Oxidative stress and potential applications of free radical scavengers in glaucoma

References

• Tuulonen A, Airaksinen PJ, Erola E, Forsman E, Friberg K, Kaila M, et al. The Finnish evidence-based guideline for open-angle glaucoma. Acta Ophthalmol Scand 2003;81:3–18.
   PubMedGoogle Scholar
• Prokofyeva E, Zrenner E. Epidemiology of major eye diseases leading to blindness in Europe: a literature review. Ophthalmic Res 2012;47:171–88.
   PubMed Web of Science ®Google Scholar
• Aslan M, Cort A, Yucel I. Oxidative and nitrative stress markers in glaucoma. Free Radic Biol Med 2008;45:367–76.
   PubMed Web of Science ®Google Scholar
• Fechtner RD, Weinreb RN. Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol 1994;39:23–42.
   PubMed Web of Science ®Google Scholar
• Yan DB, Coloma FM, Metheetrairut A, Trope GE, Heathcote JG, Ethier CR. Deformation of the lamina cribrosa by elevated intraocular pressure. Br J Ophthalmol 1994;78:643–8.
   PubMed Web of Science ®Google Scholar
• Parisot TJ, Wood EM. A comparative study of the causative agent of a mycobacterial disease of salmonoid fishes. 2. A description of the histopathology of the disease in Chinook salmon (Oncorhynchus tshawytscha) and a comparison of the staining characteristics of the fish disease with leprosy and human tuberculosis. Am Rev Respir Dis 1960;82:212–22.
   PubMed Web of Science ®Google Scholar
• Danesh-Meyer HV, Levin LA. Neuroprotection: extrapolating from neurologic diseases to the eye. Am J Ophthalmol 2009;148:186–91.
   PubMed Web of Science ®Google Scholar
• Yan DB, Coloma FM, Metheetrairut A, Trope GE, Heathcote JG, Ethier CR. Deformation of the lamina cribrosa by elevated intraocular pressure. Br J Ophthalmol. 1994;78:643–8.
   PubMed Web of Science ®Google Scholar
• Greenfield DS. Glaucomatous versus nonglaucomatous optic disc cupping: clinical differentiation. Semin Ophthalmol 1999;14:95–108.
   PubMedGoogle Scholar
• Jonas JB, Budde WM, Lang P. Neuroretinal rim width ratios in morphological glaucoma diagnosis. Br J Ophthalmol 1998;82:1366–71.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Kitazawa Y. Vascular pathogenesis of normal-tension glaucoma: a possible pathogenetic factor, other than intraocular pressure, of glaucomatous optic neuropathy. Prog Retin Eye Res 1998;17:127–43.
   PubMed Web of Science ®Google Scholar
• Flammer J. The vascular concept of glaucoma. Surv Ophthalmol 1994;38(Suppl.):S3–6.
   PubMedGoogle Scholar
• Sacca SC, Izzotti A, Rossi P, Traverso C. Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007;84:389–99.
   PubMed Web of Science ®Google Scholar
• Tezel G. The immune response in glaucoma: a perspective on the roles of oxidative stress. Exp Eye Res 2011;93:178–86.
   PubMed Web of Science ®Google Scholar
• Sacca SC, Pascotto A, Camicione P, Capris P, Izzotti A. Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma. Arch Ophthalmol 2005;123:458–63.
   PubMed Web of Science ®Google Scholar
• Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir MK, Warholm M, et al. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci USA 1985;82:7202–6.
   PubMed Web of Science ®Google Scholar
• Izzotti A. DNA damage and alterations of gene expression in chronic-degenerative diseases. Acta Biochim Pol 2003;50:145–54.
   PubMed Web of Science ®Google Scholar
• Yagci R, Gurel A, Ersoz I, Keskin UC, Hepsen IF, Duman S, et al. Oxidative stress and protein oxidation in pseudoexfoliation syndrome. Curr Eye Res 2006;31:1029–32.
   PubMed Web of Science ®Google Scholar
• Tezel G, Yang X, Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci 2005;46:3177–87.
   PubMed Web of Science ®Google Scholar
• Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet 1988;22:631–77.
