Immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial

References

• Boswell MV, Shah RV, Everett CK, Sehgal N, Brown AM, Abdi S, et al.Interventional techniques in the management of chronic spinal pain: evidence-based practice guidelines. Pain Physician 2005;8:1–47.
   Google Scholar
• Manchikanti L, Singh V, Pampati V, Damron K, Beyer C, Barnhill R. Is there correlation of facet joint pain in lumbar and cervical spine? An evaluation of prevalence in combined chronic low back and neck pain. Pain Physician 2002;5:365–72.
   PubMedGoogle Scholar
• Gross AR, Hoving JL, Haines TA, Goldsmith CH, Kay T, Aker P, et al. A Cochrane review of manipulation and mobilization for mechanical neck disorders. Spine 2004;29:1541–48.
   PubMed Web of Science ®Google Scholar
• Gross AR, Kay T, Hondras M, Goldsmith C, Haines T, Peloso P, et al. Manual therapy for mechanical neck disorders: a systematic review. Man Ther 2002;7:131–49.
   PubMed Web of Science ®Google Scholar
• Tseng Y, Wang W, Chen W, Hou T, Chen T, Lieu F. Predictors for immediate responders to cervical manipulation in patients with neck pain. Man Ther 2006;11:306–315.
   PubMed Web of Science ®Google Scholar
• Manchikanti L, Manchikanti K, Cash K, Singh V, Giordano J. Age-related prevalence of facet-joint involvement in chronic neck and low back pain. Pain Physician 2008;11:67–75.
   PubMed Web of Science ®Google Scholar
• Manchikanti L, Manchikanti KN, Manchukonda R, Cash KA, Damron KS, Pampati V, et al. Evaluation of lumbar facet joint nerve blocks in the management of chronic low back pain: preliminary report of a randomized, double-blind controlled trial: clinical trial NCT00355914. Pain Physician 2007;10:425–40.
   PubMedGoogle Scholar
• Najm WI, Seffinger MI, Mishra SA, Dickerson VM, Adams A, Reinsch S, et al. Content validity of manual spinal palpatory exams: a systematic review. BMC Musculoskelet Disord 2003;3:1–14.
   Google Scholar
• Staud R, Vierck C, Cannon R, Mauderli A, Price D. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001;91:165–75.
   PubMed Web of Science ®Google Scholar
• Woolf C, Doubell T. The pathophysiology of chronic pain-increased sensitivity to low threshold Abeta-fibre inputs. Curr Opin Neurobiol 1994;4:525–34.
   PubMedGoogle Scholar
• Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. Man Ther 2009;14:531–8.
   PubMed Web of Science ®Google Scholar
• Bialosky JE, Bishop MD, Robinson ME, Zeppieri G, Jr, George SZ. Spinal manipulative therapy has an immediate effect on thermal pain sensitivity in people with low back pain: a randomized controlled trial. Phys Ther 2009;89:1292–303.
   PubMed Web of Science ®Google Scholar
• George SZ, Bishop MD, Bialosky JE, Zeppieri G, Jr, Robinson ME. Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study. BMC Musculoskelet Disord 2006;7:68.
   PubMed Web of Science ®Google Scholar
• van Cranenburgh B. Inleiding in the toegepaste neurowetenschappen. Vol. 1. Lochem: Uitgeversmaatchappij de Tijdstroom; 1989.
   Google Scholar
• Bialosky JE, Bishop MD, Robinson ME, George SZ. The relationship of the audible pop to hypoalgesia associated with high-velocity, low-amplitude thrust manipulation: a secondary analysis of an experimental study in pain-free participants. J Manipulative Physiol Ther 2010;33:117–24.
   PubMed Web of Science ®Google Scholar
• Paris S. S1 course notes 2000. Chicago, IL.
   Google Scholar
• Winkel D. Diagnosis and treatment of the spine. Gaithersburg, MD: Aspen Publishers, Inc.; 1996.
   Google Scholar
• Van der El A, Lunacies P, Wagemaker A. Manuele therapies. Rotterdam: Manuel; 1993.
   Google Scholar
• Cantu R, Grodin A. Myofascial manipulation, theory and clinical application. 2nd ed. Gaithersburg, MD: Aspen Publications; 2001.
