Publication Cover
Redox Report
Communications in Free Radical Research
Volume 17, 2012 - Issue 6
469
Views
3
CrossRef citations to date
0
Altmetric
Research articles

Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase

, , , &
Pages 239-245 | Published online: 19 Jul 2013

References

  • Fridovich I. Superoxide dismutases. Annu Rev Biochem. 1975;44:147–59. Epub 1975/01/01.
  • Fukai T, Ushio-Fukai M. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 2011;15(6):1583–606. Epub 2011/04/09.
  • Gao F, Kinnula VL, Myllarniemi M, Oury TD. Extracellular superoxide dismutase in pulmonary fibrosis. Antioxid Redox Signal 2008;10(2):343–54. Epub 2007/11/15.
  • Kliment CR, Tobolewski JM, Manni ML, Tan RJ, Enghild J, Oury TD. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxid Redox Signal 2008;10(2):261–8. Epub 2007/10/27.
  • Teoh ML, Fitzgerald MP, Oberley LW, Domann FE. Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion. Cancer Res 2009;69(15):6355–63. Epub 2009/07/16.
  • Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci USA 2010;107(35):15571–6. Epub 2010/08/18.
  • Nozik-Grayck E, Suliman HB, Piantadosi CA. Extracellular superoxide dismutase. Int J Biochem Cell Biol 2005;37(12):2466–71. Epub 2005/08/10.
  • Arcaroli JJ, Hokanson JE, Abraham E, Geraci M, Murphy JR, Bowler RP, et al. Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med 2009;179(2):105–12. Epub 2008/10/25.
  • Break TJ, Jun S, Indramohan M, Carr KD, Sieve AN, Dory L, et al. Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection. J Immunol 2012;188(7):3342–50. Epub 2012/03/07.
  • Iida S, Chu Y, Weiss RM, Kang YM, Faraci FM, Heistad DD. Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Am J Physiol Heart Circ Physiol 2006;291(2):H914–20. Epub 2006/07/15.
  • Tamai M, Furuta H, Kawashima H, Doi A, Hamanishi T, Shimomura H, et al. Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes. Diabetes Res Clin Pract 2006;71(2):140–5. Epub 2005/07/02.
  • Teoh ML, Sun W, Smith BJ, Oberley LW, Cullen JJ. Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res 2007;13(24):7441–50. Epub 2007/12/21.
  • Adachi T, Kodera T, Ohta H, Hayashi K, Hirano K. The heparin binding site of human extracellular-superoxide dismutase. Arch Biochem Biophys 1992;297(1):155–61. Epub 1992/08/15.
  • Chu Y, Piper R, Richardson S, Watanabe Y, Patel P, Heistad DD. Endocytosis of extracellular superoxide dismutase into endothelial cells: role of the heparin-binding domain. Arterioscler Thromb Vasc Biol 2006;26(9):1985–90. Epub 2006/07/01.
  • Bernfield M, Gotte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 1999;68:729–77. Epub 2000/06/29.
  • Capila I, Linhardt RJ. Heparin-protein interactions. Angew Chem Int Ed Engl 2002;41(3):391–412. Epub 2002/12/20.
  • Jeon B, Kim BH, Lee YS, Kim S, Yoon JB, Kim TY. Inactive extracellular superoxide dismutase disrupts secretion and function of active extracellular superoxide dismutase. BMB Rep 2011;44(1):40–5. Epub 2011/01/27.
  • Chu Y, Alwahdani A, Iida S, Lund DD, Faraci FM, Heistad DD. Vascular effects of the human extracellular superoxide dismutase R213G variant. Circulation 2005;112(7):1047–53. Epub 2005/08/10.
  • Sorheim IC, DeMeo DL, Washko G, Litonjua A, Sparrow D, Bowler R, et al. Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD 2010;7(4):262–8. Epub 2010/08/03.
  • Reikofski J, Tao BY. Polymerase chain reaction (PCR) techniques for site-directed mutagenesis. Biotechnol Adv 1992;10(4):535–47. Epub 1992/01/01.
  • Oury TD, Chang LY, Marklund SL, Day BJ, Crapo JD. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Investig 1994;70(6):889–98. Epub 1994/06/01.
  • Ukeda H, Shimamura T, Tsubouchi M, Harada Y, Nakai Y, Sawamura M. Spectrophotometric assay of superoxide anion formed in Maillard reaction based on highly water-soluble tetrazolium salt. Anal Sci 2002;18(10):1151–4. Epub 2002/10/29.
  • Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW, Domann FE. Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Mol Cancer Res 2012;10(1):40–51. Epub 2011/11/09.
  • Antonyuk SV, Strange RW, Marklund SL, Hasnain SS. The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding. J Mol Biol 2009;388(2):310–26. Epub 2009/03/18.
  • Ohta H, Adachi T, Hirano K. Internalization of human extracellular-superoxide dismutase by bovine aortic endothelial cells. Free Radic Biol Med 1994;16(4):501–7. Epub 1994/04/01.
  • Fukai T, Folz RJ, Landmesser U, Harrison DG. Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc Res 2002;55(2):239–49. Epub 2002/07/19.
  • Jeney V, Itoh S, Wendt M, Gradek Q, Ushio-Fukai M, Harrison DG, et al. Role of antioxidant-1 in extracellular superoxide dismutase function and expression. Circ Res 2005;96(7):723–9. Epub 2005/03/12.
  • Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Thogersen IB, et al. Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. J Biol Chem 2004;279(14):13705–10. Epub 2004/01/23.
  • Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M, et al. Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function. Hypertension 2008;52(5):945–51. Epub 2008/09/05.
  • Qin Z, Itoh S, Jeney V, Ushio-Fukai M, Fukai T. Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress. FASEB J 2006;20(2):334–6. Epub 2005/12/24.
  • McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244(22):6049–55.
  • Posas F, Saito H. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 1997;276(5319):1702–5. Epub 1997/06/13.
  • Chen N, Rinner O, Czernik D, Nytko KJ, Zheng D, Stiehl DP, et al. The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase. Cell Res 2011;21(6):983–6. Epub 2011/04/13.
  • Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011;145(5):732–44. Epub 2011/05/31.
  • Rauch J, Volinsky N, Romano D, Kolch W. The secret life of kinases: functions beyond catalysis. Cell Commun Signal 2011;9(1):23–0. Epub 2011/11/01.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.