- Dauer W, Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 2003; 11: 889–909
- Schober A. Classic toxin-induced animal models of Parkinson's disease: 6-0HDA and MPTP. Cell Tissue Res 2004; 318: 215–224
- Ingham CA, Hodd SH, Maldegem B, et al. Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injec-tions in to the nigrostriatal pathway. Exp Brain Res 1993; 93: 17–27
- Pickel VM, Johnson E, Carson M, et al. Ultrastructure of spared dopamine terminals in caudate—putamen nuclei of adult rats neonatally treated with intranigral 6-hydroxydopamine. Dev Brain Res 1992; 70: 75–86
- Jedrzejewska A, Wierzba-Bobrowicz T, Olejniczak P, et a/. Ultrastructure and immunocytochemistry of left and right nigros-triatal system after lesion of right side of substantia nigra of rat. Adv Neurol 1990; 53: 41–49
- Finkelstein DI, Stanic D, Parish CL, et al. Axonal sprouting following lesions of the rat substantia nigra. Neuroscience 2000; 97: 99–112
- Ingham CA, Hood SH, Arbuthnott GW. A light and electron microscopical study of enkephalin-immunoreactive structures in the rat neostriatum after removal of the nigrostriatal dopaminergic pathway. Neuroscience 1991; 42: 715–730
- Arbuthnott GW, Ingham CA, Wickens JR. Dopamine and synaptic plasticity in the neostriatum. I Anat 2000; 196: 587–596
- Stanic D, Parish CL, Zhu WM, et al. Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc. I Neurochem 2003; 86: 329–343
- Hahn Z, Karádi Z, Lenárd L. Striatal dopamine levels after unilateral lesions of the substantia nigra: Evidence for a contral-ateral decrease. Acta Physiol Acad Sci Hung 1980; 57; 249–253
- Sheng JG, Shirabe S, Nishiyama N, et al Alterations in striatal glial fibrillary acidic protein expression in response to 6-hydroxydopa-mine-induced denervation. Exp Brain Res 2004; 95: 450–456
- Xu ZC, Ling G, Sahr RN, et a/. Asymmetrical changes of dopamine receptors in the striatum after unilateral dopamine depletion. Brain Res 2005; 1038: 163–170
- Sgado P, Alberi L, Gherbassi D, et al. Slow progressive degeneration of nigral dopaminergic neurons in postnatal engrailed mutant mice. Proc Nat! Acad Sci USA 2006; 103: 1242-1247
- Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd edn, New York: Academic Press, 1986
- Ungerstedt U, Arbuthnott GW. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigros-triatal dopamine system. Brain Res 1970; 24, 485–493
- Avila-Costa MR, Colin-Barenque L, Montiel-Flores E, et al. Bromocriptine treatment in a murine Parkinson's model. Ultrastructural evaluation after dopaminergic deafferentation. Int I Neurosci 2005; 115: 851–859
- Avila-Costa MR, Colin-Barenque L, Aley-Medina P, etal. Bilateral increase of perforated synapses after unilateral dopamine deple-tion. Intl Neurosci 2005; 115: 79–86
- Calverley RK, Jones DG. Serial-section study of perforated synapses in rat neocortex. Cell Tissue Res 1987; 247: 565–572
- Zuch CL, Nordstroem VK, Briedrick LA, et al. Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. I Comp Neurol 2000; 427: 440–454
- Cass WA, Harned ME, Bailey SL. Enhanced effects of 6-hydroxydopamine on evoked overflow of striatal dopamine in aged rats. Brain Res 2002; 938: 29–37
- Wakako M. Dopaminergic neuronal death in aging. Biomed Gerontol 2002; 26: 146–151
- Harada N, Nishiyama S, Satoh K, etal. Age-related changes in the striatal dopaminergic system in the living brain: A multiparametric PET study in conscious monkeys. Synapse 2002; 45: 38–45
- Siddiqi ZA, Peters A. The effect of aging on pars compacta of the substantia nigra in rhesus monkey. I Neuropathol Exp Neurol 1999; 58: 903–920
- Zaja-Milatovic S, Milatovic D, Schantz AM, et a/. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Neurology 2005; 64: 545–547
- Machado-Salas JP, lbarra O, Martinez-Fong D, et al. Degenerative ultrastructural changes observed in the neuropil of caudate nuclei from Parkinson's disease patients. Stereotact Funct Neurosurg 1989; 54-55: 297-305