   Google Scholar
• Kerry R, Taylor A, Mitchell J, McCarthy C, Brew J. Manual therapy and cervical arterial dysfunction, directions for the future: a clinical perspective. J Man Manip Ther 2008;16:39–48.
   PubMedGoogle Scholar
• Gonzalez-Iglesias J, Fernandez-De-Las-Penas C, Cleland J, Alburquerque-Sedin F, Palomeque-del-Cerro L, Mendez-Sanchez R. Inclusion of thoracic spine thrust manipulation into an electro-therapy/thermal program for the management of patients with acute mechanical neck pain: a randomized clinical trial. Man Ther 2009;14:306–13.
   Google Scholar
• Astin J, Ernst E. The effectiveness of spinal manipulation for the treatment of headache disorders: a systematic review of randomized clinical trials. Cephalagia 2002;22:617–23.
   PubMed Web of Science ®Google Scholar
• Cleland JA, Childs JD, McRae M, Palmer JA, Stowell T. Immediate effects of thoracic manipulation in patients with neck pain: a randomized clinical trial. Man Ther 2005;10:127–35.
   PubMed Web of Science ®Google Scholar
• Dishman J, Greco D, Burke J. Motor-evoked potentials recorded from lumbar erector spinae muscles: a study of corticospinal excitability changes associated with spinal manipulation. J Manipulative Physiol Ther 2008;31:258–69.
   PubMed Web of Science ®Google Scholar
• Benarroch E. Pain-autonomic interactions. Neurol Sci 2006;27(Suppl. 2):S130–3.
   PubMedGoogle Scholar
• Barman S, Wurster R. Interaction of descending spinal sympathetic pathways and afferent nerves. Am J Physiol 1978;234: H223–9.
   Google Scholar
• Cortelli P, Pierangeli G. Chronic pain-autonomic interactions. Neurol Sci 2003;24:S68–70.
   PubMedGoogle Scholar
• Benarroch E. Pain-autonomic interactions: a selective review. Clin Auton Res 2001;11:343–9.
   PubMed Web of Science ®Google Scholar
• Zusman M. Forebrain-mediated sensitization of central pain pathways: “non-specific” pain and a new image for MT. Man Ther 2002;7:80–8.
   PubMed Web of Science ®Google Scholar
• Sato A. Somato-sympathetic reflex discharges evoked through supramedullary pathways. Pflugers Arch 1972;332:117–26.
   PubMed Web of Science ®Google Scholar
• Sato A. Neural mechanisms of autonomic responses elicted by somatic stimulation. Neurosci Behav Physiol 1997;27:610–21.
   PubMedGoogle Scholar
• Schwartzman R, Alexander G, Grothusen J. Pathophysiology of complex regional pain syndrome. Expert Rev Neurother 2006;6:669–81.
   PubMed Web of Science ®Google Scholar
• Cleland J, Glynn P, Whiteman J, Eberhart S, MacDonald C, Childs JD. Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the throracic spine in patients with neck pain: a randomized clinical trial. Phys Ther 2007;87:431–40.
   PubMed Web of Science ®Google Scholar
• Krauss J, Creighton D, Ely J, Podlewska-Ely J. The immediate effects of upper thoracic translatoric spinal manipulation on cervical pain and range of motion: a randomized clinical trial. J Man Manip Ther 2008;16:93–9.
   PubMedGoogle Scholar
• Fernandez-De-Las-Penas C, Palomeque-del-Cerro L, Rodriquez-Blanco C, Gomez-Conesa A, Miangolarra-Page J. Changes in neck pain and active range of motion after a single throracic spine manipulation in subjects presenting with mechanical neck pain: a case series. J Manipulative Physiol Ther 2007;30:312–20.
   Google Scholar
• Childs J, Cleland J, Elliot J, Deydre T, Wainner R, Whitman J, et al. Neck pain: clinical practice guidelines linked to the international classification of functioning, disability, and health from the orthopaedic section of the american physical therapy association. J Orthop Sports Phys Ther 2008;38:A1–34.
   Google Scholar
• Huijbregts P. Clinical prediction rules: time to sacrifice the holy cow of specificity? J Man Manip Ther 2007;15:5–7.
   PubMedGoogle Scholar
• Cleland J, Fritz J, Whiteman J, Childs JD, Palmer JA. The use of a lumbar spine manipulation technique by physical therapists in patients who satisfy a clinical prediction rule: a case series. J Orthop Sports Phys Ther 2006;36:209–14.