   PubMed Web of Science ®Google Scholar
• Caprioli J, Kitano S, Morgan JE. Hyperthermia and hypoxia increase tolerance of retinal ganglion cells to anoxia and excitotoxicity. Invest Ophthalmol Vis Sci 1996;37:2376–81.
   PubMed Web of Science ®Google Scholar
• Caprioli J, Ishii Y, Kwong JM. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Trans Am Ophthalmol Soc 2003;101:39–50; discussion 50–1.
   PubMedGoogle Scholar
• Albrecht J, Sonnewald U, Waagepetersen HS, Schousboe A. Glutamine in the central nervous system: function and dysfunction. Front Biosci 2007;12:332–43.
   PubMed Web of Science ®Google Scholar
• Linser PJ, Sorrentino M, Moscona AA. Cellular compartmentalization of carbonic anhydrase-C and glutamine synthetase in developing and mature mouse neural retina. Brain Res 1984;315:65–71.
   PubMedGoogle Scholar
• Babizhayev MA, Bunin A. Lipid peroxidation in open-angle glaucoma. Acta Ophthalmol 1989;67:371–7.
   Google Scholar
• Gartaganis SP, Patsoukis NE, Nikolopoulos DK, Georgiou CD. Evidence for oxidative stress in lens epithelial cells in pseudoexfoliation syndrome. Eye 2007;21:1406–11.
   Google Scholar
• Yucel I, Akar Y, Yucel G, Ciftcioglu MA, Keles N, Aslan M. Effect of hypercholesterolemia on inducible nitric oxide synthase expression in a rat model of elevated intraocular pressure. Vision Res 2005;45:1107–14.
   PubMed Web of Science ®Google Scholar
• Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 1997;17:5089–100.
   PubMed Web of Science ®Google Scholar
• Malone PE, Hernandez MR. 4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. Exp Eye Res 2007;84:444–54.
   PubMed Web of Science ®Google Scholar
• Fridovich I. Superoxide dismutases. Adv Enzymol Relat Areas Mol Biol 1986;58:61–97.
   PubMedGoogle Scholar
• Costarides AP, Riley MV, Green K. Roles of catalase and the glutathione redox cycle in the regulation of anterior-chamber hydrogen peroxide. Ophthalmic Res 1991;23:284–94.
   PubMed Web of Science ®Google Scholar
• De La Paz MA, Epstein DL. Effect of age on superoxide dismutase activity of human trabecular meshwork. Invest Ophthalmol Vis Sci 1996;37:1849–53.
   PubMed Web of Science ®Google Scholar
• Riley MV. Physiologic neutralization mechanisms and the response of the corneal endothelium to hydrogen peroxide. CLAO J 1990;16:S16–21; discussion S21–2.
   PubMedGoogle Scholar
• Zoric L, Miric D, Milenkovic S, Jovanovic P, Trajkovic G. Pseudoexfoliation syndrome and its antioxidative protection deficiency as risk factors for age-related cataract. Eur J Ophthalmol 2006;16:268–73.
   PubMed Web of Science ®Google Scholar
• Richer SP, Rose RC. Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide. Vision Res 1998;38:2881–8.
   PubMed Web of Science ®Google Scholar
• Koliakos GG, Konstas AG, Schlotzer-Schrehardt U, Hollo G, Katsimbris IE, Georgiadis N, et al. 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol 2003;87:353–6.
   PubMed Web of Science ®Google Scholar
• May JM. Is ascorbic acid an antioxidant for the plasma membrane? FASEB J 1999;13:995–1006.
   PubMed Web of Science ®Google Scholar
• Asregadoo ER. Blood levels of thiamine and ascorbic acid in chronic open-angle glaucoma. Ann Ophthalmol 1979;11:1095–100.
   PubMedGoogle Scholar
• Gherghel D, Griffiths HR, Hilton EJ, Cunliffe IA, Hosking SL. Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2005;46:877–83.
   PubMed Web of Science ®Google Scholar
• Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM, et al. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radic Biol Med 2004;37:1152–9.
