Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria

REFERENCES

• Basco, L. K. & le Bras, J. (1994). In vitro reversal of chloroquine resistance with chlorpheniramine in African isolates of Plasmodium falciparum. Japanese Journal of Biology, 47,59–63.
   PubMedGoogle Scholar
• Dorsey, G., Kamya, M. R., Ndeezi, G., Barbiye, J. N., Phares, C. R, Olson, J. E., Katabira, E. T. & Rosenthal, P. J. (2000). Predictors of chloroquine treatment failure in children and adults with falci-parum malaria in Kampala, Uganda. American Journal of Tropical Medicine and Hygiene, 62, 686–692.
   PubMed Web of Science ®Google Scholar
• Ezeilo, G. C. (1971). Neutropenia in Africans. Tropical and Geographical Medicine, 23, 264–267.
   PubMedGoogle Scholar
• Hamer, D. H., Macleod, W. B., Addo-Yobo, E., Duggan, C. P., Estrella, B., Fawzi, W. W., Konde-Lule, J. K., Mwanakasale, V., Premji, Z. G., Sempértegui, F., Ssengooba, F. P., Yeboa-Antwi, K. & Simon, J. L. (2003). Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97, 422–428.
   PubMed Web of Science ®Google Scholar
• Hess, F. I., Iannuzzi, A., Leafasia, J., Cowdrey, D., Nothdurft, H. D., von Sonnenburg, F., Loscher, T. & Rieckmann, K. H. (1996). Risk factors of chloroquine resistance in Plasmodium falciparum. Acta Tropica, 61, 293–306.
   PubMed Web of Science ®Google Scholar
• Oduola, A. M. J., Sowunmi, A., Milhous, W. K., Brewer, T. G., Kyle, D. E., Gerena, L., Rossan, R., Salako, L. A. & Schuster, B. G. (1998). In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine. American Journal of Tropical Medicine and Hygiene, 58, 625–629.
   PubMed Web of Science ®Google Scholar
• Peters, W., Ekong, R., Robinson, B. L. & Warhurst, D. C. (1989). Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum. Lancet, ii, 334–335.
   PubMed Web of Science ®Google Scholar
• Salako, L. A., Ajayi, F. O., Sowunmi, A. & Walker, O. (1990). Malaria in Nigeria: a revisit. Annals of Tropical Medicine and Parasitology, 84, 435–445.
   PubMed Web of Science ®Google Scholar
• Shaper, A. G. & Lewis, P. (1971). Genetic neutropenia in people of African origin. Lancet, ii, 1021–1023.
   Google Scholar
• Singhasivanon, V., Chongsuphajasiddhi, T., Sabcharoen, A., Attanath, P., Webster, H. K., Wemsdorfer, W. H., Sheth, U. K. & Djaja Lika, I. (1992). Pharmacokinetics of mefloquine in children aged 6 to 24 months. European Journal of Drug Metabolism and Pharmacokinetks, 17,275–279.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. (2003). A randomized comparison of chloroquine and chloroquine plus ketotifen, in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology, 97, 103–117.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A. & Oduola, A. M. J. (1997). Comparative efficacy of chloroquine-chlorpheniramine combina-tion and mefloquine in the treatment of chloroquine-resistant Plasmodium falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 689–693.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Akindele, J. A. & Balogun, M. A. (1995). Leukocyte counts in falciparum malaria in African children from an endemic area. African Journal of Medicine and Medical Sciences, 24,145–149.
   PubMedGoogle Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T., Falade, C. O., Gbotosho, G. O. & Salako, L. A. (1997a). Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncompli-cated falciparum malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 63–67.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T., Fehintola, F. A. & Salako, L. A. (1997b). Pharmacokinetic interactions of chlorpheniramine and chloroquine in volunteers from Nigeria. American Journal of Tropical Medicine and Hygiene, 57 (Suppl.), 102–103.
   Google Scholar
• Sowunmi, A., Fehintola, F. A., Ogundahunsi, O. A. T. & Oduola, A. M. J. (1998a). Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 441–445.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T. & Salako, L. A. (1998b). Enhancement of the antimalarial effect of chloroquine by chlorphenira-mine in vivo. Tropical Medicine and International Health, 3, 177–183.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Oduola, A. M. J., Ogundahunsi, O. A. T. & Salako, L. A. (1998c). Comparative efficacy of chloroquine plus chlorpheniramine and pyrimetha-mine-sulphadoxine in acute uncomplicated falci-parum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 77–81.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Adedapo, A. D. A., Fehintola, F. A., Sowunmi, C. O., Adedeji, A. A., Falade, A. G. & Oduola, A. M. J. (2000a). Comparative efficacy and safety of two regimens of chlorpheniramine plus chloroquine in acute, uncomplicated, falciparum malaria in children. Clinical Drug Investigation, 20, 317–325.
   Web of Science ®Google Scholar
• Sowunmi, A., Fehintola, F. A., Adedeji, A. A., Falade, A. G., Falade, C. O., Akinyinka, O. O., & Oduola, A. M. J. (2000b). Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimetharnine, for the treatment of acute, uncomplicated, falci-parum malaria in children. Annals of Tropical Medicine and Parasitology, 94, 209–217.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Ayede, A. I., Falade, A. G., Ndikum, V. N., Sowunmi, C. O., Adedeji, A. A., Falade, C. O., Happi, T. C. & Oduola, A. M. J. (2001). Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncompli-cated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology, 95, 549–558.
   PubMed Web of Science ®Google Scholar
• Sowunmi, A., Fateye, B. A., Adedeji, A. A., Fehintola, F. A. & Happi, T. C. (2004). Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children. Parasitology, 129, 255–262.
   PubMed Web of Science ®Google Scholar
• Walker, O., Dawodu, A. H., Adeyokunnu, A. A., Salako, L. A. & Alvan, G. (1983). Plasma chlor-oquine and desthylchloroquine concentration in children during and after chloroquine treatment for malaria. British Journal of Clinical Pharmacology, 16, 701–705.
   PubMed Web of Science ®Google Scholar
• Walker, O., Salako, L. A., Alvan, G., Ericsson, Ö. & Sjöqvist, F. (1987). The disposition of chloroquine in healthy Nigerians after single intravenous and oral doses. British Journal of Clinical Pharmacology, 23, 295–301.
   PubMed Web of Science ®Google Scholar
• World Health Organization (1973). Chemotherapy of Malaria and Resistance to Antimalarials. Technical Report Series No. 529. Geneva: WHO.
   Google Scholar
• World Health Organization (2000). Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 94 (Suppl.), 1–90.
   Google Scholar