Publication Cover
Redox Report
Communications in Free Radical Research
Volume 10, 2005 - Issue 6
659
Views
36
CrossRef citations to date
0
Altmetric
Research Articles

A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners

, , , , , , & show all
Pages 325-331 | Published online: 19 Jul 2013

References

  • Lee IM, Sesso HD, Oguma Y, Paffenbarger RS Jr. The ‘weekend wanior’ and risk of mortality. Am J Epidemiol 2004; 160: 636–641.
  • Nieman DC, Pedersen BK. Exercise and immune function - recent developments. Sports Med 1999; 27: 73–80.
  • Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991; 325: 147–152.
  • Lee IM, Paffenbarger Jr RS, Hsieh C. Physical activity and risk of developing colorectal cancer among college alumni. J Natl Cancer Inst 1991; 83: 1324–1329.
  • Paffenbarger Jr RS, Hyde RT, Wing AL, Lee IM, Jung DL, Kampen JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993; 328: 538–545.
  • US Department of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta; GA (1996) National Center for Chronic Disease Prevention and Health Promotion, US Department of Health and Human Services, 1996.
  • Leeuwenburgh C, Heinecke JW. Oxidative stress and antioxidants in exercise. Curr Med Chem 2001; 8: 829–838.
  • Leeuwenburgh C, Hollander J, Leichtweis S, Griffiths M, Gore M, Ji LL. Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am J Physiol 1997; 272: R363–R369.
  • Powers SK, Criswell D, Lawler J et al. Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium. Am J Physiol 1993; 265: H2094–H2098.
  • Venditti P, Masullo P, Di Meo S. Effect of training on H(2)0(2) release by mitochondria from rat skeletal muscle. Arch Biochem Biophys 1999; 372: 315–320.
  • Chevion S, Moran DS, Heled Yet al. Plasma antioxidant status and cell injury after severe physical exercise. Proc Natl Acad Sci USA 2003; 100: 5119–5123.
  • Hartmann A, Pfuhler S, Dennog C, Germadnik D, Pilger A, Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2'-deoxyguanosine or induction of micronuclei. Free Radic Biol Med 1998; 24: 245–251.
  • Gleeson M, Nieman DC, Pedersen BK. Exercise, nutrition and immune function. J Sports Sci 2004; 22: 115–125.
  • Billat VL, Hill DW, Pinoteau J, Petit B, Koralsztein JP. Effect of protocol on determination of velocity at V02 max and on its time to exhaustion. Arch Physiol Biochem 1996; 104: 313–321.
  • Briviba K, Kulling SE, Moseneder J, Watzl B, Rechkemmer G, Bub A. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy nonsmokers and smokers. Carcinogen esis 2004; 25: 2373–2378.
  • Bub A, Watzl B, Abrahamse SL et al. Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. J Nutr 2000; 130: 2200–2206.
  • Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the FRAP assay. Anal Biochem 1996; 239: 70–76.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999; 26: 1231–1237.
  • Cao G, Prior RL. Measurement of oxygen radical absorbance capacity in biological samples. Methods Enzymol 1999; 299: 50–62.
  • Watzl B, Bub A, Blockhaus M et al. Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. J Nutr 2000; 130: 1719–1723.
  • Roller M, Rechkemmer, G, Watzl B. Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats. J Nutr 2004; 134: 153–156.
  • Watzl B, Bub A, Pretzer G, Roser S, Barth S, Rechkemmer G. Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men. Eur J Clin Nutr 2004; 58: 40–45.
  • Mastaloudis A, Yu TW, O'Donnell RP, Frei B, Dashwood RH, Traber MG. Endurance exercise results in DNA damage as detected by the comet assay. Free Radic Biol Med 2004; 36: 966–975.
  • Tsai K, Hsu TG, Hsu KM et al. Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise. Free Radic Biol Med 2001; 31: 1465–1472.
  • Mastaloudis A, Morrow JD, Hopkins DW, Devaraj S, Traber MG. Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med 2004; 36: 1329–1341.
  • Gey KF. Cardiovascular disease and vitamins. Concurrent correction of ‘suboptimal’ plasma antioxidant levels may, as important part of ‘optimal’ nutrition, help to prevent early stages of cardiovascular disease and cancer, respectively. Bibl Nutr Dieta 1995; 52: 75–91.
  • Liu ML, Bergholm R, Makimattila S et al. A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. Am J Physiol 1999; 276: E1083–E1091.
  • Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. Br J Sports Med 2000; 34: 246–251.
  • Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR et al. Effects of mode and carbohydrate on the granulocyte and monocyte response to intensive, prolonged exercise. J Appl Physiol 1998; 84: 1252–1259.
  • Suzuki K, Nakaji S, Yamada M et al. Impact of competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 2003; 35: 348–355.
  • Yamada M, Suzuki K, Kudo S et al. Effect of exhaustive exercise on human neutrophils in athletes. Luminescence 2000; 15: 15–20.
  • Niess AM, Baumann M, Roecker K, Horstmann T, Mayer F, Dickhuth HU. Effects of endurance exercise on DNA damage in leucocytes. J Sports Med Phys Fitness 1998; 38: 111–115.
  • Mooren FC, Bloming D, Lechtermann A, Lerch MM, Volker K. Lymphocyte apoptosis after exhaustive and moderate exercise. J Appl Physiol 2002; 93: 147–153.
  • Nieman DC, Henson DA, McAnulty SR et al. Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol 2002; 92: 1970–1977.
  • Steensberg A, Toft AD, Bruunsgaard H, Sandmand M, Halkjaer-Kristensen J, Pedersen BK. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol 2001; 91: 1708–1712.
  • Baum M, Muller-Steinhardt M, Liesen H, Kirchner H. Moderate and exhaustive endurance exercise influences the interferon-gamma levels in whole-blood culture supernatants. Eur J Appl Physiol Occup Physiol 1997; 76: 165–169.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.