaud M, Madri JA. PECAM‐1: a multifaceted regulator of megakaryocytopoiesis. Blood 2007;110:851–9.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Aze Y, Fujita T. Adhesion molecule LFA‐1/ICAM‐1 influences on LPS‐induced megakaryocytic emperipolesis in the rat bone marrow. Vet Pathol 1997;34:463–6.
   PubMed Web of Science ®Google Scholar
• Cobankara V, Oran B, Ozatli D, Haznedaroglu IC, Kosar A, Buyukasik Y, et al.. Cytokines, endothelium, and adhesive molecules in pathologic thrombopoiesis. Clin Appl Thromb Hemost 2001;7:126–30.
   PubMed Web of Science ®Google Scholar
• Wickenhauser C, Schmitz B, Baldus SE, Henze F, Farahmand P, Frimpong S, et al.. Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte–fibroblast interactions in human bone marrow. Leuk Res 2000;24:1013–21.
   PubMed Web of Science ®Google Scholar
• Kaushansky K. Thrombopoietin. N Engl J Med 1998;339:746–54.
   PubMed Web of Science ®Google Scholar
• Yang M, Chesterman CN, Chong BH. Recombinant PDGF enhances megakaryocytopoiesis in vitro. Br J Haematol 1995;91:285–9.
   PubMed Web of Science ®Google Scholar
• Yang M, Li K, Chui CM, Yuen PM, Chan PK, Chuen CK, et al.. Expression of interleukin (IL) 1 type I and type II receptors in megakaryocytic cells and enhancing effects of IL‐1beta on megakaryocytopoiesis and NF‐E2 expression. Br J Haematol 2000;111:371–80.
   PubMed Web of Science ®Google Scholar
• Yang M, Li K. The role of cytokines and transcription factors in megakaryocytopoiesis. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2002;10:580–5.
   PubMedGoogle Scholar
• Perez LE, Alpdogan O, Shieh JH, Wong D, Merzouk A, Salari H, et al.. Increased plasma levels of stromal‐derived factor‐1 (SDF‐1/CXCL12) enhance human thrombopoiesis and mobilize human colony‐forming cells (CFC) in NOD/SCID mice. Exp Hematol 2004;32:300–7.
   PubMed Web of Science ®Google Scholar
• Hodohara K, Fujii N, Yamamoto N, Kaushansky K. Stromal cell‐derived factor‐1 (SDF‐1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU‐MK). Blood 2000;95:769–75.
   PubMed Web of Science ®Google Scholar
• Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest 2005;115:3339–47.
   PubMed Web of Science ®Google Scholar
• Kaushansky K. Thrombopoietin and the hematopoietic stem cell. Ann NY Acad Sci 2005;1044:139–41.
   PubMed Web of Science ®Google Scholar
• Deutsch V, Tomer A. Megakaryocyte development and platelet production. Br J Haematol 2006;134:453–66.
   PubMed Web of Science ®Google Scholar
• Nagata Y, Nagahisa H, Nagasawa T, Todokoro K. Regulation of megakaryocytopoiesis by thrombopoietin and stromal cells. Leukemia 1997;11(Suppl. 3):435–8.
   PubMedGoogle Scholar
• Nagahisa H, Nagata Y, Ohnuki T, Osada M, Nagasawa T, Abe T, et al.. Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 1996;87:1309–16.
   PubMed Web of Science ®Google Scholar
• Wang JF, Liu ZY, Groopman JE. The alpha‐chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion. Blood 1998;92:756–64.
   PubMed Web of Science ®Google Scholar
• Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, et al.. Chemokine‐mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004;10:64–71.
   PubMed Web of Science ®Google Scholar
• Pang L, Weiss MJ, Poncz M. Megakaryocyte biology and related disorders. J Clin Invest 2005;115:3332–8.
   PubMed Web of Science ®Google Scholar
• Lane WJ, Dias S, Hattori K, Heissig B, Choy M, Rabbany SY, et al.. Stromal‐derived factor 1‐induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood 2000;96:4152–9.
   PubMed Web of Science ®Google Scholar
• Gutierrez‐Ramos JC, Olsson C, Palacios R. Interleukin (IL1 to IL7) gene expression in fetal liver and bone marrow stromal clones: cytokine‐mediated positive and negative regulation. Exp Hematol 1992;20:986–90.
   PubMed Web of Science ®Google Scholar
• Su R, Li K, Yang M, Zhang X, Tsang K, Fok T, et al.. Platelet‐derived growth factor enhances ex vivo expansion of megakaryocytic progenitors from human cord blood. Bone Marrow Transplant 2001;27:1075.
   PubMed Web of Science ®Google Scholar
• Su R, Zhang X, Li K, Yang M, Li C, Fok T, et al.. Platelet‐derived growth factor promotes ex vivo expansion of CD34+ cells from human cord blood and enhances long‐term culture‐initiating cells, non‐obese diabetic/severe combined immunodeficient repopulating cells and formation of adherent cells. Br J Haematol 2002;117:735–46.
   PubMed Web of Science ®Google Scholar
• Bruno E, Miller ME, Hoffman R. Interacting cytokines regulate in vitro human megakaryocytopoiesis. Blood 1989;73:671–7.
   PubMed Web of Science ®Google Scholar
• Fry T, Mackall C. The many faces of IL‐7: from lymphopoiesis to peripheral T cell maintenance. J Immnol 2005;174:6571–6.