   PubMed Web of Science ®Google Scholar
• Moreno MC, Campanelli J, Sande P, Sanez DA, Keller Sarmiento MI, Rosenstein RE. Retinal oxidative stress induced by high intraocular pressure. Free Radic Biol Med 2004;37:803–12.
   PubMed Web of Science ®Google Scholar
• Yucel YH, Zhang Q, Weinreb RN, Kaufman PL, Gupta N. Atrophy of relay neurons in magno- and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci 2001;42:3216–22.
   PubMed Web of Science ®Google Scholar
• Xu X, Ichida JM, Allison JD, Boyd JD, Bonds AB, Casagrande VA. A comparison of koniocellular, magnocellular and parvocellular receptive field properties in the lateral geniculate nucleus of the owl monkey (Aotus trivirgatus). J Physiol 2001;531:203–18.
   PubMed Web of Science ®Google Scholar
• Zhao B, Ranguelova K, Jiang J, Mason RP. Studies on the photosensitized reduction of resorufin and implications for the detection of oxidative stress with Amplex Red. Free Radic Biol Med 2011;51:153–9.
   PubMed Web of Science ®Google Scholar
• Wood JP, Lascaratos G, Bron AJ, Osborne NN. The influence of visible light exposure on cultured RGC-5 cells. Mol Vis. 2007;14:334–44.
   Web of Science ®Google Scholar
• Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci 1994;14:4368–74.
   PubMed Web of Science ®Google Scholar
• Kerrigan LA, Zack DJ, Quigley HA, Smith SD, Pease ME. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol 1997;115(8):1031–5.
   PubMedGoogle Scholar
• Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. The molecular basis of retinal ganglion cell death in glaucoma. Prog Retin Eye Res 2012;31:152–81.
   PubMed Web of Science ®Google Scholar
• Kanamori A, Catrinescu MM, Kanamori N, Mears KA, Beaubien R, Levin LA. Superoxide is an associated signal for apoptosis in axonal injury. Brain 2010;133:2612–25.
   PubMed Web of Science ®Google Scholar
• Higgins GC, Devenish RJ, Beart PM, Nagley P. Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death. Free Radic Biol Med 2012;53:1960–7.
   PubMed Web of Science ®Google Scholar
• Springer JE, Azbill RD, Mark RJ, Begley JG, Waeg G, Mattson MP. 4-Hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake. J Neurochem 1997;68:2469–76.
   PubMed Web of Science ®Google Scholar
• Aslan M, Yucel I, Akar Y, Yucel G, Ciftcioglu MA, Sanlioglu S. Nitrotyrosine formation and apoptosis in rat models of ocular injury. Free Radic Res 2006;40:147–53.
   PubMed Web of Science ®Google Scholar
• Liu B, Neufeld AH. Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head. Glia 2000;30:178–86.
   PubMed Web of Science ®Google Scholar
• Shareef S, Sawada A, Neufeld AH. Isoforms of nitric oxide synthase in the optic nerves of rat eyes with chronic moderately elevated intraocular pressure. Invest Ophthalmol Vis Sci 1999;40:2884–91.
   PubMed Web of Science ®Google Scholar
• Neufeld AH, Sawada A, Becker B. Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad Sci USA 1999;96:9944–48.
   PubMed Web of Science ®Google Scholar
• Sarih M, Souvannavong V, Adam A. Nitric oxide synthase induces macrophage death by apoptosis. Biochem Biophys Res Commun 1993;191:503–18.
   PubMed Web of Science ®Google Scholar
• Hu J, Van Eldik LJ. S100 beta induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway. Biochim Biophys Acta 1996;1313:239–45.
   PubMed Web of Science ®Google Scholar
• Heneka MT, Loschmann PA, Gleichmann M, Weller M, Schulz JB, Wullner U, et al. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J Neurochem 1998;71:88–94.
   PubMed Web of Science ®Google Scholar
• Reed JC. Mechanisms of apoptosis. Am J Pathol 2000;157:1415–30.
   PubMed Web of Science ®Google Scholar
• Kim HS, Park CK. Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program. Brain Res 2005;1057:17–28.
