3′,4′-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia

References

• Roine RO. Global cerebral ischemia. In: Fisher M Bogouslavsky J, (eds.) Current review of cerebrovascular disease. Philadelphia: Current Medicine, 1997. p. 159–77.
   Google Scholar
• Garcia JH. The evolution of brain infarcts. A review. J Neuropathol Exp Neurol 1992;51(4):387–93. doi: 10.1097/00005072-199207000-00001
   PubMed Web of Science ®Google Scholar
• Kirino T. Delayed neuronal death. Neuropathology 2000;20(Suppl):S95–7. doi: 10.1046/j.1440-1789.2000.00306.x
   Google Scholar
• Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999;79(4):1431–568.
   PubMed Web of Science ®Google Scholar
• Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982;239(1):57–69. doi: 10.1016/0006-8993(82)90833-2
   PubMed Web of Science ®Google Scholar
• Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982;297(5868):681–3. doi: 10.1038/297681a0
   PubMed Web of Science ®Google Scholar
• Block F. Global ischemia and behavioural deficits. Prog Neurobiol 1999;58(3):279–95. doi: 10.1016/S0301-0082(98)00085-9
   PubMed Web of Science ®Google Scholar
• Hartman RE, Lee JM, Zipfel GJ, Wozniak DF. Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats. Brain Res 2005;1043(1–2):48–56. doi: 10.1016/j.brainres.2005.02.030
   PubMed Web of Science ®Google Scholar
• Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 1986;6(10):2950–67.
   PubMed Web of Science ®Google Scholar
• Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52(4):673–751.
   PubMed Web of Science ®Google Scholar
• Hendriks JJ, Alblas J, van der Pol SM, van Tol EA, Dijkstra CD, de Vries HE. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J Exp Med 2004;200(12):1667–72. doi: 10.1084/jem.20040819
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001;74(4):418–25.
   PubMed Web of Science ®Google Scholar
• Zhao G, Zang SY, Jiang ZH, Chen YY, Ji XH, Lu BF, et al. Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model. J Nutr Biochem 2011;22(10):929–36. doi: 10.1016/j.jnutbio.2010.07.014
   PubMed Web of Science ®Google Scholar
• Crozier A, Burns J, Aziz AA, Stewart AJ, Rabiasz HS, Jenkins GI, et al. Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability. Biol Res 2000;33(2):79–88. doi: 10.4067/S0716-97602000000200007
   PubMed Web of Science ®Google Scholar
• Chan EC, Drummond GR, Woodman OL. 3′,4′-dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat. J Cardiovasc Pharmacol 2003;42(6):727–35. doi: 10.1097/00005344-200312000-00006
   PubMed Web of Science ®Google Scholar
• Wang S, Dusting GJ, May CN, Woodman OL. 3′,4′-Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep. Br J Pharmacol 2004;142(3):443–52. doi: 10.1038/sj.bjp.0705815
   PubMed Web of Science ®Google Scholar
• Roulston CL, Callaway JK, Jarrott B, Woodman OL, Dusting GJ. Using behaviour to predict stroke severity in conscious rats: post-stroke treatment with 3′,4′-dihydroxyflavonol improves recovery. Eur J Pharmacol 2008;584(1):100–10. doi: 10.1016/j.ejphar.2008.01.046
   PubMed Web of Science ®Google Scholar
• Singh DP, Chopra K. Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. Eur J Pharmacol 2013;720(1–3):98–106. doi: 10.1016/j.ejphar.2013.10.043
   PubMed Web of Science ®Google Scholar
• Karakas A, Coskun H, Kaya A, Kucuk A, Gunduz B. The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. Behav Brain Res 2011;222(1):141–50. doi: 10.1016/j.bbr.2011.03.029
   PubMed Web of Science ®Google Scholar
• Kanhere R, Anjana A, Anbu J, Sumithra M, Ahamed N. Neuroprotective and antioxidant potential of terpenoid fraction from Hygrophila auriculata against transient global cerebral ischemia in rats. Pharm Biol 2013;51(2):181–9. doi: 10.3109/13880209.2012.716851
