Advanced search
Publication Cover
Redox Report
Communications in Free Radical Research
Volume 6, 2001 - Issue 5
Submit an article Journal homepage
485
Views
66
CrossRef citations to date
0
Altmetric
Reviews

Regulatory roles of thioredoxin in oxidative stress-induced cellular responses

Y. NishinakaHuman Stress Signal Research Center National Institute of Advanced Industrial Science and Technology (AIST), Osaka , Japan
,
H. MasutaniDepartment of Biological Responses Institute for Virus Research, Kyoto University, Kyoto , Japan
,
H. NakamuraDepartment of Biological Responses Institute for Virus Research, Kyoto University, Kyoto , Japan
&
J. YodoiDepartment of Biological Responses Institute for Virus Research, Kyoto University, Kyoto , Japan
Pages 289-295 | Published online: 19 Jul 2013

  • Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 1999; 18: 6104–6111.
  • Holmgren A. Thioredoxin. Annu Rev Biochem 1985; 54: 237–271.
  • Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 1999; 31: 273–300.
  • Nakamura H, Nakamura K, Yodoi J. Redox regulation of cellular activation. Annu Rev Immunol 1997; 15: 351–369.
  • Packer L, Yodoi J. (eds) Redox Regulation of Cell Signaling and its Clinical Application. New York: Marcel Dekker, 1999.
  • Sen CK, Sies H, Baeuerle PA. Antioxidant and Redox Regulation of Genes. San Diego: Academic Press, 2000.
  • Laurent TC, Moore C, Rechard P. Enzymatic synthesis of deoxyribonucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia Coli B. J Biol Chem 1964; 239: 3436–3444.
  • Tagaya Y, Maeda Y, Mitsui A et al. ATL-derived factor (ADF),an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J 1989; 8: 757–764.
  • Wakasugi N, Tagaya Y, Wakasugi H et al. Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2. Proc Natl Acad Sci USA 1990; 87: 8282–8286.
  • Wollman EE, d'Auriol L, Rimsky L et al. Cloning and expression of a cDNA for human thioredoxin. J Biol Chem 1988; 263: 15506–15512.
  • Spyrou G, Enmark E, Miranda-Vizuete A, Gustafsson J-A. Cloning and expression of a novel mammalian thioredoxin. J Biol Chem 1997; 272: 2936–2941.
  • Lee KK, Murakawa M, Takahashi S et al. Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. J Biol Chem 1998; 273: 19160–19166.
  • Wells WW, Yang Y, Deits TL, Gan ZR. Thioltransferases. Adv Enzymol Relat Areas Mol Biol 1993; 66: 149–201.
  • Lundberg M, Johansson C, Chandra J et al. Cloning and expression of a novel human glutaredoxin(Grx2) with mitochondria' and nuclear isoforms. J Biol Chem 2001; 276: 26269–26275.
  • Kurooka H, Kato K, Minoguchi S et al. Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. Genomics 1997; 39: 331–339.
  • Matsuo Y, Akiyama N, Nakamura H, Yodoi J, Noda M, Kizaka-Kondoh S. Identification of a novel thioredoxin-related transmembrane protein. J Biol Chem 2001; 276: 10032–10038.
  • Edman JC, Ellis L, Blacher RW, Roth RA, Rutter WJ. Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Nature 1985; 317: 267–270.
  • Lundstrom-Ljung J, Birnbach U, Rupp K, Soling HD, Holmgren A. Two resident ER-proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase. FEBS Lett 1995; 357: 305–308.
  • Bennett CF, Balcarek JM, Varrichio A, Crooke ST. Molecular cloning and complete amino-acid sequence of form-I phosphoinositide-specific phospholipase C. Nature 1988; 334: 268–270.
  • Pedrajas JR, Kosmidou E, Miranda-Vizuete A, Gustafsson JA, Wright AP, Spyrou G. Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J Biol Chem 1999; 274: 6366–6373.
  • Miranda-Vizuete A, Damdimopoulos AE, Spyrou G. The mitochondria' thioredoxin system. Antioxid Redox Signal 2000; 2: 801–810.
  • Butterfield LH, Merino A, Golub SH, Shau H. From cytoprotection to tumor suppression: the multifunctorial role of peroxiredoxins. Antioxid Redox Signal 1999; 1: 385–402.
  • Bertini R, Howard OM, Dong HF et al. Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. J Exp Med 1999; 189: 1783–1789.
  • Schenk H, Vogt M, Droge W, Schulze-Osthoff K. Thioredoxin as a potent co-stimulus of cytokine expression. J Immunol 1996; 156: 765–771.