   PubMed Web of Science ®Google Scholar
• Saeki K, Kobayashi N, Inazawa Y, Zhang H, Nishitoh H, Ichijo H, et al. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. Biochem J 2002;368:705–20.
   PubMed Web of Science ®Google Scholar
• Jun CD, Oh CD, Kwak HJ, Pae HO, Yoo JC, Choi BM, et al. Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. J Immunol 1999;162:3395–401.
   PubMed Web of Science ®Google Scholar
• Hortelano S, Alvarez AM, Bosca L. Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increase of mitochondrial transmembrane potential in macrophages. FASEB J 1999;13:2311–7.
   PubMed Web of Science ®Google Scholar
• Kim YM, Bombeck CA, Billiar TR. Nitric oxide as a bifunctional regulator of apoptosis. Circ Res 1999;84:253–6.
   PubMed Web of Science ®Google Scholar
• McKinnon SJ, Lehman DM, Kerrigan-Baumrind LA, Merges CA, Pease ME, Kerrigan DF, et al. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci 2002;43:1077–87.
   PubMed Web of Science ®Google Scholar
• Levkovitch-Verbin H, Dardik R, Vander S, Melamed S. Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve. Exp Eye Res 2010;91:127–34.
   PubMed Web of Science ®Google Scholar
• Levkovitch-Verbin H, Harizman N, Dardik R, Nisgav Y, Vander S, Melamed S. Regulation of cell death and survival pathways in experimental glaucoma. Exp Eye Res 2007;85:250–8.
   PubMed Web of Science ®Google Scholar
• Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-kappa B, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 1999;45:7–17.
   PubMed Web of Science ®Google Scholar
• Peng HB, Libby P, Liao JK. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem 1995;270:14214–9.
   PubMed Web of Science ®Google Scholar
• Xu H, Chen M, Forrester JV. Para-inflammation in the aging retina. Prog Retin Eye Res 2009;28:348–68.
   PubMed Web of Science ®Google Scholar
• Schwartz M. Macrophages and microglia in central nervous system injury: are they helpful or harmful? J Cereb Blood Flow Metab 2003;23:385–94.
   PubMed Web of Science ®Google Scholar
• Ransohoff RM, Perry VH. Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol 2009;27:119–45.
   PubMed Web of Science ®Google Scholar
• Schwartz M, Kipnis J. Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'. Trends Immunol 2002;23:530–4.
   PubMed Web of Science ®Google Scholar
• Tezel G, Yang X, Luo C, Kain AD, Powell DW, Kuehn MH, et al. Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci 2010;51:5071–82.
   PubMed Web of Science ®Google Scholar
• Tezel G, Luo C, Yang X. Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci 2007;48:1201–11.
   PubMed Web of Science ®Google Scholar
• Lin L. RAGE on the Toll Road? Cell Mol Immunol 2006;3:351–8.
   PubMed Web of Science ®Google Scholar
• Pun PB, Lu J, Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res 2009;43:348–64.
   PubMed Web of Science ®Google Scholar
• Feilchenfeld Z, Yucel YH, Gupta N. Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma. Exp Eye Res 2008;87:409–14.
   PubMed Web of Science ®Google Scholar
• Luo C, Yang X, Kain AD, Powell DW, Kuehn MH, Tezel G. Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling. Invest Ophthalmol Vis Sci 2010;51:5697–707.
   PubMed Web of Science ®Google Scholar
• Roberts RL, Green J, Lewis B. Lutein and zeaxanthin in eye and skin health. Clin Dermatol 2009;27:195–201.
   PubMed Web of Science ®Google Scholar
• Rhone M, Basu A. Phytochemicals and age-related eye diseases. Nutr Rev 2008;66:465–72.
   PubMed Web of Science ®Google Scholar
• Cort A, Ozturk N, Akpinar D, Unal M, Yucel G, Aslan M, et al. Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure. Regul Toxicol Pharmacol 2010;58:121–30.
   PubMed Web of Science ®Google Scholar
• Mozaffarieh M, Grieshaber MC, Orgul S, Flammer J. The potential value of natural antioxidative treatment in glaucoma. Surv Ophthalmol 2008;53:479–505.