   PubMed Web of Science ®Google Scholar
• Flynn T, Fritz J, Whiteman J, Wainner R, Magel J, Rendeiro D, et al. A clinical prediction rule for classifying patients with low back pain who demonstrate short-term improvement with spinal manipulation. Spine 2002;27:2835–43.
   PubMed Web of Science ®Google Scholar
• Cleland J, Childs J, Fritz J, Whiteman J, Eberhart S. Development of a clinical prediction rule for guiding treatment of a subgroup of patients with neck pain: use of thoracic spine manipulation, exercise, and patient education. Phys Ther 2007;87:9–23.
   PubMed Web of Science ®Google Scholar
• Mink A, ter Veen H, Vorselaars J. Extremiteiten, functieonderzoek en manuele therapy. Utrecht: Bohn, Scheltema & Holkema; 1990.
   Google Scholar
• Lucini D, Di Fede G, Parati G, Pagani M. Impact of chronic psychosocial stress on autonomic cardiovascular reulation in otherwise healthy subjects. Hypertension 2005;46:1201–6.
   PubMed Web of Science ®Google Scholar
• Maguire AM, Craig ME, Craighead A, Chan AK, Cusumano JM, Hing SJ, et al. Autonomic nerve testing predicts the development of complications. Diabetes Care 2007;30:77–82.
   PubMed Web of Science ®Google Scholar
• Vicenzino B, Collins D, Wright T. Sudomotor changes induced by neural mobilisation techniques in asymptomatic subjects. J Man Manip Ther 1994;2:66–74.
   Google Scholar
• Butler D. The sensitive nervous system. Adelaide, SA: Noigroup Publications; 2000.
   Google Scholar
• Menck J, Requejo S, Kulig K. Thoracic spine dysfunction in upper extremity complex regional pain syndrome type I. J Orthop Sports Phys Ther 2000;30:401–9.
   PubMed Web of Science ®Google Scholar
• Bernards J, Bouman L. Fysiologie van de mens. Utrecht: Bohn, Scheltema & Holkema; 1988.
   Google Scholar
• Elenkov I, Wilder R, Chrousos G, Viziz E. The sympathetic nerve-an integrative interfase between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595–638.
   PubMed Web of Science ®Google Scholar
• Gibbons P, Gosling C, Holmes M. Short-term effects of cervical manipulation on edge light pupil cycle time: a pilot study. J Manipulative Physiol Ther 2000;23:465–9.
   PubMed Web of Science ®Google Scholar
• Oostendorp R. Functionele Vertebrobasilaire Insufficientie. Nijmegen: Drukkerij Leijn; 1988.
   Google Scholar
• Filipe J, Falcao-Reis F, Castro-Correia, Barros H. Assessment of autonomic function in high level athletes by pupillometry. Auton Neurosci 2003;104:66–72.
   PubMed Web of Science ®Google Scholar
• Pfeifer MA, Cook D, Brodsky J, Tice D, Parrish D, Reenan A, et al. Quantitative evaluation of sympathetic and parasympathetic control of iris function. Diabetes Care 1982;5:518–28.
   PubMed Web of Science ®Google Scholar
• Bertinotti L, Pietrini U, del Rosso A, Casale R, Colangelo N, Zoppi M, et al. The use of pupillometry in joint and connective tissue diseases. Ann NY Acad Sci 2002;966:446–55.
   Google Scholar
• Bitsios P, Prettyman R, Szabadi E. Changes in autonomic function with age: a study of pupillary kinetics in healthy young and old people. Age Ageing 1996;25:432–8.
   PubMed Web of Science ®Google Scholar
• Capao Filipe J, Falcao-Reis F, Castro-Correia J, Barros H. Assessment of autonomic function in high level athletes by pupillometry. Auton Neurosci 2003;104:66–72.
   PubMed Web of Science ®Google Scholar
• Fotiou F, Fountoulakis K, Goulas A, Alexopoulos L, Palikaras A. Automated standardized pupillometry with optical method for purposes of clinical practice and research. Clin Physiol 2000;20:336–47.
   PubMedGoogle Scholar
• Vicenzino B, Collins D, Wright A. The initial effects of a cervical spine manuipulative physiotherapy treatment on the pain and dysfunction of lateral epicondylalgia. Pain 1996;68:69–74.