- Bolam JP, Hanley JJ, Booth P, et al. Synaptic organisation of the basal ganglia. I Anat 2000; 196: 527–542
- Solis 0, Limon DI, Flores-Hernández J, et a/. Alterations in dendritic morphology of the prefrontal cortical and striatum neurons in the unilateral 6-0HDA-rat model of Parkinson's disease. Synapse 2007; 61: 450–458
- McNeill TH, Brownn SA, Rafols JA, etal. Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease. Brain Res 1988; 455: 148–152
- Yung KKL, Smith AD, Levey Al, et al. Synaptic connections between spiny neurons of the direct and indirect pathways in the neostriatum of the rat: Evidence from dopamine receptor and neuropeptide immunostaining. Eur Neurosci 1996; 8: 861–869
- Ingham CA, Hood SH, Taggart P, etal. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopami-nergic pathway. Neurosci 1998; 18: 4732–4743
- Seroogy KB, Lundgren KH, Tran TMD, et al. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs. I Comp Neurol 1994; 342: 321-334
- Itarat W, Jones DG. Perforated synapses are present during synaptogenesis in rat neocortex. Synapse 1992; 11: 279–286
- Sirevaag AM, Greenough WT. Differential rearing effects on rat visual cortex synapses. II. Synaptic morphometry. Dev Brain Res 1985; 19: 215–226
- Geinisman Y, Morrell F, de Toledo-Morrell L. Increase in the number of axospinous synapses with segmented postsynaptic densities following hippocampal kindling. Brain Res 1992; 569: 341–347
- Geinisman Y, Berry RW, Disterhoft JF, et al. Associative learning elicits the formation of multiple-synapse boutons. I Neurosci 2001; 21: 5568–5573
- Geinisman Y, de Toledo-Morrell L, Morrell F. Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory. Brain Res 1986; 398: 266–275
- Anglade P, Mouatt-Prigent A, Agid Y, et al. Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease. Neurodegeneration 1996; 5: 121–128
- Meshul CK, Allen C. Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-0HDA lesion. Synapse 2000; 36: 129–142
- Nieto-Sampedro M, Hoff SF, Cotman CW. Perforated postsynaptic densities: Probable intermediates in synapse turnover. Proc Nat! Acad Sci USA 1982; 79: 5718–5722
- Toni N, Buchs PA, Nikonenko I, et al. Remodeling of synaptic membranes after induction of long-term potentiation. I Neurosci 2001; 21: 6245–6251
- Meshul CK, Tan S-E. Haloperidol-induced morphological altera-tions are associated with changes in calcium/calmodulin kinase II activity and glutamate immunoreactivity. Synapse 1994; 18: 205–217
- Yang J, Sadler TR, Givrad TK, et a/. Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats. Neuroimage 2007; 36: 755–773
- Fass B, Butcher LL. Evidence for a crossed nigrostriatal pathway in rats. Neurosci Lett 1981; 22: 109–113
- Emsley JG, Lu X, Hagg T. Retrograde tracing techniques influence reported death rates of adult rat nigrostriatal neurons. Exp Neurol 2001; 168: 425–433
- Goettl VM, Wemlinger TA, Colvin AE, et a/. Motoric behavior in aged rats treated with GM1. Brain Res 2002; 906: 92–100
- Colebrooke RE, Humby T, Lynch PJ, etal. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. Eur Neurosci 2006; 24: 2622–2630
- Romanov SP, Aleksanyan ZA, Lyskov EB. Age-related changes in the activity of the human motor system. Human Physiol 2007; 33: 455–466
- Joseph JA, Denisova N, Fisher D, et al. Age-related neurodegen-eration and oxidative stress putative nutritional intervention. Neurol Clin 1998; 16: 747–755
- Delacourte A, Sergeant N, Buée L. In vitro models of age-related neurodegenerative disorders. Exp Gerontol 2003; 38: 1309–1317
Time course changes of the striatum neuropil after unilateral dopamine depletion and the usefulness of the contralateral striatum as a control structure
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