REFERENCES
- Nielsen OH, Munck LK. Drug insight: aminosalicylates for the treatment of IBD. Nat Clin Pract Gastroenterol Hepatol 2007; 4: 160–170.
- Nikfar S, Rahimi R, Rezaie A, Abdollahi M. A meta-analysis of the efficacy of sulfasalazine in comparison with 5-aminosalicylates in the induction of improvement and maintenance of remission in patients with ulcerative colitis. Dig Dis Sci 2009; 54: 1157–1170.
- Plosker GL, Croom KF. Sulfasalazine: a review of its use in the management of rheumatoid arthritis. Drugs 2005; 65: 1825–1849.
- Donahue KE, Gartlehner G, Jonas DE et al. Systematic review: comparative effectiveness and harms of disease-modifying medications for rheumatoid arthritis. Ann Intern Med 2008; 148: 124–134.
- Reed MR, Taylor AL. Tumour necrosis factor inhibitors in ankylosing spondylitis. Intern Med J2009; 38: 781-789.
- Stenson WF, Lobos E. Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils. J C1M Invest 1982; 69: 49–47.
- Hawkey CJ, Truelove SC. Inhibition of prostaglandin synthetase in human rectal mucosa. Gut 1983; 24: 213–217.
- Lauritsen K, Laursen LS, Bukhave K, Rask-Madsen J. Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levelsdetermined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 1986; 91: 837–844.
- Barrera P, Boerbooms AM, van der Putte LB, van der Meer JW. Effects of antirheumatic agents on cytokines. Semin Arthritis Rheum 1996; 25: 234–253.
- Hirohata S, Ohshima N, Yanagida T, Aramaki K. Regulation of human B cell function by sulfasalazine and its metabolites. Int Immunopharmacol 2001; 2: 631–640.
- Shanahan F, Niederlehner A, Carramanzana N, Anton P. Sulfasalazine inhibits the binding of TNF alpha to its receptor. Immunopharmacology 1990; 20: 217–224.
- Egan LJ, Mays DC, Huntoon CJ et al. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem 1999; 274: 26448–26453.
- Bantel H, Berg C, Vieth M, Stolte M, Kruis W, Schulze-Osthoff K. Mesalazine inhibits activation of transcription factor NF-03 in inflamed mucosa of patients with ulcerative colitis. Am J Gastroenterol 2000; 95: 3452–3457.
- Burress GC, Musch MW, Jurivich DA, Welk J, Chang EB. Effects of mesalamine on the hsp72 stress response in rat IEC-18 intestinal epithelial cells. Gastroenterology 1997; 113: 1474–1479.
- Ahnfelt-Ronne I, Nielson OH, Christensen A, Langholz E, Binder V, Riis P. Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid. Gastroenterology 1990; 98: 1162–1169.
- Desreumaux P, Ghosh S. Review article: mode of action and delivery of 5-aminosalicylic acid-new evidence. Aliment Pharmacol Ther 2006; 241: S2–S9.
- Dallegri F, Ottonello L, Ballestrero A, Bogliolo F, Ferrando F, Patrone F. Cytoprotection against neutrophil derived hypochlorous acid: a potential mechanism for the therapeutic action of 5-aminosalicylic acid in ulcerative colitis. Gut 1990; 31: 184–186.
- Prakash A, Markham A. Oral delayed-release mesalazine: a review of its use in ulcerative colitis and Crohn's disease. Drugs 1999; 57: 383–408.
- Sandoval M, Liu X, Mannick EE, Clark DA, Miller MJ. Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine. Gastroenterology 1997; 113: 1480–1488.
- Craven PA, Pfansteil J, Saito R, DeRubertis FR. Actions of sulfasalazine and 5-aminosalicylic acid reactive oxygen scavengers in the suppression of bile acid-induced increases in colonic epithelial cell loss and proliferative activity. Gastroenterology 1987; 92: 1998–2008.
- Kvietys PR, Morgan-Smith S, Grisham MB, Manci EA. 5-Aminosalicylic acid protects against ischemia/reperfusion-induced gastric bleeding in the rat. Gastroenterology 1988; 94: 733–738.
- Del Soldato P, Campieri M, Brignola C et al. A possible mechanism of action of sulfasalazine and 5-aminosalicylic acid in inflammatory bowel diseases: interaction with oxygen free radicals. Gastroenterology 1985; 189: 1215–1216.