   PubMed Web of Science ®Google Scholar
• Agorastos A, Huber CG. The role of melatonin in glaucoma: implications concerning pathophysiological relevance and therapeutic potential. J Pineal Res. 2011;50:1–7.
   PubMed Web of Science ®Google Scholar
• Johnson J, Maher P, Hanneken A. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. Invest Ophthalmol Vis Sci. 2009;50:2398–406.
   PubMed Web of Science ®Google Scholar
• Luna C, Li G, Liton PB, Qiu J, Epstein DL, Challa P, et al. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food Chem Toxicol 2009;47:198–204.
   PubMed Web of Science ®Google Scholar
• Chung HS, Harris A, Kristinsson JK, Ciulla TA, Kagemann C, Ritch R. Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther 1999;15:233–40.
   PubMed Web of Science ®Google Scholar
• Quaranta L, Bettelli S, Uva MG, Semeraro F, Turano R, Gandolfo E. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology 2003;110:359–62; discussion 62–4.
   PubMed Web of Science ®Google Scholar
• Ritch R. Potential role for Ginkgo biloba extract in the treatment of glaucoma. Med Hypotheses 2000;54:221–35.
   PubMed Web of Science ®Google Scholar
• Choi JH, Ryu YW, Seo JH. Biotechnological production and applications of coenzyme Q10. Appl Microbiol Biotechnol 2005;68:9–15.
   PubMed Web of Science ®Google Scholar
• Tomasetti M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J 2001;15:1425–7.
   PubMed Web of Science ®Google Scholar
• Takahashi N, Iwasaka T, Sugiura T, Onoyama H, Kurihara S, Inada M, et al. Effect of coenzyme Q10 on hemodynamic response to ocular timolol. J Cardiovasc Pharmacol 1989;14:462–8.
   PubMed Web of Science ®Google Scholar
• Saenz DA, Turjanski AG, Sacca GB, Marti M, Doctorovich F, Sarmiento MI, et al. Physiological concentrations of melatonin inhibit the nitridergic pathway in the Syrian hamster retina. J Pineal Res 2002;33:31–6.
   PubMed Web of Science ®Google Scholar
• Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004;36:1–9.
   PubMed Web of Science ®Google Scholar
• Zanon-Moreno V, Garcia-Medina JJ, Gallego-Pinazo R, Vinuesa-Silva I, Moreno-Nadal MA, Pinazo-Duran MD. Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma. Eur J Ophthalmol 2009;19:565–71.
   PubMed Web of Science ®Google Scholar
• Yu AL, Fuchshofer R, Kampik A, Welge-Lussen U. Effects of oxidative stress in trabecular meshwork cells are reduced by prostaglandin analogues. Invest Ophthalmol Vis Sci 2008;49:4872–80.
   PubMed Web of Science ®Google Scholar
• Butorov IV, Nikolenko IA, Butorov SI. [Efficacy of galavit in patients with duodenal ulcer]. Klin Med (Mosk) 2005;83:72–5.
   PubMedGoogle Scholar
• Jiang Y, Scofield VL, Yan M, Qiang W, Liu N, Reid AJ, et al. Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit). J Virol 2006;80:4557–69.
   PubMed Web of Science ®Google Scholar
• Gionfriddo JR, Freeman KS, Groth A, Scofield VL, Alyahya K, Madl JE. alpha-Luminol prevents decreases in glutamate, glutathione, and glutamine synthetase in the retinas of glaucomatous DBA/2J mice. Vet Ophthalmol 2009;12:325–32.
   PubMed Web of Science ®Google Scholar
• Dogan S, Unal M, Ozturk N, Yargicoglu P, Cort A, Aslan M, et al. Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. Exp Eye Res 2011;93:387–96.
   PubMed Web of Science ®Google Scholar
• Babizhayev MA, Kasus-Jacobi A. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases. Curr Clin Pharmacol 2009;4:4–37.
   PubMedGoogle Scholar
• Babizhayev MA. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine. Fundam Clin Pharmacol 2012;26:86–117.
   PubMed Web of Science ®Google Scholar