   PubMed Web of Science ®Google Scholar
• Milot M, Plamondon H. Ischemia-induced hyperactivity: effects of dim versus bright illumination on open-field exploration and habituation following global ischemia in rats. Behav Brain Res 2008;192(2):166–72. doi: 10.1016/j.bbr.2008.03.044
   PubMed Web of Science ®Google Scholar
• Plamondon H, Khan S. Characterization of anxiety and habituation profile following global ischemia in rats. Physiol Behav 2005;84(4):543–52. doi: 10.1016/j.physbeh.2005.02.001
   PubMed Web of Science ®Google Scholar
• Block F, Schwarz M. Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats. Brain Res 1996;741(1–2):153–9. doi: 10.1016/S0006-8993(96)00916-X
   PubMed Web of Science ®Google Scholar
• Karasawa Y, Araki H, Otomo S. Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in Mongolian gerbils. Stroke 1994;25(3):645–50. doi: 10.1161/01.STR.25.3.645
   PubMed Web of Science ®Google Scholar
• Hamadate N, Yamaguchi T, Sugawara A, Togashi H, Izumi T, Yoshida T, et al. Liposome-encapsulated hemoglobin ameliorates impairment of fear memory and hippocampal dysfunction after cerebral ischemia in rats. J Pharmacol Sci 2010;114(4):409–19. doi: 10.1254/jphs.10207FP
   PubMed Web of Science ®Google Scholar
• Girbovan C, Morin L, Plamondon H. Repeated resveratrol administration confers lasting protection against neuronal damage but induces dose-related alterations of behavioral impairments after global ischemia. Behav Pharmacol 2012;23(1):1–13. doi: 10.1097/FBP.0b013e32834eafa3
   PubMed Web of Science ®Google Scholar
• Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1(2):848–58. doi: 10.1038/nprot.2006.116
   PubMed Web of Science ®Google Scholar
• Cheng O, Li Z, Han Y, Jiang Q, Yan Y, Cheng K. Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis. Brain Res 2012;1470:111–8. doi: 10.1016/j.brainres.2012.06.026
   PubMed Web of Science ®Google Scholar
• Hu X, Zhang Y, Li W, Liu J, Li Y. Preconditioning with sevoflurane ameliorates spatial learning and memory deficit after focal cerebral ischemia-reperfusion in rats. Int J Dev Neurosci 2013;31(5):328–33. doi: 10.1016/j.ijdevneu.2013.04.004
   PubMed Web of Science ®Google Scholar
• Han B, Wang Q, Cui G, Shen X, Zhu Z. Post-treatment of Bax-inhibiting peptide reduces neuronal death and behavioral deficits following global cerebral ischemia. Neurochem Int 2011;58(2):224–33. doi: 10.1016/j.neuint.2010.12.008
   PubMed Web of Science ®Google Scholar
• Wang S, Dusting GJ, Woodman OL, May CN. Selective vasodilator and chronotropic actions of 3′,4′-dihydroxyflavonol in conscious sheep. Eur J Pharmacol 2004;491(1):43–51. doi: 10.1016/j.ejphar.2004.03.012
   PubMed Web of Science ®Google Scholar
• Wang S, Fei K, Xu YW, Wang LX, Chen YQ. Dihydroxyflavonol reduces post-infarction left ventricular remodeling by preventing myocyte apoptosis in the non-infarcted zone in goats. Chin Med J 2009;122(1):61–7.
   PubMed Web of Science ®Google Scholar
• Qin CX, Williams SJ, Woodman OL. Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts. Free Radic Biol Med 2011;51(7):1437–44. doi: 10.1016/j.freeradbiomed.2011.07.003
   PubMed Web of Science ®Google Scholar
• Leo CH, Hart JL, Woodman OL. 3′,4′-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries. PLoS One 2011;6(6):e20813. doi: 10.1371/journal.pone.0020813
   Google Scholar
• Woodman OL, Chan E. Vascular and anti-oxidant actions of flavonols and flavones. Clin Exp Pharmacol Physiol 2004;31(11):786–90. doi: 10.1111/j.1440-1681.2004.04072.x
   PubMed Web of Science ®Google Scholar