   PubMed Web of Science ®Google Scholar
• Gupta P, Blazar BR, Gupta K, Verfaillie CM. Human CD34+ bone marrow cells regulate stromal production of interleukin‐6 and granulocyte colony‐stimulating factor and increase the colony‐stimulating activity of stroma. Blood 1998;91:3724–33.
   PubMed Web of Science ®Google Scholar
• Baatout S: Interleukin‐6 and megakaryocytopoiesis: an update. Ann Hematol 1996;73:157–62.
   PubMed Web of Science ®Google Scholar
• Fujiki H, Kimura T, Minamiguchi H, Harada S, Wang JF, Nakao M, et al.. Role of human interleukin‐9 as a megakaryocyte potentiator in culture. Exp Hematol 2002;30:1373–80.
   PubMed Web of Science ®Google Scholar
• Teramura M, Kobayashi S, Hoshino S, Oshimi K, Mizoguchi H. Interleukin‐11 enhances human megakaryocytopoiesis in vitro. Blood 1992;79:327.
   PubMed Web of Science ®Google Scholar
• Du X, Williams D. Interleukin‐11: review of molecular, cell biology, and clinical use. Blood 1997;89:3897.
   PubMed Web of Science ®Google Scholar
• Avraham H, Vannier E, Cowley S, Jiang SX, Chi S, Dinarello CA, et al.. Effects of the stem cell factor, c‐kit ligand, on human megakaryocytic cells. Blood 1992;79:365–71.
   PubMed Web of Science ®Google Scholar
• Friel J, Itoh K, Bergholz U, Jucker M, Stocking C, Harrison P, et al.. Hierarchy of stroma‐derived factors in supporting growth of stroma‐dependent hemopoietic cells: membrane‐bound SCF is sufficient to confer stroma competence to epithelial cells. Growth Factors 2002;20:35–51.
   PubMed Web of Science ®Google Scholar
• Erickson‐Miller CL, Ji H, Murphy MJ. Megakaryocytopoiesis and platelet production: does stem cell factor play a role? Stem Cells 1993;11(Suppl. 2):163–9.
   PubMedGoogle Scholar
• Piacibello W, Garetto L, Sanavio F, Severino A, Fubini L, Stacchini A, et al.. The effects of human FLT3 ligand on in vitro human megakaryocytopoiesis. Exp Hematol 1996;24:340–6.
   PubMed Web of Science ®Google Scholar
• Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Agnarsson BA, Gudmundsson S. Flt3/Flk‐2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem Cells Dev 2004;13:183–91.
   PubMed Web of Science ®Google Scholar
• Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Gudmundsson S. Flt3/Flk‐2‐ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum‐free cultures initiated with CD34+ cells. J Hematother Stem Cell Res 2002;11:389–400.
   PubMedGoogle Scholar
• Allouche M, Bikfalvi A. The role of fibroblast growth factor‐2 (FGF‐2) in hematopoiesis. Prog Growth Factor Res 1995;6:35–48.
   PubMedGoogle Scholar
• Quito F, Beh J, Bashayan O, Basilico C, Basch R. Effects of fibroblast growth factor‐4 (k‐FGF) on long‐term cultures of human bone marrow cells. Blood 1996;87:1282.
   PubMed Web of Science ®Google Scholar
• Liu CH, Hwang SM. Cytokine interactions in mesenchymal stem cells from cord blood. Cytokine 2005;32:270–9.
   PubMed Web of Science ®Google Scholar
• Bikfalvi A, Han ZC, Fuhrmann G. Interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis and demonstration of FGF receptor expression in megakaryocytes and megakaryocytic‐like cells. Blood 1992;80:1905–13.
   PubMed Web of Science ®Google Scholar
• Shivdasani RA. Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells 2001;19:397–407.
   PubMed Web of Science ®Google Scholar
• Gewirtz AM, Zhang J, Ratajczak J, Ratajczak M, Park KS, Li C, et al.. Chemokine regulation of human megakaryocytopoiesis. Blood 1995;86:2559–67.
   PubMed Web of Science ®Google Scholar
• Scandura JM, Boccuni P, Massague J, Nimer SD. Transforming growth factor beta‐induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up‐regulation. Proc Natl Acad Sci USA 2004;101:15231–6.
   PubMed Web of Science ®Google Scholar
• Verma A, Deb DK, Sassano A, Uddin S, Varga J, Wickrema A, et al.. Activation of the p38 mitogen‐activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor‐beta on normal hematopoiesis. J Biol Chem 2002;277:7726–35.
   PubMed Web of Science ®Google Scholar
• Cheng L, Qasba P, Vanguri P, Thiede MA. Human mesenchymal stem cells support megakaryocyte and pro‐platelet formation from CD34+ hematopoietic progenitor cells. J Cell Physiol 2000;184:58–69.
   PubMed Web of Science ®Google Scholar
• Almeida‐Porada G, Porada CD, Tran N, Zanjani ED. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 2000;95:3620–7.
   PubMed Web of Science ®Google Scholar
• Chung NG, Jeong DC, Park SJ, Choi BO, Cho B, Kim HK, et al.. Cotransplantation of marrow stromal cells may prevent lethal graft‐versus‐host disease in major histocompatibility complex mismatched murine hematopoietic stem cell transplantation. Int J Hematol 2004;80:370–6.
   PubMed Web of Science ®Google Scholar