   PubMed Web of Science ®Google Scholar
• George S, Bishop M, Bialosky J, Zeppieri G, Robinson M. Immediate effects of spinal manipulation on theral pain sensitivity: an experimental study. BMC Musculoskelet Disord 2006;7:1471–81.
   Google Scholar
• Bialosky JE, Bishop MD, Robinson ME, Barabas JA, George SZ. The influence of expectation on spinal manipulation induced hypoalgesia: an experimental study in normal subjects. BMC Musculoskelet Disord 2008;9:19.
   PubMed Web of Science ®Google Scholar
• Cleland J, Flynn T, Childs JD, Eberhart S. The audible pop from thoracic spine thrust manipulation and its relation to short-term outcomes in patients with neck pain. J Man Manip Ther 2007;15:143–54.
   PubMedGoogle Scholar
• Elliott A, Smith B, Penny K, Smith W, Chambers W. The epidemiology of chronic pain in the community. Lancet 1999;354:1248–52.
   PubMed Web of Science ®Google Scholar
• Ries A. Minimally Clinically important difference for the UCSD Shortness of Breath Questionnaire, Borg Scale, and Visual Analogue Scale. COPD 2005;2:105–10.
   PubMedGoogle Scholar
• Bird S, Dickson E. Clinically significant changes in pain along the Visual Analoge Scale. Ann Emerg Med 2001;38:639–43.
   PubMed Web of Science ®Google Scholar
• Jensen M. The validity and reliability of pain measures in adults with cancer. J Pain 2003;4:2–21.
   PubMed Web of Science ®Google Scholar
• Jensen M, Connie C, Brugger A. Postsurgical pain outcome assessment. Pain 2002: 99;101–9.
   Google Scholar
• Jensen M, Turner J, Romano J, Fisher L. Comparative reliability and validity of chronic pain intensity measures. Pain 1999;83:157–62.
   PubMed Web of Science ®Google Scholar
• Gallagher E, Liebman M, Bijur P. Prosepctive validation of clinically important changes in pain severity measured on a visual analoge scale. Ann Emerg Med 2001;38:633–8.
   PubMed Web of Science ®Google Scholar
• Bijur P, Silver W, Gallagher E. Reliabilty of the Visual Analog Scale for measurement of acute pain. Acad Emerg Med 2001;8:1153–7.
   PubMed Web of Science ®Google Scholar
• Harle D, Wolffsohn J, Evans B. The pupillary light reflex in migraine. Ophthalmic Physiol Opt 2005;25:240–5.
   PubMed Web of Science ®Google Scholar
• Dutsch M, Hilz M, Raunhut U, Solomon J, Neundorfer B, Axelrod F. Sympathetic and parasympathetic pupillary dysfunction in familial dysautonomia. J Neurol Sci 2002;195:77–83.
   PubMed Web of Science ®Google Scholar
• Boxer Walcher B, Krueger R. Agreement and repeatability of infrared pupillometry and the comparison method. Ophthalmology 1999;106:319–23.
   PubMed Web of Science ®Google Scholar
• Boxer Walcher B, Krueger R. Agreement and repeatability of pupillometry using videokeratography and infrared devices. J Cataract Refract Surg 2000;26:35–40.
   PubMed Web of Science ®Google Scholar
• Levy D, Rowley D, Abraham R. Portable infrared pupilloemtry using Pupilscan: relation to somatic and autonomic nerve function in diabetes mellitus. Clin Auton Res 1992;2:335–41.
   PubMedGoogle Scholar
• Meeker M, Du R, Bachetti C, Larson M, Holland M, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs 2005;37:34–40.
   PubMedGoogle Scholar
• Piha S, Halonen J-P. Infrared pupillometry in the assessment of autonomic function. Diabetes Res Clin Pract 1994;26:61–6.
   PubMed Web of Science ®Google Scholar
• Pop M, Payette Y, Santoriello E. Comparison of the pupil card and pupillometer in measuring pupil size. J Cataract Refract Surg 2002;28:281–8.
   Web of Science ®Google Scholar
• Twa M, Bailey M, Hayes J, Bullimore M, McOptom. Estimation of pupil size by digital photography. J Cataract Refract Surg 2004;30:381–9.
   PubMed Web of Science ®Google Scholar
• Boev AN, Fountas KN, Karampelas I, Machinis TG, Feltes C, Okosun I, et al. Quantitative pupillometry: normative data in healthy pediatric volunteers. J Neurosurg 2005;103:496–500.
