Publication Cover
Redox Report
Communications in Free Radical Research
Volume 14, 2009 - Issue 1
346
Views
26
CrossRef citations to date
0
Altmetric
Research articles

N-Acetyl cysteine restores viability and function of rat odontoblast-like cells impaired by polymethylmethacrylate dental resin extract

, , , , &
Pages 13-22 | Published online: 19 Jul 2013

References

  • Furuya K. [Electron microscopic study of canine dentin and odontoblast following the insertion of various composite resin monomers]. Fukuoka Shika Daigaku Gakkai Zasshi 1989; 16: 572–599.
  • Schweikl H, Spagnuolo G, Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res 2006; 85: 870–877.
  • Cavalcanti BN, Rode SM, Marques MM. Cytotoxicity of substances leached or dissolved from pulp capping materials. Int Endodont J 2005; 38: 505–509.
  • Annunziata M, Aversa R, Apicella A et al. In vitro biological response to a light-cured composite when used for cementation of composite inlays. Dent Mater 2006; 22: 1081–1085.
  • Paranjpe A, Cacalano NA, Hume WR, Jewett A. N-Acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells. Free Radic Biol Med 2007; 43: 1394–1408.
  • Eropkina EM, Mamaeva EG, Eropkin M. [Effect of the bone cement on human fibroblast culture and possible ways of its correction by cytoprotector preparations]. Eksp Klin Farmakol 2003; 66: 48–52.
  • Ciapetti G, Granchi D, Savarino L et al. In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells. Biomaterials 2002; 23: 617–627.
  • Vale FM, Castro M, Monteiro J et al. Acrylic bone cement induces the production of free radicals by cultured human fibroblasts. Biomaterials 1997; 18: 1133–1135.
  • Yamada M, Kojima N, Paranjpe A et al. N-Acetyl cysteine (NAC)-assisted detoxification of PMMA resin. J Dent Res 2008; 87: 372–377.
  • Lean JM, Davies JT, Fuller K et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 2003; 112: 915–923.
  • Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983; 52: 711–760.
  • Gillissen A, Bartling A, Schoen S, Schultze-Werninghaus G. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 1997; 175: 235–242.
  • Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in antioxidant therapy. Respir Med 1998; 92: 609–623.
  • Nakamura H, Saruwatari L, Aita H, Takeuchi K, Ogawa T. Molecular and biomechanical characterization of mineralized tissue by dental pulp cells on titanium. J Dent Res 2005; 84: 515–520.
  • Hague T, Uludag H, Zemicke RF, Winn SR, Sebald W. Bone marrow cells from normal and ovariectomized rats respond differently to basic fibroblast growth factor and bone morphogenetic protein 2 treatment in vitro. Tissue Eng 2005; 11: 634–644.
  • Yamamura T. Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J Dent Res 1985; 64 ( Special): 530-540.
  • Sloan AJ, Smith AJ. Stem cells and the dental pulp: potential roles in dentine regeneration and repair. Oral Dis 2007; 13: 151–157.
  • About I, Bottero MJ, de Denato P, Camps J, Franquin JC, Mitsiadis TA. Human dentin production in vitro. Exp Cell Res 2000; 258: 33–41.
  • Gronthos S, Brahim J, Li W et al. Stem cell properties of human dental pulp stem cells. J Dent Res 2002; 81: 531–535.
  • Liu J, Jin T, Ritchie HH, Smith AJ, Clarkson BH. In vitro differentiation and mineralization of human dental pulp cells induced by dentin extract. In Vitro Cell Dev Biol Anim 2005; 41: 232–238.
  • Yokose S, Kadokura H, Tajima Y et al. Establishment and characterization of a culture system for enzymatically released rat dental pulp cells. Cakif Tissue Int 2000; 66: 139–144.
  • Ciapetti G, Granchi D, Cenni E, Savarino L, Cavedagna D, Pizzoferrato A. Cytotoxic effect of bone cements in HL60 cells: distinction between apoptosis and necrosis. J Biomed Mater Res 2000; 52: 338–345.
  • Droge W Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47–95.
  • Spagnuolo G, Galler K, Schmalz G, Cosentino C, Rengo S, Schweikl H. Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells. J Dent Res 2004; 83: 703–707.
  • Achanta G, Huang P. Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents. Cancer Res 2004; 64: 6233–6239.
  • Besaratinia A, Pfeifer GP. DNA adduction and mutagenic properties of acrylamide. Mutat Res 2005; 580: 31–40.
  • Kleinsasser NH, Schmid K, Sassen AW et al. Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 2006; 27: 1762–1770.
  • Kleinsasser NH, Wallner BC, Harreus UA et al. Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. J Dent 2004; 32: 229–234.
  • Yoshii E. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. J Biomed Mater Res 1997; 37: 517–524.
  • Spagnuolo G, Mauro C, Leonardi A et al. NF-kappaB protection against apoptosis induced by HEMA. J Dent Res 2004; 83: 837–842.
  • Stanislawski L, Lefeuvre M, Bourd K, Soheili-Majd E, Goldberg M, Perianin A. TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. J Biomed Mater Res A 2003; 66: 476–42.
  • Lee DH, Lim BS, Lee YK, Ahn SJ, Yang HC. Involvement of oxidative stress in mutagenicity and apoptosis caused by dental resin monomers in cell cultures. Dent Mater 2006; 22: 1086–1092.
  • Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60: 6–20.
  • Haddad JJ. Oxygen sensing and oxidant/redox-related pathways. Biochem Biophys Res Commun 2004; 316: 969–977.
  • Wagner EE Functions of AP (Fos/Jun) in bone development. Ann Rheum Dis 2002; 61 (Suppl 2): ii40-ii42.
  • Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221–227.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.