  • Nilsson J, Soderberg 0, Nilsson K, Rosen A. Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells. Blood 2000; 95: 1420–1426.
  • Matsuda M, Masutani H, Nakamura H et al. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells. J Immunol 1991; 147: 3837–3841.
  • Nakamura H, Matsuda M, Furuke K et al. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide. Immunol Lett 1994; 42: 75–80.
  • Sato N, Iwata S, Nakamura K, Hon T, Mori K, Yodoi J. Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis. J Immunol 1995; 154: 3194–3203.
  • Ueda S, Nakamura H, Masutani H et al. Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c. J Immunol 1998; 161: 6689–6695.
  • Takagi Y, Mitsui A, Nishiyama A et al. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci USA 1999; 96:4131–4136.
  • Takagi Y, Hattori I, Nozaki K et al. Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice. J Cereb Blood Flow Metab 2000; 20: 829–833.
  • Matsui M, Oshima M, Oshima H et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol 1996; 178: 179–185.
  • Hotta M, Tashiro F, Ikegami H et al. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 1998; 188: 1445–1451.
  • Okamoto T, Ogiwara H, Hayashi T, Mitsui A, Kawabe T, Yodoi J. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Ira Immunol 1992; 4: 811–819.
  • Arrigo AP. Gene expression and the thiol redox state. Free Radic Biol Med 1999; 27: 936–944.
  • Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Nall Acad Sci USA 1997; 94: 3633–3638.
  • Ueno M, Masutani H, Arai RJ et al. Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J Biol Chem 1999; 274: 35809–35815.
  • Makino Y, Okamoto K, Yoshikawa N et al. Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system. J Clin Invest 1996; 98: 2469–2477.
  • Hayashi S, Hajiro-Nakanishi K, Makino Y, Eguchi H, Yodoi J, Tanaka H. Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator. Nucleic Acids Res 1997; 25: 4035–4040.
  • Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res 1992; 20: 3821–3830.
  • Hirota K, Murata M, Sachi Y et al. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem 1999; 274: 27891–27897.
  • Nishiyama A, Matsui M, Iwata S et al. Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem 1999; 274: 21645–21650.
  • Junn E, Han SH, Im JY et al. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 2000; 164: 6287–6295.
  • Yamanaka H, Maehira F, Oshiro M et al. A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system. Biochem Biophys Res Commun 2000; 271: 796–800.
  • Chen KS, DeLuca HF. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta 1994; 1219: 26–32.
  • Saitoh M, Nishitoh H, Fujii M et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998; 17: 2596–2606.
  • Ichijo H. From receptors to stress-activated MAP kinases. Oncogene 1999; 18: 6087–6093.
  • Liu H, Nishitoh H, Ichijo H, Kyriakis JM. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol 2000; 20: 2198–2208.
  • Nishiyama A, Ohno T, Iwata S et al. Demonstration of the interaction of thioredoxin with p4Ophox, a phagocyte oxidase component, using a yeast two-hybrid system. Immunol Lett 1999; 68: 155–159.
  • Watson JA, Rumsby MG, Wolowacz RG. Phage display identifies thioredoxin and superoxide dismutase as novel protein kinase C-interacting proteins: thioredoxin inhibits protein kinase C-mediated phosphorylation of histone. Biochem J 1999; 343: 301–305.
  • Taniguchi Y, Taniguchi-Ueda Y, Mori K, Yodoi J. A novel promotor sequence is involved in the oxidative stress-induced expression of the adult T-cell leukemia derived factor (ADF)/human thioredoxin (Trx) gene. Nucleic Acid Res 1996; 24: 2746–2752.
  • Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J. Hemin-induced activation of the thioredoxin gene by Nrf2: a differential regulation of the antioxidant responsive element (ARE) by switch of its binding factors. J Biol Chem 2001; 276: 18399–18406.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.