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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 18, 2015 - Issue 4
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Original Research Papers

Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trial

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References

  • de Wit L, van Straten A, van Herten M, Penninx B, Cuijpers P. Depression and body mass index, a u-shaped association. BMC Public Health 2009;9(1):14.
  • Sadeghirad B, Haghdoost AA, Amin-Esmaeili M, Ananloo ES, Ghaeli P, Rahimi-Movaghar A, et al. Epidemiology of major depressive disorder in Iran: a systematic review and meta-analysis. Int J Prev Med 2010;1(2):81–91.
  • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006;3(11):e442.
  • Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007;10(9):1089–93.
  • Duman R. Pathophysiology of depression: the concept of synaptic plasticity. Eur Psychiatry 2002;17:306–10.
  • Lee B-H, Kim Y-K. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Invest 2010;7(4):231–5.
  • Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood–brain barrier. Neuropharmacology 1998;37(12):1553–61.
  • Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54(1):70–5.
  • Castrén E, Võikar V, Rantamäki T. Role of neurotrophic factors in depression. Curr Opin Pharmacol 2007;7(1):18–21.
  • Lee B-H, Kim H, Park S-H, Kim Y-K. Decreased plasma BDNF level in depressive patients. J Affect Disord 2007;101(1):239–44.
  • Castrén E, Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev Neurobiol 2010;70(5):289–97.
  • Nowak G, Siwek M, Dudek D, Zieba A, Pilc A. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Pol J Pharmacol 2003;55(6):1143–7.
  • Siwek M, Dudek D, Schlegel-Zawadzka M, Morawska A, Piekoszewski W, Opoka W, et al. Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. J Affect Disord 2010;126(3):447–52.
  • Amani R, Saeidi S, Nazari Z, Nematpour S. Correlation between dietary zinc intakes and its serum levels with depression scales in young female students. Biol Trace Elem Res 2010;137(2):150–8.
  • Siwek M, Dudek D, Paul IA, Sowa-Kucma M, Zieba A, Popik P, et al. Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. J Affect Disord 2009;118(1–3):187–95.
  • Szewczyk B, Kubera M, Nowak G. The role of zinc in neurodegenerative inflammatory pathways in depression. Prog Neuropsychopharmacol Biol Psychiatry 2011;35(3):693–701.
  • Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 2010;67(3):220–9.
  • Monteleone P, Tortorella A, Martiadis V, Serritella C, Fuschino A, Maj M. Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity. Psychosom Med 2004;66(5):744–8.
  • Araya AV, Orellana X, Espinoza J. Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences. Endocrine 2008;33(3):300–4.
  • Voruganti VS, Cai G, Klohe DM, Jordan KC, Lane MA, Freeland-Graves JH. Short-term weight loss in overweight/obese low-income women improves plasma zinc and metabolic syndrome risk factors. J Trace Elem Med Biol 2010;24(4):271–6.
  • Ozata M, Mergen M, Oktenli C, Aydin A, Yavuz Sanisoglu S, Bolu E, et al. Increased oxidative stress and hypozincemia in male obesity. Clin Biochem 2002;35(8):627–31.
  • Sawada T, Yokoi K. Effect of zinc supplementation on mood states in young women: a pilot study. Eur J Clin Nutr 2010;64(3):331–3.
  • Ghassemzadeh H, Mojtabai R, Karamghadiri N, Ebrahimkhani N. Psychometric properties of a Persian-language version of the Beck Depression Inventory – Second edition: BDI-II-PERSIAN. Depress Anxiety 2005;21(4):185–92.
  • Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;195(9131/03):1381–1395.
  • Zich JM, Attkisson CC, Greenfield TK. Screening for depression in primary care clinics: the CES-D and the BDI. Int J Psychiatry Med 1990;20(3):259–77.
  • Cieślik K, Klenk-Majewska B, Danilczuk Z, Wróbel A, Łupina T, Ossowska G. Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats. Pharmacol Rep 2006;59(1):46–52.
  • Corona C, Masciopinto F, Silvestri E, Del Viscovo A, Lattanzio R, La Sorda R, et al. Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction. Cell Death Dis 2010;1(10):e91.
  • Sowa-Kućma M, Legutko B, Szewczyk B, Novak K, Znojek P, Poleszak E, et al. Antidepressant-like activity of zinc: further behavioral and molecular evidence. J Neural Transm 2008;115(12):1621–8.
  • Nowak G, Legutko B, Szewczyk B, Papp M, Sanak M, Pilc A. Zinc treatment induces cortical brain-derived neurotrophic factor gene expression. Eur J Pharmacol 2004;492(1):57–9.
  • Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 2008;63(7):642–9.
  • Gould E, Gross CG. Neurogenesis in adult mammals: some progress and problems. J Neurosci 2002;22(3):619–23.
  • Lee E, Son H. Adult hippocampal neurogenesis and related neurotrophic factors. BMB Rep 2009;42(5):239–44.
  • Radka SF, Hoist PA, Fritsche M, Altar CA. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 1996;709(1):122–30.
  • Yamamoto H, Gurney ME. Human platelets contain brain-derived neurotrophic factor. J Neurosci 1990;10(11):3469–78.
  • Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry J-M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002;109(2):143–8.
  • Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry J-M, Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005;57(9):1068–72.
  • Gonul AS, Akdeniz F, Taneli F, Donat O, Eker Ç, Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005;255(6):381–6.
  • Carpenter WT Jr. Placebo effect in depression. Am J Psychiatry 2009;166(8):935.
  • de la Fuente-Fernández R, Schulzer M, Stoessl AJ. The placebo effect in neurological disorders. Lancet Neurol 2002;1(2):85–91.
  • Makonnen B, Venter A, Joubert G. A randomized controlled study of the impact of dietary zinc supplementation in the management of children with protein–energy malnutrition in Lesotho. I: mortality and morbidity. J Trop Pediatr 2003;49(6):340–52.
  • Hwang JJ, Park M-H, Choi S-Y, Koh J-Y. Activation of the Trk signaling pathway by extracellular Zinc: role of metalloproteinases. J Biol Chem 2005;280(12):11995–2001.

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