- Ahnfelt-Ronne I, Nielson OH. The anti-inflammatory moiety of sulfasalasine, 5-aminosalacilic acid, is radical scavenger. Agents Actions 1987; 21: 191–194.
- Ahnfelt-Ronne I, Nielson OH, Bukhave K, Elmgreen J. Sulfasalazine and its anti-inflammatory metabolite 5-aminosalicylic acid: effect arachidonic acid metabolism in human neutrophils, and free radical scavenging. Adv Prostaglandin Thromboxane Leukotriene Res 1987; 17B: 918–922.
- Aruoma OI, Wasil M, Halliwell B, Hoey MB, Butler J. The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? Biochem Pharmacol 1987; 36: 3739–3742.
- Kanerud L, Hafstrom I, Ringertz B. Effect of sulphasalazine and sulphapyridine on neutrophil superoxide production: role of cytosolic free calcium. Ann Rheum Dis 1990; 49: 296–300.
- Neal TM, Winterbourn CC, Vissers MCM. Inhibition of neutrophil degranulation and superoxide production by sulfasalazine. Biochem Pharmacol 1987; 36: 2765–2768.
- Joshi R, Kumar S, Unnikrishnan M, Mukherjee T. Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity. Free Radic Res 2005; 39: 1163–1172.
- Fernandes E, Toste SA, Lima JLFC, Reis S. The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species. Free Radic Rio! Med 2003; 35: 1008–1017.
- Fernandes E, Costa D, Toste SA, Lima JLFC, Reis S. In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs. Free Radic Rio! Med 2004; 37: 1895–1905.
- Costa D, Gomes A, Reis S, Lima JLFC, Fernandes E. Hydrogen peroxide scavenging activity by non-steroidal anti-inflammatory drugs. Life Sci 2005; 76 :2841–2848.
- Costa D, Vieira A, Fernandes E. Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species. Redox Rep 2006; 11: 136–142.
- Costa D, Moutinho L, Lima JLFC, Fernandes E. Antioxidant activity and inhibition of human neutrophil oxidative burst mediated by arylpropionic acid non-steroidal anti-inflammatory drugs. Biol Pharm Bull 2006; 29: 1659–1670.
- Costa D, Gomes A, Lima JLFC, Fernandes E. Singlet oxygen scavenging activity by non-steroidal anti-inflammatory drugs. Redox Rep 2008; 13: 153–160.
- Gomes A, Fernandes E, Silva AM et al. 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species. Bioorg Med Chem 2007; 15: 6027–6036.
- Whiteman M, Ketsawatsakul U, Halliwell B. A reassessment of the peroxynitrite scavenging activity of uric acid. Ann NY Acad Sci 2002; 962: 242–259.
- Kettle AJ, Winterbourn CC. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol 1991; 41: 1485–1492.
- Winterbourn CC, Vissers MC, Kettle AJ. Myeloperoxidase. Curr Opin Hematol 2000; 7: 53–58.
- Liu ZC, McClelland RA, Uetrecht JP. Oxidation of 5-aminosalicylic acid by hypochlorous acid to a reactive iminoquinone. Possible role in the treatment of inflammatory bowel diseases. Drug Metab Dispos 1995; 23: 246–250.
- Steinbeck MJ, Khan AU, Kamovsky MJ. Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap. J Biol Chem 1992; 267: 13425–13433.
- Molin L, Stendahl O. The effect of sulfasalazine and its active components on human polymorphonuclear leukocyte function in relation to ulcerative colitis. Acta Med Scand 1979; 206: 451–457.
- Stenson WF, Mehta J, Spilberg I. Sulfasalazine inhibition of binding of N-formyl-methionyl-leucyl-phenylalanine (fMLP) to its receptor on human neutrophils. Biochem Pharmacol 1984; 33: 407–412.
- Miyachi Y, Yoshioka A, Imamura S, Niwa Y. Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species. Gut 1987; 28: 190–195.
- Radi R, Cosgrove TP, Beckman JS, Freeman BA. Peroxynitrite-induced luminol chemiluminescence. Biochem J1993; 290: 51-57.
- Denicola A, Freeman BA, Trujillo M, Radi R. Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations. Arch Biochem Biophys 1996; 333: 49–58.
- Squadrito GL, Pryor WA. Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic Biol Med 1998; 25: 392–403.