   PubMed Web of Science ®Google Scholar
• Taylor WR, Chen JW, Meltzer H, Gennarelli TA, Kelbch C, Knowlton S, et al. Quantitative pupillometry, a new technology: normative data and preliminary observations in patients with acute head injury. J Neurosurg 2003;98:205–13.
   PubMed Web of Science ®Google Scholar
• Mylius V, Braune H, Schepelmann K. Dysfunction of the pupillary light reflex following migraine headache. Clin Auton Res 2003;13:16–21.
   PubMed Web of Science ®Google Scholar
• Neil HA, Smith SA. A simple clinical test of pupillary autonomic function, correlation with cardiac autonomic function tests in diabetes. Neuro-ophtalmology 1989;9:237–42.
   Web of Science ®Google Scholar
• Giakoumaki S, Hourdaki E, Grinakis V, Theou K, Bitsios P. Effects of peripheral sympatehtic blockade with dapiprazole on the fear-inhibited light reflex. J Psychopharmacol 2005;19:139–48.
   PubMed Web of Science ®Google Scholar
• Miciele G, Tassorelli C, Martignoni E, Marcheselli S, Rossi F, Nappi G. Further characterization of autonomic involvement in multiple system atrophy: a pupillometric study. Funct Neurol 1995;10:273–80.
   PubMed Web of Science ®Google Scholar
• Brismee JM, Gipson D, Ivie D, Lopez A, Moore M, Matthijs O, et al. Interrater reliability of a passive physiological intervertebral motion test in the mid-thoracic spine. J Manipulative Physiol Ther 2006;29:368–73.
   PubMed Web of Science ®Google Scholar
• Vleeming A, Winkel D, Meijer O. Weke delen aandoeningen van het bewegingsapparaat. Vol. 1. Utrecht/Antwerpen: Bohn, Scheltema & Holkema; 1984.
   Google Scholar
• Hartman L. Handbook of osteopathic technique. 3rd ed. Cheltenham: Stamley Thornes Ltd; 1997.
   Google Scholar
• Cleland J, Selleck B, Stowell T. Short-term effects of thoracic manipulation on lower trapezius muscle strength. J Man Manip Ther 2004;12:82–90.
   Google Scholar
• Cronk B. How to use SPSS: a step-by-step guide to analysis and interpretation. 2nd ed. Los Angeles, CA: Pyrczak Publishing; 2002.
   Google Scholar
• Portney L, Watkins M. Foundations of clinical research, application to practice. 2nd ed. Saddle River, NJ: Prentice-Hall; 2000.
   Google Scholar
• Ma Y-T, Ma M, Cho ZH. Biomedical acupuncture for pain management; an integrative approach. St Louis, MO: Elsevier Churchill Livingstone; 2005.
   Google Scholar
• Smith S, Vale W. The role of the hypothalamic-pituitaryadrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 2006;8:383–95.
   PubMedGoogle Scholar
• Merritt S, Keegan A, Mercer P. Artifact management in pupillometry. Nurs Res 1994;43:56–9.
   PubMed Web of Science ®Google Scholar
• Yang L, Niemann C, Larson M. Mechansim of pupillary reflex dilation in awake volunteers and in organ donors. Anesthesiology 2003;99:1281–6.
   PubMed Web of Science ®Google Scholar
• Ellermeier W, Westphal W. Gender differences in pain ratings and pupil reactions to painful pressure stimuli. Pain 1995;61:435–9.
   PubMed Web of Science ®Google Scholar
• Oka S, Chapman R, Kim B, Nahajima I, Shimizu O, Oi Y. Pupil dilation response to noxious stimulation: effect of varying nitrous oxide concentration. Clin Neurophysiol 2007;118:2016–24.
   PubMed Web of Science ®Google Scholar
• Wilson S, Amling J, Floyd S, McNair N. Determining interrater reliability of nurses’ assessments of pupillary size and reaction. J Neurosci Nurs 1988;20:189–92.
   PubMedGoogle Scholar
• Hreidarsson A. Pupil size in insulin-dependent diabetes: relationship to duration, metabolic control, and long-term manifestations. Diabetes 1982;31:442–8.
   PubMed Web of Science ®Google Scholar
• Loewenfeld I, Newsome D. Iris mechanics. I. Influance of pupil size on dynamics of pupillary movements. Am J Ophthalmol 1971;71:347–62.
   PubMed Web of Science ®Google Scholar
• Bakes A, Bradshaw M, Szabadi E. Attentuation of the pupillary light reflex in anxious patients. Br J Clin Pharmacol 1990;30:377–81.
   PubMed Web of Science ®Google Scholar
• Kawasaki A. Physiology, assessment, and disorders of the pupil. Curr Opin Opthalmol 1999;10:394–400.
   PubMedGoogle Scholar
• Driscoll M, Hall M. Effects of spinal manipulative therapy on autonomic activity and the cardiovascular system: a case study using the electrocardiogram and arterial tonometry. J Manipulative Physiol Ther 2000;23:545–50.
   PubMed Web of Science ®Google Scholar
• Rhudy J, Williams A, McCabe K, Thu M, Nguyen V, Rambo P. Affective modulation of nociception at spinal and supraspinal levels. Psychophysiology 2005;42:579–87.
   PubMed Web of Science ®Google Scholar
• Rhudy J, Williams A, McCabe K, Rambo P, Russell J. Emotional modulation of spinal nociception and pain: the impact of predictable noxious stimulation. Pain 2006;126:221–33.
   PubMed Web of Science ®Google Scholar
• Coutaux A, Adam F, Willer J, Le Bars D. Hyperalgesia and allodynia: peripheral mechanisms. Joint Bone Spine 2005;72:359–71.
   PubMed Web of Science ®Google Scholar
• Watkins L, Milligan E, Maier S. Spinal cord glia: new players in pain. Pain 2001;93:201–05.
   PubMed Web of Science ®Google Scholar
• Dung H, Chen S. Bipolar nature of pain. Taipei: Yi Hsien Publishing Co, ltd; 2008.
   Google Scholar
• Zusman M. Spinal manipulative therapy: review of some proposed mechanisms, and a new hypothesis. Australian J Physiother 1986;32:89–99.
   PubMedGoogle Scholar
• Dubner R, Ren K. Endogenous mechanisms of sensory modulation. Pain 1999; Suppl. 6:S45–53.
   Google Scholar
• Slater H, Vicenzino B, Wright A. “Sympathetic slump”: the effects of a noval manual therapy technique on peripheral sympatehtic nervous system function. J Man Manip Ther 1994;2:156–62.
   Google Scholar
• Skyba D, Radhakrishnan R, Rohlwing J, Wright A, Sluka K. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opiod or GABA receptors in the spinal cord. Pain 2003;106:159–68.
   PubMed Web of Science ®Google Scholar
• Vicenzino B, Cartwright T, Collins D, Wright A. Cardiovascular and respiratory changes produced by lateral glide mobilization of the cervical spine. Man Ther 1998;3:67–71.
   Google Scholar
• Vicenzino B, Collins D, Benson H, Wright A. An investigation of the interrelationship between manipulative-induced hypoalgesia and sympathoexcitation. J Manipulative Physiol Ther 1998;21:448–53.
   PubMed Web of Science ®Google Scholar
• Paungmali A, O’Leary S, Souvlis T, Vicenzino B. Hypoalgesic and sympathoexcitatory effects of mobilization with movement for lateral epicondylalgia. Phys Ther 2003;83:374–83.
   PubMed Web of Science ®Google Scholar
• Fernandez-De-Las-Penas C, Perez-De-Heredia M, Brea-Rivero M, Miangolarra-Page J. Immediate effects on pressure pain threshold following a single cervical spine manipulation in healthy subjects. J Orthop Sports Phys Ther 2007;37:325–9.
   PubMed Web of Science ®Google Scholar
• Taylor H, Murphy B. Altered Sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther 2008;31:116–25.
   Google Scholar
• Herzog W, Scheele D, Conway P. Electromyographic responses of back and limb muscles associated with spinal manipulative therapy. Spine 1999;24:146–53.
   PubMed Web of Science ®Google Scholar
• Haavik-Taylor H, Murphy B. Cervical spine manipulation alters sensorimotor integration: a somatosensory evoked potential study. Clin Neurophysiol 2007;118:391–402.
   PubMed Web of Science ®Google Scholar
• Millan M. Descending control of pain. Prog Neurobiol 2002;66:355–474.
   PubMed Web of Science ®Google Scholar